|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
26-444 |
5.70e-178 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 503.60 E-value: 5.70e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 26 KTVIAASMVGTAIEFYDFYAYGTAAANYFPHIFFSDkANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVV 105
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPA-VDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 106 SLMTMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNG 185
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 186 TYFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAV 265
Cdd:cd17369 160 VFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 266 TYTLFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFP 345
Cdd:cd17369 240 ENVLFYLFTTFALSYATQ-------TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 346 FLLDgqvvGQHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWG-V 424
Cdd:cd17369 313 WLLD----TGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGsW 388
|
410 420
....*....|....*....|
gi 1307912705 425 HSVGLYLAVMAVCCLVSVLT 444
Cdd:cd17369 389 WPVALYLAALAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
35-439 |
5.97e-130 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 381.24 E-value: 5.97e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 35 GTAIEFYDFYAYGTAAANYFPHIFFSdKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGT 114
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPP-SGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 115 FLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESFN 194
Cdd:TIGR00883 80 LLIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 195 DQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYTLA 274
Cdd:TIGR00883 160 GDDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLIT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 275 TWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLdgqvVG 354
Cdd:TIGR00883 240 TYLPTYLTQ-------TLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMAL----LD 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 355 QHNFFAnMVFLCVGFALMGIA-FGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWL-AHNWGVHSVGLYLA 432
Cdd:TIGR00883 309 SGSFTL-FFFLVLGMALIGGMyTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALvAMTGDWYAIGYYLA 387
|
....*..
gi 1307912705 433 VMAVCCL 439
Cdd:TIGR00883 388 ALALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
32-450 |
3.26e-74 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 239.63 E-value: 3.26e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 32 SMVGTAIEFYDFYAYGTAAANYFPHIFFSdKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMG 111
Cdd:PRK09952 27 SFAGAVVDWYDFLLYGITAALVFNREFFP-QVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 112 VGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLE 191
Cdd:PRK09952 106 IATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLIS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 192 SFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKS--PLTEVFRKSWRQVLQATFLVAVTYTL 269
Cdd:PRK09952 186 MMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKKriPVIEALLRHPGAFLKIIALRLCELLT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 270 FYTLATWSLAWGTKDtangggsLGFTNQeylLMLMISICVFAlfivLSCL-------YADKLGRRRVltFSSCALVVFAV 342
Cdd:PRK09952 266 MYIVTAFALNYSTQN-------LGLPRE---LFLNIGLLVGG----LSCLtipcfawLADRFGRRRV--YITGALIGTLS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 343 LFPFLLDGQvvgqhnffANMVFLCVGFALM--GIAFGPI----GAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIAT 416
Cdd:PRK09952 330 AFPFFMALE--------AQSIFWIVFFSIMlaNIAHDMVvcvqQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAA 401
|
410 420 430
....*....|....*....|....*....|....*...
gi 1307912705 417 WL----AHNWgvHSVGLYLavmAVCCLVSVLTCKETKD 450
Cdd:PRK09952 402 ALvtyfGGSW--HSVAIYL---LAGCLISAMTALLMKD 434
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
29-449 |
3.08e-72 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 233.34 E-value: 3.08e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 29 IAASMVGTAIEFYDFYAYGtAAANYFPHIFFSDKaNPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLM 108
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYA-AFALYFAPQFFPSG-DPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 109 TMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYF 188
Cdd:cd17367 79 LMAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 189 VLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKSPLTEvFRKSWRQVLQATFLVAVTYT 268
Cdd:cd17367 159 VLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRE-LRRHPRELLLVVGLTAGGTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 269 LFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLL 348
Cdd:cd17367 238 AFYTWTTYLQKFLVN-------TAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 349 DGQVVGQHNFFANMVFLCVGFALMGIAfgpiGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWGVHSVG 428
Cdd:cd17367 311 DHTDSPYTAFALVLVGLVFLSGYTSIN----AVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFF 386
|
410 420
....*....|....*....|.
gi 1307912705 429 LYLAVMAVCCLVSVLTCKETK 449
Cdd:cd17367 387 WYVAGLIAISLVVYLRMPETR 407
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
23-448 |
3.28e-70 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 230.75 E-value: 3.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 23 DSVKTVIAASMVGTAIEFYDFYAYGTAAAnYFPHIFFSDkANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTT 102
Cdd:PRK10642 12 GKLRKAITAASLGNAMEWFDFGVYGFVAY-ALGKVFFPG-ADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 103 LVVSLMTMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFL 182
Cdd:PRK10642 90 LAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 183 SNGTYFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIF-----RMAQEQKKVVKSP----LTEVFRKSW 253
Cdd:PRK10642 170 GAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdKLEQGDREGLQDGpkvsFKEIATKHW 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 254 RQVLQATFLVAVTYTLFYTLATWSLAWGTKdtangggSLGFTnQEYLLMLMISICVFALFIV-LSCLYADKLGRRRVLTF 332
Cdd:PRK10642 250 RSLLTCIGLVIATNVTYYMLLTYMPSYLSH-------NLHYS-EDHGVLIIIAIMIGMLFVQpVMGLLSDRFGRRPFVIL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 333 SSCALVVFAVLFPFLLDGQVVGQhnFFANMVFLCVgfaLMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVgAAFVP 412
Cdd:PRK10642 322 GSVALFVLAIPAFILINSNVIGL--IFAGLLMLAV---ILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTP 395
|
410 420 430
....*....|....*....|....*....|....*..
gi 1307912705 413 TIATWLAHNWG-VHSVGLYLAVMAVCCLVSVLTCKET 448
Cdd:PRK10642 396 TLAAWLVESTQnLMMPAYYLMVVAVIGLITGVTMKET 432
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
29-448 |
1.88e-66 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 217.61 E-value: 1.88e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 29 IAASMVGTAIEFYDFYAYGTAAAnYFPHIFFSDkANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLM 108
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAV-TIGKVFFPG-GDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 109 TMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYF 188
Cdd:cd17366 79 LMAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 189 VLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRvhmeetpifrmaqeqkkvvkspltevfrkswRQVLQATFLVAVTYT 268
Cdd:cd17366 159 LLTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR-------------------------------RPLLICIGLVLVFNV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 269 LFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLL 348
Cdd:cd17366 208 TNYMLLSYMPSYLEE-------TLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLM 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 349 DGQVVGqhnffanmvFLCVGFALMGIAF----GPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWGV 424
Cdd:cd17366 281 NSGSIA---------AIFIGLLVLGLLLscytATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGN 351
|
410 420
....*....|....*....|....*
gi 1307912705 425 HSV-GLYLAVMAVCCLVSVLTCKET 448
Cdd:cd17366 352 PLMpAYYLMVAAVVGLVAVLFLTET 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
29-448 |
2.23e-60 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 202.60 E-value: 2.23e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 29 IAASMVGTAIEFYDFYAYGTAAAnYFPHIFFSdKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLM 108
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAV-YIGRLFFP-SGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 109 TMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYF 188
Cdd:cd17368 79 IMALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 189 VLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRmaQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYT 268
Cdd:cd17368 159 LLSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFL--ERKARPTRRELFALLANNRRIILLGMLLVAGSTV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 269 LFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCAlvVFAVLFPFLL 348
Cdd:cd17368 237 TFYFTTVYTPTYAKT-------VLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLA--ALVTLYPVFA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 349 dgQVVGQHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWG-VHSV 427
Cdd:cd17368 308 --WLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGsPLAP 385
|
410 420
....*....|....*....|.
gi 1307912705 428 GLYLAVMAVCCLVSVLTCKET 448
Cdd:cd17368 386 AWYLMGAALLGLLATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
29-443 |
3.21e-57 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 192.43 E-value: 3.21e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 29 IAASMVGTAIEFYDFYAYGTAAAnyfphiFFSDKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLM 108
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAP------VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 109 TMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYF 188
Cdd:cd17316 75 LFGLATLLIGLLPTP--------ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 189 VLESFNDQSamlaWGWRVPFLLSAILVIVGLVVRvhmeetpifrmaqeqkkvvkspltevfrkswRQVLQATFLVAVTYT 268
Cdd:cd17316 147 LLIPLLSGD----WGWRILFLIGALPALLALLLR-------------------------------RRTLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 269 LFYTLATWSLAWGTKDtangggsLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLL 348
Cdd:cd17316 192 GYYGLTTFLPTYLQTV-------LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 349 DGqvvgqhNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWGVHSVG 428
Cdd:cd17316 265 SG------SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
410
....*....|....*
gi 1307912705 429 LYLAVMAVCCLVSVL 443
Cdd:cd17316 339 LILALLAIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
35-444 |
5.11e-43 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 157.03 E-value: 5.11e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 35 GTAIEFYDFYAYGTAAAnYFPHIFFSdKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGT 114
Cdd:PRK15075 23 GNFLEMFDFFLFGFYAT-AIAKTFFP-AGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 115 FLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESFN 194
Cdd:PRK15075 101 LLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 195 DQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFrmaqEQKKVVKSpLTEVFR---KSWRQVLQATFLVAVTYTLFY 271
Cdd:PRK15075 181 SPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEF----LARKHRPS-MREIFRslaANWRIVLAGMLMVAMTTVSFY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 272 TLATWSLAWGTKdtangggSLGFTNQEYLLM-LMISICVFALFIVLSCLyADKLGRRRVLTFssCALVVFAVLFPFLldg 350
Cdd:PRK15075 256 LITVYTPTFGKT-------VLHLSAADSLLVtLCVGVSNFIWLPIGGAL-SDRIGRRPVLIA--FTVLAILTAYPAL--- 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 351 QVVGQHNFFANM--VFLCVGFaLMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTIATWLAHNWGVHSV- 427
Cdd:PRK15075 323 SWLVAAPSFARMlaVELWLSF-LYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAAp 401
|
410
....*....|....*..
gi 1307912705 428 GLYLAVMAVCCLVSVLT 444
Cdd:PRK15075 402 GYWLSFAAVCGLIATLV 418
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-403 |
1.18e-39 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 147.65 E-value: 1.18e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 1 MTATVEETGLGQAASKAtamvRDSVKTVIAASMvGTAIEFYDFYAYGTAAAnYFPHIFFSdKANPTVALLMSLLTFAIAF 80
Cdd:PRK10406 1 MAESTVTADSKLTSSDT----RRRIWAIVGASS-GNLVEWFDFYVYSFCSL-YFAHIFFP-SGNTTTQLLQTAGVFAAGF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 81 IARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENA 160
Cdd:PRK10406 74 LMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 161 PEDKRALYGSFPELGAPIGFFLSNGTYFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETpifrmAQEQKKV 240
Cdd:PRK10406 154 VEGRKGFYASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-----SQQETRA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 241 VKSPLTevFRKSWRQvlQATFLVAVTYTL-----FYTLATWSLAWgTKDTAngggslGFTNQEYLLMLMISICVFALFIV 315
Cdd:PRK10406 229 LKEAGS--LKGLWRN--RRAFIMVLGFTAagslcFYTFTTYMQKY-LVNTA------GMHANVASGIMTAALFVFMLIQP 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 316 LSCLYADKLGRRRVLTFSSCALVVFAVlfPFLLDGQVVGQhnffANMVFLCVGFALMGIAF--GPIGAFLPELFDANVRY 393
Cdd:PRK10406 298 LIGALSDKIGRRTSMLCFGSLAALFTV--PILSALQNVSS----PYAAFGLVMCALLIVSFytSISGILKAEMFPAQVRA 371
|
410
....*....|
gi 1307912705 394 SGSGIGYNLA 403
Cdd:PRK10406 372 LGVGLSYAVA 381
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
74-440 |
1.95e-30 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 121.26 E-value: 1.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQvgvaavaiLCLLRFIQGIGLGGEWSGAA 153
Cdd:cd17371 38 LLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESFndqsAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRM 233
Cdd:cd17371 110 ALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPL----LPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 234 AQEQKKVVKSP--LTEVFRKSWRQV-LQATFLVAVTYTLFYTLATWSLAWGTkdtanggGSLGFTNQEYLLMLMISICVF 310
Cdd:cd17371 186 ARAARRHFADRpsLRELFSPPLLRTtLLASLLATGALGGYYGITTWLPSYLT-------GERGLSFEGSAGYLVVTILGG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 311 ALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGqvvgqhnffaNMVFLCVGFAL---MGIAFGPIGAFLPELF 387
Cdd:cd17371 259 FLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLS----------PTLILILGFPLgffASGPFSGMGAYLTELF 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1307912705 388 DANVRYSGSGIGYNLAAIVGAAFvPTIATWLAHNWGVHSVGLYLAVMAVCCLV 440
Cdd:cd17371 329 PTAVRATAQGFCYNVGRIIGALF-PFLVGFLATSGSLGTAIAVFAAVYYIAGL 380
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-449 |
3.82e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.67 E-value: 3.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 28 VIAASMVGTAIEFYDFYAYGTAAANYFPHIFFSdkaNPTVALLmslltFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSL 107
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLS---AAQLGLL-----FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 108 MTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTY 187
Cdd:COG2223 78 LLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 188 FVLesfndqsaMLAWGWRVPFLLSAI-LVIVGLVVRVHMEETPIFRMAQEQKKVvkSPLTEVFRKswRQVLQATFLVAVT 266
Cdd:COG2223 150 PLL--------IAAFGWRNAFLILGIlLLVVAVLAWLFLRDPPAGAAAAAKASL--RDQLEALRD--PRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 267 YTLFYTLATWSLAWGTkdtanggGSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPF 346
Cdd:COG2223 218 FGSFIGFSSWLPPYLV-------DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 347 LLdgqvvgqHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGYnLAAIVGAAFVPTIATWLAHNWGVHS 426
Cdd:COG2223 291 AL-------GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGSYT 362
|
410 420
....*....|....*....|....
gi 1307912705 427 VGLY-LAVMAVCCLVSVLTCKETK 449
Cdd:COG2223 363 AAFLvFAVLALVALVLTLLLYRRP 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-444 |
4.70e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.50 E-value: 4.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 28 VIAASMVGTAIEFYDFYAYGTAAANYFPHIFFSDKAnptvallMSLLtFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSL 107
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ-------LGLL-ASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 108 MTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTY 187
Cdd:COG2271 83 LLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 188 FVLesfndqsaMLAWGWRVPFLLSAILVIVGLVVRvhmeetpifrmaqeqkkvvkspltevfrkswrqVLQATFLVAVTY 267
Cdd:COG2271 155 GWL--------LAAFGWRAAFLILGLPGLLLALLR---------------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 268 TLFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFL 347
Cdd:COG2271 194 FALYGFLTWLPTYLVE-------VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 348 LdgqvvgQHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIgYNLAAIVGAAFVPTIATWLAHNWGVHSV 427
Cdd:COG2271 267 L------LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
410
....*....|....*..
gi 1307912705 428 GLYLAVMAVCCLVSVLT 444
Cdd:COG2271 340 FLLLAALALLAALLALL 356
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
26-453 |
1.78e-26 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 111.21 E-value: 1.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 26 KTVIAAsmVGTAIEFYDFYAYGTAAA-NYFPHIFFSDKANPTVALLMSL--LTFAIAFIARPLGSLVFGHFGDRMGRKTT 102
Cdd:pfam00083 1 VALVAA--LGGFLFGYDTGVIGAFLTlIDFFKNFGLSKSVSSLAALSVLsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 103 LVVSLMTMGVGTFLIGCLPTYdqvgvAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFL 182
Cdd:pfam00083 79 LLIANVLFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 183 SNGTYFVLESFNDqsamlAWGWRVPFLLSAILVIVGLVVRVHMEETPifRMAQEQKKVVKSplTEVFRKSWRQVLQ---- 258
Cdd:pfam00083 154 AYIFGLGLNKTSN-----SDGWRIPLGLQLVPALLLIIGLLFLPESP--RWLVEKGRLEEA--REVLAKLRGVPDVdrel 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 259 ATFLVAVTYTLFYTLATWSLAWGTKD----TANGGGSLGFTN--------------------QEYLLMLMISICVFALFI 314
Cdd:pfam00083 225 DEIKDSLEAGQEAEKASWKELFSTKTrrqrLLIGVMLQIFQQltginaifyysttifenlglSDSFLVTIIVGVVNFVFT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 315 VLSCLYADKLGRRRVLTFS----SCALVVFAVLFPFLLDGQVVGQhnfFANMVFLCVGFALMGIAFGPIGAFL-PELFDA 389
Cdd:pfam00083 305 FIAIFLVDRFGRRPLLLLGaagmAICFVILGIVALLGVSKSDWAG---IVAIVFIALFIAFFAMGWGPVPWVIvSELFPL 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 390 NVRYSGSGIGYN---LAAIVGAAFVPTIATWLaHNWGVHSVglYLAVMAVCCLVSVLTCKETKDVDF 453
Cdd:pfam00083 382 SVRSKAMALATAanwLANFLIGFLFPIITDAI-GLGYTFFI--FAGLLVLFIIFVFFFVPETKGRTL 445
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
28-282 |
1.74e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 105.66 E-value: 1.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 28 VIAASMVGTAIEFYDFYAYGTAAANYFPHIFFSdkanptvaLLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSL 107
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGAS--------SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 108 MTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTY 187
Cdd:COG0477 87 LLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 188 FVLesfndqsaMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTY 267
Cdd:COG0477 159 GLL--------VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALL 230
|
250
....*....|....*
gi 1307912705 268 TLFYTLATWSLAWGT 282
Cdd:COG0477 231 ALLLAGAALLLLLAL 245
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-409 |
8.39e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.89 E-value: 8.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 26 KTVIAASMVGTAIEFYDFYAYGTAAANYFPHIFFSDkanptvalLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVV 105
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASP--------AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 106 SLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNG 185
Cdd:COG2814 81 GLLLFALGSLLCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 186 TYFVLesfndqsaMLAWGWRVPFLLSAIL-VIVGLVVRVHMEETPifrmaQEQKKVVKSPLTEVFRksWRQVLQATFLVA 264
Cdd:COG2814 153 LGGLL--------ADLFGWRWVFLVNAVLaLLALLLLLRLLPESR-----PAARARLRGSLRELLR--RPRLLLLLLLAF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 265 VTYTLFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLF 344
Cdd:COG2814 218 LLGFGFFALFTYLPLYLQE-------VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1307912705 345 PFLldgqvvgqHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAA 409
Cdd:COG2814 291 ALA--------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
74-443 |
8.11e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.49 E-value: 8.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAA 153
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--------WQLLLARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRA----LYGSFPELGAPIGFFLSNGTYFvlesfndqsamlAWGWRVPFLLSAILVIVGLVVRVHMEETP 229
Cdd:cd17325 107 ALIADIAPPEERGramgIFSSAIGLGFLIGPLLGGLLAD------------ALGYRAPFLVCAALALLALVLALLLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 230 IFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYTL-ATWSLAWGTKdtangggsLGFTNQEYLLMLMISIC 308
Cdd:cd17325 175 RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALePFLPLYAAEL--------GGLSPAQIGLLFGAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 309 VFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLldgqvvgqHNFFANMVFLCVGFALMGIAFGPIGAFLPELFD 388
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--------TSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1307912705 389 ANVRYSGSGIgYNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:cd17325 319 PEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-410 |
2.48e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.77 E-value: 2.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 33 MVGTAIEFYDFYAYGTAAANYFPHIFFSDKAnpTVALLMSLLTFAIAfiarpLGSLVFGHFGDRMGRKTTLVVSLMTMGV 112
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPT--EIGLLLTLFSLGYA-----LAQPLAGRLSDRFGRRRVLLIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 113 GTFLIgclptydqVGVAAVAILCLLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSN--GTYFVl 190
Cdd:pfam07690 75 GLLLL--------LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPllGGLLA- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 191 esfndqsamLAWGWRVPFLLSAILVIVGLVVRVHMEETP---IFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTY 267
Cdd:pfam07690 146 ---------SLFGWRAAFLILAILSLLAAVLLLLPRPPPeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 268 TLFYTLATWSLawgtkdtanggGSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFL 347
Cdd:pfam07690 217 FGLLTYLPLYQ-----------EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1307912705 348 ldgqVVGQHNFFANMVFLCVGFAlMGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAF 410
Cdd:pfam07690 286 ----SLTLSSLWLLLALLLLGFG-FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
56-443 |
1.29e-15 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 78.43 E-value: 1.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 56 HIFFSDKANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGClptydqvgVAAVAILC 135
Cdd:PRK12307 39 YIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL--------ASGVIMLT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 136 LLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNgtyFVLESFNDqsamlAWGWRVPFLLSAILV 215
Cdd:PRK12307 111 LSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAA---YFMPSFAE-----AYGWRAAFFVGLLPV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 216 IVGLVVRVHMEETPIF---------RMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAvtYTLFYtlATWSLaWGTKDTA 286
Cdd:PRK12307 183 LLVIYIRARAPESKEWeeaklsgkgKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVL--FSIFG--ANWPI-FGLLPTY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 287 NGGGslGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRvlTFSSCALVVFAVLFPFLLdgqvVGQHNFFanMVFLC 366
Cdd:PRK12307 258 LAGE--GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKK--TFSIGLLMSFLFIFPLFR----IPQDNYL--LLGAC 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 367 VgFALMGIAFGPIG---AFLPELFDANVRYSGSGIGYNLAAiVGAAFVPTIATWLAHNWGVhSVGLYLAVMAVCCLVSVL 443
Cdd:PRK12307 328 L-FGLMATNVGVGGlvpKFLYDYFPLEVRGLGTGLIYNLAA-TSGTFNSMAATWLGITMGL-GAALTFIVAFWTATILLI 404
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
79-436 |
2.63e-14 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 74.73 E-value: 2.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 79 AFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATE 158
Cdd:PRK03893 64 AFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGY--------WTLFIARLVIGMGMAGEYGSSATYVIE 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 159 NAPEDKRALYGSFPELGAPIGfflsngtyFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQK 238
Cdd:PRK03893 136 SWPKHLRNKASGFLISGFSIG--------AVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 239 KVVKSPLTEVFRKSWRQ--VLQATFLVAVTYTLF--YTLATWSLAWGTkdTANGGGSLGFTNQ----EYLLMLMISICVF 310
Cdd:PRK03893 208 APVRTMVDILYRGEHRIinILLTLAAAAALWFCFagNLQNAAIVAVLG--LLCAAIFISFMVQssgkRWPTGVMLMVVVL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 311 ALFI---------------------------------------VLSCLYADKLGRRRVLTFSSCALVVFaVLFPFLLDGq 351
Cdd:PRK03893 286 FAFLyswpiqallptylktdlgydphtvanvlffsgfgaavgcCVGGFLGDWLGTRKAYVCSLLISQLL-IIPVFAIGG- 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 352 vvgqhnffANMVFLCVGFALMGIAFGPIGAFLPEL----FDANVRYSGSGIGYNLAAIvGAAFVPTIATWLAHNWGvhsV 427
Cdd:PRK03893 364 --------ANVWVLGLLLFFQQMLGQGISGLLPKLiggyFDTEQRAAGLGFTYNVGAL-GGALAPILGALIAQRLD---L 431
|
....*....
gi 1307912705 428 GLYLAVMAV 436
Cdd:PRK03893 432 GTALASLSF 440
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
65-443 |
8.48e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.58 E-value: 8.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 65 PTVALLMSLLTFAIAfiarpLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIG 144
Cdd:cd17324 34 AQAGLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 145 LGGEWSGAALVATENAPEDKR----ALYGSFPE----LGAPIGFFLSNgtyfvlesfndqsamlAWGWRVPFLLSAIL-V 215
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRgraiGLVFSGLTlglvLGRPLGGLLGQ----------------LLGWRAAFLAIAVLaL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 216 IVGLVVRVHMEETPIFRmaqEQKKVVKSPLTEVFRKswRQVLQATFLVAVTYTLFYTLATWSLAWGTKDTANGGGSLGft 295
Cdd:cd17324 165 LAALLLWRLLPSLPPKK---PGSLGLLSSLLLLLRN--PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 296 nqeylLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLldgqvvgqhnffANMVFLCVGFALMGIA 375
Cdd:cd17324 238 -----GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG------------PSPLLLLVGLVLWGLG 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 376 FGPIGAFLPE-LFDANVRYSGSGIGYNLAAI-VGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:cd17324 301 FFAAHSALQTrVLRLAPEARGLASSLYLAAYnLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-419 |
1.34e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.00 E-value: 1.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 18 TAMVRDSVKTVIAASMVGTAIEFYDFYAYGTAAanyfPHIffSDKANPTVALLMSLLTFAIAFIArpLGSLVFGHFGDRM 97
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAA----PAI--SAEWGLDPVQLGFLFSAGLIGMA--FGALFFGPLADRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 98 GRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVaavailclLRFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAP 177
Cdd:TIGR00895 80 GRRRVLLWSILLFSVFTLLCALATNVTQLLI--------LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 178 IGFFLsnGTYFvlesfndqSAML--AWGWRVPFLLSAIL-VIVGLVVRVHMEETPIFRMAQEQKKVVKS----------- 243
Cdd:TIGR00895 152 IGAAV--GGFL--------AGWLipVFGWRSLFYVGGIApLLLLLLLMRFLPESIDFLVSKRPETVRRIvnaiapqmqae 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 244 -----PLTEVFRKSWRQVLQA---------TFLVAVTYTL----FYTLATWsLAWGTKDTangggslGFTNQEYLLMLMI 305
Cdd:TIGR00895 222 aqsalPEQKSTQGTKRSVFKAlfqgktariTVLLWLLYFMllvgVYFLTNW-LPKLMVEL-------GFSLSLAATGGAL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 306 SICVFALFIVLSCLYADKLGrRRVLTFSSCALVVFAVLfpflldgqVVGQHNFFANMVFL--CVGFALMGiAFGPIGAFL 383
Cdd:TIGR00895 294 FNFGGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVL--------VGSTLFSPTLLLLLgaIAGFFVNG-GQSGLYALM 363
|
410 420 430
....*....|....*....|....*....|....*.
gi 1307912705 384 PELFDANVRYSGSGIGYNLAAiVGAAFVPTIATWLA 419
Cdd:TIGR00895 364 ALFYPTAIRATGVGWAIGIGR-LGAIIGPILAGYLL 398
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
77-444 |
3.78e-13 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 70.77 E-value: 3.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 77 AIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVaaVAILCLLRFIQGIGLGGEWSGAALVA 156
Cdd:cd17364 46 AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGV--MGWLIFFRFLLGIGIGGDYPLSATIM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 157 TENAPEDKR----ALYGSFPELGAPIGFFLSNGTYFVLESFNDQSAM--LAWGWRVPFLLSAILVIVGLVVRVHmeetpi 230
Cdd:cd17364 124 SEYANKKRRgaliAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYhhADLVWRIVLGLGAIPALSVLYFRKH------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 231 frmaqeqkkvvkspltevfrkswrqvlqatfLVAVTYTLF-YTLATWSLAWGTKDTANGGGSLGFTNQEYLLM------L 303
Cdd:cd17364 198 -------------------------------LLGTAGTWFlLDIAFYGQNLFQSTIISAIGFSKTMNAYQELFniavgqL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 304 MISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVGQHNFFAnmvflCVGFALMGIAFGP---IG 380
Cdd:cd17364 247 IIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFFV-----LYGLTFFFSNFGPnttTF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 381 AFLPELFDANVRYSGSGIGY---NLAAIVGAAFVPtiatWLAHNWGvhsVGLYLAVMAVCCLVSVLT 444
Cdd:cd17364 322 IVPAEVFPARVRSTCHGISAasgKIGAIVGSFLFL----SLTQNIG---VRNVLIILAGVALLGIIL 381
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
74-452 |
1.62e-12 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 69.27 E-value: 1.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAA 153
Cdd:TIGR00898 131 LTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAV 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRALYGSFPELGAPIGFFLSNG-TYFVLEsfndqsamlawgWRVPFLLSAILVIVGLVVRVHMEETPIFR 232
Cdd:TIGR00898 203 VLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLvAYFIPD------------WRWLQLAVSLPTFLFFLLSWFVPESPRWL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 233 MAQEQ------------KKVVKSPLTEVFRKSWRQVL-----QATFLVAV-TYTLFYTLATWSLAWGTK---------DT 285
Cdd:TIGR00898 271 ISQGRieealkilqriaKINGKKLPAEVLSLSLEKDLssskkQYSFLDLFrTPNLRKTTLCLMMLWFTTafsyyglvlDL 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 286 ANGGGSLgftnqeYLLMLMISICVF-ALFIVLscLYADKLGRRRVLTFSscaLVVFAVLFPFLldgQVVGQHNFFANMVF 364
Cdd:TIGR00898 351 GNLGGNI------YLDLFISGLVELpAKLITL--LLIDRLGRRYTMAAS---LLLAGVALLLL---LFVPVDLYFLRTAL 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 365 LCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIGyNLAAIVGAAFVPTIATWLAHNWgvhsvGLYLAVMAVCCLV-SVL 443
Cdd:TIGR00898 417 AVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVC-STMARVGSIISPFLVYLGEKWL-----FLPLVLFGGLALLaGIL 490
|
410
....*....|.
gi 1307912705 444 TC--KETKDVD 452
Cdd:TIGR00898 491 TLflPETKGVP 501
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
74-443 |
2.83e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.84 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAA 153
Cdd:cd06174 35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLesfndqSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRM 233
Cdd:cd06174 107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL------ASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 234 AQEQKKVVKSPLTEVFRKSWRQ--VLQATFLVAVTYTLFYTLATWSLAWGTKDtangggsLGFTNQEYLLMLMISICVFA 311
Cdd:cd06174 181 RAKNEEASSKSVLKLLKRVLKNpgLWLLLLAIFLVNLAYYSFSTLLPLFLLDL-------GGLSVAVAGLLLSLFGLAGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 312 LFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVGqhnffanMVFLCVGFALMGIAFGPIGAFLPELFDANV 391
Cdd:cd06174 254 LGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL-------LLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1307912705 392 RYSGSGIGYNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:cd06174 327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
74-444 |
4.55e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 67.21 E-value: 4.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGclptydqvGVAAVAILCLLRFIQGIGLGGEWSGAA 153
Cdd:cd17319 42 LIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTG--------FATSLTSLYVLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRALYGSFPELGAPIGFFLsnGTYFVLesfndqSAMLAWGWRVPFLLSAILVIVGLVVrvhmeetpifrm 233
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAI--GPPLSG------WLLLLFGWRWAFIIEGLLGLLLAVL------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 234 aqeqkkvvkspltevFRKSWRQVLQATFLVAVTYTLFYTLATWSLAWGTKdtangggSLGFTNQEY-LLMLMISICVFAL 312
Cdd:cd17319 174 ---------------WWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQ-------ARGFSLKQVgLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 313 FIVLSCLyADKL--GRRRVLTFSSCALVVFAVLFPFLLdgqvvgqHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDAN 390
Cdd:cd17319 232 MILGGRL-SDRLlrGARRLVIIIGLLLAAVGLLLAYLT-------TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGE 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1307912705 391 VRYSGSGIgYNLAAIVGAAFVPTIATWLAHNWGVHSVGL-YLAVMAVCCLVSVLT 444
Cdd:cd17319 304 AAATAGGL-INSGGNLGGFVAPLLIGYLVDATGSYTAAFlFLAAVALLAALLVLL 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
67-440 |
7.44e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 7.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 67 VALLMSLLTFAIAFIARPLGSLvfghfGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLG 146
Cdd:cd17474 36 VGLLITAFTLPAAVLMPVAGVL-----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--------ALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 147 GEWSGAALVATENAPEDKRA----LYGSFPELGAPIGFFLSngtyfvlesfndqSAMLAWGWRVPFLLSAILVIVGLVVR 222
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAkamgLYEAALGLGIAVGPLLG-------------GLLAAISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 223 VHMEETPifrMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYTLATWSlawgtkdtangggSLgFTNQEYLLM 302
Cdd:cd17474 170 LFLLPEP---KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYL-------------PF-LLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 303 LMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAvlfpFLLDGQVVGQHNFFANMVFLCVGFALMGIAFG----P 378
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIG----LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGlnlpL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1307912705 379 IGAFLPELFDANVRYSGSGIgYNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLV 440
Cdd:cd17474 309 LTTLVTELAPEEERGTASSL-YNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
77-442 |
1.16e-11 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 66.06 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 77 AIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPtydqvgvaAVAILCLLRFIQGIGLGGEWSGAALVA 156
Cdd:cd17315 41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAP--------NVWVLIVGRFLLGLGVGLASVLVPLYI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 157 TENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLesfndqSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAqe 236
Cdd:cd17315 113 SEIAPAKIRGALGTLNQLMITFGILLAYLLGLAL------SLSPPGWWRLMFALAAVPALLQLLLMFFLPESRALLVG-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 237 qkkvvkspltevfrkSWRQVLQAtfLVAVTYTLFYTLATWSLAWGTKDTANGGGSLGFTNqeyllmlmisicvfALFIVL 316
Cdd:cd17315 185 ---------------VGLQLLQQ--LTGINAVMYYAPTIFKSAGGGTASILASIIVGVVN--------------LLATLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 317 SCLYADKLGRRRVLTFS----SCALVVFAVLFPFLLDGQVVGQHNFFANMVFLCvGFAlmgIAFGPIGAFL-PELFDANV 391
Cdd:cd17315 234 AIRLVDKVGRRPLLLIGfagmAASLLLLAIAFLLPALAKAAGWLALLGILLYIA-AFA---MGAGPVPWLLlSEIFPLRI 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 392 RysGSGIGYNLAA------IVGAAFVPTIATwlahnWGVHSVGLYLAVMAVCCLVSV 442
Cdd:cd17315 310 R--GKGMAIATLVnwifnfIVGLTFLIMVST-----IGLAGVFIFFAAVCLLALVFV 359
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
63-414 |
2.86e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 64.95 E-value: 2.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 63 ANPTVALLMSLlTFAIAFIarpLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQvgvaavaiLCLLRFIQG 142
Cdd:cd17328 31 IDDSLAGLLQT-VFIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 143 IGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSngtyFVLESfndQSAMLAWGWRVPFLLSAIL-VIVGLVV 221
Cdd:cd17328 99 IGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG----YVVGG---LVAQATGGWRWAFRVTGVLgVLLAILL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 222 RVHMEETPifRMAQEQKKVVKSPLT-------EVFRKS--WRQVLQATFLVAVTYTLfytlATWSLAWGTKDTANGGGSL 292
Cdd:cd17328 172 LLFVREPP--RGAAEGGVMAKSTATsfladlkALAKNPsfILSTLGFTAVSFVTGAL----AFWAPTFFLRAFGVGDLSS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 293 GFTNqeylLMLMISICVFALF-IVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVGQHNFFANMVFLCVGFAL 371
Cdd:cd17328 246 ADVG----LIFGAITCIAGVLgVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1307912705 372 MGIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAFVPTI 414
Cdd:cd17328 322 LSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYL 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
71-443 |
5.83e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.10 E-value: 5.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 71 MSLLTFAIaFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWS 150
Cdd:COG0738 45 AGLLLFAF-FLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 151 GAALVATENAPEDKRA---LYGSFPELGAPIGFFLsnGTYFVLESFNDQsamlawgWRVPFLLSAILVIVGLVVrVHMEE 227
Cdd:COG0738 116 AANPYVAALGPETAASrlnLLHAFFSLGALLGPLL--GGLLILLGLSLS-------WHLPYLILAVLLLLLALL-FLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 228 TPIFRMAQEQKKVVKSPLTEVFRKswRQVLQATFLVAVTYTLFYTLATWSLAWGTKdtangggSLGFTNQEYLLMLMISI 307
Cdd:COG0738 186 LPEIEEEEEEAAGSAASLKSLLKN--PRLLLGGLAIFLYVGAEGAIGDWLPLYLKD-------VLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 308 CVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFpflldgqVVGQHNFFANMVFLCVGFAlMGIAFGPIGAFLPELF 387
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA-------LLAPGPWLALIGLALVGLG-LSLMFPTIFSLALDGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1307912705 388 DANVRYSGSGIGynLAAIVGAAFVPTIATWLAHNWGVHSVglyLAVMAVCCLVSVL 443
Cdd:COG0738 329 GKRTAAAVSAVL--IMGIVGGAIGPPLIGFLADAFGLRAA---FLVPLVCYLLILL 379
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
76-444 |
1.20e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 62.60 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 76 FAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGvaavailcLLRFIQGIGLGGEWSGAALV 155
Cdd:cd17365 40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA--------LLRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 156 ATENAPEDKRAL-----YGSFPeLGAPIGFFLSngtyfvlesfndqSAML-AWGWRVPFLLSAILVIVGLVvrvhmeetp 229
Cdd:cd17365 112 VSEYAPARRRSLavtlmFCGYP-LGAALGGFLA-------------AALIpAFGWRSVFLLGGVPPLILLP--------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 230 ifrmaqeqkkvvkspltevfrkswrqVLQATFLVAVTY----TLFYTLATWslawgtkdTANGGGSLGFTNQEYLLMLMI 305
Cdd:cd17365 169 --------------------------LLRGTLLLWVTFfmglLLVYLLNSW--------LPKLMVEAGYSLSQALTITLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 306 SICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVgqhnffANMVFLCVGFALMGIAFGpIGAFLPE 385
Cdd:cd17365 215 LNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVL------LYVLVFLAGACVNGAQVG-LYALAAR 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1307912705 386 LFDANVRysGSGIGYNLAA-IVGAAFVPTIATWL-AHNWGVHSVGLYLAVMAVCCLVSVLT 444
Cdd:cd17365 288 FYPTEVR--ATGVGWALGVgRLGAILGPLLGGLLlAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-450 |
7.49e-10 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 60.74 E-value: 7.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 64 NPTVALLMSLLTfAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGC---LPTYDQVGVAavailcllRFI 140
Cdd:cd17357 44 DSELDLLWSLIV-SIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPELLIFG--------RFL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 141 QGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSN--GTYFVLESFNdqsamlawGWRVPFLLSAILVIVG 218
Cdd:cd17357 115 VGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQvfGLPSVLGTET--------LWPYLLFFPGIPALLQ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 219 LVVRVHMEETPIF--------------------------------RMAQEQKKVVKSP-LTEVFRKSwRQVLQATFLVAV 265
Cdd:cd17357 187 LAALPFFPESPKFlliskgdeeeaekslkflrgieddvdqeleeiKKESEQMGDQKQVsLMQLLRDP-SLRLPLLLVLVV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 266 TYTLFYTLATWSLAWGTKDTANGGGSLGFTNQEYLLMLMISIcvfaLFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFP 345
Cdd:cd17357 266 SASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNV----LSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMS 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 346 FLLDGQVVGQHNFFANMVFLCVGFALMGIAFGPIGAFLP-ELFDANVRYSGSGIGYNLAAIVgaAFVPTIATWLAHN-WG 423
Cdd:cd17357 342 VFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGaELFPQAPRSAAQSLGSSVNWTS--NFIVGMAFPPLQSiGG 419
|
410 420
....*....|....*....|....*..
gi 1307912705 424 VHSVGLYLAVMAVCCLVSVLTCKETKD 450
Cdd:cd17357 420 GFVFIIFAIPCALFLLYLYRYLPETKG 446
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
74-443 |
1.04e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.52 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAA 153
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY--------ELFLVLRFLVGVTSAGIFTVGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESfndqsamlawgWRvpfLLSAILVIVGLVVRVHMEETPifrm 233
Cdd:cd17317 101 VLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-----------WR---WLQLAISLPGLLFLLLLWWLP---- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 234 aqeqkkvvkspltevfrkswRQVLQATFLVAVTYTLFYTLATWSlawgtkdtANGGGSLgFTNQEYLLMLMISICVFALF 313
Cdd:cd17317 163 --------------------RRTIIVGLIWFVTSLVYYGLSLNS--------SNLGGNL-YLNFFLSGLVEIPAYFLALL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 314 IVlsclyaDKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVgqhnffANMVFLCVGFALMGIAFGPIGAFLPELFDANVRY 393
Cdd:cd17317 214 LL------DRLGRRWTLSGSLLLAGLACLVTALLPDDENT------LALTLALVGKFAISAAFSVIYLYTAELYPTVVRN 281
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1307912705 394 SGSGIGyNLAAIVGAAFVPTIATWLAHNWGVHSVglYLAVMAVCCLVSVL 443
Cdd:cd17317 282 TGVGLC-STVARVGAILAPFIVLLGKIGPLLPLI--IFGVLALLGGLLTL 328
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
85-399 |
1.85e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 59.34 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDK 164
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNY--------PVLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 165 RALYGSFPELGAPIGFFLSngtYFVLESFNDQSAMLawGWRVPFLLSAILVIVGLVVRVHMEETPifRMAQEQKKVVKSP 244
Cdd:cd17437 119 RGFLTSFPEIFINIGILLG---YVSNYAFSGLPLHV--GWRLMLGVGAVPSLFLAIGVLAMPESP--RWTPAVRRMLIAA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 245 LTEVFRKswrqvlQATFLVAVTYtlfYTLATWSLAwgtkdtangggslGFTNQEYLLMLMISICVF-ALFIVLSCLYADK 323
Cdd:cd17437 192 LGIHFFQ------QASGIDAVVL---YSPRIFKKA-------------GIKSKDKLLLATVAVGVTkTLFILVATFLLDK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 324 LGRRRVLTFSSCALVV--FAVLFPFLLDGQVVGQHNFFANM--VFLCVGFALMGIAFGPIGAFL-PELFDANVRYSGSGI 398
Cdd:cd17437 250 VGRRPLLLTSTGGMTLslTALATSLTFIDRNGGGLTWALVLaiTAVCSFVAFFSIGAGPITWVYsSEIFPLRLRAQGASL 329
|
.
gi 1307912705 399 G 399
Cdd:cd17437 330 G 330
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-440 |
2.00e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.14 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 63 ANPTVA-LLMSLLTFAiAFIARPLGslvfGHFGDRMGRKTTLVVSLMTMGVGTFLIGClptydqvgVAAVAILCLLRFIQ 141
Cdd:cd17489 28 GSEAVAgLVVGLFTLA-ALLARPFA----GRLLDRFGRKRLLLIGLLIFALATLLYLL--------ATSVALLLVLRLIH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 142 GIGLGGEWSGAALVATENAPEDKRA----LYGSFPELGAPIGFFLSNgtyfvlesfndqSAMLAWGWRVPFLLSAILVIV 217
Cdd:cd17489 95 GIGWGAFTTAAATLVADIIPPSRRGegigYYGLATTLAMALGPALGL------------FLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 218 GLVVRVHMEETPifRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYT-LATWslawgtkdtangGGSLGFTN 296
Cdd:cd17489 163 ALLLVFLVKDPP--PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTfLPLY------------AAERGISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 297 qeYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLldgqvvgqhnffANMVFLCVGFALMGIAF 376
Cdd:cd17489 229 --AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA------------GSPWMLLLAAVLYGLGF 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 377 GPIGAFLPELFDANVRYSGSGIG---YNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLV 440
Cdd:cd17489 295 GLLFPALQALAVDLVPPHRRGAAngtFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
66-443 |
2.03e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 59.12 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 66 TVALLMSLLTFAIAFiarplGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGL 145
Cdd:cd17359 37 LEGLVVSSALLGAAI-----GALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPN--------FTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 146 GGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHM 225
Cdd:cd17359 104 GGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 226 EETPIFRMAQEQKKVVKSPLTEVFRkswrqvlQATFLVAVTYtlfYTLATWSLAwgtkdtangggslGFTNQEYLLMLMI 305
Cdd:cd17359 184 PESPRWLVSKGKPILIIGIGLAIFQ-------QFVGINVIFY---YGPEIFQNA-------------GFSENAALLQTIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 306 SICVFALFIVLSCLYADKLGRRRVL----TFSSCALVVFAVLFPFLLDGQVVGqhnfFANMVFLCVGFALMGIAFGPIG- 380
Cdd:cd17359 241 IGVVNVIFTIIAILLVDKVGRKPLLligsIGMAISLLLIGTAFYFAPGSQASG----IVALVLILLFVAFFAMSWGPVTw 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1307912705 381 AFLPELFDANVRYSGSGIgynlaaivgAAFVPTIATWL------AHNWGVHSVGLYLaVMAVCCLVSVL 443
Cdd:cd17359 317 VLLSEIFPNRIRGLAMGI---------AVFFLWIANFLvsltfpILLAAFGLAFTFL-IFAVICVLAFL 375
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
85-449 |
3.69e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 58.13 E-value: 3.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDK 164
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSY--------PVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 165 RALYGSFPELGAPIGFFLSngtYFVLESFNDqsamLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQEQKKVVKSP 244
Cdd:cd17362 126 RGLLVSLKELFIVLGILLG---YVSGYAFAD----VVGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQGNYRKPLIIGLG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 245 LteVFRKswrqvlQATFLVAVtytLFYTLATWSlawgtkdtangggSLGFTNQEYLLMLMISICVFALF-IVLSCLYADK 323
Cdd:cd17362 199 L--VLFQ------QITGQPSV---LYYAATIFK-------------SAGFSAASDATLVSVGLGVFKLLmTIVAVLLVDK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 324 LGRRRVLtFSSCALVVFAVLFPFLLDGQVVGQHNFFA--NMVFLCVGFALMGIAFGPIG-AFLPELFDANVRYSGSGIG- 399
Cdd:cd17362 255 LGRRPLL-LGGVSGMVVSLFLLAAYNLFVQMGPAGLAwlSLVALLLYVGAYQISFGPISwLMVSEIFPLRVRGRAIALAv 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1307912705 400 ---YNLAAIVGAAFVPTIATwlahnWGVHSVGLYLAVMAVCCLVSV-LTCKETK 449
Cdd:cd17362 334 lvnFGSNALVSLAFLPLQEL-----IGLPGTFLGFGVIGVLALLFIyFTVPETK 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
57-410 |
6.08e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 6.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 57 IFFSD--KANPTVALLMSLLTFAIAFIARPLGSLVFGHFGDRMG-RKTTLVVSLMTMGVGTFLIGCLPTYDQVGVAAVAI 133
Cdd:COG2211 35 YFYTDvlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYAL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 134 LCLLRFIQGIGLGGEwSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESFNDQSAmlAWGWRVPFLLSAI 213
Cdd:COG2211 115 VTYLLLGLAYTLVNI-PYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAV 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 214 LVIVGLVVRVHMeeTPIFRMAQEQKKVVKSPLTEVFR-KSWRQVLQATFLVAVTYTLFYTLATWSLAWgtkdtangggSL 292
Cdd:COG2211 192 LGLLAFLLTFFG--TKERPVPEEEKVSLKESLKALLKnRPFLLLLLAYLLFFLALALVAALLLYYFKY----------VL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 293 GFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGqvvgqhnffaNMVFLCVGFALM 372
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG----------NLWLLLVLAALA 329
|
330 340 350
....*....|....*....|....*....|....*...
gi 1307912705 373 GIAFGPIGAFLPELFDANVRYSGSGIGYNLAAIVGAAF 410
Cdd:COG2211 330 GIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIF 367
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
72-229 |
1.53e-08 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 56.66 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 72 SLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVaaVAILCLLRFIQGIGLGGEWSG 151
Cdd:TIGR00887 58 SAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSV--MATLCFWRFWLGVGIGGDYPL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 152 AALVATENAPEDKR-ALYGS------FPEL-GAPIGFFLSNGTYFVLESFNDQSAMLA-------WGWRVPFLLSAILVI 216
Cdd:TIGR00887 136 SAIITSEFATKKWRgAMMAAvfamqgFGILaGAIVALIVLAGFKHSLEAAADEASCTGscvpavdYMWRILIGFGAVPAL 215
|
170
....*....|...
gi 1307912705 217 VGLVVRVHMEETP 229
Cdd:TIGR00887 216 LALYFRLTIPETP 228
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
66-444 |
3.70e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.87 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 66 TVALLMSLLTFAIAfiarpLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGL 145
Cdd:cd17477 32 LIGLVASAYYLGIL-----LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 146 GGEWsgaalVATEN-----APEDKRALYGSFPELGAPIGFFLSngtYFVLESFNDQSAMlawgwrvPFLLSAILVIVGLV 220
Cdd:cd17477 99 AGLF-----VVSESwlnalATNENRGRVLGLYSTVLGLGFALG---PLLLALVGTAGAL-------PFLIAAVLLLLALV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 221 VrVHMeetpIFRMAQEQKKVVKSPLTEVFRKSWRQVLqATFLVAVTYTLFYTLATWSLAwgtkdtangggSLGFTNQEYL 300
Cdd:cd17477 164 P-LLL----TRRAAPEIEEAESISLRRLLRIAPLALL-GAFVAGFLEGAFYSLLPLYGL-----------RLGLSVAQAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 301 LMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFlldgqvvgqhnFFANMVFLCVGFALMGIAFGPI- 379
Cdd:cd17477 227 LLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPL-----------VPGLPLALLVLLFLWGGAAGPLy 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1307912705 380 ---GAFLPELFDANVRYSGSGiGYNLAAIVGAAFVPTIATWLAHNWGVHsvGLYLAVMAVCCLVSVLT 444
Cdd:cd17477 296 tlaLALAGDRLPGDELVAANA-ALLLLYGLGSVIGPLLAGALMDAFGPH--GLFLFLAAVALLFLLFL 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
66-443 |
4.05e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.87 E-value: 4.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 66 TVALLMSLLTFAIAFIarplgSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGL 145
Cdd:cd17478 32 QAGLLVSVFSITSSLL-----QPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY--------WLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 146 GGEWSGAALVATENAPEdKRALYGSFPELGAPIGFFLsnGTYFVLesfndqSAMLAWGWRVPFLLSAILVIVGLVVRVHM 225
Cdd:cd17478 99 AAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFAL--GPLIAA------ALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 226 EETPIFRMAQEQKKVVkspLTEVFRKSWRQVLQATFLVAVTYTLFYTLATWSLAWGTkdtangggSLGFTNQEYLLMLMI 305
Cdd:cd17478 170 RPLKKPEAKKAAAKSS---ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV--------QRGYSLVFAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 306 SICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFlldgqvvgqHNFFANMVFLCVGFALMGIAFGPIGAFLPE 385
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL---------TPGIWSYILLVLAGFLLFASFPVTVVLAQE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1307912705 386 LFDANVRYsGSGIGYNLAAIVGAAFVPtIATWLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:cd17478 310 LLPGNVGL-ASGLMMGLSFGLGGIGAP-VLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
66-444 |
6.78e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 6.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 66 TVALLMSLLTFAIAfiarpLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaaVAILcLLRFIQGIGL 145
Cdd:cd17473 36 LVPLLLTLPALFIA-----LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL-------YALL-ASRALLGIGV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 146 GGEWSGAALVATENAPEDKR----ALYGSFPELGApIGFFLSNGtyfvlesfndqsAMLAWGWRVPFLLSAI-LVIVGLV 220
Cdd:cd17473 103 AGIMTLATALIGDYFEGEERakmlGLQSAAMSLGG-VVFLLLGG------------ALAEIGWRAPFLVYLLaLPVLILV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 221 VRVhmeetpIFRMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYTLATW-SLAWgtkdTANGGGSLGFTNqey 299
Cdd:cd17473 170 LLF------LPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQlPFLL----QERGGGSAALIG--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 300 llmLMISIcvFALFIVLSCLYADKLGRRrvLTFSSCALVVFAVL-FPFLLDGQVVGQHNFFANMVFLCVGFalmGIAFGP 378
Cdd:cd17473 237 ---LALAI--ASLAGAIGALLFGRLKRR--LGKRRLLAIGFALMaLGFLLLALASGLWVVLLGAILAGLGF---GLLLPT 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 379 IGAFLPELFDANVRysGSGIGYNLAAIVGAAFV-PTIATWLAHNWGVHSvGLYLAVMAVCCLVSVLT 444
Cdd:cd17473 307 LNSWAMSLVPPELR--GRAMGIVTSAFFLGQFLsPLVLGPLVNLTGGLS-GAFLILGVLALVLAIVL 370
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
77-449 |
1.05e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 53.73 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 77 AIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGLGGEWSGAALVA 156
Cdd:cd17358 48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKD--------VWMLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 157 TENAPEDKRALYGSFPELGAPIGFFLSngtyFVLESFNDqsamlawgWRVPFLLSAILVIVGLVVRVHMEETPIF----- 231
Cdd:cd17358 120 AEIAPKNVRGALGSLNQLLVNIGILLG----YVLGSFLP--------WRTLALIGAIPPVVFLILLFFIPESPRWlakkg 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 232 ----------------------------RMAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTL-------FYTLATW 276
Cdd:cd17358 188 reeeaekslqflrgkdadiskeaaeiqeELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLsginaviFYASSIF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 277 SLAWGTKDTANGGgslgftnqeyllmlMISICVFALFIVLSCLYADKLGRRRVLTFSSC----ALVVFAVLFPFLLDGQV 352
Cdd:cd17358 268 DEAGSGLDPNTAT--------------IIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIgmgiGLLALGLYFYLQEHGAL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 353 VGQHNFFAnMVFLCVGFALMGIAFGPIGAF-LPELFDANVRysgsGIGYNLAAIVGAAFVpTIATW----LAHNWGVHSV 427
Cdd:cd17358 334 LSSVSWLP-LVGLVIYIISFSIGLGPLPWViMSEIFPAKIK----GLAGSLVTLVNWLFA-FIVTKtfpfLTLAWGASGT 407
|
410 420
....*....|....*....|...
gi 1307912705 428 GLYLAVMAVCCLVSVLTC-KETK 449
Cdd:cd17358 408 FWIFAGICGLALVFVLLFvPETK 430
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
80-443 |
6.52e-07 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 51.21 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 80 FIARPLGSLVFGHFGD-RMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATE 158
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY--------WVYAFLRFLTGFGRSGIGTCALVLATE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 159 NAPEDKRALYGSFPELGAPIGFF-LSNGTYFVLESfndqsamlawgWRVPFLLSAILVIVGLVvrvhmeetpifrmaqeq 237
Cdd:cd17378 115 PVGPKWRGQVGMSTFFFFVLGFMsLPGIAYLNGSS-----------WRVLYFWTSIPALIYCI----------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 238 kkvvkspLTEVFRKSWRQVLQATFLVAVTYtlfYTLatwSLAWGtkdtaNGGGSLGFTnqeyllmLMISICVFALFIVLS 317
Cdd:cd17378 167 -------LVYLFARRLLAVMVIGFGIGMVY---YGI---PLAVG-----NLKFNIYLS-------VALNALSELPAFVIT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 318 CLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVGqhnffANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSG 397
Cdd:cd17378 222 AFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTS-----LQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALG 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1307912705 398 IgYNLAAIVGAAFVPTIATwLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:cd17378 297 M-LRQALVVGGIFAPFIVS-LGRKNAALSFGVFGVAILLLGLFALG 340
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
74-445 |
7.00e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.04 E-value: 7.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 74 LTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQvgvaavaiLCLLRFIQGIGLGGEWSGAA 153
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSVVAR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 154 LVATENAPEDKRALYGSF--------PELGAPIGFFLsngtyfvlesfndqsaMLAWGWRVPFL-LSAILVIVGLVVRVH 224
Cdd:cd17320 110 AIVRDLYSGAELAKIFSLlmmilaiaPALAPLLGGLL----------------LLFFGWRAIFVfLALLGLLLLLLVLLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 225 MEETPIFRMAQEQKKVVKSPLTEVFRKswRQVLQATFLVAVTYTLFYTLATWSLAWGTKDtangggsLGFTNQEYLLMLM 304
Cdd:cd17320 174 LPETLPEEKRKPLLSSLLRAYKRVLKN--RRFLGYALALGLSFAGLFAYLAAAPFIYIEQ-------LGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 305 ISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLfpfLLDGQVVGQHNFFANMVFLCVGFALMGIAFGPIGAFLP 384
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALV---LLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1307912705 385 ELFDaNVRYSGSGIgYNLAAIVGAAFVPTIATWLaHNWGVHSVGLYLAVMAVCCLVSVLTC 445
Cdd:cd17320 322 EPFP-HVAGTASAL-LGFLQFLIGALAGALVGLL-PNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
77-190 |
2.50e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 49.21 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 77 AIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVA 156
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF--------PVYCVLRFLAGFAVSGISINTLILG 113
|
90 100 110
....*....|....*....|....*....|....
gi 1307912705 157 TENAPEDKRALYGSFPELGAPIGFFLSNGTYFVL 190
Cdd:cd17374 114 TEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAI 147
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
50-398 |
3.32e-06 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 49.17 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 50 AANYFPHIFFSDK----------ANPTVALLMSLLTFAiAFIARPLGSLVFGHFGdrmgRKTTLVVSlmtmGVgTFLIGC 119
Cdd:cd17361 26 LEKFFPSVYEKKKgasennyckyDDQLLQLFTSSLYLA-GLVASLLASYVTRKWG----RKPSMLIG----GV-LFLVGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 120 LptydqVGVAAVAILCLL--RFIQGIGLGGEWSGAALVATENAPEDKRALYGSFPELGAPIGFFLSNGTYFVLESfndqs 197
Cdd:cd17361 96 A-----LNAAAQNIAMLIvgRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLINYGTSK----- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 198 aMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRMaqeqkkVVKSPLTEVFRKswrqvlqatfLVAVTYTLFYTLATWS 277
Cdd:cd17361 166 -IKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQ------LVIAILIPFFQQ----------LTGINVIMFYAPVLFQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 278 lawgtkdtangggSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSS----CALVVFAVLFPFLLDGQVV 353
Cdd:cd17361 229 -------------TLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGvqmlASQVAIGILLAVKFGDGGE 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1307912705 354 GQHNF-FANMVFLCVGFALMGIAFGPIGAFLP-ELFDANVRYSGSGI 398
Cdd:cd17361 296 LPKAYaIAVVVLICLYVAAFAWSWGPLGWLVPsEIFPLETRSAGQSL 342
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
88-443 |
3.91e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.71 E-value: 3.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 88 LVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGlggewsGAALVATENA------P 161
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIG------AAAIMPASLAliaatfP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 162 EDKR----ALYGSFPELGAPIGFFLSNgtyFVLESFndqsamlawGWRVPFLLSAILVIVGLVVrvhmeeTPIFRMAqeq 237
Cdd:cd17321 115 GERRgralGLWGAVVGIGAALGPLLGG---LLLELF---------GWRWIFLINVPIGLVALLL------ARTFSGA--- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 238 kkvvkspltevfrkswrqVLQATFLVAVTYTLFYTLATWSLAWGTKDTANGGgslgftnqeyLLMLMISIcVFALFIVLS 317
Cdd:cd17321 174 ------------------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG----------LALLPLAL-AMLVAAPLA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 318 CLYADKLGRRRVLTFSSCALVVFAVLFPFLldGQVVGQHNFFANMVFLCVGfalMGIAFGPIGAFLPELFDANVRYSGSG 397
Cdd:cd17321 225 GRLADRFGPRLVLVAGLLLTAVGLLLLALL--GADSSVWLLLPGLVLLGLG---LGLFATPLTNAALSSVPKEKAGAASG 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1307912705 398 I---GYNLAAIVGAAFVPTIATWL----------------AHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:cd17321 300 IlntARQLGGALGVALLGALLTAGlsanlgdsgvaallsaAAAAFAAGFHLAFLVAAALALLAAL 364
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
160-444 |
9.92e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 47.62 E-value: 9.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 160 APEDKR---ALYGSFPELGAPIGFFLSngtyFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVH----MEETPIFR 232
Cdd:cd17313 135 PPEQRSkanGIINFMGGLGGVLGYLLG----AILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFfvkePPLSPEAG 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 233 MAQEQKK--VVKSPLTEVFR---KSWRQVLQATFLVAV---TYTLFYTLATWSLAWGTKDTAngGGSLGFTNQEYLLMLM 304
Cdd:cd17313 211 EHSENPSlgEVLKSLLKLLKimpRSLLRLLLVIFFWWIaffPFELFFTDYMGEEVYHGTSAA--SSHYGAGVRMGAWGLL 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 305 ISICVFALFIVLSCLYADKLGRRRVLTFSscaLVVFAVLFPFLLdgqvvgqhnFFANMVFLCVGFALMGIAFGPIG---- 380
Cdd:cd17313 289 IFSLAFLIFSLPIGKLGKKIGRKKVYLIG---LVLFAVGMALMA---------LVHNVTVALVLFALGGIGWATINinpy 356
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1307912705 381 AFLPELFDANVRYSGSGIG-YNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVLT 444
Cdd:cd17313 357 PLVSDYHSESGRGQGTDTGlLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
259-443 |
1.03e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 259 ATFLVAVTYTLFYTLATWSLAwgtkdtanggGSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSscaLV 338
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLA----------EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 339 VFAVLFPFLLdgqvvgqhnFFANMVFLCVGFALMGIAFG----PIGAFLPELFDANVRYSGSGIgYNLAAIVGAAFVPTI 414
Cdd:pfam07690 71 LFALGLLLLL---------FASSLWLLLVLRVLQGLGAGalfpAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLL 140
|
170 180
....*....|....*....|....*....
gi 1307912705 415 ATWLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:pfam07690 141 GGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
67-445 |
1.70e-05 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 46.73 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 67 VALLMSlltfaIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLG 146
Cdd:cd17441 36 VALLTS-----VVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIY--------SWILVLRGLVGFGIG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 147 GEWSGAALVAtENAPEDKRA----LYGSFPELGAPIGFFLSngtYFVLESFndqsamlawGWRVPFLLSAILVIVGLVVR 222
Cdd:cd17441 103 GVPQSVTLYA-EFLPMKSRAkcilLIEVFWALGTVFEVLLA---VFVMPTL---------GWRWLLILSALPLLIFAVLC 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 223 VHMEETPIFRmaqeqkkvvksplTEVFRksWRQVLQATF----LVAVTYTLFYTLATWSLAWGTKdtANGGGSLG---FT 295
Cdd:cd17441 170 FWLPESARYW-------------TTILL--WFIWFSNAFsyygLVLLTTELFQAGDVCSGSSGKK--VEGKCSLEceyLT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 296 NQEYLLMLMISICVFAlFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGqvvgqhnfFANMVFLCVGFALMGIA 375
Cdd:cd17441 233 TSDYMDLLWTTLSEFP-GLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGR--------FSLTVLLFIARAFISGG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 376 FGPIGAFLPELFDANVRYSGSGiGYNLAAIVGAAFVPTIATWLAHNwgvhSVGLYLAVMAVCCLVSVLTC 445
Cdd:cd17441 304 FQAAYVYTPEVYPTATRALGLG-TCSGMARVGALITPFIAQVMLES----SVYLTLSVYSGCCLLAAIAS 368
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
85-449 |
2.96e-05 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 46.09 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVvslmtMGVGTFLIGCLptydqVGVAAV-AILCLL--RFIQGIGLGGEWSGAALVATENAP 161
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQ-----IGCVIYIIGAI-----IQVAAIgKWYQLIvgRIIAGLGVGFASVLVPVYQSEVAP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 162 EDKR----ALYGSFPELGAPIGFFLSNGTyfvleSFNDQSAMlawgWRVPF---LLSAILVIVGLVVrvhMEETPIFrma 234
Cdd:cd17356 130 KHIRgtlvSLYQLAITIGILVAYCINYGT-----HKLDGSAQ----WRIPLglqIVWGLLLLIGMFF---LPESPRW--- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 235 qeqkkvVKSPLTEVFRKSWRQvlqatfLVAVTYTLFYtlATWSLAwgtkdtangggSLGFTNQEYLLMLMISICVFALFI 314
Cdd:cd17356 195 ------LYRTILGIMLQLFQQ------LTGINYFFYY--GTTIFQ-----------STGLTGSSPLLTSIILYIVNFVST 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 315 VLSCLYADKLGRRRVLTFSS-----CALVVFAVLFPFLLDGQVVGQHNFFAN---MVFLCVGFALMGIAFGPIGAFLP-E 385
Cdd:cd17356 250 IPGLFFVDKFGRRTCLLIGAagmsiCLFIYAAVGVRYLIPNPQSGTSNKSAGngmIVFICLFIFSFATTWGPIAWVYVaE 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1307912705 386 LFDANVRYSGSGI---GYNLAAIVGAAFVPTIATwlAHNWGvhsVGLYLAVMAVCCLVSV-LTCKETK 449
Cdd:cd17356 330 VFPLRVRSKGMALataFNWLWNFLISFFTPFIIG--SIGFK---YYYIFAGCNLLAFIVVfFFVPETK 392
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
250-436 |
3.43e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 250 RKSWRQVLQATFLVAVTYTLFYTLATWSLAWGTKdtangggsLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRV 329
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEE--------FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 330 LTFSSCALVVFAVLFPFLldgqvvgqHNFFANMVFLCVGFALMGIAFGPIGAFLPELFDANVRYSGSGIgYNLAAIVGAA 409
Cdd:COG2223 73 LLIGLLLLGIGLLLLALA--------VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGL-AAGGGNLGAA 143
|
170 180
....*....|....*....|....*..
gi 1307912705 410 FVPTIATWLAHNWGVHSVGLYLAVMAV 436
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLL 170
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
72-443 |
5.14e-05 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 45.22 E-value: 5.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 72 SLLTfAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSG 151
Cdd:cd17372 37 ALIT-SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY--------MWLIILRCLVGLGLGGGPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 152 AALvATENAPEDKRALYGSFPELgapigfFLSNGTYF--VLESFndqsAMLAWGWRVPFLLSAILVIVGLVVRVHMEETP 229
Cdd:cd17372 108 ASW-YLEFLPAKSRGTWMVLFSV------FWTVGTIFeaSLAWL----VMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTT 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 230 IFRmaqeqkkvvkspltevfrksWRQVLQATFLVAVTYTLFYTLATWSLAWGTKDTANGGGSLG------FTNQEYLLML 303
Cdd:cd17372 177 LLL--------------------WVIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDSDSGESPTekqcrnSNDVDYRDVF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 304 MISICVFALfIVLSCLYADKLGRRrvLTFSSCaLVVFAVLFPFLLDGQvvgqhNFFANMVFLCVGFALMGIAFGPIGAFL 383
Cdd:cd17372 237 IATFAEFPG-LLISAAMIDRLGRK--ASMASM-LFTCCIFLLLLLICQ-----SPFILTVLLFGGRACISAAFTVVYIYT 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 384 PELFDANVRYSGSGIGYNLAAIvGAAFVPTIATWLAHNwgvhSVGLYLAVMAVCCLVSVL 443
Cdd:cd17372 308 PEVYPTAVRALGVGTGSSVGRI-GAILCPFIAQVLVHG----SQTIALLLFSVVCLVSAI 362
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
90-444 |
6.03e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 90 FGHFGDRMGRKTTLVVSLMTMGVGTFLigclptydqvgvAAVA----ILCLLRFIQGIGLGGEwSGAALVAtENAPEDKR 165
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLL------------AAYAtsiyGLILGRALQGSGAISS-VVMALLA-DLTREENR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 166 ALygSFPELGAPIGFFLSNGTYFvlesfndqSAMLA--WGWRVPFLLSAILVIVGLVV--RVHMEETPIFRMAQEQKKVV 241
Cdd:cd17472 118 TK--AMALIGASIGIAFAISMVL--------GPLLAahLGVSGLFLITAILSLVSLLIllFFVPDPPKIVQISEKEKKKL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 242 KSPLTEvfRKSWRQVLQATFLVAVTYTLFYTLATWSlawgtkdtANGGGSLGFTNQEYLLMLMISICVFALFIVlsclYA 321
Cdd:cd17472 188 KKLLKN--KRLLRLDFSIFILHFVLMAFFYILPLLL--------TQLGGGKGQLWKVYLPAILIGFILMVPFVI----YA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 322 DKLGRRRVLTFSSCALVVFAVLFPFLLDGQVVGqhnFFANMVFLCVGFALMgiafgpiGAFLPELF--DANVRYSGSGIG 399
Cdd:cd17472 254 EKKGKMKQVFVSSILLIAVGFLLLLFAATSLWL---LIIGLIIFFIGFNLL-------EALLPSLVskIAPKEYRGTAMG 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1307912705 400 -YNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVLT 444
Cdd:cd17472 324 iYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFL 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
66-443 |
1.11e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 66 TVALLMSLLTFAIAfiarpLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVAAVAILCllrfiqGIGL 145
Cdd:COG2807 54 QAGLLTTLPLLAFG-----LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA------GIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 146 GGewSGAALVATENAPeDKRALYGSFPELGAPIGFFLSNGTYFVLESfndqsamlAWGWRVPFLLSAILVIVGLVVRVhm 225
Cdd:COG2807 123 GN--VLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAA--------ALGWRGALAVWALLALLALLLWL-- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 226 eetPIFRM--AQEQKKVVKSPLTEVFRKswRQVLQATFLVAVTYTLFYTLATWSLAWGTkdtangggSLGFTNQEYLLML 303
Cdd:COG2807 190 ---PLLRRrpAAAAAAPAAASLRSLWRS--PLAWLLTLFFGLQSLLYYAVVAWLPPILR--------DAGLSAATAGLLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 304 MISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVvgqhnFFANMVFLCVGfalMGIAFGPIGAFL 383
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSL-----PWLWAVLLGLG---QGGLFPLALTLI 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 384 PELFdANVRYSGS------GIGYnlaaiVGAAFVPTIATWLAHNWGVHSVGLY-LAVMAVCCLVSVL 443
Cdd:COG2807 329 GLRA-RTPAEAAAlsgmaqSVGY-----LLAALGPLLVGALHDATGSWTAALLlLAALAVLMLVAGL 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
291-443 |
1.14e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 291 SLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLldgqvvgqhnffANMVFLCVGFA 370
Cdd:COG2814 39 DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA------------PSLWLLLAARF 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1307912705 371 LMGIAFGPIG----AFLPELFDANVRysGSGIGYNLAAI-VGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVL 443
Cdd:COG2814 107 LQGLGAGALFpaalALIADLVPPERR--GRALGLLGAGLgLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLL 182
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-445 |
3.38e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPtydqvGVAAVAILCLLrfiqgIGLGG---EWSGAALVATENAP 161
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH-----SPWLFAIALVL-----TGFGGglfEPASEAMIADVTTP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 162 EDKRALYGSF---PELGAPIGFFLsnGTYFVLESFndqsamlawgwRVPFLLSAIL-VIVGLVVRVHMEETPIFRMAQEQ 237
Cdd:cd17329 120 ENRTRAFSLLywaINLGVAIGPLL--GGLLLLYSF-----------RLLFLAAAVLfLLAALVLLFLLPETRPKRRAAEK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 238 KKVvkspltevfRKSWRQVLQATFLVAVTYTLFYTLATWSlAWGTKDTANGGGSLGFTNQEYLLMLMISICVFALFIVLS 317
Cdd:cd17329 187 TEI---------LRGYKIVLRDRAFLLFLLASFLISLIYF-QLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 318 CLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGQVvgqhnFFANMVFLCVGFALMGIAFGPIGAFLpelfdANVRYSGSG 397
Cdd:cd17329 257 ARLVERFRLRKILMIGILLFAIGFAVLAFANTLAV-----LILAMIVLTLGEMLVFPAVQTLVAAL-----APPDKRGSY 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1307912705 398 IG-YNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVLTC 445
Cdd:cd17329 327 MGfYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
85-236 |
7.28e-04 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 41.71 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVAAVAIlcllrfiqGIGLGGEWSGAALVATENAPEDK 164
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAI--------GVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1307912705 165 RALYGSFPELGAPIGFFLSNGTYFVLESFNDqsamlawGWRVPFLLSAILVIVGLVVRVHMEETPIFRMAQE 236
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISNYAFANVSN-------GWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKD 187
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
85-192 |
1.27e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 40.80 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDK 164
Cdd:cd17379 48 IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100
....*....|....*....|....*...
gi 1307912705 165 RALYGSFPELGAPIGFFLSNGTYFVLES 192
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLILPGIAYFIPH 147
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
80-444 |
1.34e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.64 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 80 FIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGLGGEWSGAALVATEN 159
Cdd:cd17504 41 LLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--------LPVLIAGRALQGIGGAVFPLAFALVREEF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 160 APEDKR-------ALYGSFPELGAPIGFFLSNgtyfvlesfndqsamlAWGWRVPFLLSAILVIVGLVVrvhmeeTPIFR 232
Cdd:cd17504 113 PPERVPvaqgilsATFGIGAGIGLPLGGWIVQ----------------HLGWRWIFWTAAPVAVLLAAL------VPLID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 233 MAQeqkkvvksplteVFRKSWRQVLQATFLVAVTYTLFYTLATWSLAwgtkDTANGGGSLGFTnQEYLLMLMISIcVFAL 312
Cdd:cd17504 171 LRL------------LRRRNVLLANITALLAGFGMFMVFQLLPQLLQ----LPTPTGFGLGIT-EAGLLLLPGAL-VMLI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 313 FIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLDGqvvgqhnffanMVFLCVGFALMGIAFGPIGAFLPEL------ 386
Cdd:cd17504 233 AGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSS-----------LWALVVALLLIGIGLGLAFASLPNIvvesvp 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 387 ---------FDANVRYSGSGIGYNLAAIVGAAFVPTIATwlahnWGVHSVGLYLAVMAVCCLVSVLT 444
Cdd:cd17504 302 pdrtgiatgMNTVLRTIGSAIGPAIAGAILTTYTVSITS-----GGVPTEGAYVLAFLIGAALALAA 363
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
78-231 |
1.39e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 41.12 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 78 IAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaAVAILCllRFIQGIGLGGEWSGAALVAT 157
Cdd:TIGR01299 210 IVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGY------GFFLFC--RLLSGFGIGGAIPIVFSYFA 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1307912705 158 ENAPEDKRALYGSFPELGAPIGFFLSNGTYFVL-----ESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIF 231
Cdd:TIGR01299 282 EFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIiphygWSFQMGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
291-449 |
1.56e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.18 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 291 SLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSSCALVVFAVLFPFLLdgqvvgqhnffaNMVFLCVGFA 370
Cdd:COG0477 43 DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP------------SPELLIAARA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 371 LMGIA----FGPIGAFLPELFDANVRYSGSGIgYNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAVMAVCCLVSVLTCK 446
Cdd:COG0477 111 LQGIGagglMPGALALIAELFPARERGRALGL-WGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
|
...
gi 1307912705 447 ETK 449
Cdd:COG0477 190 ESR 192
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
85-221 |
1.59e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.78 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 85 LGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVATENAPEDK 164
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNI--------TVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 165 RALYGSFPELGAPIGFFLSNgtyfVLESFNDQsamlAWGWRVPFLLSAILVIVGLVV 221
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGP----PLGGVLAQ----FLGWRAPFLFLAILALAAFIL 133
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
76-249 |
2.35e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.95 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 76 FAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQvgvaavaiLCLLRFIQGIGLGGEWSGAALV 155
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 156 ATENAPEDKRALYGSFPELGAPIGfflsngtyFVLESFNDQSAMLAWGWRVPFLLSAI--LVIVGLVVRvHMEETPIFRM 233
Cdd:PRK11551 128 TSEAVGPRLRGTAVSLMYCGVPFG--------GALASVIGVLAAGDAAWRHIFYVGGVgpLLLVPLLMR-WLPESRAFAQ 198
|
170
....*....|....*.
gi 1307912705 234 AQEQKKVVKSPLTEVF 249
Cdd:PRK11551 199 AAGAGKQRAPVLRALF 214
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
67-221 |
2.92e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 67 VALLMSLLTFAIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIgclptydqVGVAAVAILCLLRFIQGIGLG 146
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF--------ALGSSLWLLLLGFILWGLYMG 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1307912705 147 -GEWSGAALVAtENAPEDKRAL-YGSFpELGAPIGFFLSNGTYFVLESFndqsamlaWGWRVPFLLSAILVIVGLVV 221
Cdd:cd17370 303 aQESIERAAVA-DLVPAELRGTaYGLF-NTVVGIGWLLASLIAGYLWDL--------ISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
71-221 |
3.38e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 71 MSLLTFAIAFIarpLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYDQVGVAAVAIlcllrFIQGIGLGGEWS 150
Cdd:cd17321 208 LALLPLALAML---VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGL-----VLLGLGLGLFAT 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 151 GAALVATENAPEDKR----ALYGSFPELGAPIG---------FFLSNGTYFVLESFNDQSAMLAW--GWRVPFLLSAILV 215
Cdd:cd17321 280 PLTNAALSSVPKEKAgaasGILNTARQLGGALGvallgalltAGLSANLGDSGVAALLSAAAAAFaaGFHLAFLVAAALA 359
|
....*.
gi 1307912705 216 IVGLVV 221
Cdd:cd17321 360 LLAALL 365
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
198-440 |
4.56e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 198 AMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFrmAQEQKKVVKSPLTEVFRKSWRQVLQATFLVAVTYTLFYTLATWS 277
Cdd:cd17370 149 YLLGGNYRTIFLLAAIPALLALLILLFVVKEYPR--PPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRA 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 278 lawgtkdtanggGSLGFTNQEYLLMLMISICVFALFIVLSCLYADKLGRRRVLTFSscALVVFAVLFPFLldgqvvgqhn 357
Cdd:cd17370 227 ------------QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG--YLSLALAYLGFA---------- 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 358 FFANMVFLCVGFALMGIAFGPIG----AFLPELFDANVRYSGSGIgYNLAAIVGAAFVPTIATWLAHNWGVHSVGLYLAV 433
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQEsierAAVADLVPAELRGTAYGL-FNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAV 361
|
....*..
gi 1307912705 434 MAVCCLV 440
Cdd:cd17370 362 LALIALL 368
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
78-231 |
5.28e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.14 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 78 IAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTYdqvgvaavAILCLLRFIQGIGLGGEWSGAALVAT 157
Cdd:cd17438 42 IVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGY--------GAFLFCRLISGFGIGGSLPIVFAYFS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 158 ENAPEDKRALYGSFPELgapigFFLSNGTYfvlesfndqSAMLAWG-------------------WRVPFLLSAILVIVG 218
Cdd:cd17438 114 EFLAREKRGEHLSWLCM-----FWMIGGLY---------ASAMAWSiiphygwgfsmgtnyhfhsWRVFVIICALPCIAS 179
|
170
....*....|...
gi 1307912705 219 LVVRVHMEETPIF 231
Cdd:cd17438 180 IIALKFMPESPRF 192
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
77-369 |
6.12e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 77 AIAFIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGclptydqVGVAAVAILCLLRFIQGIGLGGEWSGAALVA 156
Cdd:TIGR00886 44 AVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAG-------LAVQSYSVLLLIRLFIGIAGGSFASCMPWIS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 157 TENAPEDK---RALYGSFPELGAPIGFFLSNGTYFVLESFNDQSAMLAWGWRVPFLLSAILVIVGLVVRVHMEETPIFRM 233
Cdd:TIGR00886 117 FFFPKKIQgtaLGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADTPPGKP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 234 AqEQKKVVKSPLtEVFRKSwrqvlqATFLVAVTYtlfytlatwSLAWGTKDTANGGGSLGFTNQEYLLMLMI----SICV 309
Cdd:TIGR00886 197 A-TGKLSFKEAL-KVFGNR------HTWILALLY---------SVTFGSFLGVSSIFAMLFKDQFGLSKVQAgayaSLGG 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1307912705 310 F--ALFIVLSCLYADKLGRRRVLTFSSC--ALVVFAVLFPFLLDGQVVGqhnFFANMVFLCVGF 369
Cdd:TIGR00886 260 FlgSLARPAGGAISDRLGGARKLLMNFLgvAMGAFLVVLGLVSDGSLAA---FIVLFVALFFFA 320
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
71-229 |
9.37e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.13 E-value: 9.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 71 MSLLTFAIAfIARPLGSLVFGHFGDRMGRKTTLVVSLMTMGVGTFLIGCLPTydqvgvaaVAILCLLRFIQGIGLGGEWS 150
Cdd:TIGR00881 32 LGLLLSSFS-IAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS--------LWVMAALWALNGIFQGMGWP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1307912705 151 GAALVATENAPEDKRALYGSFPELGAPIGFFLsnGTYFVLESFNdqsamLAWGWRVPFLLSAIL-VIVGLVVRVHMEETP 229
Cdd:TIGR00881 103 PCGRTVTKWFSRSERGTWVSFWNCSHNVGGGL--LPPLVLFGIA-----ELYSWHWVFIVPGIIaIIVSLICFLLLRDSP 175
|
|
| |
