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Conserved domains on  [gi|1327192159|gb|PMN56826|]
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anti-anti-sigma factor [Enterovibrio norvegicus]

Protein Classification

STAS domain-containing protein( domain architecture ID 10162419)

STAS (Sulphate Transporter and AntiSigma factor antagonist) domain-containing protein similar to Streptomyces coelicolor anti-sigma-B factor antagonist, a positive regulator of sigma-B activity

CATH:  3.30.750.24
Gene Ontology:  GO:0043856|GO:0006355
PubMed:  22116355|10662676
SCOP:  4003567

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-103 5.48e-20

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


:

Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 77.18  E-value: 5.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   5 HIQQPDDTLTLVICGDMDAQGCSEIQPELDQLVnDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHG 84
Cdd:cd07043     2 TVEERGGVLVVRLSGELDAATAPELREALEELL-AEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSP 80

                          90
                  ....*....|....*....
gi 1327192159  85 QPMEIIQLLRINSAISVKP 103
Cdd:cd07043    81 AVRRVLELTGLDRLFPIYP 99
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-103 5.48e-20

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 77.18  E-value: 5.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   5 HIQQPDDTLTLVICGDMDAQGCSEIQPELDQLVnDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHG 84
Cdd:cd07043     2 TVEERGGVLVVRLSGELDAATAPELREALEELL-AEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSP 80

                          90
                  ....*....|....*....
gi 1327192159  85 QPMEIIQLLRINSAISVKP 103
Cdd:cd07043    81 AVRRVLELTGLDRLFPIYP 99
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 6-96 6.38e-18

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 71.81  E-value: 6.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   6 IQQPDDTLTLVICGDMDAQGCSEIQPELDQLVnDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQ 85
Cdd:COG1366     4 VEVRDGVLVLPLIGELDAARAPELREALLEAL-ETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82

                          90
                  ....*....|.
gi 1327192159  86 PMEIIQLLRIN 96
Cdd:COG1366    83 VARVLELTGLD 93
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 6-93 6.55e-12

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 56.85  E-value: 6.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   6 IQQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQ 85
Cdd:pfam01740   4 AEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPE 83


                  ....*...
gi 1327192159  86 PMEIIQLL 93
Cdd:pfam01740  84 VARTLEKT 91
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-95 5.55e-10

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 51.84  E-value: 5.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   1 MQIEhIQQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLI 80
Cdd:TIGR00377   3 LNIE-TEVQEGVVVVRLSGELDAHTAPLLREKVTPAAERTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLV 81

                          90
                  ....*....|....*...
gi 1327192159  81 QVHG---QPMEIIQLLRI 95
Cdd:TIGR00377  82 SVSPrvaRLLDITGLLRI 99
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-103 5.48e-20

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 77.18  E-value: 5.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   5 HIQQPDDTLTLVICGDMDAQGCSEIQPELDQLVnDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHG 84
Cdd:cd07043     2 TVEERGGVLVVRLSGELDAATAPELREALEELL-AEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSP 80

                          90
                  ....*....|....*....
gi 1327192159  85 QPMEIIQLLRINSAISVKP 103
Cdd:cd07043    81 AVRRVLELTGLDRLFPIYP 99
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 6-96 6.38e-18

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 71.81  E-value: 6.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   6 IQQPDDTLTLVICGDMDAQGCSEIQPELDQLVnDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQ 85
Cdd:COG1366     4 VEVRDGVLVLPLIGELDAARAPELREALLEAL-ETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82

                          90
                  ....*....|.
gi 1327192159  86 PMEIIQLLRIN 96
Cdd:COG1366    83 VARVLELTGLD 93
SpoIIAA COG5815
Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, ...
 1-85 1.02e-14

Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444517  Cd Length: 110  Bit Score: 64.38  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   1 MQIEhIQQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLI 80
Cdd:COG5815     1 MEVD-FEKKGDTLIVRLEGELDHHTAEELREKIDRAIEKGGVKHLILNLEGVSFMDSSGLGVILGRYKKIKALGGKVAVI 79


                  ....*
gi 1327192159  81 QVHGQ 85
Cdd:COG5815    80 NVSPQ 84
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 6-93 6.55e-12

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 56.85  E-value: 6.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   6 IQQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQ 85
Cdd:pfam01740   4 AEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPE 83


                  ....*...
gi 1327192159  86 PMEIIQLL 93
Cdd:pfam01740  84 VARTLEKT 91
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-95 5.55e-10

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 51.84  E-value: 5.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   1 MQIEhIQQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLI 80
Cdd:TIGR00377   3 LNIE-TEVQEGVVVVRLSGELDAHTAPLLREKVTPAAERTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLV 81

                          90
                  ....*....|....*...
gi 1327192159  81 QVHG---QPMEIIQLLRI 95
Cdd:TIGR00377  82 SVSPrvaRLLDITGLLRI 99
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 15-96 9.14e-10

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 50.69  E-value: 9.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159  15 LVICGDMDAQGCSEIQPELDQLVNdeTPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQPMEIIQLLR 94
Cdd:pfam13466   1 LSLSGELDADTAPALREALLAALA--AGSPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLG 78


                  ..
gi 1327192159  95 IN 96
Cdd:pfam13466  79 LD 80
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 7-100 1.13e-08

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 48.32  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327192159   7 QQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDetPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQP 86
Cdd:COG3113     6 LWNAEGGTLRLSGELTRDTVLALWAQLLALLAA--GGAVEIDLSGVTRVDSAGLALLLELLREARAQGKTLRLTGVPEQL 83

                          90
                  ....*....|....
gi 1327192159  87 MEIIQLLRINSAIS 100
Cdd:COG3113    84 RTLAALYGLDELLP 97
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 32-100 1.32e-06

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 45.10  E-value: 1.32e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1327192159  32 ELDQLVNDetPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQPMEIIQLLRINSAIS 100
Cdd:COG0659   443 RLDALAPD--PRVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLLDELG 509
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 32-91 1.81e-06

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 43.00  E-value: 1.81e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1327192159  32 ELDQLVNDETP-KDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQVHGQPMEIIQ 91
Cdd:cd07042    30 RLLRLVDEDPPlKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLE 90
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 6-82 9.16e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 32.84  E-value: 9.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1327192159   6 IQQPDDTLTLVICGDMDAQGCSEIQPELDQLVNDETPKDITLDLHNVDFLDSSGIGAIVFLFKRLKAKGKALSLIQV 82
Cdd:cd06844     3 LEKVDDYWVVRLEGELDHHSVEQFKEELLHNITNVAGKTIVIDISALEFMDSSGTGVLLERSRLAEAVGGQFVLTGI 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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