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Conserved domains on  [gi|1308796177|gb|PKN37034|]
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glycosyl transferase family 2 [Deltaproteobacteria bacterium HGW-Deltaproteobacteria-2]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10118426)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  9445404|12691742
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-189 1.13e-38

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


:

Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 136.65  E-value: 1.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   3 KITVIIHTRDSEATLPRLLESV-NWAEERIVVDMESRDRTCEITRQNGATLFSTPavprIDGI---RNDFLERGKHEWVF 78
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVkWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRW----WDGFgaqRNFALELATNDWVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  79 VLDSDEYLAADAEQVVRDLLEQHgqSCDAFFIPRHNMIAGQIMRGRGWYPDHQIRLFRKGCVHWGD-TTHklPEVLTGQK 157
Cdd:cd02511    77 SLDADERLTPELADEILALLATD--DYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDgRVH--EQVVVDGG 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1308796177 158 RLHTLEPpgclHIHHENYISVEQFIERQVKYA 189
Cdd:cd02511   153 VGIVLKG----DILHYGYKSLEEFLEKHNRYS 180
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-189 1.13e-38

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 136.65  E-value: 1.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   3 KITVIIHTRDSEATLPRLLESV-NWAEERIVVDMESRDRTCEITRQNGATLFSTPavprIDGI---RNDFLERGKHEWVF 78
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVkWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRW----WDGFgaqRNFALELATNDWVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  79 VLDSDEYLAADAEQVVRDLLEQHgqSCDAFFIPRHNMIAGQIMRGRGWYPDHQIRLFRKGCVHWGD-TTHklPEVLTGQK 157
Cdd:cd02511    77 SLDADERLTPELADEILALLATD--DYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDgRVH--EQVVVDGG 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1308796177 158 RLHTLEPpgclHIHHENYISVEQFIERQVKYA 189
Cdd:cd02511   153 VGIVLKG----DILHYGYKSLEEFLEKHNRYS 180
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-141 1.97e-10

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 59.33  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   1 MLKITVIIHTRDSEATLPRLLESVNWAEER----IVVDMESRDRTCEITRQNGAtlfstpAVPRIDGIRNDF-------- 68
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPdfeiIVVDDGSTDGTAEILRELAA------KDPRIRVIRLERnrgkgaar 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  69 ---LERGKHEWVFVLDSDEYLAADAEQVVRDLLEQHGQSC---------DAFFIPRHNMIAGQIMRGRGWYPDHQ--IRL 134
Cdd:COG0463    75 nagLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLvygsrlireGESDLRRLGSRLFNLVRLLTNLPDSTsgFRL 154


                  ....*..
gi 1308796177 135 FRKGCVH 141
Cdd:COG0463   155 FRREVLE 161
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-143 1.65e-04

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 41.61  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   5 TVIIHTRDSEATLPRLLESV------NWaeERIVVDMESRDRTCEITRQ-----NGATLFSTPAVPRIDGIRNDFLERGK 73
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlnqtypNF--EIIVVDDGSTDGTVEIAEEyakkdPRVRVIRLPENRGKAGARNAGLRAAT 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  74 HEWVFVLDSDEYLAADAEQVVRDLLEQHGQSCDAFFIPRHNMIAGQIMRGRGWYPDHQIRLFRKGCVHWG 143
Cdd:pfam00535  79 GDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLN 148
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 1-63 1.03e-03

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 40.29  E-value: 1.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308796177   1 MLKITVIIHTRDSEATLPRLLESVNWA------EERIVVDMESRDRTCEITRQNGATLFST----PAVPRIDG 63
Cdd:PRK13915   30 GRTVSVVLPALNEEETVGKVVDSIRPLlmeplvDELIVIDSGSTDATAERAAAAGARVVSReeilPELPPRPG 102
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-189 1.13e-38

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 136.65  E-value: 1.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   3 KITVIIHTRDSEATLPRLLESV-NWAEERIVVDMESRDRTCEITRQNGATLFSTPavprIDGI---RNDFLERGKHEWVF 78
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVkWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRW----WDGFgaqRNFALELATNDWVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  79 VLDSDEYLAADAEQVVRDLLEQHgqSCDAFFIPRHNMIAGQIMRGRGWYPDHQIRLFRKGCVHWGD-TTHklPEVLTGQK 157
Cdd:cd02511    77 SLDADERLTPELADEILALLATD--DYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDgRVH--EQVVVDGG 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1308796177 158 RLHTLEPpgclHIHHENYISVEQFIERQVKYA 189
Cdd:cd02511   153 VGIVLKG----DILHYGYKSLEEFLEKHNRYS 180
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-141 1.97e-10

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 59.33  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   1 MLKITVIIHTRDSEATLPRLLESVNWAEER----IVVDMESRDRTCEITRQNGAtlfstpAVPRIDGIRNDF-------- 68
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPdfeiIVVDDGSTDGTAEILRELAA------KDPRIRVIRLERnrgkgaar 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  69 ---LERGKHEWVFVLDSDEYLAADAEQVVRDLLEQHGQSC---------DAFFIPRHNMIAGQIMRGRGWYPDHQ--IRL 134
Cdd:COG0463    75 nagLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLvygsrlireGESDLRRLGSRLFNLVRLLTNLPDSTsgFRL 154


                  ....*..
gi 1308796177 135 FRKGCVH 141
Cdd:COG0463   155 FRREVLE 161
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-102 1.99e-07

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 50.76  E-value: 1.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   1 MLKITVIIHTRDSEATLPRLLESV----NWAEERIVVDMESRDRTCEITRQ---NGATLFSTPAVPRIDGIRNDFLERGK 73
Cdd:COG1216     2 RPKVSVVIPTYNRPELLRRCLESLlaqtYPPFEVIVVDNGSTDGTAELLAAlafPRVRVIRNPENLGFAAARNLGLRAAG 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1308796177  74 HEWVFVLDSDEYLAADA-EQVV--------RDLLEQHG 102
Cdd:COG1216    82 GDYLLFLDDDTVVEPDWlERLLaaacllirREVFEEVG 119
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-95 2.00e-06

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 48.58  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   1 MLKITVIIHTRDSEATLPRLLESV---NWAEER---IVVDMESRDRTCEITRQNGA-----TLFSTPAVPRIDGIRNDFL 69
Cdd:COG1215    28 LPRVSVIIPAYNEEAVIEETLRSLlaqDYPKEKlevIVVDDGSTDETAEIARELAAeyprvRVIERPENGGKAAALNAGL 107

                          90       100
                  ....*....|....*....|....*..
gi 1308796177  70 ERGKHEWVFVLDSDEYLAADA-EQVVR 95
Cdd:COG1215   108 KAARGDIVVFLDADTVLDPDWlRRLVA 134
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 4-108 7.90e-06

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 46.02  E-value: 7.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   4 ITVIIHTRDSEATLPRLLESV----NWAEERIVVDMESRDRTCEITRQNGATLFSTPAvpridGirndfleRGKH----- 74
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLrrlnPLPLEIIVVDGGSTDGTVAIARSAGVVVISSPK-----G-------RARQmnaga 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1308796177  75 -----EWVFVLDSDEYLAADAEQVVRDLLEQHGQSCDAF 108
Cdd:cd02522    69 aaargDWLLFLHADTRLPPDWDAAIIETLRADGAVAGAF 107
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-102 6.14e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 42.49  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   6 VIIHTRDSEATLPRLLESV------NWaeERIVVDMESRDRTCEITRQNGA-----TLFSTPAVPRIDGIRNDFLERGKH 74
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLlaqtypNF--EVIVVDDGSTDGTLEILEEYAKkdprvIRVINEENQGLAAARNAGLKAARG 78

                          90       100
                  ....*....|....*....|....*....
gi 1308796177  75 EWVFVLDSDEYLAADA-EQVVRDLLEQHG 102
Cdd:cd00761    79 EYILFLDADDLLLPDWlERLVAELLADPE 107
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-143 1.65e-04

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 41.61  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   5 TVIIHTRDSEATLPRLLESV------NWaeERIVVDMESRDRTCEITRQ-----NGATLFSTPAVPRIDGIRNDFLERGK 73
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlnqtypNF--EIIVVDDGSTDGTVEIAEEyakkdPRVRVIRLPENRGKAGARNAGLRAAT 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  74 HEWVFVLDSDEYLAADAEQVVRDLLEQHGQSCDAFFIPRHNMIAGQIMRGRGWYPDHQIRLFRKGCVHWG 143
Cdd:pfam00535  79 GDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLN 148
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 1-63 1.03e-03

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 40.29  E-value: 1.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308796177   1 MLKITVIIHTRDSEATLPRLLESVNWA------EERIVVDMESRDRTCEITRQNGATLFST----PAVPRIDG 63
Cdd:PRK13915   30 GRTVSVVLPALNEEETVGKVVDSIRPLlmeplvDELIVIDSGSTDATAERAAAAGARVVSReeilPELPPRPG 102
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 5-137 6.32e-03

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 37.14  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177   5 TVIIHTRDSEATLPRLLESV------NWaeERIVVDMESRDRTCEITRQNG---ATLFSTPavpriD-GIR---NDFLER 71
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVlsqtypNI--EYIVIDGGSTDGTVDIIKKYEdkiTYWISEP-----DkGIYdamNKGIAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308796177  72 GKHEWVFVLDSDEYLAADA-EQVVRDLLEQhgQSCDAFF-----------IPRHNMIAGQIMRG--RGWYPDHQIRLFRK 137
Cdd:cd06433    74 ATGDIIGFLNSDDTLLPGAlLAVVAAFAEH--PEVDVVYgdvllvdengrVIGRRRPPPFLDKFllYGMPICHQATFFRR 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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