Chain A, C-C motif chemokine 20
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Chemokine super family | cl00134 | Chemokine: small cytokines, including a number of secreted growth factors and interferons ... |
4-63 | 1.59e-25 | ||
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups. The actual alignment was detected with superfamily member cd01119: Pssm-ID: 469625 Cd Length: 61 Bit Score: 88.62 E-value: 1.59e-25
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| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CC_DCCL | cd01119 | Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ... |
4-63 | 1.59e-25 | ||
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238539 Cd Length: 61 Bit Score: 88.62 E-value: 1.59e-25
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| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
4-63 | 8.82e-20 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 74.23 E-value: 8.82e-20
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| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
5-63 | 3.23e-16 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 64.96 E-value: 3.23e-16
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| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CC_DCCL | cd01119 | Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ... |
4-63 | 1.59e-25 | ||
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238539 Cd Length: 61 Bit Score: 88.62 E-value: 1.59e-25
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| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
4-63 | 8.82e-20 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 74.23 E-value: 8.82e-20
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| Chemokine | cd00169 | Chemokine: small cytokines, including a number of secreted growth factors and interferons ... |
6-63 | 1.02e-17 | ||
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups. Pssm-ID: 238098 Cd Length: 59 Bit Score: 68.90 E-value: 1.02e-17
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| Chemokine_CC | cd00272 | Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
6-63 | 1.43e-16 | ||
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD. Pssm-ID: 238170 Cd Length: 57 Bit Score: 66.11 E-value: 1.43e-16
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| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
5-63 | 3.23e-16 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 64.96 E-value: 3.23e-16
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| Chemokine_C | cd00271 | Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on ... |
7-61 | 2.94e-05 | ||
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) subclass. The two other subclasses each have a single known member: fractalkine for the CX3C (cd00274) class and lymphotactin for the C (cd00271) class. Chemokine_Cs differ structurally since they contain only one of the two disulfide bridges that are conserved in all other chemokines and they possess a unique C-terminal extension, which is required for biological activity and thought to play a role in receptor binding. Lymphotactin, a mediator of mucosal immunity, has been found to chemoattract neutrophils and B cells through the XCR1 receptor and thought to be a factor in acute allograft rejection and inflammatory bowel disease. Pssm-ID: 238169 Cd Length: 72 Bit Score: 37.91 E-value: 2.94e-05
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| Chemokine_CX3C | cd00274 | Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
26-57 | 7.25e-04 | ||
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups. Pssm-ID: 238172 Cd Length: 76 Bit Score: 34.27 E-value: 7.25e-04
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