NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1325317238|ref|XP_023340361|]
View 

galactokinase [Eurytemora carolleeae]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
21-390 1.32e-176

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 496.60  E-value: 1.32e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  21 LIDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSEKDDDIAEFNVKQL 100
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 101 TPGS-PSWANYVKGVVANF-HAPDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAgSDEEKALACQAAEH 178
Cdd:COG0153    81 EPGEeDGWANYVRGVAWALqERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGL-DPVELAKIGQRAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 179 QYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDPSIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLGIESL 258
Cdd:COG0153   160 EFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 259 RETNLPAVESKRSEF-DDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAALK 337
Cdd:COG0153   240 RDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1325317238 338 VDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSYT----GTPTFYVCKPSPGA 390
Cdd:COG0153   320 EAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGA 376
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
21-390 1.32e-176

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 496.60  E-value: 1.32e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  21 LIDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSEKDDDIAEFNVKQL 100
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 101 TPGS-PSWANYVKGVVANF-HAPDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAgSDEEKALACQAAEH 178
Cdd:COG0153    81 EPGEeDGWANYVRGVAWALqERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGL-DPVELAKIGQRAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 179 QYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDPSIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLGIESL 258
Cdd:COG0153   160 EFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 259 RETNLPAVESKRSEF-DDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAALK 337
Cdd:COG0153   240 RDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1325317238 338 VDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSYT----GTPTFYVCKPSPGA 390
Cdd:COG0153   320 EAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGA 376
PRK05101 PRK05101
galactokinase; Provisional
 19-390 9.30e-130

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 377.73  E-value: 9.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  19 KDLIDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKK-SGNGVSRMRSEKDDDIAEFNV 97
Cdd:PRK05101    1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrDDRIVRVIAADYDNQQDEFSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  98 KQLTPGSPS--WANYVKGVV-------ANFHAPDLipnfnaVVVGSVPLGGGVSSSASVEVAMYTFLEELtGSTAGSDEE 168
Cdd:PRK05101   81 DAPIVPHPEqqWANYVRGVVkhlqernPDFGGADL------VISGNVPQGAGLSSSASLEVAVGQTFQQL-YHLPLSGAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 169 KALACQAAEHQYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDpSIAVLITNSNVKHQLTGSEYPSRRAACLN 248
Cdd:PRK05101  154 IALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPE-GVAVVIINSNVKRGLVDSEYNTRRQQCET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 249 AAKVLGIESLRETNLPAVESKRSEFDDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPEL 328
Cdd:PRK05101  233 AARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQI 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1325317238 329 DQLVE---AALKVDGvyGSRMTGGGFGGCTVTLL---KQECVKSAIEEILKSYTG-TPTFYVCKPSPGA 390
Cdd:PRK05101  313 DTLVEivkAVIGDQG--GVRMTGGGFGGCIVALVpeeLVEAVRQAVAEQYEAKTGlKETFYVCKASQGA 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-390 1.75e-113

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 336.80  E-value: 1.75e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  22 IDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSEK-DDDIAEFNVKQL 100
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANaDNKFAERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 101 TPGSPS--WANYVKGVVANFHA--PDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELtGSTAGSDEEKALACQAA 176
Cdd:TIGR00131  81 LDGSEVsdWANYFKGVLHVAQErfNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNM-GHLPLDSKQILLRIQVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 177 EHQYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDPSIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLG-- 254
Cdd:TIGR00131 160 ENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAat 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 255 -IESLRE---TNLPAVESKRSEFDDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQ 330
Cdd:TIGR00131 240 dKGALRDfmnEYFARYIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDE 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1325317238 331 LVEAALKVDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSY---TGTP-TFYVCKPSPGA 390
Cdd:TIGR00131 320 LVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYpkkTGLElTFYVIVSKPGA 383
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 27-76 3.85e-23

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 90.97  E-value: 3.85e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1325317238  27 ELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKK 76
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
21-390 1.32e-176

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 496.60  E-value: 1.32e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  21 LIDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSEKDDDIAEFNVKQL 100
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 101 TPGS-PSWANYVKGVVANF-HAPDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAgSDEEKALACQAAEH 178
Cdd:COG0153    81 EPGEeDGWANYVRGVAWALqERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGL-DPVELAKIGQRAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 179 QYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDPSIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLGIESL 258
Cdd:COG0153   160 EFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 259 RETNLPAVESKRSEF-DDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAALK 337
Cdd:COG0153   240 RDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1325317238 338 VDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSYT----GTPTFYVCKPSPGA 390
Cdd:COG0153   320 EAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGA 376
PRK05101 PRK05101
galactokinase; Provisional
 19-390 9.30e-130

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 377.73  E-value: 9.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  19 KDLIDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKK-SGNGVSRMRSEKDDDIAEFNV 97
Cdd:PRK05101    1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrDDRIVRVIAADYDNQQDEFSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  98 KQLTPGSPS--WANYVKGVV-------ANFHAPDLipnfnaVVVGSVPLGGGVSSSASVEVAMYTFLEELtGSTAGSDEE 168
Cdd:PRK05101   81 DAPIVPHPEqqWANYVRGVVkhlqernPDFGGADL------VISGNVPQGAGLSSSASLEVAVGQTFQQL-YHLPLSGAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 169 KALACQAAEHQYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDpSIAVLITNSNVKHQLTGSEYPSRRAACLN 248
Cdd:PRK05101  154 IALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPE-GVAVVIINSNVKRGLVDSEYNTRRQQCET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 249 AAKVLGIESLRETNLPAVESKRSEFDDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPEL 328
Cdd:PRK05101  233 AARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQI 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1325317238 329 DQLVE---AALKVDGvyGSRMTGGGFGGCTVTLL---KQECVKSAIEEILKSYTG-TPTFYVCKPSPGA 390
Cdd:PRK05101  313 DTLVEivkAVIGDQG--GVRMTGGGFGGCIVALVpeeLVEAVRQAVAEQYEAKTGlKETFYVCKASQGA 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-390 1.75e-113

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 336.80  E-value: 1.75e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  22 IDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSEK-DDDIAEFNVKQL 100
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANaDNKFAERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 101 TPGSPS--WANYVKGVVANFHA--PDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELtGSTAGSDEEKALACQAA 176
Cdd:TIGR00131  81 LDGSEVsdWANYFKGVLHVAQErfNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNM-GHLPLDSKQILLRIQVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 177 EHQYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDPSIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLG-- 254
Cdd:TIGR00131 160 ENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAat 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 255 -IESLRE---TNLPAVESKRSEFDDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQ 330
Cdd:TIGR00131 240 dKGALRDfmnEYFARYIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDE 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1325317238 331 LVEAALKVDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSY---TGTP-TFYVCKPSPGA 390
Cdd:TIGR00131 320 LVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYpkkTGLElTFYVIVSKPGA 383
PRK05322 PRK05322
galactokinase; Provisional
 22-390 3.34e-113

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 336.06  E-value: 3.34e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  22 IDQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSE--KDDDIAEFNVKQ 99
Cdd:PRK05322    3 KEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAnfEDLGIIEFDLDD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 100 LTP-GSPSWANYVKGVVANF--HAPDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGstAGSDE-EKALACQA 175
Cdd:PRK05322   83 LSFdKEDDWANYPKGVLKFLqeAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFN--LDLDRlELVKLGQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 176 AEHQYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETR--KVELKDPSIavLITNSNVKHQLTGSEYPSRRAACLNA---- 249
Cdd:PRK05322  161 TENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEyvPLDLGDYVI--VIMNTNKRRELADSKYNERRAECEKAleel 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 250 AKVLGIESLRETNLpaveskrSEF--------DDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDF 321
Cdd:PRK05322  239 QKKLDIKSLGELTE-------EEFdeysylikDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDY 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1325317238 322 EVSCPELDQLVEAALKVDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSYTGT----PTFYVCKPSPGA 390
Cdd:PRK05322  312 EVTGLELDTLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKigyaASFYVAEIGDGA 384
PRK03817 PRK03817
galactokinase; Provisional
 43-390 9.29e-100

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 300.37  E-value: 9.29e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  43 APGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNgvSRMRSEKDDDIAEFNVKQLTPGSpSWANYVKGVVANFHAPD 122
Cdd:PRK03817    5 SPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEK--FIFYSENFNEEKTFELDKLEKLN-SWADYIKGVIWVLEKRG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 123 L-IPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAgSDEEKALACQAAEHQYAGMPCGIMDQFISVMGEEGSA 201
Cdd:PRK03817   82 YeVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNL-SKLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 202 VLIDCKTMETRKVELKDpSIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLGIESLRETNlpavESKRSEFDDVTFRRI 281
Cdd:PRK03817  161 IFLDTMTLEYEYVPFPE-DYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVT----EEDLSKLPPLLRKRA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 282 RHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAALKVdGVYGSRMTGGGFGGCTVTLLKQ 361
Cdd:PRK03817  236 GYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGFGGSAIALVDK 314

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1325317238 362 ECVKSAIEEILKSYTG----TPTFYVCKPSPGA 390
Cdd:PRK03817  315 GKFESIGEELLEEYKKrfgiDPKYFVVESSDGV 347
PRK00555 PRK00555
galactokinase; Provisional
 39-394 3.56e-86

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 265.96  E-value: 3.56e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  39 VGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKKSGNGVSRMRSEKDDDIAEFNVKQlTPGSPS-WANYVKGVV-A 116
Cdd:PRK00555    3 VRYAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSARIPLDT-TPGQVTgWAAYAAGVIwA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 117 NFHAPDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAGSDEEKALAcQAAEHQYAGMPCGIMDQFISVMG 196
Cdd:PRK00555   82 LRGAGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLA-QRAENEYVGAPTGLLDQLAALFG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 197 EEGSAVLIDCKTMETRKVELkDP---SIAVLITNSNVKHQLTGSEYPSRRAACLNAAKVLGIESLRETNLPAVESKRSEF 273
Cdd:PRK00555  161 APKTALLIDFRDLTVRPVAF-DPdaaGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRGLAALGAIA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 274 DDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAALKVdGVYGSRMTGGGFGG 353
Cdd:PRK00555  240 DPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRA-GALGARMTGGGFGG 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1325317238 354 CTVTLLKQECVKSAIEEILKSYTGT----PTFYVCKPSPGALPVK 394
Cdd:PRK00555  319 CVIALVPADRAEDVADTVRRAAVTAgypePAVSRTYAAPGAGECR 363
PLN02521 PLN02521
galactokinase
 23-390 1.67e-45

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 163.34  E-value: 1.67e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  23 DQAKELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVV-LGKKSGNGVSRMRSEKDD-DIAEFNV--- 97
Cdd:PLN02521   33 ARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVaIRRAEGSKKLRIANVNDKyTTCTFPAdpd 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  98 KQLTPGSPSWANYV----KGVVANFHA-PDLIP---NFNAVVVGSVPLGGGVSSSA----SVEVAMYTFLEELTGSTAGS 165
Cdd:PLN02521  113 QEVDLANHKWGNYFicgyKGVFEFLKSkGVDVGppvGLDVVVDGTVPTGSGLSSSAalvcSAAIAIMAALGLNFTKKEVA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 166 DeekaLACQAAEHqyAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDPS---IAVLITNSNvKHQLTGSEYPSR 242
Cdd:PLN02521  193 Q----FTCKCERH--IGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGtfvIANSLAESN-KAVTAATNYNNR 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 243 RAACLNAAKVLG-----------------------------------------------------IESLRETNLPAVESK 269
Cdd:PLN02521  266 VVECRLAAIVLAvklgmsaeeaiskvktlsdveglcvsfagshgssdpavavkellhegpytaeeIEEILGESLTSIFKN 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 270 RSEFDDVT--------FRRIRHVVTEISR-----TVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAAl 336
Cdd:PLN02521  346 SPTSLAVLkaakhfklHQRAVHVYSEAKRvhafrDTVSSSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVC- 424

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1325317238 337 KVDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSYTGT-------------PTFYVCKPSPGA 390
Cdd:PLN02521  425 RDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKSriekgvikeedlgLYVFASKPSSGA 491
PLN02865 PLN02865
galactokinase
 43-375 9.59e-39

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 143.79  E-value: 9.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  43 APGRVNLIGEHTDYNMGFVLPMAL-----------PLVTVVLGKKSGNGVSRMRSekddDIAEFNVKQLTPGSP---SWA 108
Cdd:PLN02865   35 SPYRICPLGAHIDHQGGTVSAMTInkgillgfvpsGDPEVLLRSAQFEGEVRFRV----DEIQHPIANVSSDSKeesNWG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 109 NYVKGVVanfHA-----PDLIPNFNAVVVGSVPL-GGGVSSSASVEVAMYTFLEELTGSTAGSDEEKALAcQAAEHQYAG 182
Cdd:PLN02865  111 DYARGAV---YAlqsrgHALSQGITGYISGSEGLdSSGLSSSAAVGVAYLLALENANNLTVSPEDNIELD-RLIENEYLG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 183 MPCGIMDQFISVMGEEGSAVLIDCKTMETRKVELKDP------SIAVLITNSNVKHQLTGSE-YPSRRAACLNAAKVLGI 255
Cdd:PLN02865  187 LRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQqpggekPFKILLAFSGLRHALTNKPgYNLRVSECQEAARFLLE 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 256 ESLRETNLP--------AVESKRSEFDDVTFRRIRHVVTEISRTVEAADALDKANYQLFGKLMVDSHNSLRDDFEVSCPE 327
Cdd:PLN02865  267 ASGNDELEPllcnvepeVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGCEP 346

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1325317238 328 LDQLVEAALKVDGVYGSRMTGGGFGGCTVTLLKQECVKSAIEEILKSY 375
Cdd:PLN02865  347 LIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEY 394
PTZ00290 PTZ00290
galactokinase; Provisional
 18-373 8.46e-38

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 141.88  E-value: 8.46e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  18 LKDLIDQAKELFKETFGEEPQ------VGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVL-GKKSGNGVSRMRSEKDD 90
Cdd:PTZ00290   11 LDSTLSTLKPIFLETFKVENDadvewlLFTFAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILvGRVKHFCDHKLRFATET 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  91 DiAEFNVKQLTPG--SPSWANYVKGVVA---NFH-----APDLiPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEE-LT 159
Cdd:PTZ00290   91 D-EHFVLDHLGGAkhNKAWTTFVRGAATlrlNRLgvaidAPSL-QGVCMVVHGTLPMGAGMSASASFGVALLNAINTvVT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 160 GSTAG----------------SDEEKALACQA--AEHQYAGMPCGIMDQFISVMGEEGSAVLIDCKTMETRKVE----LK 217
Cdd:PTZ00290  169 RRYKGcptspgrrysilppmsKEELIELAKQArrIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDmtplLG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 218 DPSIAVLItNSNVKHQLTGSE---YPSRRAACLNAAKVLGIESLRetNLPA---------------------VESKRSEF 273
Cdd:PTZ00290  249 DGACFLLI-DSMIKHDLLGGTagmYNTVRSDQEGAQKKIGKHRYR--GKPFtfsdlvrnpkkytfdgdvvafMESCKPLM 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 274 DDVTFRRIRHVVTEISRTVEAADALDKA-------NYQLFGKLMVDSHNSLRDDFEVSCPELDQLVEAALKVDGVYGSRM 346
Cdd:PTZ00290  326 TPGEFERGTYNIMEQIRTLEFIKLNDPElplsreeRFRKAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRM 405

                         410       420
                  ....*....|....*....|....*..
gi 1325317238 347 TGGGFGGCTVTLLKqecvKSAIEEILK 373
Cdd:PTZ00290  406 MGGGFGGCIILLLK----KNAVDRVVA 428
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 27-76 3.85e-23

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 90.97  E-value: 3.85e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1325317238  27 ELFKETFGEEPQVGGSAPGRVNLIGEHTDYNMGFVLPMALPLVTVVLGKK 76
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 43-358 2.18e-21

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 92.74  E-value: 2.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  43 APGRVNLIGEHtdynmgFV------LPMALPLVTVVLGKKSGNGVSRMRSEKDDDIAEFnvKQLTPGSPSwanYVKGVVA 116
Cdd:TIGR00549   1 APGKIILFGEH------AVvygepaIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDDA--PDELDGLKY---VLAEFLS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 117 NFHAPDLIPnFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAgSDEEKALACQAAEHQYAGMPCGImDQFISVMg 196
Cdd:TIGR00549  70 RFSELNPPP-LEITIESEIPPGRGLGSSAAVAVALIRALADYFGSEL-SKEELAELANEAEKIAHGKPSGI-DTATSTS- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 197 eeGSAVLIDCKTMETRKveLKDPSIAVLITNSNVKHQltgseypSRRAaclnaakvlgIESLREtnlpavesKRSEFDDV 276
Cdd:TIGR00549 146 --GGPVYFEKGEGEFTK--LISLDGYFVIADTGVSGS-------TKEA----------VARVRQ--------LLERFPEL 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 277 TFRRIRHvVTEISRtvEAADALDKANYQLFGKLMVDSHnSLRDDFEVSCPELDQLVEAALKVdGVYGSRMTGGGFGGCTV 356
Cdd:TIGR00549 197 IDSIMDA-IGELTL--EAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGGGCMI 271


                  ..
gi 1325317238 357 TL 358
Cdd:TIGR00549 272 AL 273
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 43-358 4.89e-20

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 89.13  E-value: 4.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  43 APGRVNLIGEHtdynmgFV------LPMALPLVTVVLGKKSGNGVSRMRSekDDDIAEFNVKQLTPGSPSwanYVKGVVA 116
Cdd:COG1577     1 APGKLILFGEH------AVvygqpaIAVAVDRRATVTVEPSDDDKLRIES--PDLGGTLDLDPLADAALR---YIKAAIE 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 117 NFH--APDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGSTAGSDEEKALAcQAAEHQYAGMPCGiMDQFISV 194
Cdd:COG1577    70 AALeyLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLA-LEAEKIVHGNPSG-LDTAAST 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 195 MGeegSAVLIDCKTMEtRKVELKDPsIAVLITNSNVKHQlTGseypsrraaclnaAKVLGIESLRETNLPAVEskrsefd 274
Cdd:COG1577   148 YG---GPIYYQRGDRA-EPLELPKN-LPLVVGDTGVPAS-TK-------------ELVAKVRKLKERNPELYE------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 275 dvtfrrirHVVTEISRTVEAA-DALDKANYQLFGKLMVDSHNsLRDDFEVSCPELDQLVEAALKVdGVYGSRMTGGGFGG 353
Cdd:COG1577   202 --------AFLEEIGDLVEEAiEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARKA-GALGAKLTGAGGGG 271


                  ....*
gi 1325317238 354 CTVTL 358
Cdd:COG1577   272 CVIAL 276
PRK03926 PRK03926
mevalonate kinase; Provisional
 42-387 5.53e-14

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 72.01  E-value: 5.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238  42 SAPGRVNLIGEHTdynmgfvlpmalplvtVVLGKKS-GNGVS-RMRSEkdddiAEFNVKQLTPGS-----PSWANYVKGV 114
Cdd:PRK03926    5 SAPGKIYLFGEHA----------------VVYGKPAiACAIDlRTYVR-----AEFNDDSIYIESdygktGEKHPYVSAA 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 115 VANFHAPDLIPNFNAVVVGSVPLGGGVSSSASVEVAMYTFLEELTGsTAGSDEEKALACQAAEHQYAGMPCGImDQFISV 194
Cdd:PRK03926   64 IEKMREEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLG-LGLSLEEIAKLGHKVELLVQGAASPT-DTYVST 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 195 MGeeGSAVLIDCKTmetrkveLKDPSIAVLITNsnvkhqlTGSEYPSRRAaclnaakVLGIESLREtnlpaveskrsEFD 274
Cdd:PRK03926  142 MG--GFVTIPDRKK-------LPFPECGIVVGY-------TGSSGSTKEL-------VANVRKLKE-----------EYP 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 275 DVtfrrIRHVVTEISRTVEAADALDKAN-YQLFGKLMVDSHnSLRDDFEVSCPELDQLVEAAlKVDGVYGSRMTGGGFGG 353
Cdd:PRK03926  188 EL----IEPILSSIGKISEKGEELILSGdYVSLGELMNINQ-GLLDALGVSTKELSELIYAA-RTAGALGAKITGAGGGG 261

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1325317238 354 CTVTLLKQECVKSAIEEILKSYtGTPTfyVCKPS 387
Cdd:PRK03926  262 CMVALAAPEKQSEVATAIKIAG-GKPI--ITKIT 292
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 294-375 5.71e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 55.55  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 294 AADALDKANYQLFGKLMVDSHNSL--RDDFEVSCPELDQLVEAALKVDgvYGSRMTGGGFGGCTVTLLKQECVKSAIEEI 371
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG--LGAKLSGSGGGPTVFALFKDEDDAEEVARA 78


                  ....
gi 1325317238 372 LKSY 375
Cdd:pfam08544  79 LREA 82
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 130-197 3.18e-09

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 52.55  E-value: 3.18e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1325317238 130 VVVGSVPLGGGVSSSASVEVAMYTFLEELTGstagsdEEKALACQAAEHQYAGMPCGIMDQFISVMGE 197
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFG------LPLAKLALEAEELAGGGRGGGMDVAASLYGG 64
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 267-390 6.36e-07

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 50.62  E-value: 6.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325317238 267 ESKRSEFDDVtFRRIRHVVTEisrtveAADALDKANYQLFGKLMVDSHNSLRDdFEVSCPELDQLVEAAlKVDGVYGSRM 346
Cdd:PTZ00298  210 ENQPTWFNRL-LENYNACVSE------AKEALQKGNLFRVGELMNANHDLCQK-LTVSCRELDSIVQTC-RTYGALGAKM 280

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1325317238 347 TGGGFGGCTVTLLKQECVKSAIEEILKSYTGTPTF---YVCKPSPGA 390
Cdd:PTZ00298  281 SGTGRGGLVVALAASEDQRDAIAKAVRARCPEAKFvwrYTVQPSSAK 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH