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Conserved domains on  [gi|1330817596|gb|PNE67311|]
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GntR family transcriptional regulator [Burkholderia cenocepacia]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-220 1.62e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.87  E-value: 1.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  13 RSLADRIAVALADRIISGVIAPGEWLRQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEMAKMR 92
Cdd:COG1802    10 ESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  93 AAFEALALREAMPALDARALEELDAILDQESAAHG---IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRASSRHLYAT 169
Cdd:COG1802    90 AALEGLAARLAAERATPADLARLRALLEELEAAAAagdVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1330817596 170 WQQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSAHVLAAGDALAQALRRR 220
Cdd:COG1802   170 LRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-220 1.62e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.87  E-value: 1.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  13 RSLADRIAVALADRIISGVIAPGEWLRQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEMAKMR 92
Cdd:COG1802    10 ESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  93 AAFEALALREAMPALDARALEELDAILDQESAAHG---IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRASSRHLYAT 169
Cdd:COG1802    90 AALEGLAARLAAERATPADLARLRALLEELEAAAAagdVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1330817596 170 WQQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSAHVLAAGDALAQALRRR 220
Cdd:COG1802   170 LRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 87-204 6.28e-14

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 65.85  E-value: 6.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  87 EMAKMRAAFEALALREAMPALDARALEELDAILDQESAAHG---IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRASS 163
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADagdLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1330817596 164 RHLYATWQQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSA 204
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 87-206 8.90e-13

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 62.76  E-value: 8.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596   87 EMAKMRAAFEALALREAMPALDARALEELDAILDQESAAHG----IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRAS 162
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAagddLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1330817596  163 SRHLYAtwqQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSAHV 206
Cdd:smart00895  81 RRLRRL---SLEAARRALDEHRAILDAIRARDAEAARAAMREHL 121
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-76 3.04e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 59.77  E-value: 3.04e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1330817596  14 SLADRIAVALADRIISGVIAPGEWLR-QDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVR 76
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTF 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 23-220 1.14e-11

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 61.83  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  23 LADRIISGVIAPGEWLRQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEMAKMRAAFEALALR- 101
Cdd:PRK11534   16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSl 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596 102 ---------EAMPALDARALEELDAIldqESAAHGIAVLGTLNLRFHRALTARCGMPRLIDAIGDM--HRASSRHLYATW 170
Cdd:PRK11534   96 aiarggdewEADVLAKAHLLSKLEAC---DASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLfdLAARYRFIWLRR 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1330817596 171 QQLDWQ--DRSNDEHRNIVRAIRDGDVDAACAALSAHVLAAGDALAQALRRR 220
Cdd:PRK11534  173 TVLSVEmlEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAGN 224
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-220 1.62e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.87  E-value: 1.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  13 RSLADRIAVALADRIISGVIAPGEWLRQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEMAKMR 92
Cdd:COG1802    10 ESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  93 AAFEALALREAMPALDARALEELDAILDQESAAHG---IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRASSRHLYAT 169
Cdd:COG1802    90 AALEGLAARLAAERATPADLARLRALLEELEAAAAagdVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1330817596 170 WQQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSAHVLAAGDALAQALRRR 220
Cdd:COG1802   170 LRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
13-220 9.55e-26

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 99.62  E-value: 9.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  13 RSLADRIAVALADRIISGVIAPGEWL---RQdhIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAP---------- 79
Cdd:COG2186     6 RSLAEQVAEQLRELILSGELKPGDRLpseRE--LAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREpspwalldpl 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  80 -----LEPADVLEMAKMRAAFEALALREAMPALDARALEELDAILDQESAAHG-IAVLGTLNLRFHRALTARCGMPRLID 153
Cdd:COG2186    84 alllaLDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADdGEAFAEADLAFHRAIAEASGNPLLAL 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1330817596 154 AIGDMHRASSRHLYATWQQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSAHVLAAGDALAQALRRR 220
Cdd:COG2186   164 LLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAER 230
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 87-204 6.28e-14

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 65.85  E-value: 6.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  87 EMAKMRAAFEALALREAMPALDARALEELDAILDQESAAHG---IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRASS 163
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADagdLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1330817596 164 RHLYATWQQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSA 204
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 87-206 8.90e-13

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 62.76  E-value: 8.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596   87 EMAKMRAAFEALALREAMPALDARALEELDAILDQESAAHG----IAVLGTLNLRFHRALTARCGMPRLIDAIGDMHRAS 162
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAagddLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1330817596  163 SRHLYAtwqQLDWQDRSNDEHRNIVRAIRDGDVDAACAALSAHV 206
Cdd:smart00895  81 RRLRRL---SLEAARRALDEHRAILDAIRARDAEAARAAMREHL 121
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-76 2.03e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 59.94  E-value: 2.03e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1330817596  15 LADRIAVALADRIISGVIAPGEWL-RQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVR 76
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTF 63
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-76 3.04e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 59.77  E-value: 3.04e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1330817596  14 SLADRIAVALADRIISGVIAPGEWLR-QDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVR 76
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTF 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 23-220 1.14e-11

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 61.83  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  23 LADRIISGVIAPGEWLRQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEMAKMRAAFEALALR- 101
Cdd:PRK11534   16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSl 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596 102 ---------EAMPALDARALEELDAIldqESAAHGIAVLGTLNLRFHRALTARCGMPRLIDAIGDM--HRASSRHLYATW 170
Cdd:PRK11534   96 aiarggdewEADVLAKAHLLSKLEAC---DASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLfdLAARYRFIWLRR 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1330817596 171 QQLDWQ--DRSNDEHRNIVRAIRDGDVDAACAALSAHVLAAGDALAQALRRR 220
Cdd:PRK11534  173 TVLSVEmlEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAGN 224
PRK11414 PRK11414
GntR family transcriptional regulator;
14-198 9.70e-10

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 56.42  E-value: 9.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  14 SLADRIAVALADRIISGVIAPGEWLRQDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEMAKMRA 93
Cdd:PRK11414   11 SLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  94 AFEALALREAMPALDARALEELDAILDQESAAHGIAVLGTL---NLRFHRALTARCGMPRLIDAIGDM--HRASSRH-LY 167
Cdd:PRK11414   91 ELELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIinaNRLFRLAIYHRSNMPILCEMIEQLwvRMGPSLHyLY 170

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1330817596 168 ATWQQLDWQDRSNDeHRNIVRAIRDGDVDAA 198
Cdd:PRK11414  171 EAINPAELREHIEN-YRLLLAALKAKDKEGC 200
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-76 4.68e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 51.04  E-value: 4.68e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1330817596   19 IAVALADRIISGVIAPGEWLR-QDHIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVR 76
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTF 59
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 10-173 4.38e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 52.52  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  10 KDDRSLADRIAVALADRIISGVIAPGEWL---RQdhIAAEFGASHVPVREAFRRLEAQGLAVVEPRRGVRAAPLEPADVL 86
Cdd:COG1167     8 DSSGPLYLQLADALREAILSGRLPPGDRLpssRE--LAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  87 E------------MAKMRAAFEALALREAMPALDARALEELDAILDQESAAHGIAVLGTLNLRfhraltarcGMPRLIDA 154
Cdd:COG1167    86 ApraaaavaapalRRLLEAAPGVIDLGSGAPDPDLFPLAALRRALRRALRRLPPALLGYGDPQ---------GLPELREA 156

                         170
                  ....*....|....*....
gi 1330817596 155 IGDmhRASSRHLYATWQQL 173
Cdd:COG1167   157 IAR--YLARRGVPASPDQI 173
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 13-205 2.05e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 46.94  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  13 RSLADRIAVALADRIISGVIAPGEWLRQDH-IAAEFGASHVPVREAFRRLEAQGLavVEPRRGVRAAPLEP------ADV 85
Cdd:PRK03837   12 KKLSEEVEERLEQMIRSGEFGPGDQLPSEReLMAFFGVGRPAVREALQALKRKGL--VQISHGERARVSRPsadtiiGQL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330817596  86 LEMAKM---------------RAAFEALALREAMPALDARALEELDAILDQESAAHGIAVLGT-LNLRFHRALTARCG-- 147
Cdd:PRK03837   90 SGMAKDflsqspdglahlkqaRLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIrSDMEFHRVIAEIPGnp 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1330817596 148 -MPRLIDAIGDMHRASSRHLyatwqqLDWQDRSN---DEHRNIVRAIRDGDVDAACAALSAH 205
Cdd:PRK03837  170 iFMAIHEALLDWLIEARPEV------VILHGHENvtlQEHIAIVDAIRAHDPDEADRALQSH 225
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
18-81 2.97e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 43.70  E-value: 2.97e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1330817596  18 RIAVALADRIISGVIAPGEWL---RQdhIAAEFGASHVPVREAFRRLEAQGLAVVEPRRG--VRAAPLE 81
Cdd:COG2188     9 QIADALRERIESGELPPGDRLpseRE--LAEEFGVSRMTVRKALDELVEEGLLERRQGRGtfVAEPKIE 75
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
49-111 4.52e-03

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 36.92  E-value: 4.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1330817596  49 ASHVP---VREAFRRLEAQGLAVVEPRRGVRAAPLEPADVLEmaKMRAAFEAlALREAMPALDARA 111
Cdd:COG1378    36 ASGVPrsrVYDVLESLEEKGLVEVSEGRPKRYRAVPPEEALE--RLLEEREE-ELEELREELEELY 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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