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Conserved domains on  [gi|1337767441|ref|WP_103327718|]
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endonuclease III [Bacteroidetes bacterium endosymbiont of Geopemphigus sp.]

Protein Classification

endonuclease III( domain architecture ID 11415064)

endonuclease III is a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

EC:  4.2.99.18
Gene Symbol:  nth
Gene Ontology:  GO:0051539|GO:0140078

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-191 3.45e-102

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 294.70  E-value: 3.45e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  11 INILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLYNSKAKNI 90
Cdd:COG0177     1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  91 QALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQTEKDAKNLFPR 170
Cdd:COG0177    81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                         170       180
                  ....*....|....*....|.
gi 1337767441 171 ELWNKLHLQIIYYGREYSPAR 191
Cdd:COG0177   161 EYWGDLHHLLILHGRYICKAR 181
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-191 3.45e-102

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 294.70  E-value: 3.45e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  11 INILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLYNSKAKNI 90
Cdd:COG0177     1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  91 QALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQTEKDAKNLFPR 170
Cdd:COG0177    81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                         170       180
                  ....*....|....*....|.
gi 1337767441 171 ELWNKLHLQIIYYGREYSPAR 191
Cdd:COG0177   161 EYWGDLHHLLILHGRYICKAR 181
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 4-191 1.06e-81

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 242.67  E-value: 1.06e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   4 KDRINLIINILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLY 83
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  84 NSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQTEKD 163
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180
                  ....*....|....*....|....*...
gi 1337767441 164 AKNLFPRELWNKLHLQIIYYGREYSPAR 191
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKAR 188
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-186 2.69e-54

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 171.29  E-value: 2.69e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   39 LSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLYNSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337767441  119 GHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSV-EQTEKDAKNLFPRELWNKLHLQIIYYGRE 186
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTpEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-184 1.17e-50

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 162.41  E-value: 1.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  31 FTLLISVLLSAQSTDKKVNEISSDLFTK-ADTPEKMAALEVKKISELIKKIGlYNSKAKNIQALSKILIEKHHGQV---P 106
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337767441 107 DSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGL-SSGKSVEQTEKDAKNLFPRELWNKLHLQIIYYG 184
Cdd:cd00056    80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLiPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
PRK10702 PRK10702
endonuclease III; Provisional
 1-191 2.41e-50

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 163.26  E-value: 2.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   1 MQMKDRINlIINILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKI 80
Cdd:PRK10702    1 MNKAKRLE-ILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  81 GLYNSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQT 160
Cdd:PRK10702   80 GLYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQV 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1337767441 161 EKDAKNLFPRELWNKLHLQIIYYGREYSPAR 191
Cdd:PRK10702  160 EEKLLKVVPAEFKVDCHHWLILHGRYTCIAR 190
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-170 7.03e-40

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 134.33  E-value: 7.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  35 ISVLLSAQSTDKKVNEISSDLFTK-ADTPEKMAALEVKKISELIKKIGLYNSKAKNIQALSKILIEKHHGQVPDSFEELE 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1337767441 114 K-LPGVGHKTASVVMSQAF--SKTAFPVDTHIHRLMYRWGLSSG-KSVEQTEKDAKNLFPR 170
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALgrPDPLPVVDTHVRRVLKRLGLIKEkPTPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-191 3.45e-102

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 294.70  E-value: 3.45e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  11 INILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLYNSKAKNI 90
Cdd:COG0177     1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  91 QALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQTEKDAKNLFPR 170
Cdd:COG0177    81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                         170       180
                  ....*....|....*....|.
gi 1337767441 171 ELWNKLHLQIIYYGREYSPAR 191
Cdd:COG0177   161 EYWGDLHHLLILHGRYICKAR 181
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 4-191 1.06e-81

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 242.67  E-value: 1.06e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   4 KDRINLIINILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLY 83
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  84 NSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQTEKD 163
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180
                  ....*....|....*....|....*...
gi 1337767441 164 AKNLFPRELWNKLHLQIIYYGREYSPAR 191
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKAR 188
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-186 2.69e-54

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 171.29  E-value: 2.69e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   39 LSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKIGLYNSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337767441  119 GHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSV-EQTEKDAKNLFPRELWNKLHLQIIYYGRE 186
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTpEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-184 1.17e-50

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 162.41  E-value: 1.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  31 FTLLISVLLSAQSTDKKVNEISSDLFTK-ADTPEKMAALEVKKISELIKKIGlYNSKAKNIQALSKILIEKHHGQV---P 106
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337767441 107 DSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGL-SSGKSVEQTEKDAKNLFPRELWNKLHLQIIYYG 184
Cdd:cd00056    80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLiPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
PRK10702 PRK10702
endonuclease III; Provisional
 1-191 2.41e-50

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 163.26  E-value: 2.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   1 MQMKDRINlIINILESLYPNPSIPLQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKADTPEKMAALEVKKISELIKKI 80
Cdd:PRK10702    1 MNKAKRLE-ILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  81 GLYNSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRLMYRWGLSSGKSVEQT 160
Cdd:PRK10702   80 GLYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQV 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1337767441 161 EKDAKNLFPRELWNKLHLQIIYYGREYSPAR 191
Cdd:PRK10702  160 EEKLLKVVPAEFKVDCHHWLILHGRYTCIAR 190
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-170 7.03e-40

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 134.33  E-value: 7.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  35 ISVLLSAQSTDKKVNEISSDLFTK-ADTPEKMAALEVKKISELIKKIGLYNSKAKNIQALSKILIEKHHGQVPDSFEELE 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1337767441 114 K-LPGVGHKTASVVMSQAF--SKTAFPVDTHIHRLMYRWGLSSG-KSVEQTEKDAKNLFPR 170
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALgrPDPLPVVDTHVRRVLKRLGLIKEkPTPKEVERELEELWPP 141
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 1-187 2.18e-18

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 80.66  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441   1 MQMKDRINLIINILESLYPNpsiplQH----KDPFTLLISVLLsAQSTD-KKVnEISSDLFTKAD--TPEKMAALEVKKI 73
Cdd:COG2231     1 MNTKEDLLEIYERLLEHYGP-----QHwwpaETPFEVIVGAIL-TQNTSwKNV-EKAIANLKEAGllDPEALAALDPEEL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  74 SELIKKIGLYNSKAKNIQALSKILIEKHHGQVPDSF--------EELEKLPGVGHKTASVVMSQAFSKTAFPVDTHIHRL 145
Cdd:COG2231    74 AELIRPSGFYNQKAKRLKNLARWLVERYGGGLEKLKalpteelrEELLSLKGIGPETADSILLYAFNRPVFVVDAYTRRI 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1337767441 146 MYRWGLSSGKSveqTEKDAKNLFPR------ELWNKLHLQIIYYGREY 187
Cdd:COG2231   154 FSRLGLIEEDA---SYDELQRLFEEnlppdvALYNEFHALIVEHGKEY 198
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 81-139 1.35e-11

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 63.23  E-value: 1.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  81 GL-YNSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKTAFPVD 139
Cdd:COG1194    78 GLgYYSRARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVD 137
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 39-168 7.28e-10

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 57.72  E-value: 7.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  39 LSAQSTDKKVNEISSDLFTKA-DTPEKMAALEVKKISELIKKIGLYnSKAKNIQALSKILIEKHHGQVPDSFEELEKLPG 117
Cdd:PRK13910    1 MSQQTQINTVVERFYSPFLEAfPTLKDLANAPLEEVLLLWRGLGYY-SRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1337767441 118 VGHKTASVVMSQAFSKTAFPVDTHIHRLMYR-WGLSSGKSVEQTEKDAKNLF 168
Cdd:PRK13910   80 IGAYTANAILCFGFREKSACVDANIKRVLLRlFGLDPNIHAKDLQIKANDFL 131
PRK10880 PRK10880
adenine DNA glycosylase;
81-160 3.32e-09

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 56.26  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  81 GL-YNSKAKNIQALSKILIEKHHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKtAFPV-DTHIHRLMYRWGLSSG---- 154
Cdd:PRK10880   79 GLgYYARARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGK-HFPIlDGNVKRVLARCYAVSGwpgk 157


                  ....*.
gi 1337767441 155 KSVEQT 160
Cdd:PRK10880  158 KEVENR 163
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 28-173 3.75e-09

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 55.69  E-value: 3.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  28 KDPFTLLISVLLSA---------------QSTDKKVNEISSDLFTKADTPEKMAALEVKkisELIKKIGLyNSKAKNIQA 92
Cdd:TIGR00588 117 QDPFECLISFICSSnnniaritrmverlcQAFGPRLITLDGVTYHGFPSLHALTGPEAE---AHLRKLGL-GYRARYIRE 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  93 LSKILIEKHHG----------QVPDSFEELEKLPGVGHKTASVVMSQAFSKT-AFPVDTHIHRLM---YRWGLSSGKS-- 156
Cdd:TIGR00588 193 TARALLEEQGGrawlqqirgaSYEDAREALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIAnrdYPWHPKTSRAkg 272

                         170
                  ....*....|....*...
gi 1337767441 157 -VEQTEKDAKNLFpRELW 173
Cdd:TIGR00588 273 pSPFARKELGNFF-RSLW 289
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 100-128 2.89e-06

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 42.79  E-value: 2.89e-06
                          10        20
                  ....*....|....*....|....*....
gi 1337767441 100 KHHGQVPDSFEELEKLPGVGHKTASVVMS 128
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILS 29
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 25-195 4.16e-06

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 46.42  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  25 LQHKDPFTLLISVLLSAQSTDKKVNEISSDLFTKAD--------------TPEKMAALEVkkisELIKKIGLYNSKAKNI 90
Cdd:COG0122    79 PRRPDPFEALVRAILGQQVSVAAARTIWRRLVALFGepiegpggglyafpTPEALAAASE----EELRACGLSRRKARYL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  91 QALSKILIEK-------HHGQVPDSFEELEKLPGVGHKTASVVMSQAFSKT-AFPV-DTHIHRLMyRWGLSSGKSVeqTE 161
Cdd:COG0122   155 RALARAVADGeldlealAGLDDEEAIARLTALPGIGPWTAEMVLLFALGRPdAFPAgDLGLRRAL-GRLYGLGERP--TP 231

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1337767441 162 KDAknlfpRElwnklhlqiiyYGREYSPARG---WYL 195
Cdd:COG0122   232 KEL-----RE-----------LAEPWRPYRSyaaRYL 252
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 63-150 8.19e-04

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 39.45  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337767441  63 EKMAALEVKKISELIKKIGLYNSKAKNIQALSKILIEKHhgQVPDSFEE------LEKLPGVGHKTASVVMSQAFSKTAF 136
Cdd:PRK13913   70 KKIAYIEFSKLAECVRPSGFYNQKAKRLIDLSENILKDF--GSFENFKQevtrewLLDQKGIGKESADAILCYVCAKEVM 147

                          90
                  ....*....|....
gi 1337767441 137 PVDTHIHRLMYRWG 150
Cdd:PRK13913  148 VVDKYSYLFLKKLG 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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