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Conserved domains on  [gi|1335046375|gb|PNW80985|]
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hypothetical protein CHLRE_07g338200v5 [Chlamydomonas reinhardtii]

Protein Classification

protein phosphatase 1 regulatory subunit 42( domain architecture ID 15347297)

protein phosphatase 1 regulatory subunit 42 (PPP1R42) regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-319 9.57e-91

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


:

Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 274.74  E-value: 9.57e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375  98 LASQSHLHLNGCHIGRITNLRSLQTLEVLYLYDNQISLIENVAPLRRLTHLYLTSNNIREISGLAGLPNLQKLYIEKNCL 177
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 178 TTVSGLEHCPSLEELHVSQQRLPPGTPLAFAPASVAALSVSLRVLTAGQCNISsgSVGQLRGLSRLRRLDLSHNGLDSFE 257
Cdd:cd21340    81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLE 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1335046375 258 ALDPVLQPCAVLGSLDLRGNPLCRQPKYRDTIILMNDSVTTVDDEPVAAQHREFLLRLHIRR 319
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-319 9.57e-91

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 274.74  E-value: 9.57e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375  98 LASQSHLHLNGCHIGRITNLRSLQTLEVLYLYDNQISLIENVAPLRRLTHLYLTSNNIREISGLAGLPNLQKLYIEKNCL 177
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 178 TTVSGLEHCPSLEELHVSQQRLPPGTPLAFAPASVAALSVSLRVLTAGQCNISsgSVGQLRGLSRLRRLDLSHNGLDSFE 257
Cdd:cd21340    81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLE 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1335046375 258 ALDPVLQPCAVLGSLDLRGNPLCRQPKYRDTIILMNDSVTTVDDEPVAAQHREFLLRLHIRR 319
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-284 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375  98 LASQSHLHLNGCHIGRI-TNLRSLQTLEVLYLYDNQIS-LIENVAPLRRLTHLYLTSNNIREIS-GLAGLPNLQKLYIEK 174
Cdd:COG4886   112 LTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTdLPEPLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 175 NCLTTVSG-LEHCPSLEELHVSqqrlppGTPLAFAPASVAALSvSLRVLTAgqcnissgsvgqlrglsrlrrldlSHNGL 253
Cdd:COG4886   192 NQITDLPEpLGNLTNLEELDLS------GNQLTDLPEPLANLT-NLETLDL------------------------SNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1335046375 254 DSFealdPVLQPCAVLGSLDLRGNPLCRQPK 284
Cdd:COG4886   241 TDL----PELGNLTNLEELDLSNNQLTDLPP 267
LRR_8 pfam13855
Leucine rich repeat;
143-199 6.92e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1335046375 143 RRLTHLYLTSNNIREISG--LAGLPNLQKLYIEKNCLTTVSG--LEHCPSLEELHVSQQRL 199
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-319 9.57e-91

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 274.74  E-value: 9.57e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375  98 LASQSHLHLNGCHIGRITNLRSLQTLEVLYLYDNQISLIENVAPLRRLTHLYLTSNNIREISGLAGLPNLQKLYIEKNCL 177
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 178 TTVSGLEHCPSLEELHVSQQRLPPGTPLAFAPASVAALSVSLRVLTAGQCNISsgSVGQLRGLSRLRRLDLSHNGLDSFE 257
Cdd:cd21340    81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLE 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1335046375 258 ALDPVLQPCAVLGSLDLRGNPLCRQPKYRDTIILMNDSVTTVDDEPVAAQHREFLLRLHIRR 319
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-284 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375  98 LASQSHLHLNGCHIGRI-TNLRSLQTLEVLYLYDNQIS-LIENVAPLRRLTHLYLTSNNIREIS-GLAGLPNLQKLYIEK 174
Cdd:COG4886   112 LTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTdLPEPLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 175 NCLTTVSG-LEHCPSLEELHVSqqrlppGTPLAFAPASVAALSvSLRVLTAgqcnissgsvgqlrglsrlrrldlSHNGL 253
Cdd:COG4886   192 NQITDLPEpLGNLTNLEELDLS------GNQLTDLPEPLANLT-NLETLDL------------------------SNNQL 240

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1335046375 254 DSFealdPVLQPCAVLGSLDLRGNPLCRQPK 284
Cdd:COG4886   241 TDL----PELGNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-199 7.55e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 7.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 103 HLHLNGCHIGRITN-LRSLQTLEVLYLYDNQISLI-ENVAPLRRLTHLYLTSNNIREISGLAGLPNLQKLYIEKNCLTTV 180
Cdd:COG4886   186 ELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                          90
                  ....*....|....*....
gi 1335046375 181 SGLEHCPSLEELHVSQQRL 199
Cdd:COG4886   266 PPLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-257 1.34e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 1.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 103 HLHLNGCHIGRI-TNLRSLQTLEVLYLYDNQISLI-ENVAPLRRLTHLYLTSNNIREISG-LAGLPNLQKLYIEKNCLTT 179
Cdd:COG4886   140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTD 219

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1335046375 180 VS-GLEHCPSLEELHVSQQRLppgTPLAfapaSVAALSvSLRVLTAGQCNISSgsVGQLRGLSRLRRLDLSHNGLDSFE 257
Cdd:COG4886   220 LPePLANLTNLETLDLSNNQL---TDLP----ELGNLT-NLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLK 288
LRR_8 pfam13855
Leucine rich repeat;
143-199 6.92e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1335046375 143 RRLTHLYLTSNNIREISG--LAGLPNLQKLYIEKNCLTTVSG--LEHCPSLEELHVSQQRL 199
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 144-185 6.57e-08

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 48.78  E-value: 6.57e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1335046375 144 RLTHLYLTSNNIREISGLAGLPNLQKLYIEKN-CLTTVSGLEH 185
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-163 1.68e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 47.63  E-value: 1.68e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1335046375 121 QTLEVLYLYDNQISLIENVAPLRRLTHLYLTSNN-IREISGLAG 163
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-279 1.22e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 114 ITNLRSLQTLEVLYLYDNQISLIENVAPLRRLTHLYLTSNNireisGLAGLPNLQKLYIEKNCLTTV-SGLEHCPSLEEL 192
Cdd:COG4886    67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 193 HVSqqrlppGTPLAFAPASVAALSvSLRVLTAGQCNISSgsvgqlrglsrlrrldlshngldsfeaLDPVLQPCAVLGSL 272
Cdd:COG4886   142 DLS------NNQLTDLPEPLGNLT-NLKSLDLSNNQLTD---------------------------LPEELGNLTNLKEL 187


                  ....*..
gi 1335046375 273 DLRGNPL 279
Cdd:COG4886   188 DLSNNQI 194
LRR_9 pfam14580
Leucine-rich repeat;
104-192 1.89e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 47.84  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 104 LHLNGCHIGRITNL-RSLQTLEVLYLYDNQISLIENVAPLRRLTHLYLTSNNIREIS-GLA-GLPNLQKLYIEKNCLTTV 180
Cdd:pfam14580  24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGeGLGeALPNLTELILTNNNLQEL 103

                          90
                  ....*....|..
gi 1335046375 181 SGLEHCPSLEEL 192
Cdd:pfam14580 104 GDLDPLASLKKL 115
LRR_8 pfam13855
Leucine rich repeat;
104-155 2.70e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1335046375 104 LHLNGCHIGRI--TNLRSLQTLEVLYLYDNQISLIENVA--PLRRLTHLYLTSNNI 155
Cdd:pfam13855   6 LDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-175 2.84e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1335046375 121 QTLEVLYLYDNQISLIENVAP--LRRLTHLYLTSNNIREISG--LAGLPNLQKLYIEKN 175
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 165-195 2.44e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 2.44e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1335046375 165 PNLQKLYIEKNCLTTVSGLEHCPSLEELHVS 195
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLS 31
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 104-199 2.37e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375 104 LHLNGCHIGR------ITNLRSLQTLEVLYLYDNQIS------LIENVAPLRRLTHLYLTSNNIRE------ISGLAGLP 165
Cdd:COG5238   213 LWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGdegviaLAEALKNNTTVETLYLSGNQIGAegaialAKALQGNT 292

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1335046375 166 NLQKLYIEKNCLTT------VSGLEHCPSLEELHVSQQRL 199
Cdd:COG5238   293 TLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGI 332
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 103-143 1.42e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1335046375 103 HLHLNGCHIGRITNLRSLQTLEVLYLYDNQisLIENVAPLR 143
Cdd:pfam12799   5 VLDLSNNQITDIPPLAKLPNLETLDLSGNN--KITDLSDLA 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 98-204 4.94e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335046375  98 LASQSHLH---LNGCHIGRI------TNLRSLQTLEVLYLYDNQISLI-------ENVAPLRRLTHLYLTSNNIR----- 156
Cdd:cd00116   189 LKANCNLEvldLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAgaaalasALLSPNISLLTLSLSCNDITddgak 268

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1335046375 157 -EISGLAGLPNLQKLYIEKNCLTTVSGLEHCPSLEELHVSQQRLPPGTP 204
Cdd:cd00116   269 dLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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