NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1317124935|ref|XP_023274396|]
View 

Krueppel-like factor 10 [Seriola lalandi dorsalis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 19-373 1.25e-114

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 337.73  E-value: 1.25e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  19 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDCSEDDSAPLASAVLQDSPLCMTPPYSPPHCEDTHPASAATLHQ 98
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  99 lavagsPAWQTAEETHLHRHTAASQQRFQCTSVIRHTADGQHCCCDVHPvskrdrltqvhtkdskrdlnfedgphtrdse 178
Cdd:cd21572    81 ------PAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 179 mvvimqsdsgdatpqkpltatlpnvlkdsqtqmrlsspvdksDTPQSVSSVPAGVNGVSPVPVYCQILPVSSPSTSVVrk 258
Cdd:cd21572   124 ------------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVV-- 159

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 259 pvtafeshrqhplptasavttvhtqqqpiQQQHALLQPQTQAASSAQVFLLGGQVAKGPLMLLVSQPAVPTLYVQPALVT 338
Cdd:cd21572   160 -----------------------------AAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVT 210

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1317124935 339 PGGTKLPAIAPAPGHTPLEQRQSSLQPEVSRVRSH 373
Cdd:cd21572   211 PGGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
353-428 1.62e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1317124935 353 HTPLEQRQSSLQPEVSRVRSHVCPRedCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRFARSDELSRHRRTHT 428
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 19-373 1.25e-114

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 337.73  E-value: 1.25e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  19 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDCSEDDSAPLASAVLQDSPLCMTPPYSPPHCEDTHPASAATLHQ 98
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  99 lavagsPAWQTAEETHLHRHTAASQQRFQCTSVIRHTADGQHCCCDVHPvskrdrltqvhtkdskrdlnfedgphtrdse 178
Cdd:cd21572    81 ------PAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 179 mvvimqsdsgdatpqkpltatlpnvlkdsqtqmrlsspvdksDTPQSVSSVPAGVNGVSPVPVYCQILPVSSPSTSVVrk 258
Cdd:cd21572   124 ------------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVV-- 159

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 259 pvtafeshrqhplptasavttvhtqqqpiQQQHALLQPQTQAASSAQVFLLGGQVAKGPLMLLVSQPAVPTLYVQPALVT 338
Cdd:cd21572   160 -----------------------------AAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVT 210

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1317124935 339 PGGTKLPAIAPAPGHTPLEQRQSSLQPEVSRVRSH 373
Cdd:cd21572   211 PGGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
353-428 1.62e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1317124935 353 HTPLEQRQSSLQPEVSRVRSHVCPRedCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRFARSDELSRHRRTHT 428
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-416 1.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.71e-04
                          10        20
                  ....*....|....*....|....*...
gi 1317124935 389 HLKAHMRTHTGEKPFKCKweGCERRFAR 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 19-373 1.25e-114

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 337.73  E-value: 1.25e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  19 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDCSEDDSAPLASAVLQDSPLCMTPPYSPPHCEDTHPASAATLHQ 98
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  99 lavagsPAWQTAEETHLHRHTAASQQRFQCTSVIRHTADGQHCCCDVHPvskrdrltqvhtkdskrdlnfedgphtrdse 178
Cdd:cd21572    81 ------PAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 179 mvvimqsdsgdatpqkpltatlpnvlkdsqtqmrlsspvdksDTPQSVSSVPAGVNGVSPVPVYCQILPVSSPSTSVVrk 258
Cdd:cd21572   124 ------------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVV-- 159

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 259 pvtafeshrqhplptasavttvhtqqqpiQQQHALLQPQTQAASSAQVFLLGGQVAKGPLMLLVSQPAVPTLYVQPALVT 338
Cdd:cd21572   160 -----------------------------AAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVT 210

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1317124935 339 PGGTKLPAIAPAPGHTPLEQRQSSLQPEVSRVRSH 373
Cdd:cd21572   211 PGGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 20-373 3.79e-90

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 274.50  E-value: 3.79e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  20 GAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDCSEDDSAPLASAVLQD-SPLCMTPPYSPPHCEDTHPASAATLHQ 98
Cdd:cd21974     1 EQGDLEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSlSSLCMTPPYSPPFFEASHSPSVASLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  99 LAVAGspaWQTAEETHLHRHTAASQQRFQCTSVIRHTADgqhcccdvhpvskrdrltqvhtkdskrdlnfedgphtrdse 178
Cdd:cd21974    81 PSAAS---SQPPPEPESSEPPAASPQRAQATSVIRHTAD----------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 179 mvvimqsdsgdatpqkpltatlpnvlkdsqtqmrlsspvdksdtpqsvssvpagVNGVSPVPVYCQILPVSSPSTSVVRK 258
Cdd:cd21974   117 ------------------------------------------------------PVPVSPPPVLCQMLPVSSSSGVIVAF 142

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 259 PVTAfeshrqhplptasavttvhtqqqpiqqQHALLQPQTQAASSAQVFLLGGQVAKGPLMLLVSQPAVPTLYVQPALVT 338
Cdd:cd21974   143 LKAP---------------------------QQPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQPTVVT 195

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1317124935 339 PGGTKLPAIAPAPGHTPLEQRqSSLQPEVSRVRSH 373
Cdd:cd21974   196 PGGTKLLPIAPAPGFIPSGQS-SAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 23-351 1.11e-14

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 73.11  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  23 DMEAVEALMSMTKhWKTRSFR--LRHFRPLTPSSDCseDDSAPLASAVLQD-------SPLCMTPPYSPPHCEDThpasa 93
Cdd:cd21584     5 DLEAVEALVCMSS-WGQRSQKgdLLKIRPLTPASDS--CDSLTLHPAAPELpkdfhslSSLCMTPPHSPSFAEPS----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935  94 atlhqlavAGSPawqtaeeTHLHRHTAasqqrfqcTSVIRHTADgqhcccdvhpvskrdrltqvhtkdskrdlnfedgph 173
Cdd:cd21584    77 --------TTAP-------PPPCRAMA--------TSVIRHTAD------------------------------------ 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 174 trdsemvvimqsdsgdatpqkpltatlpnvlkdsqtqmrlsspvdksdtpqSVSSVPagvngVSPVPVYCQILPVSSPST 253
Cdd:cd21584    98 ---------------------------------------------------SSPPVP-----VPSPPVLCQMIPVSGQSG 121

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 254 SVVrkpvtAFeshRQHPLPTASAVTTVhtqqqpiqqqhallqpQTQAASSAQVFLLGGQVAKGPLMLLVSQPAVP-TLYV 332
Cdd:cd21584   122 MIS-----AF---LQPPALSAGTVKPI----------------LPQTAPASQPLLVGSPVPQGTVMLVLPQASVPqPPQC 177

                         330
                  ....*....|....*....
gi 1317124935 333 QPALVTPGGTKLPAIAPAP 351
Cdd:cd21584   178 PQTVMTLGNTKLLPLAPAP 196
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
353-428 1.62e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1317124935 353 HTPLEQRQSSLQPEVSRVRSHVCPRedCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRFARSDELSRHRRTHT 428
Cdd:COG5048    14 SVLSSTPKSTLKSLSNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-416 1.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.71e-04
                          10        20
                  ....*....|....*....|....*...
gi 1317124935 389 HLKAHMRTHTGEKPFKCKweGCERRFAR 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
371-463 3.47e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317124935 371 RSHVCPREDCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCPV--CHSRFM 443
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90       100
                  ....*....|....*....|
gi 1317124935 444 RSDHLAKHARRHLAMRRMPC 463
Cdd:COG5048   400 RDSNLSLHIITHLSFRPYNC 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH