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bacterial regulatory protein, arsR family [archaeon BMS3Bbin15]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
HTH_ARSR | cd00090 | Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ... |
8-71 | 4.54e-13 | ||
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions. : Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 61.16 E-value: 4.54e-13
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DUF4430 super family | cl20531 | Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the ... |
93-151 | 2.25e-04 | ||
Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus. The actual alignment was detected with superfamily member pfam14478: Pssm-ID: 433979 Cd Length: 72 Bit Score: 38.05 E-value: 2.25e-04
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Name | Accession | Description | Interval | E-value | |||
HTH_ARSR | cd00090 | Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ... |
8-71 | 4.54e-13 | |||
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions. Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 61.16 E-value: 4.54e-13
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ArsR | COG0640 | DNA-binding transcriptional regulator, ArsR family [Transcription]; |
2-84 | 2.77e-12 | |||
DNA-binding transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 440405 [Multi-domain] Cd Length: 92 Bit Score: 59.52 E-value: 2.77e-12
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HTH_metalloreg | NF033788 | metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ... |
6-79 | 1.85e-09 | |||
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes. Pssm-ID: 411368 [Multi-domain] Cd Length: 76 Bit Score: 51.69 E-value: 1.85e-09
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HTH_ARSR | smart00418 | helix_turn_helix, Arsenical Resistance Operon Repressor; |
18-82 | 5.20e-09 | |||
helix_turn_helix, Arsenical Resistance Operon Repressor; Pssm-ID: 197713 [Multi-domain] Cd Length: 66 Bit Score: 50.29 E-value: 5.20e-09
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HTH_20 | pfam12840 | Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ... |
5-58 | 1.61e-08 | |||
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. Pssm-ID: 432824 [Multi-domain] Cd Length: 61 Bit Score: 48.69 E-value: 1.61e-08
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DUF4430 | pfam14478 | Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the ... |
93-151 | 2.25e-04 | |||
Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus. Pssm-ID: 433979 Cd Length: 72 Bit Score: 38.05 E-value: 2.25e-04
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Name | Accession | Description | Interval | E-value | |||
HTH_ARSR | cd00090 | Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ... |
8-71 | 4.54e-13 | |||
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions. Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 61.16 E-value: 4.54e-13
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ArsR | COG0640 | DNA-binding transcriptional regulator, ArsR family [Transcription]; |
2-84 | 2.77e-12 | |||
DNA-binding transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 440405 [Multi-domain] Cd Length: 92 Bit Score: 59.52 E-value: 2.77e-12
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COG1777 | COG1777 | Predicted transcriptional regulator, ArsR family [Transcription]; |
4-64 | 5.53e-10 | |||
Predicted transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 441383 Cd Length: 113 Bit Score: 53.88 E-value: 5.53e-10
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HTH_metalloreg | NF033788 | metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ... |
6-79 | 1.85e-09 | |||
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes. Pssm-ID: 411368 [Multi-domain] Cd Length: 76 Bit Score: 51.69 E-value: 1.85e-09
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HTH_ARSR | smart00418 | helix_turn_helix, Arsenical Resistance Operon Repressor; |
18-82 | 5.20e-09 | |||
helix_turn_helix, Arsenical Resistance Operon Repressor; Pssm-ID: 197713 [Multi-domain] Cd Length: 66 Bit Score: 50.29 E-value: 5.20e-09
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HTH_20 | pfam12840 | Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ... |
5-58 | 1.61e-08 | |||
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. Pssm-ID: 432824 [Multi-domain] Cd Length: 61 Bit Score: 48.69 E-value: 1.61e-08
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COG4189 | COG4189 | Predicted transcriptional regulator, ArsR family [Transcription]; |
4-58 | 2.73e-08 | |||
Predicted transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 443343 [Multi-domain] Cd Length: 97 Bit Score: 49.19 E-value: 2.73e-08
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HTH_5 | pfam01022 | Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ... |
13-57 | 4.76e-08 | |||
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition. Pssm-ID: 425993 [Multi-domain] Cd Length: 45 Bit Score: 47.05 E-value: 4.76e-08
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COG3398 | COG3398 | Predicted transcriptional regulator, contains two HTH domains [Transcription]; |
7-65 | 6.26e-07 | |||
Predicted transcriptional regulator, contains two HTH domains [Transcription]; Pssm-ID: 442625 [Multi-domain] Cd Length: 159 Bit Score: 46.80 E-value: 6.26e-07
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COG4742 | COG4742 | Predicted transcriptional regulator, contains HTH domain [Transcription]; |
4-59 | 2.17e-04 | |||
Predicted transcriptional regulator, contains HTH domain [Transcription]; Pssm-ID: 443776 [Multi-domain] Cd Length: 267 Bit Score: 40.26 E-value: 2.17e-04
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DUF4430 | pfam14478 | Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the ... |
93-151 | 2.25e-04 | |||
Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus. Pssm-ID: 433979 Cd Length: 72 Bit Score: 38.05 E-value: 2.25e-04
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COG3432 | COG3432 | Predicted transcriptional regulator [Transcription]; |
18-69 | 2.29e-04 | |||
Predicted transcriptional regulator [Transcription]; Pssm-ID: 442658 [Multi-domain] Cd Length: 83 Bit Score: 38.31 E-value: 2.29e-04
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COG2345 | COG2345 | Predicted transcriptional regulator, ArsR family [Transcription]; |
1-58 | 3.58e-04 | |||
Predicted transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 441914 [Multi-domain] Cd Length: 217 Bit Score: 39.52 E-value: 3.58e-04
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PH_TBC1D2A | cd01265 | TBC1 domain family member 2A pleckstrin homology (PH) domain; TBC1D2A (also called PARIS-1 ... |
38-73 | 3.59e-03 | |||
TBC1 domain family member 2A pleckstrin homology (PH) domain; TBC1D2A (also called PARIS-1/Prostate antigen recognized and identified by SEREX 1 and ARMUS) contains a PH domain and a TBC-type GTPase catalytic domain. TBC1D2A integrates signaling between Arf6, Rac1, and Rab7 during junction disassembly. Activated Rac1 recruits TBC1D2A to locally inactivate Rab7 via its C-terminal TBC/RabGAP domain and facilitate E-cadherin degradation in lysosomes. The TBC1D2A PH domain mediates localization at cell-cell contacts and coprecipitates with cadherin complexes. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 269966 Cd Length: 102 Bit Score: 35.38 E-value: 3.59e-03
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HTH_24 | pfam13412 | Winged helix-turn-helix DNA-binding; |
15-57 | 5.31e-03 | |||
Winged helix-turn-helix DNA-binding; Pssm-ID: 404317 [Multi-domain] Cd Length: 45 Bit Score: 33.56 E-value: 5.31e-03
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MarR_2 | pfam12802 | MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
22-60 | 8.51e-03 | |||
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. Pssm-ID: 432797 [Multi-domain] Cd Length: 60 Bit Score: 33.33 E-value: 8.51e-03
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