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Conserved domains on  [gi|1319839448|gb|PLL27915|]
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D-alanine--D-alanine ligase [Klebsiella pneumoniae]

Protein Classification

D-alanine--D-alanine ligase family protein( domain architecture ID 11479728)

D-alanine--D-alanine ligase family protein similar to D-alanine--D-alanine ligase that catalyzes the synthesis of D-alanyl-D-alanine, an essential component of bacterial peptidoglycan, and is involved in cell wall formation

EC:  6.3.2.-
Gene Ontology:  GO:0009252|GO:0008716|GO:0046872|GO:0005524
SCOP:  4002041|4003870

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-352 0e+00

D-alanine--D-alanine ligase;


:

Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 543.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   1 MAKMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWHINDAGNYLLNAQDPARIALRpstvtlaqip 80
Cdd:PRK01966    1 MMKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNMELADDDNDKEDLS---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 greaqQLINAESGQplAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFIT 160
Cdd:PRK01966   71 -----LLILPSGGS--EEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVV 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 161 LTRANRAQFSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDhPQ 240
Cdd:PRK01966  144 LTRGDWEEASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGND-PK 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 241 ASTCGEIVLNSEFYAYDTKYIDDQgAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTLP 320
Cdd:PRK01966  223 ASVPGEIVKPDDFYDYEAKYLDGS-AELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMP 301

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1319839448 321 GFTNISMYPKLWQASGLDYTSLITRLIELALE 352
Cdd:PRK01966  302 GFTPISMYPKLWEASGLSYPELIDRLIELALE 333
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-352 0e+00

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 543.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   1 MAKMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWHINDAGNYLLNAQDPARIALRpstvtlaqip 80
Cdd:PRK01966    1 MMKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNMELADDDNDKEDLS---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 greaqQLINAESGQplAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFIT 160
Cdd:PRK01966   71 -----LLILPSGGS--EEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVV 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 161 LTRANRAQFSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDhPQ 240
Cdd:PRK01966  144 LTRGDWEEASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGND-PK 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 241 ASTCGEIVLNSEFYAYDTKYIDDQgAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTLP 320
Cdd:PRK01966  223 ASVPGEIVKPDDFYDYEAKYLDGS-AELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMP 301

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1319839448 321 GFTNISMYPKLWQASGLDYTSLITRLIELALE 352
Cdd:PRK01966  302 GFTPISMYPKLWEASGLSYPELIDRLIELALE 333
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 4-351 1.52e-159

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 449.17  E-value: 1.52e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   4 MRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLwhindagnyllnaqdPARIALrpstvtlaqipgre 83
Cdd:COG1181     1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDL---------------PAALKE-------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  84 aqqlinaesgqplAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFITLTR 163
Cdd:COG1181    52 -------------LKPDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRR 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 164 ANRAqfSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDHPQAST 243
Cdd:COG1181   119 GELA--DLEAIEEELGLPLFVKPAREGSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGPRALP 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 244 CGEIVLNSEFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTLPGFT 323
Cdd:COG1181   197 PIEIVPENGFYDYEAKYTDG-GTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMT 275

                         330       340
                  ....*....|....*....|....*...
gi 1319839448 324 NISMYPKLWQASGLDYTSLITRLIELAL 351
Cdd:COG1181   276 PTSLLPKAAAAAGISYEELIERIIELAL 303
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 5-350 8.31e-152

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 430.17  E-value: 8.31e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   5 RVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWhindagnyllNAQDPARIALrpstvtlaqipgrea 84
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGSW----------TYKDLPQLIL--------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  85 qqlinaESGQPLAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFITLTRa 164
Cdd:TIGR01205  56 ------ELGALLEGIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQ- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 165 NRAQFSFAD---VEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDH--P 239
Cdd:TIGR01205 129 NRASADELEceqVAEPLGFPVIVKPAREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEalP 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 240 QASTCGEIVLnseFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTL 319
Cdd:TIGR01205 209 IIEIVPEIEG---FYDYEAKYLDG-STEYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTI 284

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1319839448 320 PGFTNISMYPKLWQASGLDYTSLITRLIELA 350
Cdd:TIGR01205 285 PGMTAISLFPKAAAAAGIEFSQLVERILELA 315
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 147-348 3.80e-107

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 312.33  E-value: 3.80e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 147 LLRDAGLAVAPFITLTRANRAQ---FSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQG 223
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADWKLnpkEWCAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 224 IKGREIECAVLGNDHPQASTCGEIVLNSEFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDV 303
Cdd:pfam07478  81 IEGREIECAVLGNEDPEVSPVGEIVPSGGFYDYEAKYIDD-SAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1319839448 304 FLTADNEVVINEINTLPGFTNISMYPKLWQASGLDYTSLITRLIE 348
Cdd:pfam07478 160 FLTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-352 0e+00

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 543.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   1 MAKMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWHINDAGNYLLNAQDPARIALRpstvtlaqip 80
Cdd:PRK01966    1 MMKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNMELADDDNDKEDLS---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 greaqQLINAESGQplAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFIT 160
Cdd:PRK01966   71 -----LLILPSGGS--EEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVV 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 161 LTRANRAQFSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDhPQ 240
Cdd:PRK01966  144 LTRGDWEEASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGND-PK 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 241 ASTCGEIVLNSEFYAYDTKYIDDQgAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTLP 320
Cdd:PRK01966  223 ASVPGEIVKPDDFYDYEAKYLDGS-AELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMP 301

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1319839448 321 GFTNISMYPKLWQASGLDYTSLITRLIELALE 352
Cdd:PRK01966  302 GFTPISMYPKLWEASGLSYPELIDRLIELALE 333
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 4-351 1.52e-159

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 449.17  E-value: 1.52e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   4 MRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLwhindagnyllnaqdPARIALrpstvtlaqipgre 83
Cdd:COG1181     1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDL---------------PAALKE-------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  84 aqqlinaesgqplAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFITLTR 163
Cdd:COG1181    52 -------------LKPDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRR 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 164 ANRAqfSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDHPQAST 243
Cdd:COG1181   119 GELA--DLEAIEEELGLPLFVKPAREGSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGPRALP 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 244 CGEIVLNSEFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTLPGFT 323
Cdd:COG1181   197 PIEIVPENGFYDYEAKYTDG-GTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMT 275

                         330       340
                  ....*....|....*....|....*...
gi 1319839448 324 NISMYPKLWQASGLDYTSLITRLIELAL 351
Cdd:COG1181   276 PTSLLPKAAAAAGISYEELIERIIELAL 303
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 5-350 8.31e-152

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 430.17  E-value: 8.31e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   5 RVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWhindagnyllNAQDPARIALrpstvtlaqipgrea 84
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGSW----------TYKDLPQLIL--------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  85 qqlinaESGQPLAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFITLTRa 164
Cdd:TIGR01205  56 ------ELGALLEGIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQ- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 165 NRAQFSFAD---VEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNDH--P 239
Cdd:TIGR01205 129 NRASADELEceqVAEPLGFPVIVKPAREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEalP 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 240 QASTCGEIVLnseFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTL 319
Cdd:TIGR01205 209 IIEIVPEIEG---FYDYEAKYLDG-STEYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTI 284

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1319839448 320 PGFTNISMYPKLWQASGLDYTSLITRLIELA 350
Cdd:TIGR01205 285 PGMTAISLFPKAAAAAGIEFSQLVERILELA 315
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 1-353 7.96e-110

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 323.22  E-value: 7.96e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   1 MAKMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVllGIDkqglwhindagnyllnaqdparialrpstvtlaqiP 80
Cdd:PRK01372    2 KMFGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYDAH--PID-----------------------------------P 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 GREAQQLINAEsgqplaAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFIT 160
Cdd:PRK01372   45 GEDIAAQLKEL------GFDRVFNALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWIV 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 161 LTRANraqfSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGNdhpQ 240
Cdd:PRK01372  119 LTREE----DLLAAIDKLGLPLVVKPAREGSSVGVSKVKEEDELQAALELAFKYDDEVLVEKYIKGRELTVAVLGG---K 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 241 ASTCGEIVLNSEFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINTLP 320
Cdd:PRK01372  192 ALPVIEIVPAGEFYDYEAKYLAG-GTQYICPAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKPYLLEVNTQP 270

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1319839448 321 GFTNISMYPKLWQASGLDYTSLITRLIELALER 353
Cdd:PRK01372  271 GMTSHSLVPMAARAAGISFSELVDRILEDALCD 303
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 147-348 3.80e-107

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 312.33  E-value: 3.80e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 147 LLRDAGLAVAPFITLTRANRAQ---FSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQG 223
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADWKLnpkEWCAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 224 IKGREIECAVLGNDHPQASTCGEIVLNSEFYAYDTKYIDDqGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDV 303
Cdd:pfam07478  81 IEGREIECAVLGNEDPEVSPVGEIVPSGGFYDYEAKYIDD-SAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1319839448 304 FLTADNEVVINEINTLPGFTNISMYPKLWQASGLDYTSLITRLIE 348
Cdd:pfam07478 160 FLTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
PRK14570 PRK14570
D-alanyl-alanine synthetase A; Provisional
 3-355 6.77e-75

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173034 [Multi-domain]  Cd Length: 364  Bit Score: 235.88  E-value: 6.77e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   3 KMRVGIVFGGKSAEHEVSLQSAKNIVEAI-DKSRFDVVLLGIDK-QGLWHINDAgnyllnAQDPARIALRPSTVTLAQIP 80
Cdd:PRK14570    2 KKNLMLIFGGVSFEHEISLRSAYGIYSALlKLDKYNIYSVFIDKcTGIWYLLDS------VPDPPKLIKRDVLPIVSLIP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 GreAQQLINAESGQplaaIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFIT 160
Cdd:PRK14570   76 G--CGIFVNNKNLE----IDVVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPFIG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 161 LTR----ANRAQFSfADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLGN 236
Cdd:PRK14570  150 FRKydyfLDKEGIK-KDIKEVLGYPVIVKPAVLGSSIGINVAYNENQIEKCIEEAFKYDLTVVIEKFIEAREIECSVIGN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 237 DHPQASTCGEIVLNS-EFYAYDTKYIDDQGAQVV--VPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTAD-NEVV 312
Cdd:PRK14570  229 EQIKIFTPGEIVVQDfIFYDYDAKYSTIPGNSIVfnIPAHLDTKHLLDIKEYAFLTYKNLELRGMARIDFLIEKDtGLIY 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1319839448 313 INEINTLPGFTNISMYPKLWQASGLDYTSLITRLIELALERHA 355
Cdd:PRK14570  309 LNEINTIPGFTDISMFAKMCEHDGLQYKSLVDNLIDLAFQSYI 351
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
3-353 4.08e-56

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 196.19  E-value: 4.08e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   3 KMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWhindagnyllnaqdparialrpSTVTL--AQIP 80
Cdd:PRK14573  451 KLSLGLVCGGKSCEHDISLLSAKNIAKYLSPEFYDVSYFLINRQGLW----------------------ETVSSleTAIE 508

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 GREAQQLINAESGQPLAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFIT 160
Cdd:PRK14573  509 EDSGKSVLSSEIAQALAKVDVVLPILHGPFGEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASDVGVPVVPYQP 588

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 161 LTRANRAQ---FSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKG-REIECAVLGN 236
Cdd:PRK14573  589 LTLAGWKRepeLCLAHIVEAFSFPMFVKTAHLGSSIGVFEVHNVEELRDKISEAFLYDTDVFVEESRLGsREIEVSCLGD 668

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 237 dhpqASTCGEIVLNSE------FYAYDTKYIDD--QGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTAD 308
Cdd:PRK14573  669 ----GSSAYVIAGPHErrgsggFIDYQEKYGLSgkSSAQIVFDLDLSKESQEQVLELAERIYRLLQGKGSCRIDFFLDEE 744

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1319839448 309 NEVVINEINTLPGFTNISMYPKLWQASGLDYTSLITRLIELALER 353
Cdd:PRK14573  745 GNFWLSEMNPIPGMTEASPFLTAFVRKGWTYEQIVHQLIIDGLHK 789
PRK14572 PRK14572
D-alanyl-alanine synthetase A; Provisional
 3-352 1.95e-55

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173036 [Multi-domain]  Cd Length: 347  Bit Score: 185.11  E-value: 1.95e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   3 KMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWHINDAgnyllnaqdpARIALrPSTVTLAQIPGR 82
Cdd:PRK14572    1 MAKIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVKPILLTPDGGWVVPTV----------YRPSI-PDESGNSEDLFL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  83 EAQQLINAESGQPLAA---IDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPFI 159
Cdd:PRK14572   70 EEFQKANGVSEPADISqldADIAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 160 TLTR---ANRAQFSFADVEAkLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVL-- 234
Cdd:PRK14572  150 ELEKlkyLNSPRKTLLKLES-LGFPQFLKPVEGGSSVSTYKITNAEQLMTLLALIFESDSKVMSQSFLSGTEVSCGVLer 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 235 ---GNDHPQASTCGEIVLNSEFYAYDTKYiDDQGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDvFLTADNEV 311
Cdd:PRK14572  229 yrgGKRNPIALPATEIVPGGEFFDFESKY-KQGGSEEITPARISDQEMKRVQELAIRAHESLGCKGYSRTD-FIIVDGEP 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1319839448 312 VINEINTLPGFTNISMYPKLWQASGLDYTSLITRLIELALE 352
Cdd:PRK14572  307 HILETNTLPGMTETSLIPQQAKAAGINMEEVFTDLIEIGLK 347
PRK14571 PRK14571
D-alanyl-alanine synthetase A; Provisional
 4-350 1.09e-49

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 184751 [Multi-domain]  Cd Length: 299  Bit Score: 168.85  E-value: 1.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   4 MRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKqglwhindagNYLlnaqdparialrpstvtlaqipgRE 83
Cdd:PRK14571    1 MRVALLMGGVSREREISLRSGERVKKALEKLGYEVTVFDVDE----------DFL-----------------------KK 47

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  84 AQQLinaesgqplAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDaglavapfiTLTR 163
Cdd:PRK14571   48 VDQL---------KSFDVVFNVLHGTFGEDGTLQAILDFLGIRYTGSDAFSSMICFDKLLTYRFLKG---------TVEI 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 164 ANRAQFSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQGIKGREIECAVLG-NDHPQAS 242
Cdd:PRK14571  110 PDFVEIKEFMKTSPLGYPCVVKPRREGSSIGVFICESDEEFQHALKEDLPRYGSVIVQEYIPGREMTVSILEtEKGFEVL 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 243 TCGEIVLNSEFYAYDTKYIDDQgAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTaDNEVVINEINTLPGF 322
Cdd:PRK14571  190 PILELRPKRRFYDYVAKYTKGE-TEFILPAPLNPEEERLVKETALKAFVEAGCRGFGRVDGIFS-DGRFYFLEINTVPGL 267

                         330       340
                  ....*....|....*....|....*...
gi 1319839448 323 TNISMYPKLWQASGLDYTSLITRLIELA 350
Cdd:PRK14571  268 TELSDLPASAKAGGIEFEELVDIIIKSA 295
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 5-130 6.50e-46

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 152.76  E-value: 6.50e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   5 RVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVLLGIDKQGLWHinDAGNYLLNAQDPARIALRpstvtlAQIPGREA 84
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDKEKYEVIPIGITKDGRLG--EAALRELASDDGLLLEVD------DAPDGGPA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1319839448  85 QQLINAESGQPLAAIDVIFPIVHGTLGEDGSLQGMLRMANLPFVGS 130
Cdd:pfam01820  73 GLLFGPNVLELLIEVDVVFPVLHGPNGEDGTLQGLLELAGIPYVGS 118
PRK14569 PRK14569
D-alanyl-alanine synthetase A; Provisional
 1-350 3.58e-35

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173033 [Multi-domain]  Cd Length: 296  Bit Score: 130.57  E-value: 3.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448   1 MAKMRVGIVFGGKSAEHEVSLQSAKNIVEAIDKSRFDVVllGIDKQGlwhiNDAGNYLLNaqdpariaLRPstvtlaqip 80
Cdd:PRK14569    1 MKNEKIVVLYGGDSPEREVSLKSGKAVLDSLISQGYDAV--GVDASG----KELVAKLLE--------LKP--------- 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  81 greaqqlinaesgqplaaiDVIFPIVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLA--VAPF 158
Cdd:PRK14569   58 -------------------DKCFVALHGEDGENGRVSALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPtpMAKF 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 159 ITLTRANRAQFSFadveaklglPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDhKVVVEQGIKGREIECAVLGNDh 238
Cdd:PRK14569  119 LTDKLVAEDEISF---------PVAVKPSSGGSSIATFKVKSIQELKHAYEEASKYG-EVMIEQWVTGKEITVAIVNDE- 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 239 pqASTCGEIVLNSEFYAYDTKYiddQGAQVV-VPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEIN 317
Cdd:PRK14569  188 --VYSSVWIEPQNEFYDYESKY---SGKSIYhSPSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRGNFYIMEIN 262

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1319839448 318 TLPGFTNISMYPKLWQASGLDYTSLITRLIELA 350
Cdd:PRK14569  263 SSPGMTDNSLSPKSAAAEGVDFDSFVKRIIEQA 295
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 124-351 8.55e-26

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 104.18  E-value: 8.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 124 NLPFVGSDVlgSAACMDKDVTKRLLRDAGLAVAPFITLTRANRAqfsfADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQ 203
Cdd:COG0439    40 GLPGPSPEA--IRAMRDKVLMREALAAAGVPVPGFALVDSPEEA----LAFAEEIGYPVVVKPADGAGSRGVRVVRDEEE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 204 YHQAVALA------FEFDHKVVVEQGIKGREIECAVLGNDhpqastcGEIVLNSEF-YAYDTKYIDDQGAqvVVPAAIAP 276
Cdd:COG0439   114 LEAALAEAraeakaGSPNGEVLVEEFLEGREYSVEGLVRD-------GEVVVCSITrKHQKPPYFVELGH--EAPSPLPE 184

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1319839448 277 EINDKIRAIAVQAYQTLG-CSGMARVDVFLTADNEVVINEINT-LPGftniSMYPKLWQ-ASGLDytsLITRLIELAL 351
Cdd:COG0439   185 ELRAEIGELVARALRALGyRRGAFHTEFLLTPDGEPYLIEINArLGG----EHIPPLTElATGVD---LVREQIRLAL 255
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 91-356 3.41e-16

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 78.06  E-value: 3.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  91 ESGQPLAAIDVIF----PIVHGTlgedgSLQGMLRMANLPFVgSDVLGSAACMDKDVTKRLLRDAGLAVAPFITLTRANR 166
Cdd:COG0189    49 YRGEDLSEFDAVLpridPPFYGL-----ALLRQLEAAGVPVV-NDPEAIRRARDKLFTLQLLARAGIPVPPTLVTRDPDD 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 167 AqfsfADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVALAFEFDHKVVVEQ----GIKGREIECAVLGndhpqas 242
Cdd:COG0189   123 L----RAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESILEALTELGSEPVLVQefipEEDGRDIRVLVVG------- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 243 tcGEIVlnsefYAYdtKYIDDQGAQVVVPA----AIAPEINDKIRAIAVQAYQTLGCsGMARVDVFLTADNEVVInEINT 318
Cdd:COG0189   192 --GEPV-----AAI--RRIPAEGEFRTNLArggrAEPVELTDEERELALRAAPALGL-DFAGVDLIEDDDGPLVL-EVNV 260

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1319839448 319 LPGFTNISmypklwQASGLDytslITRLIELALERHAA 356
Cdd:COG0189   261 TPGFRGLE------RATGVD----IAEAIADYLEARAA 288
ATP-grasp pfam02222
ATP-grasp domain; This family does not contain all known ATP-grasp domain members. This family ...
 149-316 4.99e-15

ATP-grasp domain; This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 396689 [Multi-domain]  Cd Length: 169  Bit Score: 72.29  E-value: 4.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 149 RDAGLAVAPFITLTRANraqfSFADVEAKLGLPLFVKPANQGSS-VGVSKVKNEEQYHQAVALAFefDHKVVVEQGIKgR 227
Cdd:pfam02222   1 QKLGLPTPRFMAAESLE----ELIEAGQELGYPCVVKARRGGYDgKGQYVVRSEADLPQAWEELG--DGPVIVEEFVP-F 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 228 EIECAVLGndhpqASTcgeivLNSEFYAYD---TKYIDDQGAQVVVPAAIAPEINDKIRAIAVQAYQTLGCSGMARVDVF 304
Cdd:pfam02222  74 DRELSVLV-----VRS-----VDGETAFYPvveTIQEDGICRLSVAPARVPQAIQAEAQDIAKRLVDELGGVGVFGVELF 143

                         170
                  ....*....|..
gi 1319839448 305 LTADNEVVINEI 316
Cdd:pfam02222 144 VTEDGDLLINEL 155
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 138-317 4.24e-14

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 72.22  E-value: 4.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 138 CMDKDVTKRLLRDAGLAVApfITLTRANRAQFSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQyhqaVALAFEFDHK 217
Cdd:PRK12767  109 CNDKWLTYEFLKENGIPTP--KSYLPESLEDFKAALAKGELQFPLFVKPRDGSASIGVFKVNDKEE----LEFLLEYVPN 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 218 VVVEQGIKGREIECAVLgNDhpqastcgeivLNSEFYAYDT-KYID------DQGaqVVVPaaiAPEINDKIRAIAvqay 290
Cdd:PRK12767  183 LIIQEFIEGQEYTVDVL-CD-----------LNGEVISIVPrKRIEvragetSKG--VTVK---DPELFKLAERLA---- 241

                         170       180
                  ....*....|....*....|....*..
gi 1319839448 291 QTLGCSGMARVDVFLTaDNEVVINEIN 317
Cdd:PRK12767  242 EALGARGPLNIQCFVT-DGEPYLFEIN 267
PurK COG0026
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and ...
 129-316 7.57e-12

Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439797 [Multi-domain]  Cd Length: 353  Bit Score: 65.87  E-value: 7.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 129 GSDVLgsAACMDKDVTKRLLRDAGLAVAPFITLTranraqfSFADVEA---KLGLPLFVKPANQGS-SVGVSKVKNEEQY 204
Cdd:COG0026    80 GPEAL--EIAQDRLLEKAFLAELGIPVAPFAAVD-------SLEDLEAaiaELGLPAVLKTRRGGYdGKGQVVIKSAADL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 205 HQAVALAFEFDhkVVVEQGIK-GREIecAVLGndhpqA-STCGEIVlnsefyAYD---TKYIDDQGAQVVVPAAIAPEIN 279
Cdd:COG0026   151 EAAWAALGGGP--CILEEFVPfEREL--SVIV-----ArSPDGEVA------TYPvveNVHRNGILDESIAPARISEALA 215

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1319839448 280 DKIRAIAVQAYQTLGCSG-MArVDVFLTADNEVVINEI 316
Cdd:COG0026   216 AEAEEIAKRIAEALDYVGvLA-VEFFVTKDGELLVNEI 252
PRK06019 PRK06019
phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed
 127-316 1.01e-09

phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed


Pssm-ID: 235674 [Multi-domain]  Cd Length: 372  Bit Score: 59.40  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 127 FVGSDVLGSAAcmDKDVTKRLLRDAGLAVAPFITLTRANraqfSFADVEAKLGLPLFVKPANQGss-vGVSKVKNEEQYH 205
Cdd:PRK06019   89 PPGPDALAIAQ--DRLTEKQFLDKLGIPVAPFAVVDSAE----DLEAALADLGLPAVLKTRRGGydgkGQWVIRSAEDLE 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 206 QAVAlafEFDHK-VVVEQGIKGREiECAVLGndhpqA-STCGEIVlnsefyAYD-TKYIDDQG--AQVVVPAAIAPEIND 280
Cdd:PRK06019  163 AAWA---LLGSVpCILEEFVPFER-EVSVIV-----ArGRDGEVV------FYPlVENVHRNGilRTSIAPARISAELQA 227

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1319839448 281 KIRAIAVQAYQTLGCSG-MArVDVFLTADNEVVINEI 316
Cdd:PRK06019  228 QAEEIASRIAEELDYVGvLA-VEFFVTGDGELLVNEI 263
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 137-228 8.67e-09

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 57.09  E-value: 8.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 137 ACmDKDVTKRLLRDAGLAVAPFITLTRANRAqfsfadVEA--KLGLPLFVKP--ANQGSsvGVS-KVKNEEQYHQAVALA 211
Cdd:PRK14016  212 AC-DKELTKRLLAAAGVPVPEGRVVTSAEDA------WEAaeEIGYPVVVKPldGNHGR--GVTvNITTREEIEAAYAVA 282

                          90
                  ....*....|....*..
gi 1319839448 212 FEFDHKVVVEQGIKGRE 228
Cdd:PRK14016  283 SKESSDVIVERYIPGKD 299
PRK02471 PRK02471
bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;
141-237 7.00e-07

bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;


Pssm-ID: 179427 [Multi-domain]  Cd Length: 752  Bit Score: 51.08  E-value: 7.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 141 KDVTKRLLRDAGLAVAPFITLTRANRAQFSFADVEAKlglPLFVKPANQGSSVGVS---KVKNEEQYHQAVALAFEFDHK 217
Cdd:PRK02471  489 KVVTKKILAEAGFPVPAGDEFTSLEEALADYSLFADK---AIVVKPKSTNFGLGISifkEPASLEDYEKALEIAFREDSS 565

                          90       100
                  ....*....|....*....|
gi 1319839448 218 VVVEQGIKGREIECAVLGND 237
Cdd:PRK02471  566 VLVEEFIVGTEYRFFVLDGK 585
PRK10446 PRK10446
30S ribosomal protein S6--L-glutamate ligase;
179-363 1.18e-06

30S ribosomal protein S6--L-glutamate ligase;


Pssm-ID: 182468 [Multi-domain]  Cd Length: 300  Bit Score: 49.51  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 179 GLPLFVKPANQGSSVGVSkVKNEEQYHQAVALAFE-FDHKVVVEQGI---KGREIECAVLGNdhpqastcgEIVLNSEFY 254
Cdd:PRK10446  135 GAPLVVKLVEGTQGIGVV-LAETRQAAESVIDAFRgLNAHILVQEYIkeaQGCDIRCLVVGD---------EVVAAIERR 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 255 AYDTKYIDD--QGAqvvvpAAIAPEINDKIRAIAVQAYQTLGCSgMARVDVfLTADNEVVINEINTLPGFTNISmypklw 332
Cdd:PRK10446  205 AKEGDFRSNlhRGG-----AASVASITPQEREIAIKAARTMALD-VAGVDI-LRANRGPLVMEVNASPGLEGIE------ 271

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1319839448 333 QASGLDYTSLITRLIelalERHAADR-ALKTS 363
Cdd:PRK10446  272 KTTGIDIAGKMIRWI----ERHATTEyCLKTG 299
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 140-316 1.57e-05

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 46.59  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 140 DKDVTKRLLRDAGLAVAPFITLTRANRAQfsfaDVEAKLGLPLFVKP---ANQGSsvGVSKVKNEEQYHQAVALAFEFDH 216
Cdd:PLN02948  121 DKYAQKVHFSKHGIPLPEFMEIDDLESAE----KAGDLFGYPLMLKSrrlAYDGR--GNAVAKTEEDLSSAVAALGGFER 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 217 KVVVEQGIKGREiECAVL---GNDhpqastcGEIVLnseFYAYDTKYIDDQGAQVVVPAAIAPEINDKIRAIAVQAYQTL 293
Cdd:PLN02948  195 GLYAEKWAPFVK-ELAVMvarSRD-------GSTRC---YPVVETIHKDNICHVVEAPANVPWKVAKLATDVAEKAVGSL 263

                         170       180
                  ....*....|....*....|...
gi 1319839448 294 GCSGMARVDVFLTADNEVVINEI 316
Cdd:PLN02948  264 EGAGVFGVELFLLKDGQILLNEV 286
PRK08462 PRK08462
acetyl-CoA carboxylase biotin carboxylase subunit;
92-318 2.40e-05

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236269 [Multi-domain]  Cd Length: 445  Bit Score: 45.89  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  92 SGQPLAAIDVIFPiVHGTLGEDGSLQGMLRMANLPFVGSDVLGSAACMDKDVTKRLLRDAGLAVAPfitltranRAQFSF 171
Cdd:PRK08462   70 SAAEIFEADAIFP-GYGFLSENQNFVEICSHHNIKFIGPSVEVMALMSDKSKAKEVMKRAGVPVIP--------GSDGAL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 172 ADVEA------KLGLPLFVKPANQGSSVGVSKVKNEEQYHQAV------ALAFEFDHKVVVEQGI-KGREIECAVLGNDH 238
Cdd:PRK08462  141 KSYEEakkiakEIGYPVILKAAAGGGGRGMRVVEDESDLENLYlaaeseALSAFGDGTMYMEKFInNPRHIEVQILGDKH 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 239 PQASTCGEivLNSEFYAYDTKYIDDQGAQVvvpaaIAPEINDKIRAIAVQAYQTLGCSGMARVDVFLTADNEVVINEINT 318
Cdd:PRK08462  221 GNVIHVGE--RDCSLQRRHQKLIEESPAVV-----LDEKTRERLHETAIKAAKAIGYEGAGTFEFLLDSNLDFYFMEMNT 293
PRK06111 PRK06111
acetyl-CoA carboxylase biotin carboxylase subunit; Validated
 97-318 3.04e-05

acetyl-CoA carboxylase biotin carboxylase subunit; Validated


Pssm-ID: 180406 [Multi-domain]  Cd Length: 450  Bit Score: 45.79  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448  97 AAIDVIFPiVHGTLGEDGSLQGMLRMANLPFVGSdvlgSAACM----DKDVTKRLLRDAGLAVAPFITltranraqFSFA 172
Cdd:PRK06111   73 TGAEAIHP-GYGLLSENASFAERCKEEGIVFIGP----SADIIakmgSKIEARRAMQAAGVPVVPGIT--------TNLE 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 173 DVE------AKLGLPLFVKPANQGSSVGVSKVKNEEQYHQAVAL----AFEF--DHKVVVEQGI-KGREIECAVLGNDHp 239
Cdd:PRK06111  140 DAEeaiaiaRQIGYPVMLKASAGGGGIGMQLVETEQELTKAFESnkkrAANFfgNGEMYIEKYIeDPRHIEIQLLADTH- 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 240 qastcGEIVlnsefYAYDTKYIDDQGAQVVVPAAIAPEINDKIRA----IAVQAYQTLGCSGMARVDVFLTADNEVVINE 315
Cdd:PRK06111  219 -----GNTV-----YLWERECSVQRRHQKVIEEAPSPFLDEETRKamgeRAVQAAKAIGYTNAGTIEFLVDEQKNFYFLE 288


                  ...
gi 1319839448 316 INT 318
Cdd:PRK06111  289 MNT 291
rimK_fam TIGR00768
alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione ...
 136-347 5.60e-05

alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).


Pssm-ID: 273261 [Multi-domain]  Cd Length: 276  Bit Score: 44.26  E-value: 5.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 136 AACMDKDVTKRLLRDAGLAVApfITLTRANRAQFS-FADveaKLGLPLFVKPANQGSSVGVSKVkNEEQYHQAVALAFE- 213
Cdd:TIGR00768  84 LNAGDKFLSHQLLAKAGIPLP--RTGLAGSPEEALkLIE---EIGFPVVLKPVFGSWGRGVSLA-RDRQAAESLLEHFEq 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 214 ---FDHKVVVEQGIK---GREIECAVLGndhpqastcGEIVLnsefyAYDTKYIDDQGAQVVVPAAIAP-EINDKIRAIA 286
Cdd:TIGR00768 158 lngPQNLFLVQEYIKkpgGRDIRVFVVG---------DEVVA-----AIYRITSGHWRSNLARGGKAEPcSLTEEIEELA 223

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1319839448 287 VQAYQTLGcSGMARVDvFLTADNEVVINEINTLPGFTNISMYpklwqaSGLDYTSLITRLI 347
Cdd:TIGR00768 224 IKAAKALG-LDVAGVD-LLESEDGLLVNEVNANPEFKNSVKT------TGVNIAGKLLDYI 276
PRK05586 PRK05586
acetyl-CoA carboxylase biotin carboxylase subunit;
108-318 5.72e-04

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 180150 [Multi-domain]  Cd Length: 447  Bit Score: 41.62  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 108 GTLGEDGSLQGMLRMANLPFVGSDvlgsAACMD----KDVTKRLLRDAGLAVAP-FITLTRANRAQFSFADveaKLGLPL 182
Cdd:PRK05586   83 GFLSENSKFAKMCKECNIVFIGPD----SETIElmgnKSNAREIMIKAGVPVVPgSEGEIENEEEALEIAK---EIGYPV 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 183 FVKPANQGSSVGVSKVKNEEQYHQAV------ALAFEFDHKVVVEQGI-KGREIECAVLGNDHPQASTCGEIVLNSEfya 255
Cdd:PRK05586  156 MVKASAGGGGRGIRIVRSEEELIKAFntakseAKAAFGDDSMYIEKFIeNPKHIEFQILGDNYGNVVHLGERDCSLQ--- 232

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1319839448 256 ydtkyiddQGAQVVVPAAIAPEINDKIRA----IAVQAYQTLGCSGMARVDVFLTADNEVVINEINT 318
Cdd:PRK05586  233 --------RRNQKVLEEAPSPVMTEELRKkmgeIAVKAAKAVNYKNAGTIEFLLDKDGNFYFMEMNT 291
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 178-209 7.66e-04

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 39.57  E-value: 7.66e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1319839448 178 LGLPLFVKPANQGSSVGVSKVKNEEQYHQAVA 209
Cdd:pfam13535   1 IPYPCVIKPSVGFFSVGVYKINNREEWKAAFA 32
PRK02186 PRK02186
argininosuccinate lyase; Provisional
 125-346 2.02e-03

argininosuccinate lyase; Provisional


Pssm-ID: 235010 [Multi-domain]  Cd Length: 887  Bit Score: 40.22  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 125 LPfvGSDVLGSAACMDKDVTKRLLRDAGLAVAPfitlTRANRAQFSFADVEAKLGLPLFVKPANQGSSVGVSKVKNEEQY 204
Cdd:PRK02186   94 LP--AANTEAIRTCRDKKRLARTLRDHGIDVPR----THALALRAVALDALDGLTYPVVVKPRMGSGSVGVRLCASVAEA 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 205 --HQAVALAfEFDHKVVVEQGIKGREIECAVLGNDHPQAstCGEIVlnSEFYAYDTKYIDdqgAQVVVPAAIAPEINDKI 282
Cdd:PRK02186  168 aaHCAALRR-AGTRAALVQAYVEGDEYSVETLTVARGHQ--VLGIT--RKHLGPPPHFVE---IGHDFPAPLSAPQRERI 239

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1319839448 283 RAIAVQAYQTLGCS-GMARVDVFLTADNEVVInEINT-LPGftniSMYPKLW-QASGLDYTSLITRL 346
Cdd:PRK02186  240 VRTVLRALDAVGYAfGPAHTELRVRGDTVVII-EINPrLAG----GMIPVLLeEAFGVDLLDHVIDL 301
RimK pfam08443
RimK-like ATP-grasp domain; This ATP-grasp domain is found in the ribosomal S6 modification ...
 177-331 6.52e-03

RimK-like ATP-grasp domain; This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK.


Pssm-ID: 369879 [Multi-domain]  Cd Length: 188  Bit Score: 37.48  E-value: 6.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319839448 177 KLGLPLFVKPANQGSSVGVSKVKNEEQyhqAVALAFEFDHKVVVEQGIK---GREIECAVLGNDhpQASTCGEIVLNSEF 253
Cdd:pfam08443  38 KRQFPVIVKSIYGSQGIGVFLAEDEQK---LRQTLSATNEQILVQEFIAeanNEDIRCLVVGDQ--VVGALHRQSNEGDF 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1319839448 254 YAYDTKyiddqGAqVVVPAAIAPEIndkiRAIAVQAYQTLGCSgMARVDVFLTADNEVVInEINTLPGFTNISMYPKL 331
Cdd:pfam08443 113 RSNLHR-----GG-VGEKYQLSQEE----TELAIKAAQAMQLD-VAGVDLLRQKRGLLVC-EVNSSPGLEGIEKTLGI 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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