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Conserved domains on  [gi|132566684|ref|NP_005496|]
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scavenger receptor class B member 1 isoform 1 [Homo sapiens]

Protein Classification

CD36 family protein( domain architecture ID 10471559)

CD36 family protein belongs to a class of scavenger receptors that may play roles in various signal transduction mechanisms; CD36 is a multifunctional membrane protein that acts as the cellular receptor for thrombospondin-1 (TSP-1) and is required for the anti-angiogenic activity of TSP-1, and generally promotes thrombosis in conditions of oxidative stress

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 16-446 0e+00

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


:

Pssm-ID: 460076  Cd Length: 454  Bit Score: 571.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684   16 VAGLLCAVLGAVMIVMVPSLIKQQVLK-NVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILK-GEKPQVRERGPYV 93
Cdd:pfam01130   1 VIGLLLLVFGILLVLVFPPIIFNQIIKkELVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLGgGAKPKVEEVGPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684   94 YREFRHKSNITFN-NNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMtLKLIMTLAFTTLGERAFM 172
Cdd:pfam01130  81 YREYREKVNVTFNdDNGTVSYQQRRTYIFDPELSVGSEDDTITTPNIPLLGAASKARNSSF-LLRLLNLLLNSLGEKLFV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  173 NRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDqCN 252
Cdd:pfam01130 160 TRTVGELLFGYEDPLLDLAKKLLPSLPIPFDKFGLFYGRNGTDDGVFTVYTGKDDISKLGRIDSWNGKTHLDWWEGE-CN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  253 MINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCP-----CLESG 327
Cdd:pfam01130 239 MINGTDGTLFPPFLTKDDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTVNPDNKCFCPnkgneCLPSG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  328 IQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIE 407
Cdd:pfam01130 319 LLDVSPCKYGAPIFLSLPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLP 398

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 132566684  408 PVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQY 446
Cdd:pfam01130 399 NVILPLFWFEESAELDDELANLLKKLLLVLPNIGLYLQY 437
 
Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 16-446 0e+00

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


Pssm-ID: 460076  Cd Length: 454  Bit Score: 571.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684   16 VAGLLCAVLGAVMIVMVPSLIKQQVLK-NVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILK-GEKPQVRERGPYV 93
Cdd:pfam01130   1 VIGLLLLVFGILLVLVFPPIIFNQIIKkELVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLGgGAKPKVEEVGPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684   94 YREFRHKSNITFN-NNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMtLKLIMTLAFTTLGERAFM 172
Cdd:pfam01130  81 YREYREKVNVTFNdDNGTVSYQQRRTYIFDPELSVGSEDDTITTPNIPLLGAASKARNSSF-LLRLLNLLLNSLGEKLFV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  173 NRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDqCN 252
Cdd:pfam01130 160 TRTVGELLFGYEDPLLDLAKKLLPSLPIPFDKFGLFYGRNGTDDGVFTVYTGKDDISKLGRIDSWNGKTHLDWWEGE-CN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  253 MINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCP-----CLESG 327
Cdd:pfam01130 239 MINGTDGTLFPPFLTKDDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTVNPDNKCFCPnkgneCLPSG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  328 IQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIE 407
Cdd:pfam01130 319 LLDVSPCKYGAPIFLSLPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLP 398

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 132566684  408 PVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQY 446
Cdd:pfam01130 399 NVILPLFWFEESAELDDELANLLKKLLLVLPNIGLYLQY 437
 
Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 16-446 0e+00

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


Pssm-ID: 460076  Cd Length: 454  Bit Score: 571.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684   16 VAGLLCAVLGAVMIVMVPSLIKQQVLK-NVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILK-GEKPQVRERGPYV 93
Cdd:pfam01130   1 VIGLLLLVFGILLVLVFPPIIFNQIIKkELVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLGgGAKPKVEEVGPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684   94 YREFRHKSNITFN-NNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMtLKLIMTLAFTTLGERAFM 172
Cdd:pfam01130  81 YREYREKVNVTFNdDNGTVSYQQRRTYIFDPELSVGSEDDTITTPNIPLLGAASKARNSSF-LLRLLNLLLNSLGEKLFV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  173 NRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDqCN 252
Cdd:pfam01130 160 TRTVGELLFGYEDPLLDLAKKLLPSLPIPFDKFGLFYGRNGTDDGVFTVYTGKDDISKLGRIDSWNGKTHLDWWEGE-CN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  253 MINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCP-----CLESG 327
Cdd:pfam01130 239 MINGTDGTLFPPFLTKDDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTVNPDNKCFCPnkgneCLPSG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 132566684  328 IQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIE 407
Cdd:pfam01130 319 LLDVSPCKYGAPIFLSLPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLP 398

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 132566684  408 PVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQY 446
Cdd:pfam01130 399 NVILPLFWFEESAELDDELANLLKKLLLVLPNIGLYLQY 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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