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Conserved domains on  [gi|1317734670|gb|AUH46770|]
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phosphatase PAP2 family protein [Enterococcus faecium]

Protein Classification

PgpB family protein( domain architecture ID 11430553)

PgpB family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 61-172 9.57e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 81.62  E-value: 9.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  61 LAILIGSLIYFFVGLLFIKKTTRRKRPYEkNRRLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP--VAGILAFLFACL 138
Cdd:COG0671    75 LLLAALLLLLLLLLLLLLKYLFGRPRPFV-VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPrrWLAALLLALALL 153

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1317734670 139 IAYSRIFLLLHYPTDILGGAILGSVIGILCAAVI 172
Cdd:COG0671   154 VGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 61-172 9.57e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 81.62  E-value: 9.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  61 LAILIGSLIYFFVGLLFIKKTTRRKRPYEkNRRLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP--VAGILAFLFACL 138
Cdd:COG0671    75 LLLAALLLLLLLLLLLLLKYLFGRPRPFV-VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPrrWLAALLLALALL 153

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1317734670 139 IAYSRIFLLLHYPTDILGGAILGSVIGILCAAVI 172
Cdd:COG0671   154 VGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 61-168 2.21e-18

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 76.35  E-value: 2.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  61 LAILIGSLIYFFVGLL--FIKKTTRRKRPYEKNR---RLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP------VAG 129
Cdd:cd01610     3 LLALLLLLALLAGLLLtgVLKYLFGRPRPYFLLRcgpDGDPLLLTEGGYSFPSGHAAFAFALALFLALLLPrrllrlLLG 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1317734670 130 ILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:cd01610    83 LLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
acidPPc smart00014
Acid phosphatase homologues;
62-168 1.58e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 65.83  E-value: 1.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670   62 AILIGSLIYFfvgLLFIKKTTRRKRPYEKNRRLVLYTSKP-----KTSSFPSGHTALAFLSVAALFELSP------VAGI 130
Cdd:smart00014   1 ALLAVVSQLF---NGVIKNYFGRPRPFFLSIGDACCTPNFlltleAGYSFPSGHTAFAFAFALFLLLYLParagrkLLIF 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1317734670  131 LAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:smart00014  78 LLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 59-168 1.98e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 63.21  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  59 YGLAILIGSLIYFFvgllfIKKTTRRKRPY----EKNRRLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP-------- 126
Cdd:pfam01569   2 LLLALALAGLLSSV-----LKDYFGRPRPFflllEGGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRrlrkivrv 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1317734670 127 VAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:pfam01569  77 LLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLV 118
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 60-172 1.69e-07

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 48.86  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  60 GLAILIGSLIYFFVGLLFikkttRRKRPYEKNRRLVLYTSKPkTSSFPSGH-TALAFLSVAALFELSPVAGILAFLFACL 138
Cdd:PRK11837   65 AIALAISLLVSWTIGHLF-----PHDRPFVEGIGYNFLHHAA-DDSFPSDHgTVIFTFALAFLFWHRLWSGSLLMAIAVA 138

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1317734670 139 IAYSRIFLLLHYPTDILGGAILGsVIGILCAAVI 172
Cdd:PRK11837  139 IAWSRVYLGVHWPLDMLGALLVG-MIGCLSAQII 171
 
Name Accession Description Interval E-value
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 61-172 9.57e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 81.62  E-value: 9.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  61 LAILIGSLIYFFVGLLFIKKTTRRKRPYEkNRRLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP--VAGILAFLFACL 138
Cdd:COG0671    75 LLLAALLLLLLLLLLLLLKYLFGRPRPFV-VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPrrWLAALLLALALL 153

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1317734670 139 IAYSRIFLLLHYPTDILGGAILGSVIGILCAAVI 172
Cdd:COG0671   154 VGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 61-168 2.21e-18

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 76.35  E-value: 2.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  61 LAILIGSLIYFFVGLL--FIKKTTRRKRPYEKNR---RLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP------VAG 129
Cdd:cd01610     3 LLALLLLLALLAGLLLtgVLKYLFGRPRPYFLLRcgpDGDPLLLTEGGYSFPSGHAAFAFALALFLALLLPrrllrlLLG 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1317734670 130 ILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:cd01610    83 LLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 60-167 2.61e-15

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 67.74  E-value: 2.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  60 GLAILIGSLIYFFVGLLFIKKTTRRKRPYEKNRRlvlytskpkTSSFPSGHTALAFlSVAALFEL---SPVAGILAFLFA 136
Cdd:cd03394     4 GLLILAEAAALTAAVTEGLKFAVGRARPDGSNNG---------YRSFPSGHTASAF-AAATFLQYrygWRWYGIPAYALA 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1317734670 137 CLIAYSRIFLLLHYPTDILGGAILGSVIGIL 167
Cdd:cd03394    74 SLVGASRVVANRHWLSDVLAGAAIGILVGYL 104
acidPPc smart00014
Acid phosphatase homologues;
62-168 1.58e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 65.83  E-value: 1.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670   62 AILIGSLIYFfvgLLFIKKTTRRKRPYEKNRRLVLYTSKP-----KTSSFPSGHTALAFLSVAALFELSP------VAGI 130
Cdd:smart00014   1 ALLAVVSQLF---NGVIKNYFGRPRPFFLSIGDACCTPNFlltleAGYSFPSGHTAFAFAFALFLLLYLParagrkLLIF 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1317734670  131 LAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:smart00014  78 LLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 61-168 1.23e-13

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 64.98  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  61 LAILIGSLIYFFVGLLFIKKTTRRKRPY--EKNRRLVLYTSKPKTSSFPSGHTA--LAFLSVAALFELSPVAGILAFLFA 136
Cdd:cd03395    59 LLVLLAVGFADQLASGFLKPLVARLRPCnaLDGVRLVVLGDQGGSYSFASSHAAnsFALALFIWLFFRRGLFSPVLLLWA 138

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1317734670 137 CLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:cd03395   139 LLVGYSRVYVGVHYPGDVIAGALIGIISGLLF 170
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 60-168 1.41e-13

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 64.20  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  60 GLAILIGSLIYFFVGLLFIKKttrrkRPYEKNRRLVLYTSKPkTSSFPSGHTALAFlSVAALFELSP--VAGILAFLFAC 137
Cdd:cd03385    39 TIAVAVALLINYIIGLLYFHP-----RPFVVGLGHNLLPHAA-DSSFPSDHTTLFF-SIAFSLLLRRrkWAGWILLILAL 111

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1317734670 138 LIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:cd03385   112 LVAWSRIYLGVHYPLDMLGAALVAVLSALLV 142
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 59-168 1.98e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 63.21  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  59 YGLAILIGSLIYFFvgllfIKKTTRRKRPY----EKNRRLVLYTSKPKTSSFPSGHTALAFLSVAALFELSP-------- 126
Cdd:pfam01569   2 LLLALALAGLLSSV-----LKDYFGRPRPFflllEGGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRrlrkivrv 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1317734670 127 VAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:pfam01569  77 LLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLV 118
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 79-166 5.33e-13

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 63.99  E-value: 5.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  79 KKTTRRKRPYEKNRRLVL-----YTSKPKTSSFPSGHTALAFLSVAALFELSP-VAG-ILAFlfACLIAYSRIFLLLHYP 151
Cdd:cd03380   113 KYHYNRPRPFVAIRLQWLpictpEEGTPKHPSYPSGHATFGGAAALVLAELFPeRAAeLLAR--AAEAGNSRVVAGVHWP 190

                          90
                  ....*....|....*
gi 1317734670 152 TDILGGAILGSVIGI 166
Cdd:cd03380   191 SDVEAGRILGEAIAA 205
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 68-161 2.38e-12

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 61.18  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  68 LIYFFVGLLF-------IKKTTRRKRPYEKNRRLVLYTSkPKTSSFPSGHTALAFL---SVAALFELSPVAGILAFLFAC 137
Cdd:cd03391    49 LVNLLLGLLLdiitvaiLKALVRRRRPAYNSPDMLDYVA-VDKYSFPSGHASRAAFvarFLLNHLVLAVPLRVLLVLWAT 127

                          90       100
                  ....*....|....*....|....
gi 1317734670 138 LIAYSRIFLLLHYPTDILGGAILG 161
Cdd:cd03391   128 VVGISRVLLGRHHVLDVLAGAFLG 151
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 57-171 2.81e-10

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 56.08  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  57 REYGLAILIGSLIYFFVGL-LFIKKTTRRKRPyeknrrLVLYTSKPKTSSFPSGHTALAFLSVAALFEL------SPVAG 129
Cdd:cd03392    59 RRRRAALFLLLALLGGGALnTLLKLLVQRPRP------PLHLLVPEGGYSFPSGHAMGATVLYGFLAYLlarrlpRRRVR 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1317734670 130 ILAFLFAC----LIAYSRIFLLLHYPTDILGGAILGSVIGILCAAV 171
Cdd:cd03392   133 ILLLILAAililLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLILL 178
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 105-172 1.36e-09

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 54.25  E-value: 1.36e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1317734670 105 SFPSGHTALAFLSVAALFELSPVAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILCAAVI 172
Cdd:cd03389   119 SFPSGHSATAGAAAAALALLFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 79-164 3.29e-09

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 53.88  E-value: 3.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  79 KKTTRRKRPYEKNR-RLVLYTSKPKTS---SFPSGHTALAFLSVAALFELSP--VAGILAflFACLIAYSRIFLLLHYPT 152
Cdd:cd03397   121 KKYYNRPRPFVLNDePICTPPDESGLAkdgSYPSGHTAAGYAWALILAELVPerADEILA--RGSEYGQSRIVCGVHWPS 198

                          90
                  ....*....|..
gi 1317734670 153 DILGGAILGSVI 164
Cdd:cd03397   199 DVMGGRIMAAAL 210
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 76-167 3.57e-08

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 49.29  E-value: 3.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  76 LFIKKTTRRKRPYEKNRRLVLYTSKPKTSSFPSGH--TALAFLSVAALFELSPVAGILAFLFACLIAYSRIFLLLHYPTD 153
Cdd:cd03393    30 AALKEVFKIPRPFTYDGIQAIYEESAGGYGFPSGHaqTSATFWGSLMLHVRKKWFTLIGVVLVVLISFSRLYLGVHWPSD 109

                          90
                  ....*....|....
gi 1317734670 154 ILGGAILGSVIGIL 167
Cdd:cd03393   110 VIGGVLIGLLVLVL 123
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 105-168 6.96e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 49.91  E-value: 6.96e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1317734670 105 SFPSGHTALAF--LSVAALFELSPV-------------AGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:cd03390   111 SFPSGHSSFAFagLGFLSLYLAGKLhifdprgsswrllLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLS 189
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 60-172 1.69e-07

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 48.86  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  60 GLAILIGSLIYFFVGLLFikkttRRKRPYEKNRRLVLYTSKPkTSSFPSGH-TALAFLSVAALFELSPVAGILAFLFACL 138
Cdd:PRK11837   65 AIALAISLLVSWTIGHLF-----PHDRPFVEGIGYNFLHHAA-DDSFPSDHgTVIFTFALAFLFWHRLWSGSLLMAIAVA 138

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1317734670 139 IAYSRIFLLLHYPTDILGGAILGsVIGILCAAVI 172
Cdd:PRK11837  139 IAWSRVYLGVHWPLDMLGALLVG-MIGCLSAQII 171
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 105-167 7.60e-07

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 46.47  E-value: 7.60e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1317734670 105 SFPSGHTALAFLsvAALF---------------ELSPVAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGIL 167
Cdd:cd03384    73 SFPSGHASLSMY--AAVFlalylqarlklrgsrLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_Aur1_like cd03386
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of ...
 106-171 5.51e-06

PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.


Pssm-ID: 239481  Cd Length: 186  Bit Score: 44.61  E-value: 5.51e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1317734670 106 FPSGHTALAFLSVAALFELSPVA-GILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILCAAV 171
Cdd:cd03386   119 FPSLHVAWAVLAALFLWRHRRRLlRWLAVLWPLLIWLSTLYLGNHYFIDLVGGIALALLSFYLARRV 185
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 107-167 1.24e-05

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 42.32  E-value: 1.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1317734670 107 PSGHTALAFlSVA---ALFELSPVAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGIL 167
Cdd:cd03383    42 PSGHAAIAF-SIAtaiSLITNNPIISILSVLLAVMVAHSRVEMKIHTMWEVVVGAILGALITLL 104
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 69-168 1.28e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 43.03  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  69 IYFFVGLL-------FIKKTTRRKRPYeknRRLVLYTSKPktsSFPSGHTALAFLSVAALF------------ELSPVAG 129
Cdd:cd03382    45 IYLFIGLLanealnyVLKRIIKEPRPC---SGAYFVRSGY---GMPSSHSQFMGFFAVYLLlfiylrlgrlnsLVSRFLL 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1317734670 130 ILAFLF-ACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:cd03382   119 SLGLLLlALLVSYSRVYLGYHTVSQVVVGAIVGILLGILW 158
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 105-164 3.96e-05

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 41.45  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1317734670 105 SFPSGH----TALAFLSVAALFELSP---VAG-ILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVI 164
Cdd:cd03388    79 GFPSTHamnaTAISFYLLIYLYDRYQypfVLGlILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVLI 146
PAP2_3 pfam14378
PAP2 superfamily;
104-164 5.01e-05

PAP2 superfamily;


Pssm-ID: 433919  Cd Length: 190  Bit Score: 41.94  E-value: 5.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1317734670 104 SSFPSGHTALAFLSVAALFELSP--VAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVI 164
Cdd:pfam14378 125 AAMPSLHVAWALLCALALWRLRRtrILRWLAVAYNVLMIVSTVATGNHYLLDVVAGVALALAA 187
PLN02250 PLN02250
lipid phosphate phosphatase
 105-168 2.18e-04

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 40.29  E-value: 2.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1317734670 105 SFPSGHTA-----LAFLS------VAALFELSPVAG----ILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:PLN02250  162 SFPSGHTSwsfagLGFLSlylsgkIRVFDRRGHVAKlcivFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFC 240
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 97-170 3.18e-04

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 39.71  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  97 YTSKPKTSSFPSGHTALAFLSVAALFEL----------------SPVAGIL-----AFLFACLIAYSRIFLLLHYPTDIL 155
Cdd:cd03398   138 LAGTPPHPSYPSGHATFAGAAATVLKALfgsdkvpdtvsepdegGPSTGVTrvwaeLNELADEVAISRVYAGVHFRSDDA 217

                          90
                  ....*....|....*
gi 1317734670 156 GGAILGSVIGILCAA 170
Cdd:cd03398   218 AGAALGEQIGAAALA 232
PLN02715 PLN02715
lipid phosphate phosphatase
 105-168 5.71e-04

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 39.27  E-value: 5.71e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1317734670 105 SFPSGHTALAF--LSVAALFELSPVAG-------------ILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILC 168
Cdd:PLN02715  186 SFPSGHTSWSFagLTFLSLYLSGKIKAfngeghvaklclvIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFC 264
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 57-172 8.65e-04

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 38.43  E-value: 8.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317734670  57 REYGLAILIGSLIYFFVGLLfiKKTTRRKRPYE----------KNRRLVLYTSKPKTSSFPSGHT-------ALAFLSVA 119
Cdd:cd03396    67 RALLLLILVIGLGLLVVAIL--KSHWGRPRPWDltefggdapyTPLFSGPSNGCGKGCSFPSGHAsagfallALYFLFRR 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1317734670 120 ALFELSPVAGILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVIGILCAAVI 172
Cdd:cd03396   145 RRPRLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLLVWLIALLLYRLI 197
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 130-164 1.81e-03

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 37.80  E-value: 1.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1317734670 130 ILAFLFACLIAYSRIFLLLHYPTDILGGAILGSVI 164
Cdd:PLN02525  122 ALFCLLVALVGFGRLYLGMHSPIDIIAGLAIGLVI 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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