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Conserved domains on  [gi|1319724112|gb|PLK37539|]
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TetR family transcriptional regulator [Klebsiella variicola]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-162 5.96e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.47  E-value: 5.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319724112   8 ELIKIAALQLFREKGFSNVSTRDLTQKMNISRSHIYHYYRDWETLKKSTIQYMFENDIQECHAFLNASekmSASERVNLY 87
Cdd:COG1309     9 ERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE---DPRERLRAL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1319724112  88 IRTLLPDAPSAHWLLYLELWpMAARDADYAKLVHDYSLQWITILEGIISVGmqeGEFLAENAATSARQINTLIDG 162
Cdd:COG1309    86 LRAYLEFLAENPALARLLLA-EAAELPELRAALRALLRRLRALLAELLRAG---GLLADVDPDALARALLALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-162 5.96e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.47  E-value: 5.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319724112   8 ELIKIAALQLFREKGFSNVSTRDLTQKMNISRSHIYHYYRDWETLKKSTIQYMFENDIQECHAFLNASekmSASERVNLY 87
Cdd:COG1309     9 ERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE---DPRERLRAL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1319724112  88 IRTLLPDAPSAHWLLYLELWpMAARDADYAKLVHDYSLQWITILEGIISVGmqeGEFLAENAATSARQINTLIDG 162
Cdd:COG1309    86 LRAYLEFLAENPALARLLLA-EAAELPELRAALRALLRRLRALLAELLRAG---GLLADVDPDALARALLALLDG 156
TetR_C_6 pfam13977
BetI-type transcriptional repressor, C-terminal; This family comprises the C-terminal portion ...
 82-162 5.12e-10

BetI-type transcriptional repressor, C-terminal; This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.


Pssm-ID: 433619  Cd Length: 112  Bit Score: 54.62  E-value: 5.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319724112  82 ERVNLYIRTLLPDAP--SAHWLLYLELWPMAARDADYAKLVHDYSLQWITILEGIISVGMQEGEFLAENAATSARQINTL 159
Cdd:pfam13977   2 ERLRAILEALLPLDQerRAEARVWLAFWAEALRDPELAELQRELYRRLRSNLAALLRRLAEGGLFADADAEAEAERLAAL 81


                  ...
gi 1319724112 160 IDG 162
Cdd:pfam13977  82 IDG 84
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-162 5.96e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.47  E-value: 5.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319724112   8 ELIKIAALQLFREKGFSNVSTRDLTQKMNISRSHIYHYYRDWETLKKSTIQYMFENDIQECHAFLNASekmSASERVNLY 87
Cdd:COG1309     9 ERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE---DPRERLRAL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1319724112  88 IRTLLPDAPSAHWLLYLELWpMAARDADYAKLVHDYSLQWITILEGIISVGmqeGEFLAENAATSARQINTLIDG 162
Cdd:COG1309    86 LRAYLEFLAENPALARLLLA-EAAELPELRAALRALLRRLRALLAELLRAG---GLLADVDPDALARALLALLDG 156
TetR_C_6 pfam13977
BetI-type transcriptional repressor, C-terminal; This family comprises the C-terminal portion ...
 82-162 5.12e-10

BetI-type transcriptional repressor, C-terminal; This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.


Pssm-ID: 433619  Cd Length: 112  Bit Score: 54.62  E-value: 5.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1319724112  82 ERVNLYIRTLLPDAP--SAHWLLYLELWPMAARDADYAKLVHDYSLQWITILEGIISVGMQEGEFLAENAATSARQINTL 159
Cdd:pfam13977   2 ERLRAILEALLPLDQerRAEARVWLAFWAEALRDPELAELQRELYRRLRSNLAALLRRLAEGGLFADADAEAEAERLAAL 81


                  ...
gi 1319724112 160 IDG 162
Cdd:pfam13977  82 IDG 84
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-52 2.60e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 42.78  E-value: 2.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1319724112  13 AALQLFREKGFSNVSTRDLTQKMNISRSHIYHYYRDWETL 52
Cdd:pfam00440   4 AARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEEL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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