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Conserved domains on  [gi|1304171660|gb|PKC43685|]
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hypothetical protein CK202_4915 [Plasmodium falciparum NF54]

Protein Classification

PRESAN domain-containing protein( domain architecture ID 10560507)

PRESAN (Plasmodium RESA N-terminal) domain-containing protein, similar to Plasmodium falciparum PHIST protein that binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 121-244 3.33e-23

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


:

Pssm-ID: 430754  Cd Length: 125  Bit Score: 91.57  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304171660 121 LSNEQIKEKIDSLGEVVSVQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLSQYYDIPENIKKKCWLKASYEMEETLINK 200
Cdd:pfam09687   2 LTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKKKLWKECYKEITKELKKK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1304171660 201 ENFFFKNFHVFANIGERKRSSLLDAIYGYQKKWKEVRYTVDETW 244
Cdd:pfam09687  82 EKFYNKDFYSFLNKGKLSRDEFKEFINSCRKSWKKLRKELEKKW 125
 
Name Accession Description Interval E-value
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 121-244 3.33e-23

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


Pssm-ID: 430754  Cd Length: 125  Bit Score: 91.57  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304171660 121 LSNEQIKEKIDSLGEVVSVQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLSQYYDIPENIKKKCWLKASYEMEETLINK 200
Cdd:pfam09687   2 LTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKKKLWKECYKEITKELKKK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1304171660 201 ENFFFKNFHVFANIGERKRSSLLDAIYGYQKKWKEVRYTVDETW 244
Cdd:pfam09687  82 EKFYNKDFYSFLNKGKLSRDEFKEFINSCRKSWKKLRKELEKKW 125
P_fal_TIGR01639 TIGR01639
Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved ...
 112-172 4.41e-14

Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved sequence region of about 60 amino acids found in over 40 predicted proteins of Plasmodium falciparum. It is not found elsewhere, including closely related species such as Plasmodium yoelii. No member of this family is characterized.


Pssm-ID: 130700  Cd Length: 61  Bit Score: 65.35  E-value: 4.41e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1304171660 112 LRNKNHQRVLSNEQIKEKIDSLGEVVSVQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLS 172
Cdd:TIGR01639   1 IKYNDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQKLV 61
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 128-246 2.98e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 39.00  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304171660  128 EKIDSLGEVVS--VQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLSQYYDIPENIKKKCW---LKASYEMEETLINKEN 202
Cdd:PTZ00341   176 EKVDNLGRSGGdiIKKMQTLWDEIMDINKRKYDFLKEKLQKTYSQYKVQYDMPKEAYESKWgqcIKLIDQGGDNLEERLN 255

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1304171660  203 FFFKNFH--VFANIGERKRSSLLDAIygyqkKWKEVRYTVDETWRE 246
Cdd:PTZ00341   256 SQFKNWYrqKYLNLEEYRRLTVLNQI-----AWKALSNQIQYSCRK 296
 
Name Accession Description Interval E-value
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 121-244 3.33e-23

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


Pssm-ID: 430754  Cd Length: 125  Bit Score: 91.57  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304171660 121 LSNEQIKEKIDSLGEVVSVQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLSQYYDIPENIKKKCWLKASYEMEETLINK 200
Cdd:pfam09687   2 LTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKKKLWKECYKEITKELKKK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1304171660 201 ENFFFKNFHVFANIGERKRSSLLDAIYGYQKKWKEVRYTVDETW 244
Cdd:pfam09687  82 EKFYNKDFYSFLNKGKLSRDEFKEFINSCRKSWKKLRKELEKKW 125
P_fal_TIGR01639 TIGR01639
Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved ...
 112-172 4.41e-14

Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved sequence region of about 60 amino acids found in over 40 predicted proteins of Plasmodium falciparum. It is not found elsewhere, including closely related species such as Plasmodium yoelii. No member of this family is characterized.


Pssm-ID: 130700  Cd Length: 61  Bit Score: 65.35  E-value: 4.41e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1304171660 112 LRNKNHQRVLSNEQIKEKIDSLGEVVSVQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLS 172
Cdd:TIGR01639   1 IKYNDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQKLV 61
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 128-246 2.98e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 39.00  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304171660  128 EKIDSLGEVVS--VQDMHKIFDLIHDNEKKKFFNMKEDIHEYSEKLSQYYDIPENIKKKCW---LKASYEMEETLINKEN 202
Cdd:PTZ00341   176 EKVDNLGRSGGdiIKKMQTLWDEIMDINKRKYDFLKEKLQKTYSQYKVQYDMPKEAYESKWgqcIKLIDQGGDNLEERLN 255

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1304171660  203 FFFKNFH--VFANIGERKRSSLLDAIygyqkKWKEVRYTVDETWRE 246
Cdd:PTZ00341   256 SQFKNWYrqKYLNLEEYRRLTVLNQI-----AWKALSNQIQYSCRK 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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