|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
23-420 |
2.56e-159 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 456.18 E-value: 2.56e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 23 IIPYSQHQIDHNLLSNAAHKTIDGLQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFRRSRIIGRRFRLVH 102
Cdd:TIGR01942 1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 103 VLFGDETIEVSTFRGHHNAEGDAHtdksGRIIRDNVFGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQAGLLRM 182
Cdd:TIGR01942 81 VSFGRQIIEVATFRSGHKSSVNAE----GRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRRLRL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 183 IGNPETRYAEDPVRMLRVVRLSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHG 262
Cdd:TIGR01942 157 IGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQLLEP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 263 LLPMLDVVL-EQPKGE-RFVMLALKN-TDERILSGKSANPSFLFATLLWHEVIAAWES-YKADMPPIPALHMAMSEVIAT 338
Cdd:TIGR01942 237 LFPSVAYALrESPKFEsAFTVQALVNdTDFRVKRDKPVTPAFLYAALLWPGLVFRVADaPDQGVMPYPAVFDAIRDFVEE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 339 QAEKLAIHNRYTATMKEIWGMQPRFEQRAGKRPFGLLVHPRYRAAYDFLMLRCESGEVPAELGAWWTNFANAEGEARNAM 418
Cdd:TIGR01942 317 QCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRENAVLGEWWTPYQLASEEERTEM 396
|
..
gi 1308927341 419 LQ 420
Cdd:TIGR01942 397 TR 398
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
22-419 |
1.13e-143 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 418.77 E-value: 1.13e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 22 TIIPYSQHQIDHNLLSNAAHKTIDGLQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFRRSRIIGRRFRLV 101
Cdd:PRK11623 37 TVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 102 HVLFGDETIEVSTFRGHHNAEGD----AHTDKSGRIIRDNVFGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQA 177
Cdd:PRK11623 117 HVMFGPEIIEVATFRGHHEGNESdrntSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 178 GLLRMIGNPETRYAEDPVRMLRVVRLSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQ 257
Cdd:PRK11623 197 GVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEY 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 258 HLHHGLLPMLDVVLeQPKG----ERFVMLALKNTDERILSGKSANPSFLFATLLWHEVIAAWE--SYKADMPPIPALHMA 331
Cdd:PRK11623 277 HLFQPLFPTITRYF-TENGdspmERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQkiAQESGLAYYDAFALA 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 332 MSEVIATQAEKLAIHNRYTATMKEIWGMQPRFEQRAGKRPFGLLVHPRYRAAYDFLMLRCESGEVP--AELGAWWTNFAN 409
Cdd:PRK11623 356 MNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNAelQRLAQWWGEFQV 435
|
410
....*....|
gi 1308927341 410 AEGEARNAML 419
Cdd:PRK11623 436 SAPPQQKGML 445
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
36-404 |
4.07e-120 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 355.66 E-value: 4.07e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 36 LSNAAHKTIDGLQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFR---RSRIIGRRFRLVHVLFGDETIEV 112
Cdd:COG0617 2 LSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGGEKIEV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 113 STFRGHHnAEGDAHTDksgriirDNVFG-SLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQAGLLRMIGNPETRYA 191
Cdd:COG0617 82 ATARTER-YYGDGRRP-------FVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEERFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 192 EDPVRMLRVVRLSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHGLLpmldvvl 271
Cdd:COG0617 154 EDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVLA------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 272 eqpkgerfvmlalkntderilsgksanpsFLFATLLwHEVIAAWEsYKADMPPIPALHMAMSEVIATQAEKLAIHNRYTA 351
Cdd:COG0617 227 -----------------------------LRLAALL-HDLGKPAT-REDGLPTFHGHEEAGAELAEALLKRLRLPNRERK 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1308927341 352 TMKEIWGMQPRFEQRAGKRPFGL--LVHPRYRAAYDFLMLRCESGEVPAELGAWW 404
Cdd:COG0617 276 LVRELVELHLRFHGLGELRDSAVrrLLERGPEALEDLLLLRENGLEYPELQERLA 330
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
320-420 |
1.49e-50 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 166.99 E-value: 1.49e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 320 ADMPPIPALHMAMSEVIATQAEKLAIHNRYTATMKEIWGMQPRFEQRAGKRPFGLLVHPRYRAAYDFLMLRCESGEVPAE 399
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80
|
90 100
....*....|....*....|.
gi 1308927341 400 LGAWWTNFANAEGEARNAMLQ 420
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMIA 101
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
42-177 |
7.05e-43 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 147.74 E-value: 7.05e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 42 KTIDGLQKA-GFEAYIVGGAVRDLLLNRKPKDFDVATDA-TPEEVNRVFRRSRI----IGRRFRLVHVLFGDETIEVSTF 115
Cdd:cd05398 6 KLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKKIGGrvvgLGEEFGTATVVINGLTIDVATL 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1308927341 116 RghhnaeGDAHTDKSGRIirDNVFGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQA 177
Cdd:cd05398 86 R------TETYTDPGRRP--PVVGFTIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
23-420 |
2.56e-159 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 456.18 E-value: 2.56e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 23 IIPYSQHQIDHNLLSNAAHKTIDGLQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFRRSRIIGRRFRLVH 102
Cdd:TIGR01942 1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 103 VLFGDETIEVSTFRGHHNAEGDAHtdksGRIIRDNVFGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQAGLLRM 182
Cdd:TIGR01942 81 VSFGRQIIEVATFRSGHKSSVNAE----GRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRRLRL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 183 IGNPETRYAEDPVRMLRVVRLSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHG 262
Cdd:TIGR01942 157 IGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQLLEP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 263 LLPMLDVVL-EQPKGE-RFVMLALKN-TDERILSGKSANPSFLFATLLWHEVIAAWES-YKADMPPIPALHMAMSEVIAT 338
Cdd:TIGR01942 237 LFPSVAYALrESPKFEsAFTVQALVNdTDFRVKRDKPVTPAFLYAALLWPGLVFRVADaPDQGVMPYPAVFDAIRDFVEE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 339 QAEKLAIHNRYTATMKEIWGMQPRFEQRAGKRPFGLLVHPRYRAAYDFLMLRCESGEVPAELGAWWTNFANAEGEARNAM 418
Cdd:TIGR01942 317 QCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRENAVLGEWWTPYQLASEEERTEM 396
|
..
gi 1308927341 419 LQ 420
Cdd:TIGR01942 397 TR 398
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
22-419 |
1.13e-143 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 418.77 E-value: 1.13e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 22 TIIPYSQHQIDHNLLSNAAHKTIDGLQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFRRSRIIGRRFRLV 101
Cdd:PRK11623 37 TVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 102 HVLFGDETIEVSTFRGHHNAEGD----AHTDKSGRIIRDNVFGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQA 177
Cdd:PRK11623 117 HVMFGPEIIEVATFRGHHEGNESdrntSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 178 GLLRMIGNPETRYAEDPVRMLRVVRLSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQ 257
Cdd:PRK11623 197 GVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEY 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 258 HLHHGLLPMLDVVLeQPKG----ERFVMLALKNTDERILSGKSANPSFLFATLLWHEVIAAWE--SYKADMPPIPALHMA 331
Cdd:PRK11623 277 HLFQPLFPTITRYF-TENGdspmERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQkiAQESGLAYYDAFALA 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 332 MSEVIATQAEKLAIHNRYTATMKEIWGMQPRFEQRAGKRPFGLLVHPRYRAAYDFLMLRCESGEVP--AELGAWWTNFAN 409
Cdd:PRK11623 356 MNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNAelQRLAQWWGEFQV 435
|
410
....*....|
gi 1308927341 410 AEGEARNAML 419
Cdd:PRK11623 436 SAPPQQKGML 445
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
36-404 |
4.07e-120 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 355.66 E-value: 4.07e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 36 LSNAAHKTIDGLQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFR---RSRIIGRRFRLVHVLFGDETIEV 112
Cdd:COG0617 2 LSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGGEKIEV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 113 STFRGHHnAEGDAHTDksgriirDNVFG-SLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQAGLLRMIGNPETRYA 191
Cdd:COG0617 82 ATARTER-YYGDGRRP-------FVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEERFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 192 EDPVRMLRVVRLSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHGLLpmldvvl 271
Cdd:COG0617 154 EDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVLA------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 272 eqpkgerfvmlalkntderilsgksanpsFLFATLLwHEVIAAWEsYKADMPPIPALHMAMSEVIATQAEKLAIHNRYTA 351
Cdd:COG0617 227 -----------------------------LRLAALL-HDLGKPAT-REDGLPTFHGHEEAGAELAEALLKRLRLPNRERK 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1308927341 352 TMKEIWGMQPRFEQRAGKRPFGL--LVHPRYRAAYDFLMLRCESGEVPAELGAWW 404
Cdd:COG0617 276 LVRELVELHLRFHGLGELRDSAVrrLLERGPEALEDLLLLRENGLEYPELQERLA 330
|
|
| PRK13299 |
PRK13299 |
tRNA CCA-pyrophosphorylase; Provisional |
47-268 |
3.28e-54 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 185.81 E-value: 3.28e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 47 LQKAGFEAYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFRRSRIIGRRFRLVHVLFGDETIEVSTFRGhhnaEGDaH 126
Cdd:PRK13299 16 IKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPRTVDVGIEHGTVLVLENGEEYEVTTFRT----ESE-Y 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 127 TD----KSGRIIRdnvfgSLEEDATRRDFTVNALYYDpICQEVLDFHQGYADIQAGLLRMIGNPETRYAEDPVRMLRVVR 202
Cdd:PRK13299 91 VDyrrpSEVTFVR-----SLEEDLKRRDFTINAIAMD-ENGEIIDLFDGLEDLKNRLIRAVGNAEERFQEDALRMMRAVR 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1308927341 203 LSAKLGLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHgLLPMLD 268
Cdd:PRK13299 165 FASQLGFDLETETFEAMKTQAPLLEKISVERIFVEFEKLLLGPFWRKGLKLLIETGLYN-YLPGLK 229
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
320-420 |
1.49e-50 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 166.99 E-value: 1.49e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 320 ADMPPIPALHMAMSEVIATQAEKLAIHNRYTATMKEIWGMQPRFEQRAGKRPFGLLVHPRYRAAYDFLMLRCESGEVPAE 399
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80
|
90 100
....*....|....*....|.
gi 1308927341 400 LGAWWTNFANAEGEARNAMLQ 420
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMIA 101
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
54-181 |
7.75e-46 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 155.13 E-value: 7.75e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 54 AYIVGGAVRDLLLNRKPKDFDVATDATPEEVNRVFRRSRII----GRRFRLVHVLFGDETIEVSTFRGHHNAEGDAHTDK 129
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIFGNQILEVATFRIEFDESDFRNPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1308927341 130 SGRIirdnvfGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQAGLLR 181
Cdd:pfam01743 81 EEYT------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
42-177 |
7.05e-43 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 147.74 E-value: 7.05e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 42 KTIDGLQKA-GFEAYIVGGAVRDLLLNRKPKDFDVATDA-TPEEVNRVFRRSRI----IGRRFRLVHVLFGDETIEVSTF 115
Cdd:cd05398 6 KLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKKIGGrvvgLGEEFGTATVVINGLTIDVATL 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1308927341 116 RghhnaeGDAHTDKSGRIirDNVFGSLEEDATRRDFTVNALYYDPICQEVLDFHQGYADIQA 177
Cdd:cd05398 86 R------TETYTDPGRRP--PVVGFTIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
|
|
| PRK13297 |
PRK13297 |
tRNA CCA-pyrophosphorylase; Provisional |
50-238 |
1.29e-20 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 92.75 E-value: 1.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 50 AGFEAYIVGGAVRDLLLNRKPKDFD-VATDATPEEVNRvfrRSRI-IGRRFRL-VHVLFGDETIEVSTFRghhnaegdah 126
Cdd:PRK13297 10 AGLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMAR---RGFIpVGGDFPVfLHPRTKEEYALARTER---------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 127 tdKSGRIIRDNVF--GS---LEEDATRRDFTVNALYYDPiCQEVLDFHQGYADIQAGLLRMIGNPetrYAEDPVRMLRVV 201
Cdd:PRK13297 77 --KSGRGYKGFTFytGAdvtLEQDLQRRDLTVNAIARTP-QGELVDPLDGVADVRARVLRHVGEA---FAEDPVRILRLG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1308927341 202 RLSAKLG-LKIEPATMAPIARMADL--LQDVPPSRLFDEM 238
Cdd:PRK13297 151 RFAARFGdFSIAPETMQLCRRMVEAgeADALVPERVWKEV 190
|
|
| cca |
PRK10885 |
multifunctional CCA addition/repair protein; |
55-268 |
3.55e-20 |
|
multifunctional CCA addition/repair protein;
Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 92.22 E-value: 3.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 55 YIVGGAVRDLLLNRKPKDFD-VATDATPEE-VNRVFRRsriIGRRFRL-VHVLFGDE----TIEVSTFRGHHNAEGDAHT 127
Cdd:PRK10885 4 YLVGGAVRDALLGLPVKDRDwVVVGATPEEmLAQGYQQ---VGKDFPVfLHPKTHEEyalaRTERKSGRGYTGFTCYAAP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 128 DksgriirdnVfgSLEEDATRRDFTVNALYYDPiCQEVLDFHQGYADIQAGLLRMIGNPetrYAEDPVRMLRVVRLSAK- 206
Cdd:PRK10885 81 D---------V--TLEEDLIRRDLTINAMAQDD-DGELIDPYGGQRDLEARLLRHVSPA---FAEDPLRVLRVARFAARf 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1308927341 207 --LGLKIEPATMAPIARMADL--LQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHGLLPMLD 268
Cdd:PRK10885 146 ahLGFRIAPETLALMREMVASgeLDALTPERVWKETERALMERNPQVFFQVLRDCGALAVLLPEID 211
|
|
| PRK13298 |
PRK13298 |
tRNA CCA-pyrophosphorylase; Provisional |
53-274 |
1.47e-19 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 90.17 E-value: 1.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 53 EAYIVGGAVRDLLLNRKPKDFD-VATDATPEE-VNRVFRRsriIGRRFRlvhVLFGDETIEVSTFRGHHNAEGDAHT--- 127
Cdd:PRK13298 2 KIYLVGGAVRDSLLNLPVKDKDwVVVGGTPKIlLSINFQQ---VGKDFP---VFLHPETHEEYALARTERKSGVGYTgfi 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 128 -DKSGRIirdnvfgSLEEDATRRDFTVNALYYDPiCQEVLDFHQGYADIQAGLLRMIGNPetrYAEDPVRMLRVVRLSAK 206
Cdd:PRK13298 76 tDTSSDV-------TLEEDLIRRDLTINAIAQDE-NGNYIDPFQGKKDIQLRLLRHVSES---FIEDPLRVLRVARFAAL 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308927341 207 ---LGLKIEPATMAPIARMADL--LQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHGLLPMLDVVLEQP 274
Cdd:PRK13298 145 lvhLGFKIAKETMILMCIMVKKheLLYLTPERIWNETEKALKTDNPHVYFQVLYECNALKFLFPEIDFLYEKP 217
|
|
| PolyA_pol_RNAbd |
pfam12627 |
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
208-271 |
5.77e-19 |
|
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.
Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 80.61 E-value: 5.77e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1308927341 208 GLKIEPATMAPIARMADLLQDVPPSRLFDEMLKLFLSGHAIESVSALREQHLHHGLLPMLDVVL 271
Cdd:pfam12627 1 GFTIEPETREAIRKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLFPELAAAL 64
|
|
| PRK13296 |
PRK13296 |
CCA tRNA nucleotidyltransferase; |
53-207 |
1.96e-11 |
|
CCA tRNA nucleotidyltransferase;
Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 65.01 E-value: 1.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 53 EAYIVGGAVRDLLLNRKPKDFD-VATDATPEEVNRV-FrrSRIIGRRFRLVHVLFGDETI----EVSTFRGHHNAEgdah 126
Cdd:PRK13296 2 KFYLVGGAVRDMLLGITPKDKDwVVVGATEDEMLANgF--IKIAANFPVFIHPQTKQEYAlarsEKKTASGYHGFE---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308927341 127 TDKSGRIirdnvfgSLEEDATRRDFTVNALYYDPiCQEVLDFHQGYADIQAGLLRmigNPETRYAEDPVRMLRVVRLSAK 206
Cdd:PRK13296 76 VNFSKYI-------TLEDDLKRRDLTINSIAIDQ-NNKVIDPFNGQADLQNRILR---HTSIAFIEDPLRVVRLARFKAQ 144
|
.
gi 1308927341 207 L 207
Cdd:PRK13296 145 L 145
|
|
| |
