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Conserved domains on  [gi|1333095239|ref|XP_023547317|]
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caffeoylshikimate esterase-like [Cucurbita pepo subsp. pepo]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 7-290 6.00e-118

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02385:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 349  Bit Score: 343.27  E-value: 6.00e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   7 EEEFIVNSRGLKLFTCSWVPKNEEPKALVFLCHGYAMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNN 86
Cdd:PLN02385   62 EESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPSFDD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  87 VVDDCSSFFTSIAEKKENREKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCKIAEDMRPNALTISFLTKLCKIIP 166
Cdd:PLN02385  142 LVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLANLLP 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 167 TWKIIPTQDIIDIAFKVPEIRKQIRENRYCYKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQL 246
Cdd:PLN02385  222 KAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVSKFL 301

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1333095239 247 YDEAVSDDKTLKMYPGMWHGLLYGETPENIDIVFSDIIDWLEKR 290
Cdd:PLN02385  302 YEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSH 345
 
Name Accession Description Interval E-value
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 7-290 6.00e-118

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 343.27  E-value: 6.00e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   7 EEEFIVNSRGLKLFTCSWVPKNEEPKALVFLCHGYAMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNN 86
Cdd:PLN02385   62 EESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPSFDD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  87 VVDDCSSFFTSIAEKKENREKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCKIAEDMRPNALTISFLTKLCKIIP 166
Cdd:PLN02385  142 LVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLANLLP 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 167 TWKIIPTQDIIDIAFKVPEIRKQIRENRYCYKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQL 246
Cdd:PLN02385  222 KAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVSKFL 301

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1333095239 247 YDEAVSDDKTLKMYPGMWHGLLYGETPENIDIVFSDIIDWLEKR 290
Cdd:PLN02385  302 YEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSH 345
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 30-268 1.02e-74

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 229.41  E-value: 1.02e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  30 EPKALVFLCHGYAmECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNNVVDDCSSFFTSIAEkkENREKKR 109
Cdd:pfam12146   2 EPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIRE--EHPGLPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 110 YLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCKIAEDMrPNALTISFLTKLCKIIPTWKIiPTQDIIDIAFKVPEIRKQ 189
Cdd:pfam12146  79 FLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYL-APPILKLLAKLLGKLFPRLRV-PNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333095239 190 IRENRYCyKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQLYDEAVSDDKTLKMYPGMWHGLL 268
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELL 234
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
5-289 1.89e-40

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 140.52  E-value: 1.89e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   5 TYEEEFIVNSRGLKLFTCSWVPKnEEPKALVFLCHGYAmECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSF 84
Cdd:COG2267     2 TRRLVTLPTRDGLRLRGRRWRPA-GSPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  85 NNVVDDCSSFftsIAEKKENREKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMckiaedmrpnaltisfltklcki 164
Cdd:COG2267    80 DDYVDDLRAA---LDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA----------------------- 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 165 iptwkiiptqdiidiafkvpeirkqirenrycYKGRPRLKTGYELLRiSSELEHKLDEVSVPFLLLHGEDDRVTDKLVSK 244
Cdd:COG2267   134 --------------------------------YRADPLLGPSARWLR-ALRLAEALARIDVPVLVLHGGADRVVPPEAAR 180

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1333095239 245 QLYdEAVSDDKTLKMYPGMWHGLLYGETPEnidIVFSDIIDWLEK 289
Cdd:COG2267   181 RLA-ARLSPDVELVLLPGARHELLNEPARE---EVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 13-288 2.35e-13

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 69.43  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  13 NSRGLKLFTCSWVPKNeePKALVFLCHGYAMECSITM-------------------------DSSARRLAKEGYGVYGVD 67
Cdd:TIGR01607   4 NKDGLLLKTYSWIVKN--AIGIIVLIHGLKSHLRLQFlkinakivnndravlidtdnyyiykDSWIENFNKNGYSVYGLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  68 YEGHGKSSGLQ---GYVSSFNNVVDDCSSFF-----TSIAEKK----------ENREKKR---YLMGESMGGAVAVLVHR 126
Cdd:TIGR01607  82 LQGHGESDGLQnlrGHINCFDDLVYDVIQYMnrindSIILENEtksddesydiVNTKENRlpmYIIGLSMGGNIALRLLE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 127 ---KQPEYWD-----GAILVAPMCKIAEDMRPNALT-----ISFLTKLCKIIPTWKIIPtqdiiDIAF-KVPEIRKQIRE 192
Cdd:TIGR01607 162 llgKSNENNDklnikGCISLSGMISIKSVGSDDSFKfkyfyLPVMNFMSRVFPTFRISK-----KIRYeKSPYVNDIIKF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 193 NRYCYKGRPRLKTGYELLRISSELEHKLDEV--SVPFLLLHGEDDRVTDKLVSKQLYDEAVSDDKTLKMYPGMWHGLLYG 270
Cdd:TIGR01607 237 DKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVITIE 316

                         330
                  ....*....|....*...
gi 1333095239 271 ETPENidiVFSDIIDWLE 288
Cdd:TIGR01607 317 PGNEE---VLKKIIEWIS 331
 
Name Accession Description Interval E-value
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 7-290 6.00e-118

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 343.27  E-value: 6.00e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   7 EEEFIVNSRGLKLFTCSWVPKNEEPKALVFLCHGYAMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNN 86
Cdd:PLN02385   62 EESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPSFDD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  87 VVDDCSSFFTSIAEKKENREKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCKIAEDMRPNALTISFLTKLCKIIP 166
Cdd:PLN02385  142 LVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLANLLP 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 167 TWKIIPTQDIIDIAFKVPEIRKQIRENRYCYKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQL 246
Cdd:PLN02385  222 KAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVSKFL 301

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1333095239 247 YDEAVSDDKTLKMYPGMWHGLLYGETPENIDIVFSDIIDWLEKR 290
Cdd:PLN02385  302 YEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSH 345
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 2-290 7.54e-113

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 329.82  E-value: 7.54e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   2 ENVTYEEEFIVNSRGLKLFTCSWVPKNEE-PKALVFLCHGYAMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGY 80
Cdd:PLN02298   28 KGIKGSKSFFTSPRGLSLFTRSWLPSSSSpPRALIFMVHGYGNDISWTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  81 VSSFNNVVDDCSSFFTSIAEKKENREKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCKIAEDMRPNALTISFLTK 160
Cdd:PLN02298  108 VPNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRPPWPIPQILTF 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 161 LCKIIPTWKIIPTQDIIDIAFKVPEIRKQIRENRYCYKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDK 240
Cdd:PLN02298  188 VARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDP 267

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333095239 241 LVSKQLYDEAVSDDKTLKMYPGMWHGLLYGETPENIDIVFSDIIDWLEKR 290
Cdd:PLN02298  268 DVSRALYEEAKSEDKTIKIYDGMMHSLLFGEPDENIEIVRRDILSWLNER 317
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 30-268 1.02e-74

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 229.41  E-value: 1.02e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  30 EPKALVFLCHGYAmECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNNVVDDCSSFFTSIAEkkENREKKR 109
Cdd:pfam12146   2 EPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIRE--EHPGLPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 110 YLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCKIAEDMrPNALTISFLTKLCKIIPTWKIiPTQDIIDIAFKVPEIRKQ 189
Cdd:pfam12146  79 FLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYL-APPILKLLAKLLGKLFPRLRV-PNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333095239 190 IRENRYCyKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQLYDEAVSDDKTLKMYPGMWHGLL 268
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELL 234
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 14-290 2.09e-44

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 155.82  E-value: 2.09e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  14 SRGLKLFTCSWVPKNEEPKALVFLCHGYAmECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNNVVDDCSS 93
Cdd:PLN02652  118 ARRNALFCRSWAPAAGEMRGILIIIHGLN-EHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLHGYVPSLDYVVEDTEA 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  94 FFTSIaeKKENREKKRYLMGESMGGAVaVLVHRKQPEYWD---GAILVAPMCKIaEDMRPNALTISFLTKLckIIPTWKI 170
Cdd:PLN02652  197 FLEKI--RSENPGVPCFLFGHSTGGAV-VLKAASYPSIEDkleGIVLTSPALRV-KPAHPIVGAVAPIFSL--VAPRFQF 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 171 -------IPTQdiidiafKVPEIRKQIRENRYCYKGRPRLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVS 243
Cdd:PLN02652  271 kgankrgIPVS-------RDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGTADRVTDPLAS 343

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1333095239 244 KQLYDEAVSDDKTLKMYPGMWHGLLYgeTPENiDIVFSDIIDWLEKR 290
Cdd:PLN02652  344 QDLYNEAASRHKDIKLYDGFLHDLLF--EPER-EEVGRDIIDWMEKR 387
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
5-289 1.89e-40

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 140.52  E-value: 1.89e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   5 TYEEEFIVNSRGLKLFTCSWVPKnEEPKALVFLCHGYAmECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSF 84
Cdd:COG2267     2 TRRLVTLPTRDGLRLRGRRWRPA-GSPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  85 NNVVDDCSSFftsIAEKKENREKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMckiaedmrpnaltisfltklcki 164
Cdd:COG2267    80 DDYVDDLRAA---LDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA----------------------- 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 165 iptwkiiptqdiidiafkvpeirkqirenrycYKGRPRLKTGYELLRiSSELEHKLDEVSVPFLLLHGEDDRVTDKLVSK 244
Cdd:COG2267   134 --------------------------------YRADPLLGPSARWLR-ALRLAEALARIDVPVLVLHGGADRVVPPEAAR 180

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1333095239 245 QLYdEAVSDDKTLKMYPGMWHGLLYGETPEnidIVFSDIIDWLEK 289
Cdd:COG2267   181 RLA-ARLSPDVELVLLPGARHELLNEPARE---EVLAAILAWLER 221
PHA02857 PHA02857
monoglyceride lipase; Provisional
 31-290 6.59e-30

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 114.60  E-value: 6.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  31 PKALVFLCHGyAMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVSSFNNVVDDCSSFFTSIaeKKENREKKRY 110
Cdd:PHA02857   24 PKALVFISHG-AGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVVQHVVTI--KSTYPGVPVF 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 111 LMGESMGGAVAVLVHRKQPEYWDGAILVAPMCkiaedmrpNALTISFL----TKLCKIIPTWKIIPTqdiidiaFKVPEI 186
Cdd:PHA02857  101 LLGHSMGATISILAAYKNPNLFTAMILMSPLV--------NAEAVPRLnllaAKLMGIFYPNKIVGK-------LCPESV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 187 RKQIRENrYCYKGRP-----RLKTG--YELLRISSELEHKLDEVSVPFLLLHGEDDRVTDklVSKQLY-DEAVSDDKTLK 258
Cdd:PHA02857  166 SRDMDEV-YKYQYDPlvnheKIKAGfaSQVLKATNKVRKIIPKIKTPILILQGTNNEISD--VSGAYYfMQHANCNREIK 242

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1333095239 259 MYPGMWHGlLYGETPENIDIVFSDIIDWLEKR 290
Cdd:PHA02857  243 IYEGAKHH-LHKETDEVKKSVMKEIETWIFNR 273
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
35-289 7.69e-30

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 113.50  E-value: 7.69e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  35 VFLCHGYaMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGlqgyvsSFNNV-VDDCSSFFTSIAEKKENREKKRYLMG 113
Cdd:COG1647    18 VLLLHGF-TGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPE------DLLKTtWEDWLEDVEEAYEILKAGYDKVIVIG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 114 ESMGGAVAVLVHRKQPEYwDGAILVAPMCKIAedmRPNALTISFLTKLCKIIPTWKIIPtqdiidiafkvpeirKQIREN 193
Cdd:COG1647    91 LSMGGLLALLLAARYPDV-AGLVLLSPALKID---DPSAPLLPLLKYLARSLRGIGSDI---------------EDPEVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 194 RYCYKGRPrLKTGYELLRISSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQLYDEAVSDDKTLKMYPGMWHGLLYGetp 273
Cdd:COG1647   152 EYAYDRTP-LRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLD--- 227

                         250
                  ....*....|....*.
gi 1333095239 274 ENIDIVFSDIIDWLEK 289
Cdd:COG1647   228 KDREEVAEEILDFLER 243
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
25-289 1.26e-26

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 104.71  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  25 VPKNEEPKALVFLCHGYAMECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQGYVssfnnVVDDCSSFFTSIAEKKEN 104
Cdd:COG1506    16 LPADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD-----EVDDVLAAIDYLAARPYV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 105 REKKRYLMGESMGGAVAVLVHRKQPEYWDGAILVAPMCkiaeDMRpnaltiSFLTKLCKIIPTWKIIPTQDIidiafkvp 184
Cdd:COG1506    91 DPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVS----DLR------SYYGTTREYTERLMGGPWEDP-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 185 eirkqirenrycykgrprlktgyELLRISSELEHkLDEVSVPFLLLHGEDDRVTDKLVSKQLYDEAVS--DDKTLKMYPG 262
Cdd:COG1506   153 -----------------------EAYAARSPLAY-ADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagKPVELLVYPG 208

                         250       260
                  ....*....|....*....|....*..
gi 1333095239 263 MWHGLLYGETPEnidiVFSDIIDWLEK 289
Cdd:COG1506   209 EGHGFSGAGAPD----YLERILDFLDR 231
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 1-289 1.83e-24

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 99.22  E-value: 1.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239   1 MENVTYEEEFIVNSRGLKLFTCSWVPKNEEPK-ALVFLCHGYAmECSITMDSSARRLAKEGYGVYGVDYEGHGKSSGLQG 79
Cdd:COG1073     5 SDKVNKEDVTFKSRDGIKLAGDLYLPAGASKKyPAVVVAHGNG-GVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  80 YVSSFNNvvDDCSSFFTSIAEKKENREKKRYLMGESMGGAVavlvhrkqpeywdgAILVApmckiAEDMRPNAL-TISfl 158
Cdd:COG1073    84 EEGSPER--RDARAAVDYLRTLPGVDPERIGLLGISLGGGY--------------ALNAA-----ATDPRVKAViLDS-- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 159 tklckiiptwkiiPTQDIIDIAfkvpeiRKQIRENRYCYKG----RPRLKTGyELLRISSELEHKLDEVSVPFLLLHGED 234
Cdd:COG1073   141 -------------PFTSLEDLA------AQRAKEARGAYLPgvpyLPNVRLA-SLLNDEFDPLAKIEKISRPLLFIHGEK 200

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1333095239 235 DRVTDKLVSKQLYdEAVSDDKTLKMYPGMWHGLLYGETPEnidIVFSDIIDWLEK 289
Cdd:COG1073   201 DEAVPFYMSEDLY-EAAAEPKELLIVPGAGHVDLYDRPEE---EYFDKLAEFFKK 251
PRK10749 PRK10749
lysophospholipase L2; Provisional
 60-239 5.55e-14

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 71.18  E-value: 5.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  60 GYGVYGVDYEGHGKSSGL-----QGYVSSFNNVVDDCSSFFTSIAEKKENRekKRYLMGESMGGAVAVLVHRKQPEYWDG 134
Cdd:PRK10749   81 GYDVLIIDHRGQGRSGRLlddphRGHVERFNDYVDDLAAFWQQEIQPGPYR--KRYALAHSMGGAILTLFLQRHPGVFDA 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 135 AILVAPMCKIAEDMrpnaltisfltklckiiPTWKiipTQDIIDIAFKVPEIRK--------------------QIREnR 194
Cdd:PRK10749  159 IALCAPMFGIVLPL-----------------PSWM---ARRILNWAEGHPRIRDgyaigtgrwrplpfainvltHSRE-R 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333095239 195 YC-----YKGRPRLKTG---Y----ELLRISSELEHKLDEVSVPFLLLHGEDDRVTD 239
Cdd:PRK10749  218 YRrnlrfYADDPELRVGgptYhwvrESILAGEQVLAGAGDITTPLLLLQAEEERVVD 274
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 13-288 2.35e-13

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 69.43  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  13 NSRGLKLFTCSWVPKNeePKALVFLCHGYAMECSITM-------------------------DSSARRLAKEGYGVYGVD 67
Cdd:TIGR01607   4 NKDGLLLKTYSWIVKN--AIGIIVLIHGLKSHLRLQFlkinakivnndravlidtdnyyiykDSWIENFNKNGYSVYGLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  68 YEGHGKSSGLQ---GYVSSFNNVVDDCSSFF-----TSIAEKK----------ENREKKR---YLMGESMGGAVAVLVHR 126
Cdd:TIGR01607  82 LQGHGESDGLQnlrGHINCFDDLVYDVIQYMnrindSIILENEtksddesydiVNTKENRlpmYIIGLSMGGNIALRLLE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 127 ---KQPEYWD-----GAILVAPMCKIAEDMRPNALT-----ISFLTKLCKIIPTWKIIPtqdiiDIAF-KVPEIRKQIRE 192
Cdd:TIGR01607 162 llgKSNENNDklnikGCISLSGMISIKSVGSDDSFKfkyfyLPVMNFMSRVFPTFRISK-----KIRYeKSPYVNDIIKF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 193 NRYCYKGRPRLKTGYELLRISSELEHKLDEV--SVPFLLLHGEDDRVTDKLVSKQLYDEAVSDDKTLKMYPGMWHGLLYG 270
Cdd:TIGR01607 237 DKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVITIE 316

                         330
                  ....*....|....*...
gi 1333095239 271 ETPENidiVFSDIIDWLE 288
Cdd:TIGR01607 317 PGNEE---VLKKIIEWIS 331
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 32-290 3.09e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 65.02  E-value: 3.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  32 KALVFLcHGYAMeCSITMDSSARRLAkEGYGVYGVDYEGHGKSSGLQGYVSsFNNVVDDCSSFFTSIAEKKenrekkRYL 111
Cdd:COG0596    24 PPVVLL-HGLPG-SSYEWRPLIPALA-AGYRVIAPDLRGHGRSDKPAGGYT-LDDLADDLAALLDALGLER------VVL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 112 MGESMGGAVAVLVHRKQPEYWDGAILVApmckiaedmrpnaltisfltklckiiptwkiiptqdiidiafkvpEIRKQIR 191
Cdd:COG0596    94 VGHSMGGMVALELAARHPERVAGLVLVD---------------------------------------------EVLAALA 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 192 EN-RYCYKGRPRLKTGYELLRiSSELEHKLDEVSVPFLLLHGEDDRVTDKLVSKQLYDEAvsDDKTLKMYPGMWHGLLYg 270
Cdd:COG0596   129 EPlRRPGLAPEALAALLRALA-RTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL--PNAELVVLPGAGHFPPL- 204

                         250       260
                  ....*....|....*....|
gi 1333095239 271 etpENIDIVFSDIIDWLEKR 290
Cdd:COG0596   205 ---EQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 34-246 3.77e-05

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 44.42  E-value: 3.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  34 LVFLCHGYAMecsiTMDSS---ARRLAKEGYGVYGVDYEGHGKSSGLqgyVSSFNNVVDDCSSFFTSIAEKKENreKKRY 110
Cdd:pfam00561   2 PVLLLHGLPG----SSDLWrklAPALARDGFRVIALDLRGFGKSSRP---KAQDDYRTDDLAEDLEYILEALGL--EKVN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 111 LMGESMGGAVAVLVHRKQPEYWDGAILVAPmckiaedMRPNALTISFLTKLCKIIPTW------KIIPTQDIIDIAFKVP 184
Cdd:pfam00561  73 LVGHSMGGLIALAYAAKYPDRVKALVLLGA-------LDPPHELDEADRFILALFPGFfdgfvaDFAPNPLGRLVAKLLA 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333095239 185 EIRKQIRE-------NRYCYKGRPRLKTGY------ELLRISSELEHK-LDEVSVPFLLLHGEDDRVTDKLVSKQL 246
Cdd:pfam00561 146 LLLLRLRLlkalpllNKRFPSGDYALAKSLvtgallFIETWSTELRAKfLGRLDEPTLIIWGDQDPLVPPQALEKL 221
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 35-268 3.50e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 40.92  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239  35 VFLCHGyAMECSITMdssaRRLAKEGYGVYGVDYEGHGKSSGLQgyvSSFNNVVDDCSsfftsiAEKKENREKKRYLMGE 114
Cdd:pfam12697   1 VVLVHG-AGLSAAPL----AALLAAGVAVLAPDLPGHGSSSPPP---LDLADLADLAA------LLDELGAARPVVLVGH 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333095239 115 SMGGAVAVlvhRKQPEYWDGAILVAPMCKIAEDMRPNALTISFLTKLcKIIPTW--KIIPTQDIIDIAFKVPEIRKQIRE 192
Cdd:pfam12697  67 SLGGAVAL---AAAAAALVVGVLVAPLAAPPGLLAALLALLARLGAA-LAAPAWlaAESLARGFLDDLPADAEWAAALAR 142

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333095239 193 nrycykgRPRLKTGYELLRIsseleHKLDEVSVPFLLLHgEDDRVTDKLVSKQLydeAVSDDKTLKMYPGMWHGLL 268
Cdd:pfam12697 143 -------LAALLAALALLPL-----AAWRDLPVPVLVLA-EEDRLVPELAQRLL---AALAGARLVVLPGAGHLPL 202
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
226-290 5.61e-03

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 37.55  E-value: 5.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333095239 226 PFLLLHGEDDRVTDklVSKQLYD--EAVSDDKTLKMYPGMWHGLLYGETPENIDIVFSDIIDWLEKR 290
Cdd:COG0657   141 PTLIVTGEADPLVD--ESEALAAalRAAGVPVELHVYPGGGHGFGLLAGLPEARAALAEIAAFLRRA 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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