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Conserved domains on  [gi|1335776814|gb|AUT50466|]
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carbon monoxide dehydrogenase [Paraburkholderia caribensis]

Protein Classification

CoxG family protein( domain architecture ID 10007350)

CoxG (carbon monoxide dehydrogenase subunit G) family protein belonging to the SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) superfamily; similar to Aeropyrum pernix hypothetical protein APE2225

Gene Ontology:  GO:0005488
PubMed:  18922149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoxG COG3427
Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];
1-146 6.86e-64

Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];


:

Pssm-ID: 442653  Cd Length: 145  Bit Score: 193.92  E-value: 6.86e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   1 MELTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEG 80
Cdd:COG3427     1 MELSGSFTVPAPPEQVWAALNDPEVLAACIPGCESLEVVGDTEYEATVKVKVGPVKATFKGEVTLSELDPPESYTLTGEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335776814  81 QGGAAGFGKGQTHVTLEPDgDDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:COG3427    81 KGGRAGFAKGTATVTLEPD-GGGTRLTYDADADVGGKLAQLGRRLIDGVAKKLADQFFENLAAKLE 145
 
Name Accession Description Interval E-value
CoxG COG3427
Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];
1-146 6.86e-64

Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];


Pssm-ID: 442653  Cd Length: 145  Bit Score: 193.92  E-value: 6.86e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   1 MELTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEG 80
Cdd:COG3427     1 MELSGSFTVPAPPEQVWAALNDPEVLAACIPGCESLEVVGDTEYEATVKVKVGPVKATFKGEVTLSELDPPESYTLTGEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335776814  81 QGGAAGFGKGQTHVTLEPDgDDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:COG3427    81 KGGRAGFAKGTATVTLEPD-GGGTRLTYDADADVGGKLAQLGRRLIDGVAKKLADQFFENLAAKLE 145
CoxG cd05018
Carbon monoxide dehydrogenase subunit G (CoxG); CoxG has been shown, in Oligotropha ...
 1-146 5.23e-60

Carbon monoxide dehydrogenase subunit G (CoxG); CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.


Pssm-ID: 176853  Cd Length: 144  Bit Score: 183.94  E-value: 5.23e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   1 MELTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEG 80
Cdd:cd05018     1 MKISGEFRIPAPPEEVWAALNDPEVLARCIPGCESLEKIGPNEYEATVKLKVGPVKGTFKGKVELSDLDPPESYTITGEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335776814  81 QGGaAGFGKGQTHVTLEPDGdDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:cd05018    81 KGG-AGFVKGTARVTLEPDG-GGTRLTYTADAQVGGKLAQLGSRLIDGAARKLINQFFENLASKIG 144
COXG pfam06240
Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL ...
 6-145 1.61e-41

Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source.


Pssm-ID: 399326  Cd Length: 140  Bit Score: 136.73  E-value: 1.61e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   6 THTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGeNAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEGQGGAA 85
Cdd:pfam06240   2 SFRVSAPPEAVWEFLTDPEVLARCIPGVKSVEKEG-DEYKAVLKLQVGPLKGSYKARVELVDIEKPGSTTLEIKGNGRGA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814  86 GFGKGQTHVTLEPdGDDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQL 145
Cdd:pfam06240  81 GVAIDFAIVVLVK-PGGGTRLSWSADGNVGGLLASLGGRLIDSAARKMINRFFQCISSKL 139
 
Name Accession Description Interval E-value
CoxG COG3427
Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];
1-146 6.86e-64

Carbon monoxide dehydrogenase subunit CoxG [Energy production and conversion];


Pssm-ID: 442653  Cd Length: 145  Bit Score: 193.92  E-value: 6.86e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   1 MELTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEG 80
Cdd:COG3427     1 MELSGSFTVPAPPEQVWAALNDPEVLAACIPGCESLEVVGDTEYEATVKVKVGPVKATFKGEVTLSELDPPESYTLTGEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335776814  81 QGGAAGFGKGQTHVTLEPDgDDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:COG3427    81 KGGRAGFAKGTATVTLEPD-GGGTRLTYDADADVGGKLAQLGRRLIDGVAKKLADQFFENLAAKLE 145
CoxG cd05018
Carbon monoxide dehydrogenase subunit G (CoxG); CoxG has been shown, in Oligotropha ...
 1-146 5.23e-60

Carbon monoxide dehydrogenase subunit G (CoxG); CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.


Pssm-ID: 176853  Cd Length: 144  Bit Score: 183.94  E-value: 5.23e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   1 MELTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEG 80
Cdd:cd05018     1 MKISGEFRIPAPPEEVWAALNDPEVLARCIPGCESLEKIGPNEYEATVKLKVGPVKGTFKGKVELSDLDPPESYTITGEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335776814  81 QGGaAGFGKGQTHVTLEPDGdDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:cd05018    81 KGG-AGFVKGTARVTLEPDG-GGTRLTYTADAQVGGKLAQLGSRLIDGAARKLINQFFENLASKIG 144
COXG pfam06240
Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL ...
 6-145 1.61e-41

Carbon monoxide dehydrogenase subunit G (CoxG); The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source.


Pssm-ID: 399326  Cd Length: 140  Bit Score: 136.73  E-value: 1.61e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   6 THTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGeNAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEGQGGAA 85
Cdd:pfam06240   2 SFRVSAPPEAVWEFLTDPEVLARCIPGVKSVEKEG-DEYKAVLKLQVGPLKGSYKARVELVDIEKPGSTTLEIKGNGRGA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814  86 GFGKGQTHVTLEPdGDDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQL 145
Cdd:pfam06240  81 GVAIDFAIVVLVK-PGGGTRLSWSADGNVGGLLASLGGRLIDSAARKMINRFFQCISSKL 139
SRPBCC_5 cd07823
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 3-146 1.86e-23

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176865  Cd Length: 146  Bit Score: 90.76  E-value: 1.86e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   3 LTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTDIDAPhTYTIVFEGQG 82
Cdd:cd07823     1 LENEFTVPAPPDRVWALLLDIERVAPCLPGASLTEVEGDDEYKGTVKVKLGPISASFKGTARLLEDDEA-ARRAVLEATG 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1335776814  83 GAA-GFGKGQTHVTLEPDGDDA-TKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:cd07823    80 KDArGQGTAEATVTLRLSPAGGgTRVTVDTDLALTGKLAQFGRGGIGDVAGRLLAQFAANLEARLA 145
SRPBCC cd07812
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; SRPBCC ...
 3-145 1.17e-13

START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176854  Cd Length: 141  Bit Score: 65.04  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   3 LTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEP-DGENAYAVALSAAVGPVKARFKGRMELTDIDAPHTYTIVFEGQ 81
Cdd:cd07812     1 VEASIEIPAPPEAVWDLLSDPERWPEWSPGLERVEVlGGGEGGVGARFVGGRKGGRRLTLTSEVTEVDPPRPGRFRVTGG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1335776814  82 GGaagFGKGQTHVTLEPDGDDATKLTYTATAQVGGKLAQIGSRLVDGAARKLAGEFFRRLGEQL 145
Cdd:cd07812    81 GG---GVDGTGEWRLEPEGDGGTRVTYTVEYDPPGPLLKVFALLLAGALKRELAALLRALKARL 141
PYR_PYL_RCAR_like cd07821
Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid ...
 1-140 1.94e-05

Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.


Pssm-ID: 176863 [Multi-domain]  Cd Length: 140  Bit Score: 42.70  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   1 MELTETHTLPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAyavalsaAVGPV-KARFKGRM----ELTDIDAPH--- 72
Cdd:cd07821     1 AKVTVSVTIDAPADKVWALLSDFGGLHKWHPAVASCELEGGGP-------GVGAVrTVTLKDGGtvreRLLALDDAErry 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1335776814  73 TYTIVfegqGGAAGFGKGQTHVTLEPDGDDATKLTYTATAQVGGKLAqigsrlvDGAARKLAGEFFRR 140
Cdd:cd07821    74 SYRIV----EGPLPVKNYVATIRVTPEGDGGTRVTWTAEFDPPEGLT-------DELARAFLTGVYRA 130
Polyketide_cyc pfam03364
Polyketide cyclase / dehydrase and lipid transport; This family contains polyketide cylcases ...
 9-146 2.46e-05

Polyketide cyclase / dehydrase and lipid transport; This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.


Pssm-ID: 397441  Cd Length: 125  Bit Score: 42.10  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   9 LPVPQQRAWEALNDTEILRASIPGCDSIEPDGENAYAVALSAAVGPVKARFKGRMELTdidaPHTYTIVFEGQGgaaGFG 88
Cdd:pfam03364   1 VPAPAEQVWALVTDVERYPEFLPWCKSVEVLERDGSLADWRVAFGGLRRSFTARVTLQ----PPERIEMVLVDG---DFK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1335776814  89 KGQTHVTLEPdGDDATKLTYTATAQVGGKlaqigSRLVDGAARKLAGEFFRRLGEQLT 146
Cdd:pfam03364  74 RLEGSWRFEP-GGPGTRVKVTLELDFEFA-----SPLPGALLGFVFRRVLRTLLEAFR 125
YndB COG3832
Chalcone/flavanone-binding protein YndB, AHSA1/START/SRPBCC domain [Lipid transport and ...
 2-111 2.59e-03

Chalcone/flavanone-binding protein YndB, AHSA1/START/SRPBCC domain [Lipid transport and metabolism];


Pssm-ID: 443044 [Multi-domain]  Cd Length: 142  Bit Score: 36.55  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335776814   2 ELTETHTLPVPQQRAWEALNDTEILR---ASIPGCDSIEPDGENAYAVALSAAvGPVKARFKGRMELTDIDAPHtyTIVF 78
Cdd:COG3832     7 TITIEREIDAPPERVWRAWTDPELLArwfGPKGWATVAEFDLRVGGRFRFRMR-GPDGEEFGFEGEVLEVEPPE--RLVF 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1335776814  79 EGQGGAAGFGKGQTHVTLEPDGdDATKLTYTAT 111
Cdd:COG3832    84 TWGFEDDPEGESTVTVTLEPEG-GGTRLTLTHT 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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