insulin-like growth factor 1 transcript variant X1 [Feresa attenuata]
Protein Classification
insulin-like growth factor( domain architecture ID 10137882)
insulin-like growth factor (IlGF) plays a variety of roles in controlling processes such as growth, differentiation, and reproduction; on a cellular level they affect cell cycle, apoptosis, cell migration, proliferation, and differentiation; such as IlGF1 and IlGF2
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| IlGF | cd04368 | IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of ... |
49-116 | 2.05e-41 | ||
IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, proliferation, and differentiation. Typically, the active forms of these peptide hormones are single chains cross-linked by three disulfide bonds. : Pssm-ID: 239834 Cd Length: 67 Bit Score: 134.04 E-value: 2.05e-41
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| Name | Accession | Description | Interval | E-value | ||
| IlGF | cd04368 | IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of ... |
49-116 | 2.05e-41 | ||
IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, proliferation, and differentiation. Typically, the active forms of these peptide hormones are single chains cross-linked by three disulfide bonds. Pssm-ID: 239834 Cd Length: 67 Bit Score: 134.04 E-value: 2.05e-41
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| IlGF | smart00078 | Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, ... |
51-109 | 7.93e-22 | ||
Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration. Pssm-ID: 214506 Cd Length: 66 Bit Score: 84.01 E-value: 7.93e-22
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| Insulin | pfam00049 | Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth ... |
51-109 | 2.61e-18 | ||
Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. Pssm-ID: 459651 Cd Length: 77 Bit Score: 75.20 E-value: 2.61e-18
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| Name | Accession | Description | Interval | E-value | ||
| IlGF | cd04368 | IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of ... |
49-116 | 2.05e-41 | ||
IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, proliferation, and differentiation. Typically, the active forms of these peptide hormones are single chains cross-linked by three disulfide bonds. Pssm-ID: 239834 Cd Length: 67 Bit Score: 134.04 E-value: 2.05e-41
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| IlGF | smart00078 | Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, ... |
51-109 | 7.93e-22 | ||
Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration. Pssm-ID: 214506 Cd Length: 66 Bit Score: 84.01 E-value: 7.93e-22
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| IlGF_insulin_like | cd04367 | IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of ... |
49-109 | 1.06e-21 | ||
IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, and differentiation. With the exception of the insulin-like growth factors, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 239833 Cd Length: 79 Bit Score: 84.03 E-value: 1.06e-21
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| Insulin | pfam00049 | Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth ... |
51-109 | 2.61e-18 | ||
Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. Pssm-ID: 459651 Cd Length: 77 Bit Score: 75.20 E-value: 2.61e-18
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| IlGF_like | cd00101 | Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include ... |
53-109 | 2.01e-15 | ||
Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related peptides 1 to 5 (MIP), and C. elegans insulin-like peptides. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 238049 Cd Length: 41 Bit Score: 66.50 E-value: 2.01e-15
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| IlGF_insulin_bombyxin_like | cd04366 | IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides ... |
53-109 | 2.39e-08 | ||
IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related peptides 1 to 5 (MIP), and C. elegans insulin-like peptides. With the exception of insulin-like growth factors, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 239832 Cd Length: 42 Bit Score: 48.01 E-value: 2.39e-08
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| IlGF_relaxin_like | cd04365 | IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of ... |
53-109 | 4.42e-05 | ||
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), and insulin-like peptides 5 (INSL5) and 6 (INSL6). Members of this subgroup are widely expressed in testes (INSL3, INSL6), decidua, placenta, prostate, corpus luteum, brain (various relaxins), GI tract, and kidney (INSL5) where they serve a variety of functions in parturition and development. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 239831 Cd Length: 59 Bit Score: 39.61 E-value: 4.42e-05
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