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Conserved domains on  [gi|1308963978|gb|PKO73950|]
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hypothetical protein CVU23_00055 [Betaproteobacteria bacterium HGW-Betaproteobacteria-17]

Protein Classification

VanZ family protein( domain architecture ID 10522534)

VanZ family protein; VanZ family protein is an integral membrane protein similar to Enterococcus faecium protein VanZ, which confers low-level resistance to the glycopeptide antibiotic teicoplanin (Te)

Gene Ontology:  GO:0046677|GO:0071555|GO:0005576
PubMed:  7867956

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
10-141 2.56e-15

VanZ-like family protein (function unknown) [Function unknown];


:

Pssm-ID: 444373  Cd Length: 128  Bit Score: 72.34  E-value: 2.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308963978  10 HPRSLLWLAALVYTAFVIYGSLVPlafralpwdeavarFGAIPFLQLGIGSRADWVANLLLFIPLTFLWMGALSAGAGPL 89
Cdd:COG5652     5 QRRRLRWLLVLLWAGLIFYLSLQP--------------GEESPSLSGLVFFGFDKLAHFLAYFILGFLLALALRRSRLRR 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1308963978  90 RTALVSLALIpaAIALSVGIEFTQLFFPQRTVSQNDIYAETLGGIIGVLVWW 141
Cdd:COG5652    71 RRALLLAVLI--AVLYAILDEIHQSFVPGRSASLADVLADTLGALLGVLLVL 120
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 229-275 4.23e-04

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


:

Pssm-ID: 461467  Cd Length: 79  Bit Score: 39.00  E-value: 4.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1308963978 229 PLALLWRLDGTRSAWRVWGMTFGTAVLLEFMQLFVYSRVSDVTDLFT 275
Cdd:pfam04892  19 PFGFLLPLLFKRRFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVIL 65
 
Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
10-141 2.56e-15

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 72.34  E-value: 2.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308963978  10 HPRSLLWLAALVYTAFVIYGSLVPlafralpwdeavarFGAIPFLQLGIGSRADWVANLLLFIPLTFLWMGALSAGAGPL 89
Cdd:COG5652     5 QRRRLRWLLVLLWAGLIFYLSLQP--------------GEESPSLSGLVFFGFDKLAHFLAYFILGFLLALALRRSRLRR 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1308963978  90 RTALVSLALIpaAIALSVGIEFTQLFFPQRTVSQNDIYAETLGGIIGVLVWW 141
Cdd:COG5652    71 RRALLLAVLI--AVLYAILDEIHQSFVPGRSASLADVLADTLGALLGVLLVL 120
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 64-141 1.05e-08

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 52.09  E-value: 1.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308963978  64 WVANLLLFIPLTFLWMGALSAGAgpLRTALVSlalipaaIALSVGIEFTQLFFPQRTVSQNDIYAETLGGIIGVLVWW 141
Cdd:pfam04892  10 YVRNIAHFVPFGFLLPLLFKRRF--LKTLLLG-------FLYSLSDELHQLFVPGRSFDVDDVILNTLGALIGILLYL 78
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 229-275 4.23e-04

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 39.00  E-value: 4.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1308963978 229 PLALLWRLDGTRSAWRVWGMTFGTAVLLEFMQLFVYSRVSDVTDLFT 275
Cdd:pfam04892  19 PFGFLLPLLFKRRFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVIL 65
 
Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
10-141 2.56e-15

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 72.34  E-value: 2.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308963978  10 HPRSLLWLAALVYTAFVIYGSLVPlafralpwdeavarFGAIPFLQLGIGSRADWVANLLLFIPLTFLWMGALSAGAGPL 89
Cdd:COG5652     5 QRRRLRWLLVLLWAGLIFYLSLQP--------------GEESPSLSGLVFFGFDKLAHFLAYFILGFLLALALRRSRLRR 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1308963978  90 RTALVSLALIpaAIALSVGIEFTQLFFPQRTVSQNDIYAETLGGIIGVLVWW 141
Cdd:COG5652    71 RRALLLAVLI--AVLYAILDEIHQSFVPGRSASLADVLADTLGALLGVLLVL 120
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
30-139 1.83e-09

Glycopeptide antibiotics resistance protein [Defense mechanisms];


Pssm-ID: 443799  Cd Length: 91  Bit Score: 54.45  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308963978  30 SLVPLAFralpWDEAVARFGAIPFLQLgigsradwVANLLLFIPLTFLWMGALSAGAGPLRTALVSLALipaaialSVGI 109
Cdd:COG4767     1 NLVPFKS----ILEDLALGGSIAVIQI--------LGNILLFVPLGFLLPLLFKRLRSFKRVLLLGFLL-------SLLI 61

                          90       100       110
                  ....*....|....*....|....*....|
gi 1308963978 110 EFTQLFFPQRTVSQNDIYAETLGGIIGVLV 139
Cdd:COG4767    62 EVLQLILPGRVFDIDDLILNTLGALLGYLL 91
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 64-141 1.05e-08

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 52.09  E-value: 1.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308963978  64 WVANLLLFIPLTFLWMGALSAGAgpLRTALVSlalipaaIALSVGIEFTQLFFPQRTVSQNDIYAETLGGIIGVLVWW 141
Cdd:pfam04892  10 YVRNIAHFVPFGFLLPLLFKRRF--LKTLLLG-------FLYSLSDELHQLFVPGRSFDVDDVILNTLGALIGILLYL 78
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 229-275 4.23e-04

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 39.00  E-value: 4.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1308963978 229 PLALLWRLDGTRSAWRVWGMTFGTAVLLEFMQLFVYSRVSDVTDLFT 275
Cdd:pfam04892  19 PFGFLLPLLFKRRFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVIL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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