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Conserved domains on  [gi|13027430|ref|NP_076465|]
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WD repeat-containing protein 7 isoform 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822067)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-594 7.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 7.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  407 LKVTASVYIPAHGRLVCGREDGSIIIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYpHQvsaryDQRYLI 486
Cdd:cd00200   52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECV----------------RTLTGHTSYVSSVAF-SP-----DGRILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  487 SGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVASDHSVGLLSLREKKCIMLASRHLFPIQVI 566
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183

                        170       180
                 ....*....|....*....|....*...
gi 13027430  567 KWRPSDDYLVVGCTDGSVCVWQMDTGAL 594
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
1364-1424 9.73e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 9.73e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027430 1364 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFWQMNT 1424
Cdd:COG2319  133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
16-189 4.01e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   16 KAPTHCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVnprALLFGHTAAITCLskaCASGDKQYTVSASANGEMCLWD 95
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSV---AFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   96 VNDGRCIEftklacTHTGIQFYQFSVGNQREGRLLCHGHYPE-ILVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqe 174
Cdd:COG2319  317 LATGKLLR------TLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR--- 385

                        170
                 ....*....|....*
gi 13027430  175 dTVVALSVTGILKVW 189
Cdd:COG2319  386 -TLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-594 7.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 7.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  407 LKVTASVYIPAHGRLVCGREDGSIIIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYpHQvsaryDQRYLI 486
Cdd:cd00200   52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECV----------------RTLTGHTSYVSSVAF-SP-----DGRILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  487 SGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVASDHSVGLLSLREKKCIMLASRHLFPIQVI 566
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183

                        170       180
                 ....*....|....*....|....*...
gi 13027430  567 KWRPSDDYLVVGCTDGSVCVWQMDTGAL 594
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
458-596 7.93e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 7.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  458 RTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVA 537
Cdd:COG2319  156 RTLTGHSGAVTSV----AFSP--DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG------KLLASGS 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027430  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTGALDR 596
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
1364-1424 9.73e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 9.73e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027430 1364 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFWQMNT 1424
Cdd:COG2319  133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
16-189 4.01e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   16 KAPTHCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVnprALLFGHTAAITCLskaCASGDKQYTVSASANGEMCLWD 95
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSV---AFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   96 VNDGRCIEftklacTHTGIQFYQFSVGNQREGRLLCHGHYPE-ILVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqe 174
Cdd:COG2319  317 LATGKLLR------TLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR--- 385

                        170
                 ....*....|....*
gi 13027430  175 dTVVALSVTGILKVW 189
Cdd:COG2319  386 -TLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 8.44e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 8.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   19 THCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVnprALLFGHTAAITCLskaCASGDKQYTVSASANGEMCLWDVND 98
Cdd:cd00200  177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                 ....
gi 13027430   99 GRCI 102
Cdd:cd00200  251 GECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1355-1424 2.59e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 2.59e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027430 1355 YMVSYYERSHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSE-DGTIRVWDLRT 250
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1382-1420 3.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 3.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 13027430    1382 TGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFW 1420
Cdd:smart00320    1 SGELlKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
1386-1420 1.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 13027430   1386 QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFW 1420
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
454-498 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 13027430    454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-498 2.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 13027430     454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP------DGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 22-189 1.99e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.37  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430     22 ISSILLTDDGGTIVTGCHDGQICLWDL----SEELEV----------------NPRALLFGHTAAITCLskaCASGDKQY 81
Cdd:pfam20426  127 VSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSrntqtefprkdhviaeTPFHILCGHDDIITCL---YVSVELDI 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430     82 TVSASANGEMCLWDVNDGRCIE---------FTKLACTHTG-IQFYQ--------FSVGNQR------EGRL-------- 129
Cdd:pfam20426  204 VISGSKDGTCIFHTLREGRYVRsirhpsgcpLSKLVASRHGrIVLYAdddlslhlYSINGKHiassesNGRLncielssc 283

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027430    130 ----LCHGHYPEILVVDATSLEVL--YSLVSKIspdwISSMSIirshrTQEDTVVALSVTGILKVW 189
Cdd:pfam20426  284 geflVCAGDQGQIVVRSMNSLEVVrrYNGIGKI----ITSLTV-----TPEECFLAGTKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-47 2.21e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.21e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 13027430      16 KAPTHCISSILLTDDGGTIVTGCHDGQICLWD 47
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-594 7.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 7.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  407 LKVTASVYIPAHGRLVCGREDGSIIIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYpHQvsaryDQRYLI 486
Cdd:cd00200   52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECV----------------RTLTGHTSYVSSVAF-SP-----DGRILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  487 SGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVASDHSVGLLSLREKKCIMLASRHLFPIQVI 566
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183

                        170       180
                 ....*....|....*....|....*...
gi 13027430  567 KWRPSDDYLVVGCTDGSVCVWQMDTGAL 594
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-592 2.24e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 2.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  456 PHRTLRGHRNKVTCllyphqVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLvppenCSARvQHCVCS 535
Cdd:cd00200    1 LRRTLKGHTGGVTC------VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-----ASAD-GTYLAS 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027430  536 VASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTG 592
Cdd:cd00200   69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-592 1.28e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  408 KVTASVYIPAHGRLVCGREDGSIIivpatqtaIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIK--------VWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200   69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                        170       180
                 ....*....|....*....|....*
gi 13027430  568 WRPSDDYLVVGCTDGSVCVWQMDTG 592
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
458-596 7.93e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 7.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  458 RTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVA 537
Cdd:COG2319  156 RTLTGHSGAVTSV----AFSP--DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG------KLLASGS 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027430  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTGALDR 596
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
458-594 2.56e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 2.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  458 RTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvQHCVcSVA 537
Cdd:COG2319  198 RTLTGHTGAVRSV----AFSP--DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-----RLLA-SGS 265

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027430  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTGAL 594
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
409-596 6.15e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 6.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  409 VTASVYIPAHGRLVCGREDGSIIIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYphqvSAryDQRYLISG 488
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----------------RTLTGHSGSVRSVAF----SP--DGRLLASG 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  489 GVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvQHcVCSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKW 568
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----KL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                        170       180
                 ....*....|....*....|....*...
gi 13027430  569 RPSDDYLVVGCTDGSVCVWQMDTGALDR 596
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 COG2319
WD40 repeat [General function prediction only];
1364-1424 9.73e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 9.73e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027430 1364 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFWQMNT 1424
Cdd:COG2319  133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
1363-1427 1.46e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.46e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027430 1363 SHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNTSLL 1427
Cdd:COG2319  216 GKLLASGSADGTVRLWDLATGKLlRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
1364-1424 1.66e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.66e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027430 1364 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
16-189 4.01e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   16 KAPTHCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVnprALLFGHTAAITCLskaCASGDKQYTVSASANGEMCLWD 95
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSV---AFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   96 VNDGRCIEftklacTHTGIQFYQFSVGNQREGRLLCHGHYPE-ILVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqe 174
Cdd:COG2319  317 LATGKLLR------TLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR--- 385

                        170
                 ....*....|....*
gi 13027430  175 dTVVALSVTGILKVW 189
Cdd:COG2319  386 -TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 6.06e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 6.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   22 ISSILLTDDGGTIVTGCHDGQICLWDLSEElevNPRALLFGHTAAITCLSkacASGDKQYTVSASANGEMCLWDVNDGRC 101
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGTVRLWDLATG---KLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319  197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                 ....*...
gi 13027430  182 VTGILKVW 189
Cdd:COG2319  266 ADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 8.44e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 8.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   19 THCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVnprALLFGHTAAITCLskaCASGDKQYTVSASANGEMCLWDVND 98
Cdd:cd00200  177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                 ....
gi 13027430   99 GRCI 102
Cdd:cd00200  251 GECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
1363-1424 9.65e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 9.65e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027430 1363 SHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSA-DGTVRLWDLAT 235
WD40 COG2319
WD40 repeat [General function prediction only];
11-98 1.28e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   11 VLWGRKAPTHCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVNPralLFGHTAAITCLSkacASGDKQYTVSASANGE 90
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---LTGHTGAVTSVA---FSPDGRTLASGSADGT 395


                 ....*...
gi 13027430   91 MCLWDVND 98
Cdd:COG2319  396 VRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
1364-1424 1.83e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.83e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027430 1364 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:COG2319  343 KTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLASGSA-DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1355-1424 2.59e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 2.59e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027430 1355 YMVSYYERSHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSE-DGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
10-189 4.55e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 4.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   10 IVLW----GR-----KAPTHCISSILLTDDGGTIVTGCHDGQICLWDLSEElevNPRALLFGHTAAITCLSkacASGDKQ 80
Cdd:COG2319  144 VRLWdlatGKllrtlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVA---FSPDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   81 YTVSASANGEMCLWDVNDGRCIEFTKlacTHTG-IQFYQFSvgnqREGRLLCHGHY-PEILVVDATSLEVLYSLvsKISP 158
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLT---GHSGsVRSVAFS----PDGRLLASGSAdGTVRLWDLATGELLRTL--TGHS 288

                        170       180       190
                 ....*....|....*....|....*....|.
gi 13027430  159 DWISSMSIIRSHRtqedTVVALSVTGILKVW 189
Cdd:COG2319  289 GGVNSVAFSPDGK----LLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-588 5.12e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 5.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  458 RTLRGHRNKVTCllyphqVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCVCSVA 537
Cdd:cd00200  171 ATLTGHTGEVNS------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGS 238

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 13027430  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQ 588
Cdd:cd00200  239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1365-1424 6.24e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 6.24e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027430 1365 RIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:COG2319  302 LLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSD-DGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-274 7.63e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   16 KAPTHCISSILLTDDGGTIVTGCHDGQICLWDLSEELEVNPralLFGHTAAITCLSkacASGDKQYTVSASANGEMCLWD 95
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVA---FSPDGRILSSSSRDKTIKVWD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   96 VNDGRCIefTKLACtHTG-IQFYQFSvgnqREGRLLCHGHYP-EILVVDATSLEVLYSLvsKISPDWISSMSIIRShrtq 173
Cdd:cd00200  122 VETGKCL--TTLRG-HTDwVNSVAFS----PDGTFVASSSQDgTIKLWDLRTGKCVATL--TGHTGEVNSVAFSPD---- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  174 EDTVVALSVTGILKVWivtsEISGLQDTEpIFEEESKPIYCqncqslsfCAFTQRSLLVVCSKYW---RVFDAGDYSLLC 250
Cdd:cd00200  189 GEKLLSSSSDGTIKLW----DLSTGKCLG-TLRGHENGVNS--------VAFSPDGYLLASGSEDgtiRVWDLRTGECVQ 255

                        250       260       270
                 ....*....|....*....|....*....|...
gi 13027430  251 SGPSEDGQTW------TGGDFVSA--DK-VIIW 274
Cdd:cd00200  256 TLSGHTNSVTslawspDGKRLASGsaDGtIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1362-1424 1.41e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.41e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027430 1362 RSHRIAVGA-RHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:cd00200  103 PDGRILSSSsRDKTIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQ-DGTIKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
450-596 3.28e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  450 LRRGWPPHRTLRGHRNKVTcllyphQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT--------QLLVp 521
Cdd:COG2319   64 DAAAGALLATLLGHTAAVL------SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRsvafspdgKTLA- 136

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027430  522 pencsarvqhcvcSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTGALDR 596
Cdd:COG2319  137 -------------SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198
WD40 COG2319
WD40 repeat [General function prediction only];
1364-1424 7.99e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 7.99e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027430 1364 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLlRTLTGHTGAVRSVAFSPDGKTLASGSA-DGTVRLWDLAT 151
WD40 COG2319
WD40 repeat [General function prediction only];
22-102 1.80e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   22 ISSILLTDDGGTIVTGCHDGQICLWDLSEELevnPRALLFGHTAAITCLSkacASGDKQYTVSASANGEMCLWDVNDGRC 101
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLATGKL 154


                 .
gi 13027430  102 I 102
Cdd:COG2319  155 L 155
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1363-1424 2.13e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 2.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027430 1363 SHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFWQMNT 1424
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCvATLTGHTGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1357-1424 3.37e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 3.37e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13027430 1357 VSYYERSHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFWQMNT 1424
Cdd:cd00200   57 VAASADGTYLASGSSDKTIRLWDLETGECvRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVET 124
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-102 2.12e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430   22 ISSILLTDDGGTIVTGCHDGQICLWDLSEELevnPRALLFGHTAAITCLSkacASGDKQYTVSASANGEMCLWDVNDGRC 101
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVA---ASADGTYLASGSSDKTIRLWDLETGEC 85


                 .
gi 13027430  102 I 102
Cdd:cd00200   86 V 86
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1366-1421 2.61e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 2.61e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027430 1366 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVSFAPDGRYLATYSnTDSHISFWQ 1421
Cdd:cd00200  234 LASGSEDGTIRVWDLRTGECvQTLSGHTNSVTSLAWSPDGKRLASGS-ADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1382-1420 3.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 3.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 13027430    1382 TGKC-QTIHGHKGPITAVSFAPDGRYLATYSNtDSHISFW 1420
Cdd:smart00320    1 SGELlKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 457-542 4.59e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 4.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  457 HRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCsarvqhCVCSV 536
Cdd:cd00200  212 LGTLRGHENGVNSVAFSP------DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK------RLASG 279


                 ....*.
gi 13027430  537 ASDHSV 542
Cdd:cd00200  280 SADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
476-594 1.01e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430  476 VSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARvqhcvcSVASDHSVGLLSLREKKCIML 555
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA------SASADGTVRLWDLATGLLLRT 115

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13027430  556 ASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTGAL 594
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154
WD40 pfam00400
WD domain, G-beta repeat;
1386-1420 1.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 13027430   1386 QTIHGHKGPITAVSFAPDGRYLATySNTDSHISFW 1420
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
454-498 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 13027430    454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-95 1.70e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027430   22 ISSILLTDDGGTIVTGCHDGQICLWDLSEELEVnprALLFGHTAAITCLskaCASGDKQYTVSASANGEMCLWD 95
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV---QTLSGHTNSVTSL---AWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-498 2.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 13027430     454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP------DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1363-1424 6.13e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 6.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027430 1363 SHRIAVGARHGSVALYDIRTGKCQ-TIHGHKGPITAVSFAPDGRYLATYSNtDSHISFWQMNT 1424
Cdd:cd00200   21 GKLLATGSGDGTIKVWDLETGELLrTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 550-587 1.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 13027430     550 KKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVW 587
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 22-189 1.99e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.37  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430     22 ISSILLTDDGGTIVTGCHDGQICLWDL----SEELEV----------------NPRALLFGHTAAITCLskaCASGDKQY 81
Cdd:pfam20426  127 VSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSrntqtefprkdhviaeTPFHILCGHDDIITCL---YVSVELDI 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027430     82 TVSASANGEMCLWDVNDGRCIE---------FTKLACTHTG-IQFYQ--------FSVGNQR------EGRL-------- 129
Cdd:pfam20426  204 VISGSKDGTCIFHTLREGRYVRsirhpsgcpLSKLVASRHGrIVLYAdddlslhlYSINGKHiassesNGRLncielssc 283

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027430    130 ----LCHGHYPEILVVDATSLEVL--YSLVSKIspdwISSMSIirshrTQEDTVVALSVTGILKVW 189
Cdd:pfam20426  284 geflVCAGDQGQIVVRSMNSLEVVrrYNGIGKI----ITSLTV-----TPEECFLAGTKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-47 2.21e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.21e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 13027430      16 KAPTHCISSILLTDDGGTIVTGCHDGQICLWD 47
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1362-1424 3.35e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.44  E-value: 3.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027430 1362 RSHRIAVGARHGSVALYDIRTGKcqTIHGHKG----PITAVSFAPDGRYLATYSnTDSHISFWQMNT 1424
Cdd:cd22857  234 DGHTVYVGDTSGDLASIDLRTGK--LLGCFKGkcggSIRSIARHPELPLIASCG-LDRYLRIWDTET 297
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 1363-1415 6.18e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 6.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13027430 1363 SHRIAVGARHGSVALYDIRTGKCQTI--HGHKGPITAVSFAPDGRYLAtYSNTDS 1415
Cdd:COG4946  400 GKKIAFTDNRGRLWVVDLASGKVRKVdtDGYGDGISDLAWSPDSKWLA-YSKPGP 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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