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Conserved domains on  [gi|1305083152|gb|PKH45870|]
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recombinase family protein [Dehalococcoides mccartyi]

Protein Classification

recombinase family protein( domain architecture ID 10085488)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0000150|GO:0003677|GO:0006310|GO:0015074
PubMed:  21645851|26104451|11972771|16077726|9348666
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 9-141 6.91e-43

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


:

Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 138.16  E-value: 6.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   9 AYVRVSSVSQVEGYSLDAQERLFTELCKNRGWQSVRIYREEGKSAHvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDRWS 88
Cdd:cd00338     1 IYARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDAGSSAT--SLVDRPGLQRLLADVKAGKIDVVLVEKLDRLS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305083152  89 RNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:cd00338    79 RNLVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESKLIS 131
 
Name Accession Description Interval E-value
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 9-141 6.91e-43

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 138.16  E-value: 6.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   9 AYVRVSSVSQVEGYSLDAQERLFTELCKNRGWQSVRIYREEGKSAHvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDRWS 88
Cdd:cd00338     1 IYARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDAGSSAT--SLVDRPGLQRLLADVKAGKIDVVLVEKLDRLS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305083152  89 RNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:cd00338    79 RNLVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESKLIS 131
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 5-141 2.93e-40

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 138.62  E-value: 2.93e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   5 KRAVAYVRVSSVSQvEGYSLDAQERLFTELCKNRGWQSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTL 84
Cdd:COG1961     2 MRAAGYARVSTDDQ-EGLSLERQREALRAYAEKAGWEIVRIYVDEGVSG---TSKDRPGLQRLLADLRAGKFDTLVVWKL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305083152  85 DRWSRNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:COG1961    78 DRLGRNLADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELIS 134
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 7-141 3.23e-38

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 126.97  E-value: 3.23e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152    7 AVAYVRVSSVSQVEGySLDAQERLFTELCKNRGWQSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDR 86
Cdd:smart00857   1 AAGYARVSTDDQADG-SLERQLEALRAYAERNGWEVVRIYEDEGVSG---KKADRPGLQRLLADLRAGDIDVLVVYKLDR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1305083152   87 WSRNLTVTLESLKILGKHGIGLVSIVEN-LDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:smart00857  77 LGRSLRDLLALLELLEEKGVRLVSLKEGiLDTSTPAGRLLLDILAALAEFERELIS 132
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 7-141 2.39e-32

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 111.59  E-value: 2.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   7 AVAYVRVSSVSQveGYSLDAQERLFTELCKNRGwqSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDR 86
Cdd:pfam00239   1 AIGYARVSTEDQ--DDSLERQLEALRAYAACNG--KIVEFEDKGVSG---RKLDRPGLQRLLALLRAGKGDVLVVYKLDR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1305083152  87 WSRNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:pfam00239  74 LGRSLRDLLTLVEELREKGVDLVSLDEGIDTSTPMGRLLLTILAALAEFERALIR 128
 
Name Accession Description Interval E-value
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 9-141 6.91e-43

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 138.16  E-value: 6.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   9 AYVRVSSVSQVEGYSLDAQERLFTELCKNRGWQSVRIYREEGKSAHvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDRWS 88
Cdd:cd00338     1 IYARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDAGSSAT--SLVDRPGLQRLLADVKAGKIDVVLVEKLDRLS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305083152  89 RNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:cd00338    79 RNLVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESKLIS 131
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 5-141 2.93e-40

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 138.62  E-value: 2.93e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   5 KRAVAYVRVSSVSQvEGYSLDAQERLFTELCKNRGWQSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTL 84
Cdd:COG1961     2 MRAAGYARVSTDDQ-EGLSLERQREALRAYAEKAGWEIVRIYVDEGVSG---TSKDRPGLQRLLADLRAGKFDTLVVWKL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1305083152  85 DRWSRNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:COG1961    78 DRLGRNLADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELIS 134
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 7-141 3.23e-38

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 126.97  E-value: 3.23e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152    7 AVAYVRVSSVSQVEGySLDAQERLFTELCKNRGWQSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDR 86
Cdd:smart00857   1 AAGYARVSTDDQADG-SLERQLEALRAYAERNGWEVVRIYEDEGVSG---KKADRPGLQRLLADLRAGDIDVLVVYKLDR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1305083152   87 WSRNLTVTLESLKILGKHGIGLVSIVEN-LDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:smart00857  77 LGRSLRDLLALLELLEEKGVRLVSLKEGiLDTSTPAGRLLLDILAALAEFERELIS 132
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 7-141 2.39e-32

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 111.59  E-value: 2.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   7 AVAYVRVSSVSQveGYSLDAQERLFTELCKNRGwqSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTLDR 86
Cdd:pfam00239   1 AIGYARVSTEDQ--DDSLERQLEALRAYAACNG--KIVEFEDKGVSG---RKLDRPGLQRLLALLRAGKGDVLVVYKLDR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1305083152  87 WSRNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQYFSEALS 141
Cdd:pfam00239  74 LGRSLRDLLTLVEELREKGVDLVSLDEGIDTSTPMGRLLLTILAALAEFERALIR 128
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 7-135 7.42e-27

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 97.17  E-value: 7.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   7 AVAYVRVSSVSQvegySLDAQERLFTELCKNrgwqsVRIYREEGKSAHVDsihkRPVFRKLLEDAakDEFDVVVVHTLDR 86
Cdd:cd03768     1 VIGYARVSTDDQ----SLERQLEALKAAGEC-----DKIFEEKGSGGKKE----RPELQKLLEDL--REGDTLVVTKLDR 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1305083152  87 WSRNLTVTLESLKILGKHGIGLVSIVENLDYSKPDGILFTQMLGAFAQY 135
Cdd:cd03768    66 LGRSTKDLLEIVEELREKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEF 114
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 7-116 2.26e-09

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 52.37  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   7 AVAYVRVSS--VSQVEGYSLDAQERLFTELCKNRGWQSVRIYREEGKSAhvdSIHKRPVFRKLLEDAAKDEFDVVVVHTL 84
Cdd:cd03770     1 TALYCRLSRddDLDGESNSIENQKAILEEYAKENGLENIRHYIDDGFSG---TTFDRPGFNRMIEDIEAGKIDIVIVKDM 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1305083152  85 DRWSRN-LTVTLESLKILGKHGIGLVSIVENLD 116
Cdd:cd03770    78 SRLGRNyLKVGLYMEILFPKKGVRFIAINDGVD 110
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 7-111 1.49e-06

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 44.56  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   7 AVAYVRVSSVSQVEGysLDAQERLFTELCKNRGWQsVRIYREEGKSAHvdsiHKRPVFRKLLEDAAKDEFDVVVVHTLDR 86
Cdd:cd03769     1 TVLYARVSSHDQKDD--LERQIERLEAYATAQGWI-VEVIKDIGSGLN----EKRKGLLKLLEDVLAGKVERVVITYKDR 73

                          90       100
                  ....*....|....*....|....*
gi 1305083152  87 WSRNLTVTLESLkiLGKHGIGLVSI 111
Cdd:cd03769    74 LARFGFELLEEL--FKAYGVEIVVI 96
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 9-140 9.00e-05

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 40.00  E-value: 9.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1305083152   9 AYVRVSSVSQvegySLDAQERLFTELCKNRGWQSVRIYREEGKSAHVDsihkRPVFRKLLEDAakDEFDVVVVHTLDRWS 88
Cdd:cd03767     3 AYLRASTDEQ----DATRAKESLEAFATERGFYIAGFYVENASGAKLD----RPELFRLLDDA--QSGDVLLVEQIDRLS 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1305083152  89 RNLTVTLESLK-ILGKHGIGLVSivenldyskPDGILFTQMLGAFAQYFSEAL 140
Cdd:cd03767    73 RLPLDDWETLKaSIAAKGLRVVS---------LDLPTSHSALAAEDNDFTGRI 116
PGDH_like_2 cd12172
Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; ...
 64-134 8.75e-03

Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.


Pssm-ID: 240649 [Multi-domain]  Cd Length: 306  Bit Score: 35.16  E-value: 8.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1305083152  64 FRKLLEDAakdefDVVVVHTlDRWSRNLTVTLESLKILGKHGIGLVSIveNLDYSKPDGILFTQMLGAFAQ 134
Cdd:cd12172    41 LIELLKDA-----DGVIAGL-DPITEEVLAAAPRLKVISRYGVGYDNI--DLEAAKKRGIVVTNTPGANSN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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