NCBI Conserved Domain Search

Conserved domains on [gi|1332378068|gb|PNN75062|]

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sensor histidine kinase [Staphylococcus aureus]

Protein Classification

sensor histidine kinase( domain architecture ID 1001000)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH: 3.30.565.10

EC: 2.7.13.3

Gene Ontology: GO:0005524|GO:0007165|GO:0004673|GO:0000155

PubMed: 10637609|10339418

SCOP: 4001957

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

315-548

2.93e-102

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 313.80 E-value: 2.93e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 315 VVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIE 394
Cdd:COG5002   150 AVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLE 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 395 QHT-ELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDI-EKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYR 472
Cdd:COG5002   230 SGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLRE 309

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1332378068 473 DDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG5002   310 EDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385

RocR super family

cl34674

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

207-350

4.88e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

The actual alignment was detected with superfamily member COG3829:

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 61.71 E-value: 4.88e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 207 EQKIQSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNiEQVGYHgyVNTEIEQ-LILESFKVEKPIYEQLEV 285
Cdd:COG3829     5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPRE-EVIGKN--VTELIPNsPLLEVLKTGKPVTGVIQK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1332378068 286 AINQvhAKYFDISCVPIltRSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKG 350
Cdd:COG3829    82 TGGK--GKTVIVTAIPI--FEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDIIG 142

Name

Accession

Description

Interval

E-value

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

315-548

2.93e-102

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 313.80 E-value: 2.93e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 315 VVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIE 394
Cdd:COG5002   150 AVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLE 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 395 QHT-ELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDI-EKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYR 472
Cdd:COG5002   230 SGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLRE 309

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1332378068 473 DDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG5002   310 EDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385

phoR_proteo

TIGR02966

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...

211-548

2.97e-96

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]

Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 296.04 E-value: 2.97e-96

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 211 QSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQF----------NISHNIEQVGYHGYVNTEI--EQLILESfkvekP 278
Cdd:TIGR02966   4 LLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLglrwpddlgqRITNLIRHPEFVEYLAAGRfsEPLELPS-----P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 279 IYEQLEVAINQVHakYFDiscvpiltrsqkslQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDG 358
Cdd:TIGR02966  79 INSERVLEIRIAP--YGE--------------EQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 359 AKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTE-LDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVI 437
Cdd:TIGR02966 143 PDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASpLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVD 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 438 VKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLG 517
Cdd:TIGR02966 223 VLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLG 302

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1332378068 518 LSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:TIGR02966 303 LAIVKHVLSRHHARLEIESELGKGSTFSFIF 333

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

314-548

4.56e-55

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 191.76 E-value: 4.56e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 314 LVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAeSLDMFLNIILKESNRIESLVTDLLDLSHI 393
Cdd:PRK11006  188 LMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLLTLSKI 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 394 EQHTELDTDY-----MNLSDLTRRIIDnmMTQANQKnisIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINV 468
Cdd:PRK11006  267 EAAPTIDLNEkvdvpMMLRVLEREAQT--LSQGKHT---ITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 469 RVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK11006  342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421

HATPase

cd00075

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...

445-548

5.22e-38

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.

Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 135.04 E-value: 5.22e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKarSRDSGGTGLGLSITKHI 524
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|....
gi 1332378068 525 VEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd00075    79 VEAHGGRITVESEPGGGTTFTVTL 102

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

440-549

2.94e-36

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 130.85 E-value: 2.94e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068  440 AQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKaRSRDSGGTGLGLS 519
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 1332378068  520 ITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

442-549

1.87e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 114.77 E-value: 1.87e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 442 ESKIAQVITNLLTNAINYSYEDGDINVRVYRDDfRVIFEVQDFGIGIKLEDQQRIFERFYRVDKarsRDSGGTGLGLSIT 521
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*...
gi 1332378068 522 KHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLP 106

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

207-350

4.88e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 61.71 E-value: 4.88e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 207 EQKIQSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNiEQVGYHgyVNTEIEQ-LILESFKVEKPIYEQLEV 285
Cdd:COG3829     5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPRE-EVIGKN--VTELIPNsPLLEVLKTGKPVTGVIQK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1332378068 286 AINQvhAKYFDISCVPIltRSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKG 350
Cdd:COG3829    82 TGGK--GKTVIVTAIPI--FEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDIIG 142

ArsS_fam_HK

NF038389

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...

320-528

1.63e-08

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.

Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 56.78 E-value: 1.63e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 320 ITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGaKNDAESLDMF--LNIILKESNRIESLVTdlldlshieQHT 397
Cdd:NF038389  196 VKKIKALNESRQLFLRNIMHELKTPITKGRIVAEMLEDE-KQKERLISIFerLESLINEFAKIEQLTS---------KNY 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 398 ELDTDYMNLSDLTRRIIDNMMtqaNQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSyEDGDINVRVYRDDfrv 477
Cdd:NF038389  266 KLNKKEYRLSDIIDEAIDMLM---IDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYS-PDKKVTIEIKGDK--- 338

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1332378068 478 iFEVQDFGIGIKlEDQQRIFERFYrvdKARSRDSGGTGLGLSITKHIVEAH 528
Cdd:NF038389  339 -IEFKNKGEPLE-EPLEYYFEPFF---KGNEKSKSGFGLGLYIVKNILKAH 384

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

213-320

1.80e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 43.95 E-value: 1.80e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 213 NRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNIShnIEQVgyhgyvnteIEQLILESFKVEKPI--YEQLEVAINQV 290
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLS--REEV---------IGKSLLDLIPEEDDAevAELLRQALLQG 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1332378068 291 HA---------------KYFDISCVPILTRSQKSLqGILVVMHDI 320
Cdd:pfam00989  70 EEsrgfevsfrvpdgrpRHVEVRASPVRDAGGEIL-GFLGVLRDI 113

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

214-328

1.38e-04

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 41.89 E-value: 1.38e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 214 RLKTTIENIPSAILMIDRNGKIVVANKAYYEQFN------ISHNIEQVGYHGYVNtEIEQLILESFKVEKPIYEQLEVAI 287
Cdd:TIGR00229   4 RYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGysaeelIGRNVLELIPEEDRE-EVRERIERRLEGEPEPVSEERRVR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1332378068 288 NQV-HAKYFDISCVPIltRSQKSLQGILVVMHDITNLKQLEN 328
Cdd:TIGR00229  83 RKDgSEIWVEVSVSPI--RTNGGELGVVGIVRDITERKEAEE 122

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

214-249

9.62e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 35.07 E-value: 9.62e-03

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1332378068  214 RLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNIS 249
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYS 37

Name

Accession

Description

Interval

E-value

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

315-548

2.93e-102

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 313.80 E-value: 2.93e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 315 VVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIE 394
Cdd:COG5002   150 AVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLE 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 395 QHT-ELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDI-EKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYR 472
Cdd:COG5002   230 SGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLRE 309

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1332378068 473 DDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG5002   310 EDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385

phoR_proteo

TIGR02966

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...

211-548

2.97e-96

Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 296.04 E-value: 2.97e-96

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 211 QSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQF----------NISHNIEQVGYHGYVNTEI--EQLILESfkvekP 278
Cdd:TIGR02966   4 LLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLglrwpddlgqRITNLIRHPEFVEYLAAGRfsEPLELPS-----P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 279 IYEQLEVAINQVHakYFDiscvpiltrsqkslQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDG 358
Cdd:TIGR02966  79 INSERVLEIRIAP--YGE--------------EQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 359 AKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTE-LDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVI 437
Cdd:TIGR02966 143 PDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASpLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVD 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 438 VKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLG 517
Cdd:TIGR02966 223 VLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLG 302

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1332378068 518 LSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:TIGR02966 303 LAIVKHVLSRHHARLEIESELGKGSTFSFIF 333

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

323-548

4.58e-79

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 248.28 E-value: 4.58e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 323 LKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHT-ELDT 401
Cdd:COG2205     9 LEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKlSLEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 402 DYMNLSDLTRRIIDNMMTQANQKNISIHTDI-EKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFE 480
Cdd:COG2205    89 EPVDLAELLEEAVEELRPLAEEKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRIS 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1332378068 481 VQDFGIGIKLEDQQRIFERFYRVDkaRSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG2205   169 VSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

133-548

1.33e-77

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 250.65 E-value: 1.33e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 133 YLILTCLVVLISLYFASRsFKRTLIRPIQEVTYATQLLANGYYHIRVPESNVVETKALFVSTNDLARRLQKLNNEQKIQS 212
Cdd:COG5000    11 LLLIALLLLLLALWLALL-LARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 213 NRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHnieqvgyHGYVNTEIEQLILESFKVEkPIYEQLEVAINQVHA 292
Cdd:COG5000    90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPL-------EELIGKPLEELLPELDLAE-LLREALERGWQEEIE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 293 KYFDISCVPILTRSQKSLQGILVVMHDITNLKQLENLR--REFVANVSHELKTPITSIKGFAETL----IDGAKNDAESL 366
Cdd:COG5000   162 LTRDGRRTLLVRASPLRDDGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLrrklADKLEEDREDL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 367 DMFLNIILKESNRIESLVTDLLDLSHIEQhTELDTdyMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDV-IVKAQESKI 445
Cdd:COG5000   242 ERALDTIIRQVDRLKRIVDEFLDFARLPE-PQLEP--VDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 446 AQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYrvdkarSRDSGGTGLGLSITKHIV 525
Cdd:COG5000   319 EQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIV 392

                         410       420
                  ....*....|....*....|...
gi 1332378068 526 EAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG5000   393 EEHGGTIELESRPGGGTTFTIRL 415

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

225-548

1.66e-76

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 244.82 E-value: 1.66e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 225 AILMIDRNGKIVVANKAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISCVPILT 304
Cdd:COG0642     5 LLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 305 RSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAESldmFLNIILKESNRIESLV 384
Cdd:COG0642    85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQRE---YLETILRSADRLLRLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 385 TDLLDLSHIEQ-HTELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVI-VKAQESKIAQVITNLLTNAINYSYE 462
Cdd:COG0642   162 NDLLDLSRLEAgKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPE 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 463 DGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDkaRSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGS 542
Cdd:COG0642   242 GGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                  ....*.
gi 1332378068 543 TFKVIL 548
Cdd:COG0642   320 TFTVTL 325

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

209-548

3.66e-60

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 203.15 E-value: 3.66e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 209 KIQSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNIS------HNIEQVGYHGyvnTEIEQLILESFKVEKPIYEQ 282
Cdd:COG3852     3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSaeellgRPLAELFPED---SPLRELLERALAEGQPVTER 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 283 -LEVAINQVHAKYFDISCVPIltRSQKSLQGILVVMHDITNLKQLEN-LRR--------EFVANVSHELKTPITSIKGFA 352
Cdd:COG3852    80 eVTLRRKDGEERPVDVSVSPL--RDAEGEGGVLLVLRDITERKRLEReLRRaeklaavgELAAGLAHEIRNPLTGIRGAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 353 ETLIDgaKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEqhtELDTDYMNLSDLTRRIIDNMMTQANqKNISIHTDI 432
Cdd:COG3852   158 QLLER--ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR---PPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDY 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 433 EKDVI-VKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFR----------VIFEVQDFGIGIKLEDQQRIFERFY 501
Cdd:COG3852   232 DPSLPeVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlyVRIEVIDNGPGIPEEILDRIFEPFF 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1332378068 502 rvdkarSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG3852   312 ------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

202-548

2.59e-59

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 204.44 E-value: 2.59e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 202 QKLNNEQKIQS-NRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHN--IEQVGY---HGYVNTEIEQLILESFKV 275
Cdd:COG5809   129 RKRMEEALRESeEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEelIGKSILeliHSDDQENVAAFISQLLKD 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 276 EKPIYEQLEVAINQVHAKYFDISCVPILTRSQksLQGILVVMHDITNLKQLENLRR---------EFVANVSHELKTPIT 346
Cdd:COG5809   209 GGIAQGEVRFWTKDGRWRLLEASGAPIKKNGE--VDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPLT 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 347 SIKGFAETLIDGAKNDAEsldMFLNIILKESNRIESLVTDLLDLSHIEqhtELDTDYMNLSDLTRRIIDNMMTQANQKNI 426
Cdd:COG5809   287 SLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQ---AIKYEPKDLNTLIEEVIPLLQPQALLKNV 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 427 SIHTDIEKDV-IVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYR-DDFRVIFEVQDFGIGIKLEDQQRIFERFYrvd 504
Cdd:COG5809   361 QIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAeDDDKVVISVTDEGCGIPEERLKKLGEPFY--- 437

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1332378068 505 karSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG5809   438 ---TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

314-548

4.56e-55

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 191.76 E-value: 4.56e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 314 LVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAeSLDMFLNIILKESNRIESLVTDLLDLSHI 393
Cdd:PRK11006  188 LMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLLTLSKI 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 394 EQHTELDTDY-----MNLSDLTRRIIDnmMTQANQKnisIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINV 468
Cdd:PRK11006  267 EAAPTIDLNEkvdvpMMLRVLEREAQT--LSQGKHT---ITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 469 RVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK11006  342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

153-549

8.55e-51

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 181.85 E-value: 8.55e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 153 KRTLIRPIQEVTYATQLLANG-YYHIRV---PESNVVETKALFVSTNDLARRlqKLNNEQKIQSNRLKTTIENIPSAILM 228
Cdd:COG5805    95 IERLQKGYDVVMIEQIYCKDGeLIYVEVklfPIYNQNGQAAILALRDITKKK--KIEEILQEQEERLQTLIENSPDLICV 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 229 IDRNGKIVVANKAYYEQFNISHNiEQVG--YHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHA----KYFDISCVPI 302
Cdd:COG5805   173 IDTDGRILFINESIERLFGAPRE-ELIGknLLELLHPCDKEEFKERIESITEVWQEFIIEREIITKdgriRYFEAVIVPL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 303 LTRSQkSLQGILVVMHDITNLKQLENLRR---------EFVANVSHELKTPITSIKGFAETLidgaKNDAESLDMFLNII 373
Cdd:COG5805   252 IDTDG-SVKGILVILRDITEKKEAEELMArseklsiagQLAAGIAHEIRNPLTSIKGFLQLL----QPGIEDKEEYFDIM 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 374 LKESNRIESLVTDLLDLSHIEQHtelDTDYMNLSDLTRRIIDNMMTQANQKNISIHTD-IEKDVIVKAQESKIAQVITNL 452
Cdd:COG5805   327 LSELDRIESIISEFLALAKPQAV---NKEKENINELIQDVVTLLETEAILHNIQIRLElLDEDPFIYCDENQIKQVFINL 403

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 453 LTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYrvdkarSRDSGGTGLGLSITKHIVEAHQGNI 532
Cdd:COG5805   404 IKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTI 477

                         410
                  ....*....|....*..
gi 1332378068 533 EVNSQVGKGSTFKVILK 549
Cdd:COG5805   478 DIDSKVGKGTTFTITLP 494

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

324-548

1.37e-47

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 173.05 E-value: 1.37e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 324 KQLENLRRE---FVANVSHELKTPITSIKGFAETLID--GAKNDAESLDmFLNIILKESNRIESLVTDLLDLSHIEQhTE 398
Cdd:COG4251   273 AELERSNEEleqFAYVASHDLREPLRKISGFSQLLEEdyGDKLDEEGRE-YLERIRDAAERMQALIDDLLAYSRVGR-QE 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 399 LDTDYMNLSDLTRRIIDNMMTQANQKNISIHtdIEKDVIVKAQESKIAQVITNLLTNAINYS--YEDGDINVRVYRDDFR 476
Cdd:COG4251   351 LEFEPVDLNELLEEVLEDLEPRIEERGAEIE--VGPLPTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGE 428

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1332378068 477 VIFEVQDFGIGIKLEDQQRIFERFYRVDkaRSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG4251   429 WVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498

PRK11360

two-component system sensor histidine kinase AtoS;

103-549

6.20e-47

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 173.23 E-value: 6.20e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 103 FIFNKKVNGYhVWIkgyNNDITEMHWTLWK-----YLILTCLVVlISLyFASRSFKRTLIRPIQEVTYATQLLANGYYHi 177
Cdd:PRK11360  162 IERNGEVIGY-IWA---NELTEDIRRQAWKmdrriYAVLAAGLV-IGL-LLIFLLSRRFSANVDIIKDGLSTLENDLST- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 178 RVPESNVvETKALFVSTNDLARRLQKLNNeqkiqsnRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNiEQVGY 257
Cdd:PRK11360  235 RLPPLPG-ELGEISQAINNLAQALRETRS-------LNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRH-ELVGK 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 258 HGY----VNTEIEQLILESFKVEKPIYEQLevAINQVHAKYFDISC-VPILTRSQKSLQGILVVMHDITNLKQL-ENLRR 331
Cdd:PRK11360  306 PYSelfpPNTPFASPLLDTLEHGTEHVDLE--ISFPGRDRTIELSVsTSLLHNTHGEMIGALVIFSDLTERKRLqRRVAR 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 332 --------EFVANVSHELKTPITSIKGFAETLIDGAKNDAESldMFLNIILKESNRIESLVTDLLDLSHIEQHTeldTDY 403
Cdd:PRK11360  384 qerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQ--EYLSVVLREVDRLNKVIDQLLEFSRPRESQ---WQP 458

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 404 MNLSDLTRRIIDNMMTQANQKNISIHTDIEKDV-IVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRD-DFRVIFEV 481
Cdd:PRK11360  459 VSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsDGQVAVSI 538

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1332378068 482 QDFGIGIKLEDQQRIFERFYRVdKARsrdsgGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:PRK11360  539 EDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

311-548

1.26e-44

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 161.50 E-value: 1.26e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 311 QGILVVMHDITNLKQLEN-LRR--------EFVANVSHELKTPITSIKGFAETLID--GAKNDAESLDMFLNIILKESNR 379
Cdd:COG4191   114 RDITELERAEEELRELQEqLVQseklaalgELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAER 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 380 IESLVTDLLDLSHieqHTELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVI-VKAQESKIAQVITNLLTNAIn 458
Cdd:COG4191   194 AAEIVRSLRAFSR---RDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPpVLGDPGQLEQVLLNLLINAI- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 459 YSYEDGD---INVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFY---RVDKarsrdsgGTGLGLSITKHIVEAHQGNI 532
Cdd:COG4191   270 DAMEEGEggrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRI 342

                         250
                  ....*....|....*.
gi 1332378068 533 EVNSQVGKGSTFKVIL 548
Cdd:COG4191   343 EVESEPGGGTTFTITL 358

HATPase

cd00075

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...

445-548

5.22e-38

Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 135.04 E-value: 5.22e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKarSRDSGGTGLGLSITKHI 524
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|....
gi 1332378068 525 VEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd00075    79 VEAHGGRITVESEPGGGTTFTVTL 102

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

445-549

4.37e-37

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 133.00 E-value: 4.37e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSyEDGDINVRVYRDDF-----RVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLS 519
Cdd:cd16922     1 LRQILLNLLGNAIKFT-EEGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332378068 520 ITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:cd16922    80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

440-549

2.94e-36

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 130.85 E-value: 2.94e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068  440 AQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKaRSRDSGGTGLGLS 519
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 1332378068  520 ITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109

PRK11100

sensory histidine kinase CreC; Provisional

326-541

1.46e-35

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 138.82 E-value: 1.46e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 326 LENLRRE---------FVANVSHELKTPITSIKGFAETLIDGAknDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQH 396
Cdd:PRK11100  243 LESMRVKlegkayveqYVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQR 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 397 TELDT-DYMNLSDLTRRIIDNMMTQANQKNISIHTDIEkDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDF 475
Cdd:PRK11100  321 QELEVlEPVALAALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGE 399

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1332378068 476 RVIFEVQDFGIGIKLEDQQRIFERFY---RVDKARSrdsgGTGLGLSITKHIVEAHQGNIEVNSQVGKG 541
Cdd:PRK11100  400 QVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGG 464

PRK10549

two-component system sensor histidine kinase BaeS;

321-532

4.00e-34

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 134.76 E-value: 4.00e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 321 TNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGA-KNDAESLdmflNIILKESNRIESLVTDLLDLSHIE----- 394
Cdd:PRK10549  231 STLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVrKFTPESV----ASLQAEVGTLTKLVDDLHQLSLSDegala 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 395 -QHTELDtdymnLSDLTRRIIDNMMTQANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRD 473
Cdd:PRK10549  307 yRKTPVD-----LVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQR 381

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1332378068 474 DFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNI 532
Cdd:PRK10549  382 DKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

312-548

1.92e-33

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 131.91 E-value: 1.92e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 312 GILVVMHDITNLKQLENLRREFV------------ANVSHELKTPITSIKGFAEtLIDGAKNDAESLDMFLNIILKESNR 379
Cdd:COG5806   171 AMLIAVYLIENLIENILLRKELQraeklevvselaASIAHEVRNPLTVVRGFIQ-LLQEPELSDEKRKQYIRIALEELDR 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 380 IESLVTDLLDLS--HIEQHTELDtdymnLSDLTRRIIDNMMTQANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAI 457
Cdd:COG5806   250 AEAIITDYLTFAkpQPEKLEKID-----VSEELEHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGI 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 458 NYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYrvdkarSRDSGGTGLGLSITKHIVEAHQGNIEVNSQ 537
Cdd:COG5806   325 EAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESE 398

                         250
                  ....*....|.
gi 1332378068 538 VGKGSTFKVIL 548
Cdd:COG5806   399 VGKGTTFTITL 409

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

323-546

4.03e-32

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 128.66 E-value: 4.03e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 323 LKQLEN-LRR--EFVANVSHELKTPITSIKGFAETLIDGAKnDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQ-HTE 398
Cdd:TIGR01386 231 LGRLEDaFQRlsQFSADLAHELRTPLTNLLGQTQVALSQPR-TGEEYREVLESNLEELERLSRMVSDMLFLARADNgQLA 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 399 LDTDYMNLSDLTRRIIDNMMTQANQKNISIhtDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVI 478
Cdd:TIGR01386 310 LERVRLDLAAELAKVAEYFEPLAEERGVRI--RVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVR 387

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1332378068 479 FEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKgSTFKV 546
Cdd:TIGR01386 388 VSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFIL 454

PRK09303

histidine kinase;

323-544

5.24e-32

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 126.99 E-value: 5.24e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 323 LKQLENLRReFVANVSHELKTPITSIKGFAETLIDGAKNDAESLDMFLNIILKESNR-----IESLVTDLLDLShIEQHT 397
Cdd:PRK09303  145 LEQLKFKDR-VLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQLQDQARrqleeIERLITDLLEVG-RTRWE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 398 ELDTDY--MNLSDLTRRIIDNMMTQANQKNISIHTDIEKDV-IVKAQESKIAQVITNLLTNAINYSYEDGDINVRV-YRD 473
Cdd:PRK09303  223 ALRFNPqkLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMlHRT 302

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1332378068 474 DFRVIFEVQDFGIGIKLEDQQRIFERFYRVDkaRSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTF 544
Cdd:PRK09303  303 TQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCF 371

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

294-549

1.27e-30

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 126.98 E-value: 1.27e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 294 YFDISCVPILTRSQKSLqGILVVMHDITNLKQ----LENLRRE---FVANVSHELKTPITSIKGFAETLIDgAKNDAESL 366
Cdd:PRK11091  241 CFELRKVPFYDRVGKRH-GLMGFGRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLD-TELTAEQR 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 367 DmFLNIILKESNRIESLVTDLLDLSHIEQH-TELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDV--IVKAQES 443
Cdd:PRK11091  319 K-YLKTIHVSAITLGNIFNDIIDMDKMERRkLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLphKVITDGT 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 444 KIAQVITNLLTNAINYSYEdGDINVRVYRDDF-RVIFEVQDFGIGIKLEDQQRIFERFYRV-DKARSRDSGGTGLGLSIT 521
Cdd:PRK11091  398 RLRQILWNLISNAVKFTQQ-GGVTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVS 476

                         250       260
                  ....*....|....*....|....*...
gi 1332378068 522 KHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:PRK11091  477 KRLAQAMGGDITVTSEEGKGSCFTLTIH 504

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

442-549

1.87e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 114.77 E-value: 1.87e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 442 ESKIAQVITNLLTNAINYSYEDGDINVRVYRDDfRVIFEVQDFGIGIKLEDQQRIFERFYRVDKarsRDSGGTGLGLSIT 521
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*...
gi 1332378068 522 KHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLP 106

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

449-544

1.50e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 112.30 E-value: 1.50e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 449 ITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAH 528
Cdd:cd16952     5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84

                          90
                  ....*....|....*.
gi 1332378068 529 QGNIEVNSQVGKGSTF 544
Cdd:cd16952    85 DARLLIASELGKGSRF 100

PRK10364

two-component system sensor histidine kinase ZraS;

305-548

2.45e-28

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 117.97 E-value: 2.45e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 305 RSQKSLQGILVVMHDITNLKQLENLrrefVANVSHELKTPITSIKGFAETLidGAKNDAESLDMFL-NIILKESNRIESL 383
Cdd:PRK10364  216 RYLRSRQLLQDEMKRKEKLVALGHL----AAGVAHEIRNPLSSIKGLAKYF--AERAPAGGEAHQLaQVMAKEADRLNRV 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 384 VTDLLDLSHieqHTELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDV-IVKAQESKIAQVITNLLTNAINYSYE 462
Cdd:PRK10364  290 VSELLELVK---PTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQ 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 463 DGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYrVDKARsrdsgGTGLGLSITKHIVEAHQGNIEVNSQVGKGS 542
Cdd:PRK10364  367 HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGA 440


                  ....*.
gi 1332378068 543 TFKVIL 548
Cdd:PRK10364  441 TFTLWL 446

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

443-548

5.75e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 107.51 E-value: 5.75e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 443 SKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSrdsgGTGLGLSITK 522
Cdd:cd16943     2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSY 77

                          90       100
                  ....*....|....*....|....*.
gi 1332378068 523 HIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16943    78 RIIQKHGGTIRVASVPGGGTRFTIIL 103

PRK15347

two component system sensor kinase;

332-548

5.82e-28

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 118.98 E-value: 5.82e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 332 EFVANVSHELKTPITSIKGfAETLIDGAKNDAESLDMfLNIILKESNRIESLVTDLLDLSHIEQ-HTELDTDYMNLSDLt 410
Cdd:PRK15347  400 EHLTTISHEIRTPLNGVLG-ALELLQNTPLTAEQMDL-ADTARQCTLSLLAIINNLLDFSRIESgQMTLSLEETALLPL- 476

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 411 rriIDNMM----TQANQKNISIHTDIEKDVIVKAQESKI--AQVITNLLTNAINYSyEDGDINVRVYRDDFRVIFEVQDF 484
Cdd:PRK15347  477 ---LDQAMltiqGPAQSKSLTLRTFVGAHVPLYLHLDSLrlRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDT 552

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1332378068 485 GIGIKLEDQQRIFERFYRVDKarsrDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK15347  553 GCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612

PRK11107

hybrid sensory histidine kinase BarA; Provisional

332-544

5.56e-27

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 116.10 E-value: 5.56e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 332 EFVANVSHELKTPITSIKGFAETLIDGAKNDAEsLDmFLNIILKESNRIESLVTDLLDLShieqhtELDTDYMNLSDLT- 410
Cdd:PRK11107  295 EFLANMSHELRTPLNGVIGFTRQTLKTPLTPTQ-RD-YLQTIERSANNLLAIINDILDFS------KLEAGKLVLENIPf 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 411 --RRIIDNMMT----QANQKNISIHTDIEKDV--IVKAQESKIAQVITNLLTNAINYSyEDGDINVRVYR---DDFRVIF 479
Cdd:PRK11107  367 slRETLDEVVTllahSAHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFT-ESGNIDILVELralSNTKVQL 445

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1332378068 480 EVQ--DFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTF 544
Cdd:PRK11107  446 EVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512

envZ

PRK09467

osmolarity sensor protein; Provisional

324-535

7.70e-27

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 113.08 E-value: 7.70e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 324 KQLENLRREFVANVSHELKTPITSIKGFAETLIDGakndaeslDMFLNiilkesnriESLVTDLLD--------LSHIEQ 395
Cdd:PRK09467  223 KQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEE--------DGYLA---------ESINKDIEEcnaiieqfIDYLRT 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 396 HTELDTDYMNLSDLTRRIIdnmMTQANQKNIsIHTDI-EKDVIVKAQESKIAQVITNLLTNAINYSyeDGDINVRVYRDD 474
Cdd:PRK09467  286 GQEMPMEMADLNALLGEVI---AAESGYERE-IETALqPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEG 359

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1332378068 475 FRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSrdSGGTGLGLSITKHIVEAHQGNIEVN 535
Cdd:PRK09467  360 KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELG 418

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

320-539

7.87e-27

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 113.49 E-value: 7.87e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 320 ITNLKQLENLRREFVANVSHELKTPITSIKgFAETLI---DGAKNDAESLDMflniilkESNRIESLVTDLLDLSHIEQH 396
Cdd:PRK09470  233 VTALERMMTSQQRLLSDISHELRTPLTRLQ-LATALLrrrQGESKELERIET-------EAQRLDSMINDLLVLSRNQQK 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 397 TELDTDYMNLSDLTRRIIDNMMTQANQKNISIH-TDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDF 475
Cdd:PRK09470  305 NHLERETFKANSLWSEVLEDAKFEAEQMGKSLTvSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGL 384

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1332378068 476 RVIfeVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVN-SQVG 539
Cdd:PRK09470  385 TIT--VDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEdSPLG 447

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-532

2.12e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 100.48 E-value: 2.12e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSyeDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHI 524
Cdd:cd16949     1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78


                  ....*...
gi 1332378068 525 VEAHQGNI 532
Cdd:cd16949    79 IEQHGGKI 86

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

333-538

3.23e-25

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 108.71 E-value: 3.23e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 333 FVANVSHELKTPITSIKGFAETLIDGAKNDAEsLDMFLNIILKESNRIESLVTDLLDLSHIE-QHTELDTDYMNLSDLTR 411
Cdd:PRK09835  265 FSADIAHEIRTPITNLITQTEIALSQSRSQKE-LEDVLYSNLEELTRMAKMVSDMLFLAQADnNQLIPEKKMLDLADEVG 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 412 RIIDNMMTQANQKNISIHTDiEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLE 491
Cdd:PRK09835  344 KVFDFFEAWAEERGVELRFV-GDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPE 422

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1332378068 492 DQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQV 538
Cdd:PRK09835  423 HLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA 469

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

132-548

8.63e-24

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 103.39 E-value: 8.63e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 132 KYLILTCLVVLISLYFASRSFKRTLIRPIQEVTYATQLLANGYYHIRVPESNVVETKALFVSTNDLARRLQKLNNEQKiq 211
Cdd:COG3290    10 LLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEERE-- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 212 snrlkTTIENIPSAILMIDRNGKIVVANKAYYEQFNIShnieqvgYHGYVNTEIEQLILESFKVEKPIYeqlevainqVH 291
Cdd:COG3290    88 -----AVLESIREGVIAVDRDGRITLINDAARRLLGLD-------AIGRPIDEVLAEVLETGERDEEIL---------LN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 292 AKYFDISCVPIltRSQKSLQGILVVMHDITNLKQL-----------ENLRREfvanvSHELKTPITSIKGFAETlidgaK 360
Cdd:COG3290   147 GRVLVVNRVPI--RDDGRVVGAVATFRDRTELERLeeelegvkelaEALRAQ-----RHDFRNHLHTISGLLQL-----G 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 361 NDAESLDMflniILKESNRIESLVTDLLDLSHieqHTELDTdymnlsdltrrIIDNMMTQANQKNISIHTDIEKDVIV-K 439
Cdd:COG3290   215 EYDEALEY----IDEISEELQELIDSLLSRIG---NPVLAA-----------LLLGKAARARERGIDLTIDIDSDLPDlP 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 440 AQESKIAQVITNLLTNAI----NYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRvdkarSRDSGGTG 515
Cdd:COG3290   277 LSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRG 351

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1332378068 516 LGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG3290   352 LGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

442-532

3.04e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 94.45 E-value: 3.04e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 442 ESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSIT 521
Cdd:cd16946     2 RDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAIC 81

                          90
                  ....*....|.
gi 1332378068 522 KHIVEAHQGNI 532
Cdd:cd16946    82 HNIALAHGGTI 92

PRK10604

sensor protein RstB; Provisional

322-544

1.46e-22

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 100.45 E-value: 1.46e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 322 NLKQLENLRREFVANVSHELKTPITSIKGFAETLidgaKNDAESLDMFLNiilKESNRIESLVTDLLDLSHIE-QHTELD 400
Cdd:PRK10604  204 NINALIASKKQLIDGIAHELRTPLVRLRYRLEMS----DNLSAAESQALN---RDIGQLEALIEELLTYARLDrPQNELH 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 401 TDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDVIVkAQESKIAQVITNLLTNAINYSyeDGDINVRVYRDDFRVIFE 480
Cdd:PRK10604  277 LSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGA-LDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLI 353

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1332378068 481 VQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTF 544
Cdd:PRK10604  354 VEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARF 417

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

432-541

2.41e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 92.08 E-value: 2.41e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 432 IEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIfEVQDFGIGIKLEDQQRIFERFYRVDKarsRDS 511
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVI-RVEDNGPGIDEEELEALFERFYRSDG---QNY 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332378068 512 GGTGLGLSITKHIVEAHQGNIEVNSQVGKG 541
Cdd:cd16940    77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGG 106

PRK10490

sensor protein KdpD; Provisional

327-548

3.76e-22

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 100.88 E-value: 3.76e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 327 ENLRREFVANVSHELKTPITSIKGFAETLI-----DGAKNdAESLDMFLNIILKESNriesLVTDLLDLSHIEQH-TELD 400
Cdd:PRK10490  661 EQLRNALLAALSHDLRTPLTVLFGQAEILTldlasEGSPH-ARQASEIRQQVLNTTR----LVNNLLDMARIQSGgFNLR 735

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 401 TDYMNLSDL---TRRIIDNMMTQaNQKNISIHTDIekdVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRV 477
Cdd:PRK10490  736 KEWLTLEEVvgsALQMLEPGLSG-HPINLSLPEPL---TLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERL 811

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1332378068 478 IFEVQDFGIGIKLEDQQRIFERFYRVDKARSrdSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK10490  812 QLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880

PRK10841

two-component system sensor histidine kinase RcsC;

333-546

5.47e-22

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 100.43 E-value: 5.47e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 333 FVANVSHELKTPITSIKGFAE-----TLIDG------AKNDAESLdmFLNIIlkesnrieslvTDLLDLSHIE-QHTELD 400
Cdd:PRK10841  450 FLATVSHELRTPLYGIIGNLDllqtkELPKGvdrlvtAMNNSSSL--LLKII-----------SDILDFSKIEsEQLKIE 516

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 401 TDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEKDV--IVKAQESKIAQVITNLLTNAINYSyEDGDINVRVYRDDFRVI 478
Cdd:PRK10841  517 PREFSPREVINHITANYLPLVVKKRLGLYCFIEPDVpvALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLS 595

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1332378068 479 FEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKV 546
Cdd:PRK10841  596 FRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTI 663

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

444-548

1.38e-21

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 89.86 E-value: 1.38e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 444 KIAQVITNLLTNAINYSYEDGDINVRVYRDDF-RVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITK 522
Cdd:cd16925     4 KYERVVLNLLSNAFKFTPDGGRIRCILEKFRLnRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVK 83

                          90       100
                  ....*....|....*....|....*.
gi 1332378068 523 HIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16925    84 EFVELHGGTVTVSDAPGGGALFQVEL 109

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-544

2.25e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 88.92 E-value: 2.25e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYEDGDINVRV-YRDD-FRVIFEVQDFGIGIKLEDQQRIFERFYRVDkarSRD-SGGTGLGLSIT 521
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVgAEDVgEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREeYEGTGVGLAIV 77

                          90       100
                  ....*....|....*....|...
gi 1332378068 522 KHIVEAHQGNIEVNSQVGKGSTF 544
Cdd:cd16921    78 RKIIERHGGRIWLESEPGEGTTF 100

PRK11466

hybrid sensory histidine kinase TorS; Provisional

333-548

4.18e-21

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 97.67 E-value: 4.18e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 333 FVANVSHELKTPITSIKGFAETLIDGAKNDAESLDmfLNIILKESNRIESLVTDLLDLSHIEqhteLDTDYMNLSD---L 409
Cdd:PRK11466  447 FLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDD--LRAITDSGESLLTILNDILDYSAIE----AGGKNVSVSDepfE 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 410 TRRIIDN----MMTQANQKNISIHTDIEKDV--IVKAQESKIAQVITNLLTNAINYSyEDGDINVRVYRDDFRVIFEVQD 483
Cdd:PRK11466  521 PRPLLEStlqlMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVED 599

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1332378068 484 FGIGIKLEDQQRIFERFYRVDKARsrdsGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK11466  600 SGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

446-548

9.19e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 87.06 E-value: 9.19e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 446 AQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKarSRDSGGTGLGLSITKHIV 525
Cdd:cd16923     2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAII 79

                          90       100
                  ....*....|....*....|...
gi 1332378068 526 EAHQGNIEVNSQvGKGSTFKVIL 548
Cdd:cd16923    80 ELHGGSASAEYD-DNHDLFKVRL 101

PRK09959

acid-sensing system histidine kinase EvgS;

330-548

2.93e-20

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 95.19 E-value: 2.93e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068  330 RREFVANVSHELKTPITSIKGFAEtLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQ-HTELDTDYMNLSD 408
Cdd:PRK09959   712 KSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESgNYQLQPQWVDIPT 790

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068  409 LTRRIIDNMMTQANQKNISIH--TDIEKDVIVKAQESKIAQVITNLLTNAINYSYEdGDINVR---VYRDDFRVIFE--V 481
Cdd:PRK09959   791 LVQNTCHSFGAIAASKSIALScsSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTE-GAVKITtslGHIDDNHAVIKmtI 869

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1332378068  482 QDFGIGIKLEDQQRIFERFYRVDKARSRDsgGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK09959   870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-541

6.88e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 81.73 E-value: 6.88e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSyeDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKArsRDSGGTGLGLSITKHI 524
Cdd:cd16950     1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76

                          90
                  ....*....|....*..
gi 1332378068 525 VEAHQGNIEVNSQVGKG 541
Cdd:cd16950    77 SDAHGGSLTLANRAGGG 93

PRK10337

sensor protein QseC; Provisional

331-541

1.05e-17

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 85.86 E-value: 1.05e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 331 REFVANVSHELKTPITSIKGFAEtLIDGAKNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTEL-DTDYMNLSDL 409
Cdd:PRK10337  238 RRFTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLqDVAEIPLEDL 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 410 TRRIIDNMMTQANQKNISIHTDIE-KDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVifevQDFGIGI 488
Cdd:PRK10337  317 LQSAVMDIYHTAQQAGIDVRLTLNaHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTV----RDNGPGV 392

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1332378068 489 KLEDQQRIFERFYRvdkARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKG 541
Cdd:PRK10337  393 TPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

448-544

1.18e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 78.48 E-value: 1.18e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 448 VITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARsRDSGGTGLGLSITKHIVEA 527
Cdd:cd16948     9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLCDK 87

                          90
                  ....*....|....*..
gi 1332378068 528 HQGNIEVNSQVGKGSTF 544
Cdd:cd16948    88 LGHKIDVESEVGEGTTF 104

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

330-395

1.61e-17

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 76.87 E-value: 1.61e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1332378068 330 RREFVANVSHELKTPITSIKGFAETLIDGAKNdaESLDMFLNIILKESNRIESLVTDLLDLSHIEQ 395
Cdd:pfam00512   2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLD--EEQREYLETILRSAERLLRLINDLLDLSRIEA 65

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

428-549

2.05e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 78.32 E-value: 2.05e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 428 IHTDIEKDVI-VKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKA 506
Cdd:cd16947     3 VEINIPDRPIyANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDS 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1332378068 507 RSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:cd16947    83 RNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTLK 125

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

327-391

3.48e-17

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 75.71 E-value: 3.48e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1332378068 327 ENLRREFVANVSHELKTPITSIKGFAETLIDGAKNDAEsLDMFLNIILKESNRIESLVTDLLDLS 391
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEE-QREYLERIREEAERLLRLINDLLDLS 64

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

330-395

4.66e-17

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 75.30 E-value: 4.66e-17

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1332378068  330 RREFVANVSHELKTPITSIKGFAETLIDGAKNDAEslDMFLNIILKESNRIESLVTDLLDLSHIEQ 395
Cdd:smart00388   2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-544

1.60e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 75.16 E-value: 1.60e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYEDGDINVRVyrDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHI 524
Cdd:cd16939     1 MARALDNLLRNALRYAHRTVRIALLV--SGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78

                          90       100
                  ....*....|....*....|.
gi 1332378068 525 VEAHQGNIEV-NSQVGkGSTF 544
Cdd:cd16939    79 ALWHGGHVECdDSELG-GACF 98

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-548

3.50e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 74.36 E-value: 3.50e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAI----NYSYEDGDINVRVYRDDFR-VIFEVQDFGIGIKLEDQQRIFERFYrvdkarSRDSGGTGLGLS 519
Cdd:cd16920     1 IQQVLINLVRNGIeamsEGGCERRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLS 74

                          90       100
                  ....*....|....*....|....*....
gi 1332378068 520 ITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16920    75 ICRSIIEAHGGRLSVESPAGGGATFQFTL 103

PRK13837

two-component system VirA-like sensor kinase;

326-548

1.24e-15

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 80.11 E-value: 1.24e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 326 LENLRR-----EFVANVSHELKTPITSIKGFAEtlIDGAKNDAES-LDMFLNIILKESNRIESLVTDLLDLShieQHTEL 399
Cdd:PRK13837  441 LEHARRleavgTLASGIAHNFNNILGAILGYAE--MALNKLARHSrAARYIDEIISAGARARLIIDQILAFG---RKGER 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 400 DTDYMNLSDLTRRIIdNMMTQANQKNISIHTDIE-KDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFR-- 476
Cdd:PRK13837  516 NTKPFDLSELVTEIA-PLLRVSLPPGVELDFDQDqEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRap 594

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 477 -------------VIFEVQDFGIGIKlEDQ-QRIFERFYRvdkarSRdSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGS 542
Cdd:PRK13837  595 kvlshgvlppgryVLLRVSDTGAGID-EAVlPHIFEPFFT-----TR-AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGT 667


                  ....*.
gi 1332378068 543 TFKVIL 548
Cdd:PRK13837  668 RFDVYL 673

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-548

1.28e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 69.79 E-value: 1.28e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAIN--YSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRvdkarSRDSG-GTGLGLSIT 521
Cdd:cd16976     1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75

                          90       100
                  ....*....|....*....|....*..
gi 1332378068 522 KHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16976    76 YGIVEEHGGRLSVANEEGAGARFTFDL 102

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-548

1.73e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 69.52 E-value: 1.73e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYED-GDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKH 523
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332378068 524 IVEAHQG-----NIEVNSQVgKGSTFKVIL 548
Cdd:cd16953    81 IIEAHGGisvaeNHNQPGQV-IGARFTVQL 109

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-539

4.02e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 68.64 E-value: 4.02e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKarSRDSGG-TGLGLSITKH 523
Cdd:cd16975     5 LSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDT--SRRSGGhYGMGLYIAKN 82

                          90
                  ....*....|....*..
gi 1332378068 524 IVEAHQGNIEV-NSQVG 539
Cdd:cd16975    83 LVEKHGGSLIIeNSQKG 99

glnL

PRK11073

nitrogen regulation protein NR(II);

303-548

5.41e-14

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 73.58 E-value: 5.41e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 303 LTRSQKSLQGILVVMHDITNLKQL--ENLR-------REFVANVSHELKTPITSIKGFAEtLIDGAKNDaESLDMFLNII 373
Cdd:PRK11073   94 LTAQRLPEGMILLEMAPMDNQRRLsqEQLQhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQ-LLSKALPD-PALTEYTKVI 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 374 LKESNRIESLVTDLLDLSHIEQHTEldtdyMNLSDLTRRIIdNMMTQANQKNISIHTDIEKDVIVKAQES-KIAQVITNL 452
Cdd:PRK11073  172 IEQADRLRNLVDRLLGPQRPGTHVT-----ESIHKVAERVV-QLVSLELPDNVRLIRDYDPSLPELAHDPdQIEQVLLNI 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 453 LTNAIN-YSYEDGDINVRVyRDDFRVIF-----------EVQDFGIGIKLEDQQRIFerfYRVDKARSrdsGGTGLGLSI 520
Cdd:PRK11073  246 VRNALQaLGPEGGTITLRT-RTAFQLTLhgeryrlaariDIEDNGPGIPPHLQDTLF---YPMVSGRE---GGTGLGLSI 318

                         250       260
                  ....*....|....*....|....*...
gi 1332378068 521 TKHIVEAHQGNIEVNSQVGKgSTFKVIL 548
Cdd:PRK11073  319 ARNLIDQHSGKIEFTSWPGH-TEFSVYL 345

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

424-548

2.91e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 66.89 E-value: 2.91e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 424 KNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIfeVQDFGIGIKLEDQQRIFERFYRV 503
Cdd:cd16954    17 KGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLI--VDDDGPGVPESQRSKIFQRGQRL 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1332378068 504 DKARSrdsgGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16954    95 DEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135

PRK10755

two-component system sensor histidine kinase PmrB;

301-530

4.30e-13

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 70.77 E-value: 4.30e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 301 PILTRSqkSLQGILVVmhdITNLKQL-----ENLRRE--FVANVSHELKTPITSIKGFAETLIDGAKNDAESLdmflnii 373
Cdd:PRK10755  106 PIAIHS--STLEIEAV---TSALNQLvsrltSTLDQErlFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPL------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 374 lkeSNRIESL---VTDLLDLSHIEQhtELDTDYMNLSDLTRRIIDNM------MTQANQKNIsIHTDIEKDVIVKAQESK 444
Cdd:PRK10755  174 ---IARLDQMmhtVEQLLQLARAGQ--SFSSGHYQTVKLLEDVILPSqdelseMLEQRQQTL-LLPESAADITVQGDATL 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDkarSRdSGGTGLGLSITKHI 524
Cdd:PRK10755  248 LRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD---SR-YGGIGLGLSIVSRI 323


                  ....*.
gi 1332378068 525 VEAHQG 530
Cdd:PRK10755  324 TQLHHG 329

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

447-545

5.31e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 65.17 E-value: 5.31e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 447 QVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYRVDKARSRDSgGTGLGLSITKHIVE 526
Cdd:cd16945     7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEVAQ 85

                          90       100
                  ....*....|....*....|
gi 1332378068 527 AHQGNIEV-NSQVGKGSTFK 545
Cdd:cd16945    86 LHGGRITLrNRPDGVLAFLT 105

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

448-548

4.78e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 62.30 E-value: 4.78e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 448 VITNLLTNAINYSYEDGDINVRVY---RDDFR-VIFEVQDFGIGIKLEDQQRIFERFYRvdkarSRDSGGTGLGLSITKH 523
Cdd:cd16915     4 IVGNLIDNALDALAATGAPNKQVEvflRDEGDdLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78

                          90       100
                  ....*....|....*....|....*
gi 1332378068 524 IVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16915    79 SVERLGGSITVESEPGGGTTFSIRI 103

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-549

1.71e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 61.01 E-value: 1.71e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAINY--SYEDGDINVRV-YRDDF--RVIFEVQDFGIGIKLEDQQRIFERfYRVDKARsrdsgGTGLGLS 519
Cdd:cd16944     5 ISQVLTNILKNAAEAieGRPSDVGEVRIrVEADQdgRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLA 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332378068 520 ITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:cd16944    79 IVKKIMEEHGGRISLSNREAGGACIRIILP 108

PRK11086

sensory histidine kinase DcuS; Provisional

440-548

2.51e-11

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 66.09 E-value: 2.51e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 440 AQESKIAQVIT---NLLTNAINY--SYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFYrvdkarSRDSGGT 514
Cdd:PRK11086  426 GDEDQVHELITilgNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNR 499

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1332378068 515 GLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:PRK11086  500 GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQI 533

COG3920

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...

373-549

9.04e-11

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];

Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 64.16 E-value: 9.04e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 373 ILKES-NRIESL--VTDLLdlshieqHTELDTDYMNLSDLTRRIIDNMMTQANQKNISIHTDIEkDVIVKAQESK-IAQV 448
Cdd:COG3920   332 ALEESqNRIQALalVHELL-------YQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGP-DVELPADAAVpLGLI 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 449 ITNLLTNAINY---SYEDGDINVRVYRDDFRVIFEVQDFGIGIKLEdqqriferfyrVDKARSRdsggtGLGLSITKHIV 525
Cdd:COG3920   404 LNELVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALV 467

                         170       180
                  ....*....|....*....|....
gi 1332378068 526 EAHQGNIEVNSqvGKGSTFKVILK 549
Cdd:COG3920   468 RQLGGTLELDR--PEGTRVRITFP 489

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

445-548

2.04e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.18 E-value: 2.04e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 445 IAQVITNLLTNAIN-YSYEDGDI--------NVRVYRDDFRVIF--EVQDFGIGIKLEDQQRIFERFYrvdkarSRDSGG 513
Cdd:cd16918     1 LIQVFLNLVRNAAQaLAGSGGEIilrtrtqrQVTLGHPRHRLALrvSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1332378068 514 TGLGLSITKHIVEAHQGNIEVNSQVGKgSTFKVIL 548
Cdd:cd16918    75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSL 108

PRK10815

two-component system sensor histidine kinase PhoQ;

331-547

2.40e-10

two-component system sensor histidine kinase PhoQ;

Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 62.73 E-value: 2.40e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 331 REFVANVSHELKTPIT-------SIKGFAETLIDgaknDAESldmflnIILKESNRIESLVTDLLDLSHIE-QHTELDTD 402
Cdd:PRK10815  267 RTTLTDLTHSLKTPLAvlqstlrSLRSGKQMSVE----QAEP------IMLEQISRISQQIGYYLHRASMRsEHNLLSRE 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 403 YMNLSDLtrriIDNMMTQANQ----KNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVI 478
Cdd:PRK10815  337 LHSVAPL----LDNLTSALNKvyqrKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIV 412

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1332378068 479 feVQDFGIGIKLEDQQRIFERFYRVDKARSrdsgGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVI 547
Cdd:PRK10815  413 --VEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVI 475

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

207-350

4.88e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 61.71 E-value: 4.88e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 207 EQKIQSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNiEQVGYHgyVNTEIEQ-LILESFKVEKPIYEQLEV 285
Cdd:COG3829     5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPRE-EVIGKN--VTELIPNsPLLEVLKTGKPVTGVIQK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1332378068 286 AINQvhAKYFDISCVPIltRSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKG 350
Cdd:COG3829    82 TGGK--GKTVIVTAIPI--FEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDIIG 142

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

447-548

1.59e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 55.85 E-value: 1.59e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 447 QVITNLLTNAINYSYEDGDINVRVYR-----------DDFR----VIFEVQDFGIGIKLEDQQRIFERFYRvdkarSRDS 511
Cdd:cd16919     3 LAILNLAVNARDAMPEGGRLTIETSNqrvdadyalnyRDLIpgnyVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1332378068 512 G-GTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16919    78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

337-549

7.39e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 58.54 E-value: 7.39e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 337 VSHELKTPITSIKGFAETL-IDGAKNDAESLDMFLNIILKESNRIESLVTDLldlshiEQHTELDTDYMNLSDLTRRIID 415
Cdd:COG4192   440 LAHELNQPLNAMSMYLFSAkKALEQENYAQLPTSLDKIEGLIERMDKIIKSL------RQFSRKSDTPLQPVDLRQVIEQ 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 416 NMM---TQANQKNISIHtdIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIFEVQDFGIGIKLED 492
Cdd:COG4192   514 AWElveSRAKPQQITLH--IPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD 591

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1332378068 493 qqRIFERFYrvdkarSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTfkVILK 549
Cdd:COG4192   592 --KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAM--VILE 638

ArsS_fam_HK

NF038389

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...

320-528

1.63e-08

Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 56.78 E-value: 1.63e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 320 ITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGaKNDAESLDMF--LNIILKESNRIESLVTdlldlshieQHT 397
Cdd:NF038389  196 VKKIKALNESRQLFLRNIMHELKTPITKGRIVAEMLEDE-KQKERLISIFerLESLINEFAKIEQLTS---------KNY 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 398 ELDTDYMNLSDLTRRIIDNMMtqaNQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSyEDGDINVRVYRDDfrv 477
Cdd:NF038389  266 KLNKKEYRLSDIIDEAIDMLM---IDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYS-PDKKVTIEIKGDK--- 338

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1332378068 478 iFEVQDFGIGIKlEDQQRIFERFYrvdKARSRDSGGTGLGLSITKHIVEAH 528
Cdd:NF038389  339 -IEFKNKGEPLE-EPLEYYFEPFF---KGNEKSKSGFGLGLYIVKNILKAH 384

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

423-548

2.87e-07

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 50.66 E-value: 2.87e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 423 QKNISIH-----TDIEKDVIvkaqeSKIAQVITNLLTNAINYSYED------------GDINVRVYRDDFRVIFEVQDFG 485
Cdd:cd16916    17 GKQVELVvegedTELDKSVL-----EKLADPLTHLLRNAVDHGIEApeerlaagkppeGTITLRAEHQGNQVVIEVSDDG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 486 IGIkleDQQRIFErfyrvdKARSR--------------------------------DSGGTGLGLSITKHIVEAHQGNIE 533
Cdd:cd16916    92 RGI---DREKIRE------KAIERglitadeaatlsddevlnlifapgfstaeqvtDVSGRGVGMDVVKRSIESLGGTIE 162

                         170
                  ....*....|....*
gi 1332378068 534 VNSQVGKGSTFKVIL 548
Cdd:cd16916   163 VESEPGQGTTFTIRL 177

PAS

COG2202

PAS domain [Signal transduction mechanisms];

207-327

6.26e-07

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 50.79 E-value: 6.26e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 207 EQKIQ--SNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNiEQVG------YHGYVNTEIEQLILESFKVEKP 278
Cdd:COG2202   129 EEALResEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPE-ELLGkslldlLHPEDRERLLELLRRLLEGGRE 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1332378068 279 IYEqLEVAINQVHAKYFDISCVPILTRSQKSLQGILVVMHDITNLKQLE 327
Cdd:COG2202   208 SYE-LELRLKDGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAE 255

RsbW

COG2172

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

444-539

1.09e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.99 E-value: 1.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 444 KIAQVITNLLTNAINYSYED---GDINVRVYRDDFRVIFEVQDFGIGIKLEDqqriferfyRVDKARSRDSGGtgLGLSI 520
Cdd:COG2172    34 DLVLAVSEAVTNAVRHAYGGdpdGPVEVELELDPDGLEIEVRDEGPGFDPED---------LPDPYSTLAEGG--RGLFL 102

                          90
                  ....*....|....*....
gi 1332378068 521 TKHIVEAhqgnIEVNSQVG 539
Cdd:COG2172   103 IRRLMDE----VEYESDPG 117

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

336-548

1.54e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 49.62 E-value: 1.54e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 336 NVSHELktpiTSIKGFAETLIDGAKNDAESLDMFLNIILKESNRIeslVTDLLDLSHIEQHTELDTdyMNLSDLTRRIID 415
Cdd:COG4585    64 GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREA---LAELRRLVRGLRPPALDD--LGLAAALEELAE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 416 NMMTQANQKnISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSyEDGDINVRVYRDDFRVIFEVQDFGIGIKLEDQqr 495
Cdd:COG4585   135 RLLRAAGIR-VELDVDGDPDRLPPEVELALYRIVQEALTNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDPEAA-- 210

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1332378068 496 iferfyrvdkarsrdsGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG4585   211 ----------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

452-548

7.73e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 48.48 E-value: 7.73e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 452 LLTNAINYSYE----DGDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRIFERFyrvdkarSRDSGGTGLGLSITKHIVEA 527
Cdd:COG2972   344 LVENAIEHGIEpkegGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416

                          90       100
                  ....*....|....*....|....
gi 1332378068 528 HQGN---IEVNSQVGKGSTFKVIL 548
Cdd:COG2972   417 YYGEeygLEIESEPGEGTTVTIRI 440

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

213-320

1.80e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 43.95 E-value: 1.80e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 213 NRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNIShnIEQVgyhgyvnteIEQLILESFKVEKPI--YEQLEVAINQV 290
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLS--REEV---------IGKSLLDLIPEEDDAevAELLRQALLQG 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1332378068 291 HA---------------KYFDISCVPILTRSQKSLqGILVVMHDI 320
Cdd:pfam00989  70 EEsrgfevsfrvpdgrpRHVEVRASPVRDAGGEIL-GFLGVLRDI 113

HATPase_ETR2_ERS2-EIN4-like

cd16938

Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ...

435-548

2.06e-05

Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 44.37 E-value: 2.06e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 435 DVIVkAQESKIAQVITNLLTNAINYSYEDGDINVRVY-------RDDFRVIF--------EVQD-FGIGIKLEDQQRIFE 498
Cdd:cd16938     3 DVVV-GDERRVFQVLLHMLGNLLKMRNGGGNITFRVFleggsedRSDRDWGPwrpsmsdeSVEIrFEVEINDSGSPSIES 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1332378068 499 RFYRVD-KARSRDSG-GTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVIL 548
Cdd:cd16938    82 ASMRNSlNRRYNLSElGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133

PAS_4

pfam08448

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

220-325

7.27e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 42.02 E-value: 7.27e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 220 ENIPSAILMIDRNGKIVVANKAYYEQFNISHN-IEQVGYHGYVNTE----IEQLILESFKVEKPIYEQLEVAINQVHaKY 294
Cdd:pfam08448   2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEeLLGKTLAELLPPEdaarLERALRRALEGEEPIDFLEELLLNGEE-RH 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1332378068 295 FDISCVPILTRSQKsLQGILVVMHDITNLKQ 325
Cdd:pfam08448  81 YELRLTPLRDPDGE-VIGVLVISRDITERRR 110

PAS

COG2202

PAS domain [Signal transduction mechanisms];

207-332

8.02e-05

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 44.63 E-value: 8.02e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 207 EQKIQSNRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNiEQVG------YHGYVNTEIEQLILESFKVEKPIY 280
Cdd:COG2202     5 ALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAE-ELLGktlrdlLPPEDDDEFLELLRAALAGGGVWR 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1332378068 281 EQLEVAINQVHAKYFDISCVPILTRSQKsLQGILVVMHDITNLKQLENLRRE 332
Cdd:COG2202    84 GELRNRRKDGSLFWVELSISPVRDEDGE-ITGFVGIARDITERKRAEEALRE 134

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

214-328

1.38e-04

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 41.89 E-value: 1.38e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 214 RLKTTIENIPSAILMIDRNGKIVVANKAYYEQFN------ISHNIEQVGYHGYVNtEIEQLILESFKVEKPIYEQLEVAI 287
Cdd:TIGR00229   4 RYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGysaeelIGRNVLELIPEEDRE-EVRERIERRLEGEPEPVSEERRVR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1332378068 288 NQV-HAKYFDISCVPIltRSQKSLQGILVVMHDITNLKQLEN 328
Cdd:TIGR00229  83 RKDgSEIWVEVSVSPI--RTNGGELGVVGIVRDITERKEAEE 122

CheA

COG0643

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

362-548

3.71e-04

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 43.25 E-value: 3.71e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 362 DAESLDMFLN-----IILKesNRIESLVTDLLDlshiEQHTELDTDYMNLSDLTRRIIDNMMT----------------- 419
Cdd:COG0643   175 DVERLDRLMNlvgelVITR--ARLEQLAEELED----ESLRELEEALEQLSRLTRELQDGVMRlrmvpistvfnrfprmv 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 420 ----QANQKNISIH-----TDIEKDVIvkaqeSKIAQVITNLLTNAINYSYED------------GDINVRVYRDDFRVI 478
Cdd:COG0643   249 rdlaRELGKEVELViegeeTELDRTVL-----ERLGDPLVHLVRNAVDHGIETpeerlaagkpetGTITLSAYHEGGRVV 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 479 FEVQDFGIGIkleDQQRIFErfyrvdKARSR------------D---------SG-----------GTGLGLSITKHIVE 526
Cdd:COG0643   324 IEVSDDGRGL---DLEKIRA------KAIEKglitaeeaaalsDeellelifaPGfstaeevtdlsGRGVGMDVVKTNIE 394

                         250       260
                  ....*....|....*....|..
gi 1332378068 527 AHQGNIEVNSQVGKGSTFKVIL 548
Cdd:COG0643   395 ALGGTIEIESEPGKGTTFTLRL 416

PRK10618

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

330-549

7.31e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 42.61 E-value: 7.31e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 330 RREFVANVSHELKTPITSIKGFAETLIDGAKNDAESldMFLNIILKESNRIESLVTDLLDLSHIEQHT-ELDTDYMNLSD 408
Cdd:PRK10618  450 RKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQ--PELDQLAEQSDVLVRLVDNIQLLNMLETQDwKPEQELFSLQD 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 409 LtrriIDNMMTQA----NQK--NISIHTDIEKDVIVKAQESKIAQVITNLLTNAI-NYSYedGDINVRVYRD---DFRVI 478
Cdd:PRK10618  528 L----IDEVLPEVlpaiKRKglQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAItTTAY--GKITLEVDQDessPDRLT 601

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1332378068 479 FEVQDFGIGIKLEDQQRIfeRFYRVDKARS-RDSGGTGLGLSITKHIVEAHQGNIEVNSQVGKGSTFKVILK 549
Cdd:PRK10618  602 IRILDTGAGVSIKELDNL--HFPFLNQTQGdRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671

PAS_8

pfam13188

PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...

213-256

1.30e-03

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 37.53 E-value: 1.30e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1332378068 213 NRLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNISHNIEQVG 256
Cdd:pfam13188   1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLG 44

HATPase_RsbW-like

cd16936

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...

448-527

1.35e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.

Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.02 E-value: 1.35e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 448 VITNLLTNAINYSY---EDGDINVRVYRDDFRVIFEVQDFGIGikledqqriferfYRVDKARSRDSGGT--GLGLSITK 522
Cdd:cd16936     4 AVSEAVTNAVRHAYrhdGPGPVRLELDLDPDRLRVEVTDSGPG-------------FDPLRPADPDAGLRegGRGLALIR 70


                  ....*
gi 1332378068 523 HIVEA 527
Cdd:cd16936    71 ALMDE 75

HATPase_SpoIIAB-like

cd16942

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...

443-549

1.74e-03

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.

Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 38.67 E-value: 1.74e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 443 SKIAQVITNLLTNAINYSYED---GDINVRVYRDDFRVIFEVQDFGIGIklEDQQRIFERFYRVDKARSRdsggTGLGLS 519
Cdd:cd16942    37 TEIKTVVSEAVTNAIIHGYNNdpnGIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPELER----SGMGFT 110

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332378068 520 ITKHIVEahqgNIEVNSQVGKGSTfkVILK 549
Cdd:cd16942   111 IMENFMD----EVIVESEVNKGTT--VYLK 134

HATPase_c_2

pfam13581

Histidine kinase-like ATPase domain;

452-529

2.45e-03

Histidine kinase-like ATPase domain;

Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.04 E-value: 2.45e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332378068 452 LLTNAINYSYED---GDINVRVYRDDFRVIFEVQDFGIGIKLEDQQRiferfyRVDKARSRDSGGTGLGLSITKHIVEAH 528
Cdd:pfam13581  39 ACTNAVEHAYREgpeGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP------PDLEEPDEDRKEGGRGLALIRGLMDDV 112


                  .
gi 1332378068 529 Q 529
Cdd:pfam13581 113 E 113

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

214-249

9.62e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 35.07 E-value: 9.62e-03

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1332378068  214 RLKTTIENIPSAILMIDRNGKIVVANKAYYEQFNIS 249
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYS 37

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01