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Conserved domains on  [gi|1308718306|gb|PKM78839|]
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six-cysteine peptide SCIFF [Firmicutes bacterium HGW-Firmicutes-15]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SCIFF super family cl26253
Six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the ...
2-38 2.51e-09

Six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.


The actual alignment was detected with superfamily member pfam13165:

Pssm-ID: 452594  Cd Length: 43  Bit Score: 46.16  E-value: 2.51e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1308718306  2 VKPNLKRDKDLINCRECATSCQSACKTSCTVGNQVCK 38
Cdd:pfam13165  7 NKRNLKKTLKKGGCGECQTSCQSACKTSCTVGNQVCE 43
 
Name Accession Description Interval E-value
SCIFF pfam13165
Six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the ...
2-38 2.51e-09

Six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.


Pssm-ID: 433005  Cd Length: 43  Bit Score: 46.16  E-value: 2.51e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1308718306  2 VKPNLKRDKDLINCRECATSCQSACKTSCTVGNQVCK 38
Cdd:pfam13165  7 NKRNLKKTLKKGGCGECQTSCQSACKTSCTVGNQVCE 43
six_Cys_in_45 TIGR03973
six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the ...
3-38 3.72e-08

six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein, family TIGR03974, that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.


Pssm-ID: 274891  Cd Length: 43  Bit Score: 43.08  E-value: 3.72e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 1308718306  3 KPNLKRDKDLINCRECATSCQSACKTSCTVGNQVCK 38
Cdd:TIGR03973  8 KRNLKKSLKKGGCGECQTSCQSACKTSCTVGNQVCE 43
 
Name Accession Description Interval E-value
SCIFF pfam13165
Six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the ...
2-38 2.51e-09

Six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.


Pssm-ID: 433005  Cd Length: 43  Bit Score: 46.16  E-value: 2.51e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1308718306  2 VKPNLKRDKDLINCRECATSCQSACKTSCTVGNQVCK 38
Cdd:pfam13165  7 NKRNLKKTLKKGGCGECQTSCQSACKTSCTVGNQVCE 43
six_Cys_in_45 TIGR03973
six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the ...
3-38 3.72e-08

six-cysteine peptide SCIFF; Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein, family TIGR03974, that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.


Pssm-ID: 274891  Cd Length: 43  Bit Score: 43.08  E-value: 3.72e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 1308718306  3 KPNLKRDKDLINCRECATSCQSACKTSCTVGNQVCK 38
Cdd:TIGR03973  8 KRNLKKSLKKGGCGECQTSCQSACKTSCTVGNQVCE 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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