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Conserved domains on  [gi|13182757|gb|AAK14924|]
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HTPAP [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 2-170 1.35e-67

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 203.99  E-value: 1.35e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   2 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 81
Cdd:cd03390   1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  82 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 155
Cdd:cd03390  81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                       170
                ....*....|....*
gi 13182757 156 VIALSRTCDYKHHWQ 170
Cdd:cd03390 159 LVAVSRTRDYRHHFS 173
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 2-170 1.35e-67

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 203.99  E-value: 1.35e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   2 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 81
Cdd:cd03390   1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  82 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 155
Cdd:cd03390  81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                       170
                ....*....|....*
gi 13182757 156 VIALSRTCDYKHHWQ 170
Cdd:cd03390 159 LVAVSRTRDYRHHFS 173
PLN02250 PLN02250
lipid phosphate phosphatase
 21-173 9.75e-46

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 152.39  E-value: 9.75e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   21 VIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTG 95
Cdd:PLN02250  73 LIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTG 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13182757   96 DKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQGPF 173
Cdd:PLN02250 152 AKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF--DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVF 227
acidPPc smart00014
Acid phosphatase homologues;
62-169 2.88e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 70.45  E-value: 2.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757     62 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 141
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100
                   ....*....|....*....|....*...
gi 13182757    142 WRFCAFLspLLFAAVIALSRTCDYKHHW 169
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWP 98
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 60-169 2.31e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.60  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757    60 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqGRG 139
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLR---------RLR 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 13182757   140 KSWRFCAFLSPLLFAAVIALSRTCDYKHHW 169
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFP 101
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 13-161 1.04e-05

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 43.88  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  13 YFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlm 92
Cdd:COG0671  39 LLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG-- 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13182757  93 ctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFCAFLSPLLFAAVIALSR 161
Cdd:COG0671 116 -----------GYSFPSGHAAAAFALALVLALLL---------------PRRWLAALLLALALLVGLSR 158
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 2-170 1.35e-67

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 203.99  E-value: 1.35e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   2 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 81
Cdd:cd03390   1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  82 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 155
Cdd:cd03390  81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                       170
                ....*....|....*
gi 13182757 156 VIALSRTCDYKHHWQ 170
Cdd:cd03390 159 LVAVSRTRDYRHHFS 173
PLN02250 PLN02250
lipid phosphate phosphatase
 21-173 9.75e-46

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 152.39  E-value: 9.75e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   21 VIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTG 95
Cdd:PLN02250  73 LIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTG 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13182757   96 DKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQGPF 173
Cdd:PLN02250 152 AKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF--DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVF 227
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 21-173 4.00e-40

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 138.24  E-value: 4.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   21 VIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAH----SDLMCTGD 96
Cdd:PLN02731  92 VYAMLLPL-VIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALydslGDVICHGD 170

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13182757   97 KDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQGPF 173
Cdd:PLN02731 171 KSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF--DGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVF 245
PLN02715 PLN02715
lipid phosphate phosphatase
 21-173 4.99e-33

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 119.77  E-value: 4.99e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757   21 VIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSD----LMCTGD 96
Cdd:PLN02715  98 VYAVLLPI-ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDalggVICHGK 176

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13182757   97 KDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKswRFCAFLSPLLFAAVIALSRTCDYKHHWQGPF 173
Cdd:PLN02715 177 AAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVA--KLCLVIFPLLAACLVGISRVDDYWHHWQDVF 251
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 61-169 8.75e-24

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 91.15  E-value: 8.75e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  61 VFTNTIKLIVGRPRPDFFYRCFPDG----------LAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKL 130
Cdd:cd03384  18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARL 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 13182757 131 hcftpqgrgkSWRFCAFLSPLL------FAAVIALSRTCDYKHHW 169
Cdd:cd03384  98 ----------KLRGSRLLRPLLqflllaLALYVGLSRISDYKHHW 132
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 59-169 4.18e-18

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 75.57  E-value: 4.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  59 NGVFTNTIKLIVGRPRPDFFYRCFPDGlahsdlmctgDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLhcftpqgr 138
Cdd:cd01610  15 GLLLTGVLKYLFGRPRPYFLLRCGPDG----------DPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRL-------- 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 13182757 139 gksWRFCAFLSPLLFAAVIALSRTCDYKHHW 169
Cdd:cd01610  77 ---LRLLLGLLLLLLALLVGLSRVYLGVHYP 104
acidPPc smart00014
Acid phosphatase homologues;
62-169 2.88e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 70.45  E-value: 2.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757     62 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 141
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100
                   ....*....|....*....|....*...
gi 13182757    142 WRFCAFLspLLFAAVIALSRTCDYKHHW 169
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWP 98
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 60-169 2.31e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.60  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757    60 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqGRG 139
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLR---------RLR 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 13182757   140 KSWRFCAFLSPLLFAAVIALSRTCDYKHHW 169
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFP 101
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 60-161 2.33e-08

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 51.07  E-value: 2.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  60 GVFTNTIKLIVGRPRPDFFYRCFPDGLahsdlmctgdkdvvnegrkSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrG 139
Cdd:cd03392  75 GALNTLLKLLVQRPRPPLHLLVPEGGY-------------------SFPSGHAMGATVLYGFLAYLLARRLP-------R 128

                        90       100
                ....*....|....*....|..
gi 13182757 140 KSWRFCAFLSPLLFAAVIALSR 161
Cdd:cd03392 129 RRVRILLLILAAILILLVGLSR 150
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 13-161 1.04e-05

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 43.88  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  13 YFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlm 92
Cdd:COG0671  39 LLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG-- 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13182757  93 ctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFCAFLSPLLFAAVIALSR 161
Cdd:COG0671 116 -----------GYSFPSGHAAAAFALALVLALLL---------------PRRWLAALLLALALLVGLSR 158
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 60-167 2.48e-05

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 42.69  E-value: 2.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  60 GVFTNTIKLIVGRPRPDFFyrcFPDGLAHSDLMCTGDkdvvneGRKSFPSGHSSFAFAgLAFASFYLAGKlhcftpqgrg 139
Cdd:cd03389  82 GILVNLLKFIIGRARPKLL---FDDGLYGFDPFHADY------AFTSFPSGHSATAGA-AAAALALLFPR---------- 141

                        90       100
                ....*....|....*....|....*...
gi 13182757 140 ksWRFCAflspLLFAAVIALSRTCDYKH 167
Cdd:cd03389 142 --YRWAF----ILLALLIAFSRVIVGAH 163
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 63-124 5.49e-05

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 40.39  E-value: 5.49e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13182757  63 TNTIKLIVGRPRPDffyrcfpdglahsdlmctGDkdvvNEGRKSFPSGHSSFAFAGLAFASF 124
Cdd:cd03394  19 TEGLKFAVGRARPD------------------GS----NNGYRSFPSGHTASAFAAATFLQY 58
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 66-168 8.26e-04

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 38.07  E-value: 8.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13182757  66 IKLIVGRPRPdffyrcfpdglAHsdlMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrgkswrfc 145
Cdd:cd03391  66 LKALVRRRRP-----------AY---NSPDMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVP-------------- 117

                        90       100
                ....*....|....*....|....
gi 13182757 146 aFLSPL-LFAAVIALSRTCDYKHH 168
Cdd:cd03391 118 -LRVLLvLWATVVGISRVLLGRHH 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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