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Conserved domains on  [gi|1331215056|ref|YP_009453827|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Sundamys annandalei]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.99e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.50  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.99e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.50  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
6-98 1.65e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 65.28  E-value: 1.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  6 LNLTLAFMMSLLGtFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTY 85
Cdd:pfam00420  4 LLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTH 82

                         90
                 ....*....|...
gi 1331215056 86 GTDYVQNLNLLQC 98
Cdd:pfam00420 83 GTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.47e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 37.35  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056 12 FMMSLLGtFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:COG0713   14 FAIGLYG-VLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*
gi 1331215056 92 NLNLL 96
Cdd:COG0713   93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.99e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.50  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.33e-27

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 96.19  E-value: 1.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.02e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 86.44  E-value: 1.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.40e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 77.72  E-value: 2.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
6-98 1.65e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 65.28  E-value: 1.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  6 LNLTLAFMMSLLGtFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTY 85
Cdd:pfam00420  4 LLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTH 82

                         90
                 ....*....|...
gi 1331215056 86 GTDYVQNLNLLQC 98
Cdd:pfam00420 83 GTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 8-96 2.86e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 57.26  E-value: 2.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  8 LTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTYGT 87
Cdd:MTH00181   5 FISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGS 84


                 ....*....
gi 1331215056 88 DYVQNLNLL 96
Cdd:MTH00181  85 DHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 6.01e-11

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 53.77  E-value: 6.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1331215056 81 VSNTYGTDYVQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.71e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 48.82  E-value: 5.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSmiSMTIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00188   2 FFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVS 79

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00188  80 LIRSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 8.73e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 48.30  E-value: 8.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  9 TLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTStlNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTYGTD 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSS--SGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 1331215056 89 YVQNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 1.35e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 39.75  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056 12 FMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSmiSMTIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:MTH00162  11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNY--ELYFLLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                 .
gi 1331215056 92 N 92
Cdd:MTH00162  89 S 89
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 2.82e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 39.24  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056 12 FMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:MTH00180  13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                 ....*.
gi 1331215056 92 NLNLLQ 97
Cdd:MTH00180  93 SLNLLR 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 4.39e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.58  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056  1 MTSAILNLTLAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMtIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1331215056 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.47e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 37.35  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056 12 FMMSLLGtFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:COG0713   14 FAIGLYG-VLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*
gi 1331215056 92 NLNLL 96
Cdd:COG0713   93 DLNEL 97
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 10-97 8.36e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 35.42  E-value: 8.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331215056 10 LAFMMSLLGTFMFRSHLMSTLLCLEGMMLSLFIMISTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKVSNTYGTDY 89
Cdd:MTH00001  11 ILFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTIS 90


                 ....*...
gi 1331215056 90 VQNLNLLQ 97
Cdd:MTH00001  91 LKSLNSLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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