|
Name |
Accession |
Description |
Interval |
E-value |
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
9-469 |
0e+00 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 627.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 9 ENPVTVIEKLhLAGSPLCLLESGKGTENLARFSFLGFEPHCVFKSRGTSVEVIENGVCYNYEDDSYRRLQAVIESYQGVR 88
Cdd:COG0147 13 ETPVSLFLKL-ADGPYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 89 YDGLPKFWGGAMGYFSYDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTikiivtvspesvsgsmpayreark 168
Cdd:COG0147 92 LPGLPPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDHLKGT------------------------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 169 eigrilhlirhggpggdvvignrarsvqnrfnpECNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYK 248
Cdd:COG0147 148 ---------------------------------RSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYR 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 249 ILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLER 328
Cdd:COG0147 195 ALRRINPSPYMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLAR 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 329 NDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYT 408
Cdd:COG0147 275 NDLGRVCEPGSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYG 354
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308675506 409 GSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALE 469
Cdd:COG0147 355 GAVGYLSFDGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALE 415
|
|
| trpE_most |
TIGR00564 |
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ... |
9-469 |
0e+00 |
|
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273142 [Multi-domain] Cd Length: 454 Bit Score: 534.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 9 ENPVTVIEKLhlAGSPLCLLESGKGTENLARFSFLGFEPHCVFKSRGTSVEVIENGVCYNYEDDSYRRLQAVIESYQGVR 88
Cdd:TIGR00564 4 LTPISAYLKL--AQPGSFLLESAEPGSERGRYSFIGLNPVLTIKTEGGTEYLGADDRRSGIVGNPLDEIRDVMETFAQHS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 89 YDGLPK-FWGGAMGYFSYDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIVTVSPESvsgSMPAYREAR 167
Cdd:TIGR00564 82 DPELPIpFTGGAVGYLGYDTVRLFEKITLPPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNRTTA---SRSAKAAAD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 168 KEIGRILHLIRHGGPGGDVVIGNRARSvqnrFNPecNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLY 247
Cdd:TIGR00564 159 ARLEALVADLQDPLLPEVPVPYPAALS----FTS--NYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 248 KILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLE 327
Cdd:TIGR00564 233 RVLRIVNPSPYMYYLDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 328 RNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPY 407
Cdd:TIGR00564 313 RNDIGRVCEPGSVEVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIY 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1308675506 408 TGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALE 469
Cdd:TIGR00564 393 GGAVGYLSFDGDMDTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
|
|
| PRK13571 |
PRK13571 |
anthranilate synthase component I; Provisional |
9-478 |
1.23e-154 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184152 [Multi-domain] Cd Length: 506 Bit Score: 449.86 E-value: 1.23e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 9 ENPVTVIEKLhLAGSP-LCLLESGKGTENLARFSFLGFEPHCVFKSR-GTSVEVIENGVCYNYEDDSYRRLQAVIESYQG 86
Cdd:PRK13571 34 ETPVGAYRKL-AANRPgTFLLESAENGRSWSRWSFIGVGSPAALTVRdGEAVWLGTPPAGAPTGGDPLAALRATLELLAT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 87 VRYDGLPKFWGGAMGYFSYDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIVTV-----SPESVSGsmp 161
Cdd:PRK13571 113 PRLPGLPPLTGGMVGFLGYDAVRRLERLPELAVDDLGLPEMLLLLATDLAAVDHHEGTITLIANAvnwngTDERVDA--- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 162 AYREArkeIGRIlhlirhggpggDVVIGNRARSVQN------RFNPE--CNVTKEQFKEMVANCKEYIRAGDIFQANLSL 233
Cdd:PRK13571 190 AYDDA---VARL-----------DVMTAALAQPLPStvatfsRPVPEfrAQRTVEEFGAAVEKLVEEIRAGEAFQVVPSQ 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 234 RLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDMH------IVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALA 307
Cdd:PRK13571 256 RFEMDTTADPLDVYRVLRVTNPSPYMYLLRVPNSDggtdfsIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 308 KELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGA 387
Cdd:PRK13571 336 KELLADPKERAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGA 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 388 PKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRA 467
Cdd:PRK13571 416 PKVRAMELIEELEPTRRGLYGGVVGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLRA 495
|
490
....*....|.
gi 1308675506 468 LEIAEEMAESG 478
Cdd:PRK13571 496 IAAAETLRAPG 506
|
|
| TrpE-arch |
TIGR01820 |
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ... |
27-469 |
1.35e-154 |
|
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273819 [Multi-domain] Cd Length: 435 Bit Score: 447.20 E-value: 1.35e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 27 LLESGKGTENLARFSFLGFEPHCVFK--SRGTSVEVIENGvcynyeDDSYRRLQAVIESYQGVRYDGL-PKFWGGAMGYF 103
Cdd:TIGR01820 17 LLESAEKPSKKARYSFIGWDPEFVVRinGKGKSVEGIPED------GDVVDKLRNAFPKLKGINIPGEdRRFKGGLVGYI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 104 SYDMGR-YFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIVTVSPESvsgsmpayrearkEIGRILHLIRHGGP 182
Cdd:TIGR01820 91 AYDAVRdYWEGIVDLKRKAEDWPPAEFFIYPNTIVYDHLEGKVYYVSTPEPEA-------------ELERIVERAKRATD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 183 GGDvvigNRARSVQNRFNpecnvTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKILRQVNPSPYMSYI 262
Cdd:TIGR01820 158 PGE----AGVSFEGESLS-----DREEFEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREINPSPYMFLL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 263 DFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEV 342
Cdd:TIGR01820 229 KFGDRYLVGSSPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSVKV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 343 NELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEM 422
Cdd:TIGR01820 309 PEFMYVEKYSHVQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYFSWNGDADF 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1308675506 423 NIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALE 469
Cdd:TIGR01820 389 AIAIRTAEIDKDKLRIQAGAGIVADSIPEREFEETENKMKAVLKAIG 435
|
|
| PRK05940 |
PRK05940 |
anthranilate synthase component I; |
90-469 |
1.92e-138 |
|
anthranilate synthase component I;
Pssm-ID: 235651 [Multi-domain] Cd Length: 463 Bit Score: 406.81 E-value: 1.92e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 90 DGLPkFWGGAMGYFSYDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIVTvspesvsgsmpayreARKE 169
Cdd:PRK05940 92 EHLP-FTGGWLGWLGYDLAWEIERLPHLNPDPLPFPVAYWYEPESFAILDHQEQILWLAAS---------------DPSQ 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 170 IGRILHLIRHGGPGGDVVIGNRArsvqNRFNPECNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKI 249
Cdd:PRK05940 156 LDRLEQQLEQPTPEPDLPLDLRT----PPSSLIFYTTQQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTTSADSWQIYRR 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 250 LRQVNPSPYMSY--IDFGDMhiVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLE 327
Cdd:PRK05940 232 LQQINPSPFASYwrTPWGDV--VSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLE 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 328 RNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPY 407
Cdd:PRK05940 310 RNDLGRVCQWGSVEVDELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLF 389
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1308675506 408 TGSVGFWGYAGEMEMNIVIRTILM-----KDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALE 469
Cdd:PRK05940 390 YGSCGYLDQRGNLDLNILIRTLLYtplsrGLSTIWGQVGAGIVADSDPEKEWLESLQKAKAQLAALN 456
|
|
| PLN02445 |
PLN02445 |
anthranilate synthase component I |
24-473 |
9.32e-138 |
|
anthranilate synthase component I
Pssm-ID: 215244 [Multi-domain] Cd Length: 523 Bit Score: 407.14 E-value: 9.32e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 24 PLCLLES---GKGTENLARFSFLGFEPhcvfksrgtSVEVI--ENGVCYNYEDDSYRRLQAV----------IESYQGVR 88
Cdd:PLN02445 40 PSFLFESvepGSQSSNVGRYSVVGAQP---------AMEIVakENKVTIMDHEKGTRTEEIVedpmeiprriSEKWNPQL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 89 YDGLPK-FWGGAMGYFSYDMGRYFET--LPEST--IDDLEVPETYFMFFDKVICFDHVNHTIKIIVTVSPESVSGSMPAY 163
Cdd:PLN02445 111 IDGLPDvFCGGWVGYFSYDTVRYVEKkkLPFSGapEDDRNLPDIHLGLYDDVIVFDHVEKKAYVIHWVRLDRYSSVEEAY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 164 REARKEIGRILHLIRHGGPGGdVVIGNRARSVQNRFNP--ECNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSV 241
Cdd:PLN02445 191 EDGMKRLEALVSRLQDINPPK-LSPGSVKLSTNQFGPSleKSNMTSEEYKNAVLQAKEHILAGDIFQIVLSQRFERRTFA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 242 DPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHI 321
Cdd:PLN02445 270 DPFEVYRALRIVNPSPYMIYLQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHI 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 322 MLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEP 401
Cdd:PLN02445 350 MLVDLGRNDVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEV 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 402 TRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDS------------------MAYVQAGAGIVADSIPEREYYESMKKAEA 463
Cdd:PLN02445 430 TRRGPYSGGFGGVSFTGDMDIALALRTMVFPTAarydtmysykdtnsrrewVAHLQAGAGIVADSDPEDEYRECVNKAAG 509
|
490
....*....|
gi 1308675506 464 LLRALEIAEE 473
Cdd:PLN02445 510 LARAIDLAES 519
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
208-460 |
1.52e-128 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 373.81 E-value: 1.52e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 208 EQFKEMVANCKEYIRAGDIFQANLS--LRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLA 285
Cdd:pfam00425 1 EDYLAAVEKAKEAIRAGDLYKVVLSrrLTLPLAGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 286 ETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQL 365
Cdd:pfam00425 81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 366 AEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIV 445
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240
|
250
....*....|....*
gi 1308675506 446 ADSIPEREYYESMKK 460
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
|
|
| PabB-clade2 |
TIGR01824 |
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ... |
97-464 |
8.10e-128 |
|
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.
Pssm-ID: 130883 Cd Length: 355 Bit Score: 376.04 E-value: 8.10e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 97 GGAMGYFSYDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHvnHTIKIIVTVSPESVSGSMPAYREARKEIGRILHL 176
Cdd:TIGR01824 1 GGRLGWLAYDVARRLEGIPDLGTSDGGWPVAADFRYEAAVARDH--QRQIVALATVPAETEGEFATSSDQLPAVAAATSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 177 irhggPGGDVVIGNRarsvqnrfNPECNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTS--VDPFFLYKILRQVN 254
Cdd:TIGR01824 79 -----PSPDVGPLPV--------DLEASIDRAAYETGVRRIKDYIRAGDVFQANLSRRLTAPIAadVDPLQLFLALRAPN 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 255 PSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRV 334
Cdd:TIGR01824 146 PAPYAIYLEEPGVDVASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 335 CSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFW 414
Cdd:TIGR01824 226 CATGTVRVPELCAVESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWI 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1308675506 415 GYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEAL 464
Cdd:TIGR01824 306 DADGNADLNILIRTLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKARAL 355
|
|
| PRK09070 |
PRK09070 |
aminodeoxychorismate synthase component I; |
27-471 |
3.56e-124 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236371 [Multi-domain] Cd Length: 447 Bit Score: 369.80 E-value: 3.56e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 27 LLES-GKGTENlARFSFLGFEP-HCVFKSRGTSVEVIENGVCYNYEDDSYRRLQAVIESYqgvryDGLPkFWGGAMGYFS 104
Cdd:PRK09070 27 LLESsASGTAQ-GRWDVLLLAQgKCLRLDPDGVTRQLLEGDFLDALDAAWQAERVPHDGE-----SSLP-FRGGWAVLLD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 105 YDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIVTVSPESVSGSMPAYREARKEIgrilhlirhggPGG 184
Cdd:PRK09070 100 YELAGQVEPILKLPMRTDGLPLALALRAPAAVLRDRHSGRCVLVAEPGREHLLDQIEADLAACAAL-----------PPL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 185 DVVIGNRARSVqnrfNPEcnvtkEQFKEMVANCKEYIRAGDIFQANLS--LRLGKSTSVDPFFLYKILRQVNPSPYMSYI 262
Cdd:PRK09070 169 PVWLAPQAVEE----DPP-----ERFTDGVERVLDYIRAGDVFQVNLSraWQAQFANAVDPAALYARLRAANPAPFSGLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 263 DFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSkEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEV 342
Cdd:PRK09070 240 VAAGRAIVSSSPERLVSVQGGVVQTRPIAGTRPRFAG-DDDAALIRELVGHPKERAEHVMLIDLERNDLGRICAPGSVEV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 343 NELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEM 422
Cdd:PRK09070 319 DELMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGDMDL 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1308675506 423 NIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALEIA 471
Cdd:PRK09070 399 NILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRALEQA 447
|
|
| PRK13574 |
PRK13574 |
anthranilate synthase component I; Provisional |
27-471 |
8.42e-109 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184155 [Multi-domain] Cd Length: 420 Bit Score: 329.47 E-value: 8.42e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 27 LLESGKGTENLARFSFLGFephcvfksrGTsvevieNGVCYNYEDdsyrrLQAVIESYQ-GVRYDGLP-KFWGGAMGYFS 104
Cdd:PRK13574 28 LLESIGGPQYKARYSVIAW---------GT------NGYLKIHDD-----PVNILNSYLkDLKLVDIPgLFKGGMIGYIS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 105 YDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIkiivtvspeSVSGSMPAYrearkeigrilhlirhggpGG 184
Cdd:PRK13574 88 YDAVRFWEKIRDLKPAAEDWPYAEFFIPDNIIIYDHNEGKV---------YVNGDLSSV-------------------GG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 185 DVVIGNrarsVQNRFNPEcNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKILRQVNPSPYMSYIDF 264
Cdd:PRK13574 140 CGDMGE----FKISFYDE-SLNKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 265 GDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNE 344
Cdd:PRK13574 215 DERYLIGSSPELLFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPE 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 345 LMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNI 424
Cdd:PRK13574 295 LMYVEKYSHVQHIVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAI 374
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1308675506 425 VIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKaealLRALEIA 471
Cdd:PRK13574 375 AIRTAFLNKDLLRIQAGAGIVYDSNPESEYFETEHK----LRALKTA 417
|
|
| PRK13572 |
PRK13572 |
anthranilate synthase component I; Provisional |
10-472 |
2.30e-106 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 237432 [Multi-domain] Cd Length: 435 Bit Score: 324.00 E-value: 2.30e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 10 NPVTVIEKLHLAGSPLCLLESGKGTENlARFSFLGFEPHCVFK-SRGTSVEvienGVCYNYEDDSYRRLQAVI-ESYQGV 87
Cdd:PRK13572 10 NPLKLYSVLRDEGYPFILESAEKGQRK-ARYTYISANPEFMVRiGNKTKVD----GETISKESNPFKALKENFkITQSGD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 88 RydglpkFWGGAMGYFSYD-MGRYFEtlpestiDDLEVPeTYFMFFDKVICFDHVNHTIKIIvtvspeSVSGSMPAYREA 166
Cdd:PRK13572 85 R------FTGGFVGYIAYDaVHNYIG-------GKIEEP-SVFGYYDHVFVYDHVTRKFYFH------SLNNNPEELFNA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 167 RKEIGRILHLIRHGGPGGDVVIGnrarsvqnrfnpeCNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFL 246
Cdd:PRK13572 145 EKIVEKAKRFEIEEEDGGSEVLG-------------CDADREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 247 YKILRQVNPSPYMSYIDFgDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDL 326
Cdd:PRK13572 212 YRNLREINPSPYMFLLEF-DKDVVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 327 ERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGP 406
Cdd:PRK13572 291 ARNDVRKVSKSGSVRLERFFDVVKYSHVQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKV 370
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1308675506 407 YTGSVGFWGYAGEMEMNIVIRTILMkDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALEIAE 472
Cdd:PRK13572 371 YGGAVGYFSNSGNADLAIAIRMAEI-DKVCRVRAGAGIVADSVPEKEFYETERKMAAVLKALGVVN 435
|
|
| pabB |
TIGR00553 |
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ... |
193-461 |
9.99e-102 |
|
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273133 Cd Length: 328 Bit Score: 308.15 E-value: 9.99e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 193 RSVQNRFNPEC----NVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDMH 268
Cdd:TIGR00553 53 DAPADRQAPTSdiqsEMTRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLGDGA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 269 IVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVI 348
Cdd:TIGR00553 133 ILSLSPELFFSIDGSEIETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVV 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 349 EEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRT 428
Cdd:TIGR00553 213 ETYPTVHQLVSTITARLREDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRT 292
|
250 260 270
....*....|....*....|....*....|...
gi 1308675506 429 ILMKDSMAYVQAGAGIVADSIPEREYYESMKKA 461
Cdd:TIGR00553 293 LTLDGGRAVYGVGGGIVADSDPEAEYRECLLKA 325
|
|
| PRK13564 |
PRK13564 |
anthranilate synthase component 1; |
72-477 |
6.48e-96 |
|
anthranilate synthase component 1;
Pssm-ID: 237428 [Multi-domain] Cd Length: 520 Bit Score: 299.83 E-value: 6.48e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 72 DSYRRLQAVIESYQGVRydgLPKFWGGAmgyFSYDMGRYFETLPEstiddleVPETY----FMFF--DKVICFDHVNHTI 145
Cdd:PRK13564 125 DALRLLQKLVNTPKEER---EALFLGGL---FAYDLVAGFEPLPQ-------LPAGNncpdYCFYlaETLLVIDHQKKSA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 146 KIIVTVSPESVSgsmpAYREARKEIGRILHLIRHGGPGGDVVignrarSVQNRfNPECNVTKEQFKEMVANCKEYIRAGD 225
Cdd:PRK13564 192 RLQASLFTPDEE----EKQRLAARLAQLKQQLTQPAPPLPVT------SVPDM-EVSVNISDEEFCAVVRKLKEHIRAGD 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 226 IFQANLSLRLgkSTS-VDPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTgdlAETR-----PIAGTRRRGSS 299
Cdd:PRK13564 261 IFQVVPSRRF--SLPcPSPLAAYRVLKKSNPSPYMFYMQDEDFTLFGASPESALKYD---ASSRqveiyPIAGTRPRGRR 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 300 K------EEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLaegktRFD 373
Cdd:PRK13564 336 AdgsidrDLDSRIELELRTDHKELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRYSHVMHLVSRVVGEL-----RHD 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 374 L-----FRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADS 448
Cdd:PRK13564 411 LdalhaYRACMNMGTLTGAPKVRAMQLIREVEGQRRGSYGGAVGYLTGHGDLDTCIVIRSAFVENGIATVQAGAGVVLDS 490
|
410 420
....*....|....*....|....*....
gi 1308675506 449 IPEREYYESMKKAEALLRALEIAEEMAES 477
Cdd:PRK13564 491 DPQSEADETRNKAQAVLRAIATAHHAQET 519
|
|
| pabB |
PRK15465 |
aminodeoxychorismate synthase component 1; |
27-469 |
8.70e-93 |
|
aminodeoxychorismate synthase component 1;
Pssm-ID: 185362 [Multi-domain] Cd Length: 453 Bit Score: 289.51 E-value: 8.70e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 27 LLESGKGTENLARFSFLGFEPHCVFKSRGTSVEVIENGVCYNYEDDSYRRLQAVIES--YQGVRYDGLPkFWGGAMGYFS 104
Cdd:PRK15465 33 LLHSGYADHPYSRFDIVVADPICTLTTFGKETVVSESEKRTTTTDDPLQVLQQVLDRadIRPTHNEDLP-FQGGALGLFG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 105 YDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIvtvspesvsgsmpAYREARkeiGRILHLIR-HGGPG 183
Cdd:PRK15465 112 YDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRQTVSLL-------------SHNDVN---ARRAWLESqQFSPQ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 184 GDVVIGNRARSvqnrfnpecNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKILRQVNPSPYMSYID 263
Cdd:PRK15465 176 EDFTLTSDWQS---------NMTREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 264 FGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVN 343
Cdd:PRK15465 247 LEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVP 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 344 ELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMN 423
Cdd:PRK15465 327 ELFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTS 406
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1308675506 424 IVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALE 469
Cdd:PRK15465 407 ITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKVNRILRQLE 452
|
|
| PRK13567 |
PRK13567 |
anthranilate synthase component I; Provisional |
27-465 |
2.56e-80 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184148 [Multi-domain] Cd Length: 468 Bit Score: 257.77 E-value: 2.56e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 27 LLESGKGTENLARFSFLGFEPHCVFKSRGTSVEVIENGVCYNYEDDSYRRLQAVIESYQGVRYDG----LPkFWGGAMGY 102
Cdd:PRK13567 26 ILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKINEDYHNIQDEqlksLP-FISGYVGT 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 103 FSYDMGRY-FETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKIIVT-----VSPESVSGSMPAYREARKEIgRILHL 176
Cdd:PRK13567 105 CSFDLVRHeFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATnqfsnSTKSDLENRVNKSIEDLTKI-QPFMP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 177 irhggpggdvvignRARSVQNRFNPECNVTKEQFKEMVANCKEYIRAGDIFQANLSL------RLGKSTSVDPFFLYKIL 250
Cdd:PRK13567 184 --------------TQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRiykyahHASQHLNQLSFQLYQNL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 251 RQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERND 330
Cdd:PRK13567 250 KRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRND 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 331 LGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGS 410
Cdd:PRK13567 330 IHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGG 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1308675506 411 VGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALL 465
Cdd:PRK13567 410 VGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLL 464
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
199-461 |
1.20e-76 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 245.31 E-value: 1.20e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 199 FNPECNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLV 278
Cdd:PRK07508 103 RDPVARWDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSRSPELFF 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 279 RLTGD-LAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHI 357
Cdd:PRK07508 183 RVDGEgWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYPTVHQM 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 358 VSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTI-LMKDSMA 436
Cdd:PRK07508 263 VSRVRARLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTLsLFPGGRA 342
|
250 260
....*....|....*....|....*
gi 1308675506 437 YVQAGAGIVADSIPEREYYESMKKA 461
Cdd:PRK07508 343 VFNVGGGIVFDSTAEAEYEECLLKA 367
|
|
| PLN02889 |
PLN02889 |
oxo-acid-lyase/anthranilate synthase |
83-463 |
1.80e-73 |
|
oxo-acid-lyase/anthranilate synthase
Pssm-ID: 215481 [Multi-domain] Cd Length: 918 Bit Score: 249.38 E-value: 1.80e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 83 SYQGVRYDGLP-KFWGGAMGYFSYDM----GRYFETLPESTiddlevPETYFMFFDKVICFDHVNHTIKIIvtvSPESVS 157
Cdd:PLN02889 525 RYDEKDFEGLPfDFHGGYVGYIGYDLkvecGMASNRHKSTT------PDACFFFADNVVVIDHHYDDVYIL---SLHEGS 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 158 GSMPAYREARKEigRILHLIRHGGPGGDVVIGNRARSVQNR--FNPEcnVTKEQFKEMVANCKEYIRAGDIFQANLSLRL 235
Cdd:PLN02889 596 TATTQWLDDTEQ--KLLGLKASATRKLEVQTSPTATFSPSKagFLAD--KSREQYIKDVQKCLKYIKDGESYELCLTTQM 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 236 GKST-SVDPFFLYKILRQVNPSPYMSYIDFG--DMHIVGSSPELLVRLTGD-LAETRPIAGTRRRGSSKEEDLALAKELI 311
Cdd:PLN02889 672 RKRIgEIDSLGLYLHLREKNPAPYAAWLNFSneNLCICSSSPERFLKLDRNgMLEAKPIKGTIARGSTPEEDEQLKLQLQ 751
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 312 TDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIR 391
Cdd:PLN02889 752 YSEKDQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLR 831
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1308675506 392 SMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEA 463
Cdd:PLN02889 832 SMELLDSLESSSRGIYSGSIGFFSYNQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEMILKTRA 903
|
|
| PRK13566 |
PRK13566 |
anthranilate synthase component I; |
200-483 |
1.38e-61 |
|
anthranilate synthase component I;
Pssm-ID: 237429 [Multi-domain] Cd Length: 720 Bit Score: 214.01 E-value: 1.38e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 200 NPECNVTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGD-MHIVGSSPELLV 278
Cdd:PRK13566 236 PGFADHAPGEYAALVEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSPYGFFINLGDgEYLVGASPEMFV 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 279 RLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIV 358
Cdd:PRK13566 316 RVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIEMYSRLIHTV 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 359 SNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYV 438
Cdd:PRK13566 396 DHVEGRLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEV 475
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1308675506 439 QAGAGIVADSIPEREYYESMKKAEALLRALEIAEEMAESGELHDV 483
Cdd:PRK13566 476 RVGATLLFDSDPEAEEAETELKASALLQALRGAKPKNLSAEEPDA 520
|
|
| PRK05877 |
PRK05877 |
aminodeoxychorismate synthase component I; Provisional |
214-472 |
2.77e-60 |
|
aminodeoxychorismate synthase component I; Provisional
Pssm-ID: 235634 [Multi-domain] Cd Length: 405 Bit Score: 203.40 E-value: 2.77e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 214 VANCKEYIRAGDIFQANLSLRLGKSTSVDP--FFLyKILRQVNPSpYMSYIDfGDMHIVGS-SPELLVRLTGDLAETRPI 290
Cdd:PRK05877 148 VLACLEAIAAGEVYQACVCTQFTGTVTGSPldFFA-DGVARTAPA-RAAYLA-GDWGAVASlSPELFLRRRGSVVTSSPI 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 291 AGTRRRGSSKEEDLALAKELitdekerAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKT 370
Cdd:PRK05877 225 KGTLPLDADPSALRASAKDV-------AENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVSTVSAQVPDELP 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 371 RFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTI-LMKDSMAYVQAGAGIVADSI 449
Cdd:PRK05877 298 MSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVeFDADGNAVLGVGGGITADSD 377
|
250 260
....*....|....*....|...
gi 1308675506 450 PEREYYESMKKAEALLRALEIAE 472
Cdd:PRK05877 378 PDAEWQECLHKAAPIVGLPAAAT 400
|
|
| PRK06404 |
PRK06404 |
anthranilate synthase component I; Reviewed |
214-465 |
1.99e-58 |
|
anthranilate synthase component I; Reviewed
Pssm-ID: 102361 [Multi-domain] Cd Length: 351 Bit Score: 197.01 E-value: 1.99e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 214 VANCKEYIRAGDIFQANLSLRLGKStsVDPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGT 293
Cdd:PRK06404 111 IKELIELIRAGEVLQVVISREFEAN--IDFKEKLSEFINNDRSRYVFYYRFGKYRVVGSSPENVFTVNGNIINVDPIAGT 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 294 RrrgsskeEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRfD 373
Cdd:PRK06404 189 Y-------DDKILSNELLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKHLVSQVTAKFSNASYR-D 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 374 LFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGyAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPERE 453
Cdd:PRK06404 261 ILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS-KGYTDMALVIRTAYSHGNGFRVRAGAGIVKDSDPEDE 339
|
250
....*....|..
gi 1308675506 454 YYESMKKAEALL 465
Cdd:PRK06404 340 VNEIYSKARSVM 351
|
|
| PabB-fungal |
TIGR01823 |
aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a ... |
7-467 |
2.12e-56 |
|
aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a para-aminobenzoate synthesis enzyme, aminodeoxychorismate synthase, which acts on chorismate in a pathway that yields PABA, a precursor of folate.
Pssm-ID: 273821 [Multi-domain] Cd Length: 742 Bit Score: 200.13 E-value: 2.12e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 7 PEENPVTVIEKLHLAGSPLCLLESGKGTenlARFSFLG--------FEPHCVFKS------RGTSVEVIENGVCYNYEDD 72
Cdd:TIGR01823 258 VSEDPKLTFEICNIIREPKFVMSSSVIT---GRYSIIAlpnsasqvFTHYGAMLKttvhywQDTEISYTRLKKCLSGVDS 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 73 S------YRRLQAVIESYQGVRYDGLPKFWGGAMGYFSYDMGR-----YFETLPESTIDDLEVPETYFMFFDKVICFDHV 141
Cdd:TIGR01823 335 DldksqfWITLGKFMENKKIDNPHREIPFIGGLVGILGYEIGSdlstqYIACGRCNDDENSLVPDAKLVFINRSIVIDHK 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 142 NHTIKII-VTVSPESVSGSMPAYREARKEIGRILHLIRHGGPGGDVVignraRSVQNRfnPecnvTKEQFKEMVANCKEY 220
Cdd:TIGR01823 415 QGKLYVQsLDNTFPVALEWSGELRDSFVRKKNIKQSLSWPFYLPEEI-----DFVITF--P----DKEDYAKAFKACQDY 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 221 IRAGDIFQANLS---LRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGD-LAETRPIAGTRRR 296
Cdd:TIGR01823 484 LHAGDSYEMCLTtqtKVVPPAVISPDWEIYQRLRQRNPAPFSGFFRLKHIIFLSTSPEKFLEVGMDtHAKLRPIKGTVKK 563
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 297 GSskEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQL---AEGKTRF- 372
Cdd:TIGR01823 564 GP--QMNLEKARRILKTPKEMGENLMILDLIRNDLYELVPKNDVHVEELMSVEEHATVYQLVSVVKAHGltsASKKTRYs 641
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 373 --DLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAG--IVADS 448
Cdd:TIGR01823 642 giDVLKHSLPPGSMTGAPKKRSVQLLQDVEGGARGIYSGVTGYWDVNGNGDFSVNIRCAFSYNGGTSWRIGAGgaVTVLS 721
|
490
....*....|....*....
gi 1308675506 449 IPEREYYESMKKAEALLRA 467
Cdd:TIGR01823 722 TPEGELEEMYNKLESNLQI 740
|
|
| MenF |
COG1169 |
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ... |
186-471 |
4.00e-55 |
|
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440783 [Multi-domain] Cd Length: 353 Bit Score: 188.05 E-value: 4.00e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 186 VVIGNRARSVqnrfnpecnVTKEQFKEMVANCKEYIRAGDIFQANLS--LRLGKSTSVDPFFLYKILRQVNPSPYMSYID 263
Cdd:COG1169 76 LLLRRSRRGV---------PDPAEWREAVAQALEAIRAGELDKVVLAraLDLTLDEPIDPRALLARLRRRNPDCYTFAVE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 264 FGDMHI-VGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSfgTVEV 342
Cdd:COG1169 147 LGAGDGfVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREALAPLCS--SLDV 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 343 NELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFP----GGTitgaPKIRSMEIIEELEPTRRGPYTGSVGFWGYAG 418
Cdd:COG1169 225 PEEPELLRLRNVQHLATPITGTLDPGVSALDLAAALHPtpavGGT----PREAALALIRELEPFDRGWYAGPVGWVDADG 300
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1308675506 419 EMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALEIA 471
Cdd:COG1169 301 DGEFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALGLE 353
|
|
| isochor_syn |
TIGR00543 |
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ... |
205-468 |
1.28e-43 |
|
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273127 Cd Length: 351 Bit Score: 157.53 E-value: 1.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 205 VTKEQFKEMVANCKEYIRAGDIFQANLS--LRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDMHI-VGSSPELLVRLT 281
Cdd:TIGR00543 87 PDKAAWRTAVEEALENIRQGPLDKVVLAraLTLKFADDIDPIAVLANLRQQYPNAYIFLLEPPQGGVfLGATPERLLSRE 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 282 GDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSfgTVEVNELMVIEEYSHVIHIVSNV 361
Cdd:TIGR00543 167 KGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICT--SLDVSETPELLKLANVQHLYTPI 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 362 RGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAG 441
Cdd:TIGR00543 245 SARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRSALVEDGQVRLYAG 324
|
250 260
....*....|....*....|....*..
gi 1308675506 442 AGIVADSIPEREYYESMKKAEALLRAL 468
Cdd:TIGR00543 325 AGIVADSDPESEWEETELKLQTMLRAL 351
|
|
| PRK07912 |
PRK07912 |
salicylate synthase; |
145-460 |
2.82e-36 |
|
salicylate synthase;
Pssm-ID: 169151 [Multi-domain] Cd Length: 449 Bit Score: 139.54 E-value: 2.82e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 145 IKIIVTVSPESVSGSMPAYREArkeigrILHLIRHGGPGGDvvignRARSVQNRFNPEcnvtkeQFKEMVANCKEYIRAG 224
Cdd:PRK07912 138 TRIVVTEKGIRLFGAGIRHREA------IDRLLATGVREVP-----QSRSVDVSDDPS------GYRDRVAVAVAEIAAG 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 225 DIFQANLSLRLGKSTSVDPFFLYKILRQVNpSPYMSYI-DFGDMHIVGSSPELLVRLTGD-LAETRPIAGTRRRGSSKEE 302
Cdd:PRK07912 201 RYHKVILSRCVEVPFAVDFPATYRLGRRHN-TPVRSFLlRLGGIRALGYSPELVTAVRADgVVITEPLAGTRAFGRGAAI 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 303 DLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGG 382
Cdd:PRK07912 280 DRLARDDLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRERGSVQHLGSTVRGRLDASSDRMDALEALFPAV 359
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308675506 383 TITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKK 460
Cdd:PRK07912 360 TASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEK 437
|
|
| PRK06772 |
PRK06772 |
salicylate synthase; |
208-464 |
1.02e-34 |
|
salicylate synthase;
Pssm-ID: 102546 [Multi-domain] Cd Length: 434 Bit Score: 134.86 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 208 EQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVD--PFFLYKilRQVNpSPYMSYIDFGD-MHIVGSSPELLVRLTGDL 284
Cdd:PRK06772 173 EAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDmpATLLYG--RQAN-TPVRSFMFRQEgREALGFSPELVMSVTGNK 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 285 AETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCSFGTVEVNELMVIEEYSHVIHIVSNVRGQ 364
Cdd:PRK06772 250 VVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQ 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 365 LAEGKTRFDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAgEMEMNIVIRTILMKDSMAYVQAGAGI 444
Cdd:PRK06772 330 LAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDT-RFDAALVLRSVFQDSQRCWIQAGAGI 408
|
250 260
....*....|....*....|
gi 1308675506 445 VADSIPEREYYESMKKAEAL 464
Cdd:PRK06772 409 IAQSTPERELTETREKLASI 428
|
|
| Anth_synt_I_N |
pfam04715 |
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ... |
9-147 |
1.07e-32 |
|
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).
Pssm-ID: 428082 [Multi-domain] Cd Length: 140 Bit Score: 121.26 E-value: 1.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 9 ENPVTVIEKLHlAGSPLCLLESGKGTEnlARFSFLGFEPHCVFKSRGTSVEVIE-NGVCYNYEDDSYRRLQAVIESYQGV 87
Cdd:pfam04715 3 LTPLSVYLKLA-GEPHSFLLESAEGGE--GRYSFIGINPLLTIKSKNGEVSVSGpDGQELEQEDGPLDALRALLARFRIE 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308675506 88 R-YDGLPKFWGGAMGYFSYDMGRYFETLPESTIDDLEVPETYFMFFDKVICFDHVNHTIKI 147
Cdd:pfam04715 80 DsPPTLPPFSGGLVGYLGYDLVRYIEKLPRTAPDDLNLPDARLILYEDLIVFDHQENKLYL 140
|
|
| PRK07054 |
PRK07054 |
isochorismate synthase; |
238-475 |
1.79e-29 |
|
isochorismate synthase;
Pssm-ID: 235920 [Multi-domain] Cd Length: 475 Bit Score: 120.64 E-value: 1.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 238 STSVDPFFLYKILRQVNPSPYMSYIDFGDMHIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKER 317
Cdd:PRK07054 227 ARPVAIGPLLRRLRLRDPHAHLFAFRRGNACFLGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDR 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 318 AEHIMLVDLERNDLGRVCSfgTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKIRSMEIIE 397
Cdd:PRK07054 307 LEHALVVDAIRAALAPLSR--ALDIPDQPSLHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIR 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308675506 398 ELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALEIAEEMA 475
Cdd:PRK07054 385 AHEGFDRGWYAAPIGWLDAHGNGDFAVALRSALITGGACRLFAGCGIVADSEPASEYRETCLKLSGMREALRARDAAA 462
|
|
| PRK07093 |
PRK07093 |
para-aminobenzoate synthase component I; Validated |
205-460 |
2.79e-29 |
|
para-aminobenzoate synthase component I; Validated
Pssm-ID: 235932 [Multi-domain] Cd Length: 323 Bit Score: 117.28 E-value: 2.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 205 VTKEQFKEMVANCKEYIRAGDIFQANLSLRLGKSTSVDpffLYKILRQVNpSPYMSYI--DFgdmhiVGSSPELLVRLTG 282
Cdd:PRK07093 71 ISFEEYQQGFELVQEEIQAGNSYLLNLTYPTPIETNLS---LEEIFQASK-AKYKLLFkdQF-----VCFSPEPFVRIED 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 283 DLAETRPIAGTRrrgsskeeDLAL--AKELI-TDEKERAEHIMLVDLERNDLGRVCSfgTVEVNELMVIEE-YSH---VI 355
Cdd:PRK07093 142 NKISTYPMKGTI--------DASLpnAEEKLlNDEKEFAEHATIVDLLRNDLSMVAK--NVRVTRFRYIDKiKTNkgeIL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 356 HIVSNVRGQLAEG-KTRF-DLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFwgYAGE-MEMNIVIRTILMK 432
Cdd:PRK07093 212 QTSSEISGTLPENwQENIgDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYTGVFGY--FDGEsLDSAVMIRFIEQE 289
|
250 260
....*....|....*....|....*...
gi 1308675506 433 DSMAYVQAGAGIVADSIPEREYYESMKK 460
Cdd:PRK07093 290 NDGLYFKSGGGITIDSDLKDEYNELIQK 317
|
|
| PRK06923 |
PRK06923 |
isochorismate synthase DhbC; Validated |
208-468 |
8.81e-25 |
|
isochorismate synthase DhbC; Validated
Pssm-ID: 235886 [Multi-domain] Cd Length: 399 Bit Score: 105.97 E-value: 8.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 208 EQFKEMVANCKEYIRAGDIFQANLS--LRLGKSTSVDPFFLYKILRQVNPSPYMSYIDF----GDMH--IVGSSPELLVR 279
Cdd:PRK06923 122 EVYMNGVKQGIAKIQDGDLKKIVLSrsLDVKSSEKIDKQKLLRELAEHNKHGYTFAVNLpkdeNENSktLIGASPELLVS 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 280 LTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDLERNDLGRVCsfgtvevNELMVIEEYShVI---- 355
Cdd:PRK06923 202 RHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAALRPYC-------HTLHVPEKPS-VIhtea 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 356 --HIVSNVRGQLAEGKTR-FDLFRACFPGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVIRTILMK 432
Cdd:PRK06923 274 mwHLSTEVKGELKDPNTSsLELAIALHPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVE 353
|
250 260 270
....*....|....*....|....*....|....*.
gi 1308675506 433 DSMAYVQAGAGIVADSIPEREYYESMKKAEALLRAL 468
Cdd:PRK06923 354 ENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKAM 389
|
|
| PLN02786 |
PLN02786 |
isochorismate synthase |
232-469 |
2.02e-23 |
|
isochorismate synthase
Pssm-ID: 178383 [Multi-domain] Cd Length: 533 Bit Score: 103.32 E-value: 2.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 232 SLRLGKSTSVDPFFLYKILRQVNPSPYMSYIDFGDM-HIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKEL 310
Cdd:PLN02786 288 SSRIITDTDIDPIAWLACLQVEGQNAYQFCLQPPDApAFIGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIELDL 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 311 ITDEKERAEHIMLVDLERNDLGRVCSfgTVEVNELMVIEEYSHVIHIVSNVRGQLAEGKTRFDLFRACFPGGTITGAPKI 390
Cdd:PLN02786 368 LTSPKDDLEFSIVRENIREKLEAICD--RVVVEPHKAIRKLARVQHLYAQLAGRLRSEDDEFDILAALHPTPAVCGHPTE 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 391 RSMEIIEELEPTRRGPYTGSVGFWGyAGEMEMNIVIRTILM-KDSMAYVQAGAGIVADSIPEREYYESMKKAEALLRALE 469
Cdd:PLN02786 446 EARLLIAETESFDRGMYAGPVGWFG-GGESEFAVGIRSALVeKGLGALIYAGTGIVEGSNPSSEWNELELKISQFTKSLE 524
|
|
| PRK15016 |
PRK15016 |
isochorismate synthase EntC; Provisional |
207-465 |
1.84e-15 |
|
isochorismate synthase EntC; Provisional
Pssm-ID: 184977 [Multi-domain] Cd Length: 391 Bit Score: 77.99 E-value: 1.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 207 KEQFKEMVANCKEYIRAGDIFQANLSLRLGKST--SVDPFFLYKILRQVNPSPYMSYIDFGDMHIV-GSSPELLVRLTGD 283
Cdd:PRK15016 126 QTTFEAMVARAAALTATPQVDKVVLSRLIDITTdaAIDSGALLERLIAQNPVSYNFHVPLADGGVLlGASPELLLRKDGE 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 284 LAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHimlvDLerndlgrvcsfgtveVNELM--VIEEYSHVIH----- 356
Cdd:PRK15016 206 RFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEH----EL---------------VTQAMkeVLRERSSELHvpssp 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 357 --IVSNVRGQLA---EGKTRFD---LFRACF--PGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAGEMEMNIVI 426
Cdd:PRK15016 267 qlITTPTLWHLAtpfEGKANAQenaLTLACLlhPTPALSGFPHQAAKQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTI 346
|
250 260 270
....*....|....*....|....*....|....*....
gi 1308675506 427 RTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAEALL 465
Cdd:PRK15016 347 RCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTML 385
|
|
| PRK15012 |
PRK15012 |
menaquinone-specific isochorismate synthase; Provisional |
191-468 |
6.59e-10 |
|
menaquinone-specific isochorismate synthase; Provisional
Pssm-ID: 184974 [Multi-domain] Cd Length: 431 Bit Score: 61.01 E-value: 6.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 191 RARSVQNRFNPEcnvtKEQFKEMVANCKEYIRAGDIFQANLS--LRLGKSTSVDPFFLYKILRQVNPSPYMSYIDF-GDM 267
Cdd:PRK15012 157 HLTTTREQHWPD----KTGWTQLIELATKTIAEGELDKVVLAraTDLHFASPVNAAAMMAASRRLNLNCYHFYMAFdAEN 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 268 HIVGSSPELLVRLTGDLAETRPIAGTRRRGSSKEEDLALAKELITDEKERAEHIMLVDlerndlgRVCSFGTVEVNELMV 347
Cdd:PRK15012 233 AFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE-------DICQRLQADTQTLDV 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308675506 348 IEEYSHVIHIVSNVRGQLAEGKTRFDLFRaCF----PGGTITGAPKIRSMEIIEELEPTRRGPYTGSVGFWGYAgEMEMN 423
Cdd:PRK15012 306 LPPQVLRLRKVQHLRRCIWTSLNKADDVI-CLhqlqPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQ-QSEFC 383
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1308675506 424 IVIRTILMKDSMAYVQAGAGIVADSIPEREYYESMKKAeALLRAL 468
Cdd:PRK15012 384 VSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQEIDNKA-AGLRTL 427
|
|
| |
