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Conserved domains on  [gi|1285024735|ref|XP_023024651|]
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TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, partial [Leptinotarsa decemlineata]

Protein Classification

zinc finger Ran-binding domain-containing protein( domain architecture ID 10650940)

zinc finger Ran-binding domain-containing protein; similar to human zinc finger Ran-binding domain-containing protein 2 (ZRANB2) which is a splice factor required for alternative splicing of TRA2B/SFRS10 transcripts and whose zinc finger domains bind single-stranded RNA, and to the zinc finger domain of human TAK1-binding protein 2 (TAB2) which binds Lys 63-linked polyubiquitin chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 379-490 4.03e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.55  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 379 ARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ--------------------LTMEIRHLRRQCKVLEL 438
Cdd:COG1579    31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEArikkyeeqlgnvrnnkeyeaLQKEIESLKRRISDLED 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1285024735 439 DapvILKQEARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ 490
Cdd:COG1579   111 E---ILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 558-581 2.10e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 38.84  E-value: 2.10e-04
                           10        20
                   ....*....|....*....|....
gi 1285024735  558 KWNCGICTFLNHPILDKCEQCEMP 581
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
PRK14957 super family cl33042
DNA polymerase III subunits gamma and tau; Provisional
 19-153 2.68e-03

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14957:

Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 40.84  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  19 CITSYLQSNSQGQDLNIaDLLETALAENNSEQMGRLSQQLETPPLDQALIPDPQDDSA----QLIGSHSESaILSSTSDE 94
Cdd:PRK14957  293 CIYSFTQSLDAVNDIDV-DIINNILAKISIEQAHFLYQLTITAKKDIALAPNFETGVTmailRLIAFQKKN-LIDKTQTS 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1285024735  95 RNRVEMIESDSDIN--RNLIKPSVPNPTPreppKTIAKRPNKLDITSDCDAISDDKRKFNI 153
Cdd:PRK14957  371 KSNISPIVSKNDINllKNTFKSEQPKQTV----KAVVAQNNDSTASENTQEQSLDKKWFNL 427
 
Name Accession Description Interval E-value
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 379-490 4.03e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.55  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 379 ARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ--------------------LTMEIRHLRRQCKVLEL 438
Cdd:COG1579    31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEArikkyeeqlgnvrnnkeyeaLQKEIESLKRRISDLED 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1285024735 439 DapvILKQEARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ 490
Cdd:COG1579   111 E---ILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 558-581 2.10e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 38.84  E-value: 2.10e-04
                           10        20
                   ....*....|....*....|....
gi 1285024735  558 KWNCGICTFLNHPILDKCEQCEMP 581
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
PRK12704 PRK12704
phosphodiesterase; Provisional
 376-501 2.56e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.00  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 376 KQEAR--IERLRIELNTEK-AKLVIMKQEV----ADLEKNRLEKLADI-EMEKQLTMEIRHLRRQCKVLEldapvilKQE 447
Cdd:PRK12704   37 EEEAKriLEEAKKEAEAIKkEALLEAKEEIhklrNEFEKELRERRNELqKLEKRLLQKEENLDRKLELLE-------KRE 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1285024735 448 ARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADI--------------EMEKQLTMEIRHLRRQ 501
Cdd:PRK12704  110 EELEKKEKELEQKQQELEKKEEELEELIEEQLQELERIsgltaeeakeilleKVEEEARHEAAVLIKE 177
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 378-516 1.03e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  378 EARIERLRIELNTEKAKLVIMKQEVADLEKnRLEKLAD------------IEMEKQLTMEIRHLRRQCKVL-----ELDA 440
Cdd:TIGR02169  363 KEELEDLRAELEEVDKEFAETRDELKDYRE-KLEKLKReinelkreldrlQEELQRLSEELADLNAAIAGIeakinELEE 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  441 PV------ILKQEARIERLRIELNTEKAKLVIMKQEVADLEKnRLEKLAD--IEMEKQLTM---EIRHLRRQCKVLELDG 509
Cdd:TIGR02169  442 EKedkaleIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEK-ELSKLQRelAEAEAQARAseeRVRGGRAVEEVLKASI 520


                   ....*..
gi 1285024735  510 EAFYNNI 516
Cdd:TIGR02169  521 QGVHGTV 527
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 368-510 1.04e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 368 SSQPPVILKQEARIERLRIElnTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ-----LTMEIRHLRRQcKVLELDAPV 442
Cdd:pfam17380 337 AEQERMAMERERELERIRQE--ERKRELERIRQEEIAMEISRMRELERLQMERQqknerVRQELEAARKV-KILEEERQR 413

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1285024735 443 ILKQEARiERLRIELNTEKAKlvimKQEVADLEKNR---LEKLADIEMEKQLTMEI---RHLRRQCKVLELDGE 510
Cdd:pfam17380 414 KIQQQKV-EMEQIRAEQEEAR----QREVRRLEEERareMERVRLEEQERQQQVERlrqQEEERKRKKLELEKE 482
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 19-153 2.68e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 40.84  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  19 CITSYLQSNSQGQDLNIaDLLETALAENNSEQMGRLSQQLETPPLDQALIPDPQDDSA----QLIGSHSESaILSSTSDE 94
Cdd:PRK14957  293 CIYSFTQSLDAVNDIDV-DIINNILAKISIEQAHFLYQLTITAKKDIALAPNFETGVTmailRLIAFQKKN-LIDKTQTS 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1285024735  95 RNRVEMIESDSDIN--RNLIKPSVPNPTPreppKTIAKRPNKLDITSDCDAISDDKRKFNI 153
Cdd:PRK14957  371 KSNISPIVSKNDINllKNTFKSEQPKQTV----KAVVAQNNDSTASENTQEQSLDKKWFNL 427
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 381-508 9.53e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.85  E-value: 9.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  381 IERLRIELNTEkakLVIMKQEVADLEKNrLEKLADI-----EMEKQLTMEIRHLRRQCKVLELDAPVILKqearieRLRI 455
Cdd:smart00787 142 LEGLKEGLDEN---LEGLKEDYKLLMKE-LELLNSIkpklrDRKDALEEELRQLKQLEDELEDCDPTELD------RAKE 211

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  456 ELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQL-------TMEIRHLRRQCKVLELD 508
Cdd:smart00787 212 KLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKkselnteIAEAEKKLEQCRGFTFK 271
 
Name Accession Description Interval E-value
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 379-490 4.03e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.55  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 379 ARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ--------------------LTMEIRHLRRQCKVLEL 438
Cdd:COG1579    31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEArikkyeeqlgnvrnnkeyeaLQKEIESLKRRISDLED 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1285024735 439 DapvILKQEARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ 490
Cdd:COG1579   111 E---ILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 365-491 1.34e-06

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 51.62  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 365 LAVSSQPPVILKQEARIERLRIELN--------TEKAKLVIMKQEVADLEKNRLEKLADIEMEKQLTMEIRHLRRQckvL 436
Cdd:COG0542   404 MEIDSKPEELDELERRLEQLEIEKEalkkeqdeASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEE---L 480

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1285024735 437 ELDAPVILKQEARIERLRIELNTEKA--KLVIMKQEVAD------------LEKNRLEKLadIEMEKQL 491
Cdd:COG0542   481 EQRYGKIPELEKELAELEEELAELAPllREEVTEEDIAEvvsrwtgipvgkLLEGEREKL--LNLEEEL 547
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 378-501 9.88e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 9.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 378 EARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADI----EMEKQLTMEIRHLRRQCKVLELDapvILKQEARIERL 453
Cdd:COG1196   266 EAELEELRLELEELELELEEAQAEEYELLAELARLEQDIarleERRRELEERLEELEEELAELEEE---LEELEEELEEL 342

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1285024735 454 RIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQLTMEIRHLRRQ 501
Cdd:COG1196   343 EEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 558-581 2.10e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 38.84  E-value: 2.10e-04
                           10        20
                   ....*....|....*....|....
gi 1285024735  558 KWNCGICTFLNHPILDKCEQCEMP 581
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
PRK12704 PRK12704
phosphodiesterase; Provisional
 376-501 2.56e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.00  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 376 KQEAR--IERLRIELNTEK-AKLVIMKQEV----ADLEKNRLEKLADI-EMEKQLTMEIRHLRRQCKVLEldapvilKQE 447
Cdd:PRK12704   37 EEEAKriLEEAKKEAEAIKkEALLEAKEEIhklrNEFEKELRERRNELqKLEKRLLQKEENLDRKLELLE-------KRE 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1285024735 448 ARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADI--------------EMEKQLTMEIRHLRRQ 501
Cdd:PRK12704  110 EELEKKEKELEQKQQELEKKEEELEELIEEQLQELERIsgltaeeakeilleKVEEEARHEAAVLIKE 177
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 374-511 4.18e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 4.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 374 ILKQEARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEM----EKQLTMEIRHLRRQCKVLELDAPVILKQEA- 448
Cdd:COG1196   332 LEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEaeeeLEELAEELLEALRAAAELAAQLEELEEAEEa 411

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1285024735 449 ---RIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQLTMEIRHLRRQCKVLELDGEA 511
Cdd:COG1196   412 lleRLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
378-501 7.93e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 7.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  378 EARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADI-----EMEKQLTMEIRHLRRQ--------------CKVLEL 438
Cdd:COG4913    294 EAELEELRAELARLEAELERLEARLDALREELDELEAQIrgnggDRLEQLEREIERLEREleererrrarlealLAALGL 373

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1285024735  439 DAP----VILKQEARIERLRIELNTEKAKLvimKQEVADLEKNRLEKLADIEmekQLTMEIRHLRRQ 501
Cdd:COG4913    374 PLPasaeEFAALRAEAAALLEALEEELEAL---EEALAEAEAALRDLRRELR---ELEAEIASLERR 434
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
374-493 8.20e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.54  E-value: 8.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 374 ILKQEARIERLRIElntekaklvimkqeVADLEKNRLEKLADIEMekqLTMEIRHLRRQCKVLELDAPVILKQEARIERL 453
Cdd:COG2433   415 IRRLEEQVERLEAE--------------VEELEAELEEKDERIER---LERELSEARSEERREIRKDREISRLDREIERL 477

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1285024735 454 RIELNTEKAKLVIMKQEVAdleknRLEKLADIEMEKQLTM 493
Cdd:COG2433   478 ERELEEERERIEELKRKLE-----RLKELWKLEHSGELVP 512
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 378-516 1.03e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  378 EARIERLRIELNTEKAKLVIMKQEVADLEKnRLEKLAD------------IEMEKQLTMEIRHLRRQCKVL-----ELDA 440
Cdd:TIGR02169  363 KEELEDLRAELEEVDKEFAETRDELKDYRE-KLEKLKReinelkreldrlQEELQRLSEELADLNAAIAGIeakinELEE 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  441 PV------ILKQEARIERLRIELNTEKAKLVIMKQEVADLEKnRLEKLAD--IEMEKQLTM---EIRHLRRQCKVLELDG 509
Cdd:TIGR02169  442 EKedkaleIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEK-ELSKLQRelAEAEAQARAseeRVRGGRAVEEVLKASI 520


                   ....*..
gi 1285024735  510 EAFYNNI 516
Cdd:TIGR02169  521 QGVHGTV 527
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 368-510 1.04e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 368 SSQPPVILKQEARIERLRIElnTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQ-----LTMEIRHLRRQcKVLELDAPV 442
Cdd:pfam17380 337 AEQERMAMERERELERIRQE--ERKRELERIRQEEIAMEISRMRELERLQMERQqknerVRQELEAARKV-KILEEERQR 413

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1285024735 443 ILKQEARiERLRIELNTEKAKlvimKQEVADLEKNR---LEKLADIEMEKQLTMEI---RHLRRQCKVLELDGE 510
Cdd:pfam17380 414 KIQQQKV-EMEQIRAEQEEAR----QREVRRLEEERareMERVRLEEQERQQQVERlrqQEEERKRKKLELEKE 482
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
378-501 1.91e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 1.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  378 EARIERLRIELNTEKAKLVIMKQEVADLEKNR--LEKLADIEME----KQLTMEIRHLRRQCKVLELDAPVILKQEARIE 451
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERReaLQRLAEYSWDeidvASAEREIAELEAELERLDASSDDLAALEEQLE 695

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1285024735  452 RLRIELNTEKAKLVIMKQEVADLEKNRlekladiemeKQLTMEIRHLRRQ 501
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKEL----------EQAEEELDELQDR 735
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 382-481 2.39e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 41.26  E-value: 2.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  382 ERLRIELNTEKAKLVIMKQevadLEKNRLEKLADIEMEKQLTMEIRHLRRQCKVLEldapvilkqeaRIERLRIELNT-E 460
Cdd:PTZ00266   436 ERARIEKENAHRKALEMKI----LEKKRIERLEREERERLERERMERIERERLERE-----------RLERERLERDRlE 500

                           90       100
                   ....*....|....*....|..
gi 1285024735  461 KAKLVIMKQEVAD-LEKNRLEK 481
Cdd:PTZ00266   501 RDRLDRLERERVDrLERDRLEK 522
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 19-153 2.68e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 40.84  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  19 CITSYLQSNSQGQDLNIaDLLETALAENNSEQMGRLSQQLETPPLDQALIPDPQDDSA----QLIGSHSESaILSSTSDE 94
Cdd:PRK14957  293 CIYSFTQSLDAVNDIDV-DIINNILAKISIEQAHFLYQLTITAKKDIALAPNFETGVTmailRLIAFQKKN-LIDKTQTS 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1285024735  95 RNRVEMIESDSDIN--RNLIKPSVPNPTPreppKTIAKRPNKLDITSDCDAISDDKRKFNI 153
Cdd:PRK14957  371 KSNISPIVSKNDINllKNTFKSEQPKQTV----KAVVAQNNDSTASENTQEQSLDKKWFNL 427
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 375-506 3.21e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 375 LKQEARIERLRIELNtEKAKLVIMKQeVADLEKNRLEKLADIEMEKQLTMEIrhlrrQCKVLELDAPVILKQEARIERLR 454
Cdd:pfam13868  57 LEEEEEKEEERKEER-KRYRQELEEQ-IEEREQKRQEEYEEKLQEREQMDEI-----VERIQEEDQAEAEEKLEKQRQLR 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1285024735 455 IELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQLTMEIRHLRRQCKVLE 506
Cdd:pfam13868 130 EEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEE 181
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 409-506 5.19e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.14  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 409 RLEKLADIEMEKQltmEIRHLRRqckvleldapvilKQEARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEME 488
Cdd:COG1579     8 ALLDLQELDSELD---RLEHRLK-------------ELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEV 71

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1285024735 489 KQ--------------------LTMEIRHLRRQCKVLE 506
Cdd:COG1579    72 EArikkyeeqlgnvrnnkeyeaLQKEIESLKRRISDLE 109
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
374-511 5.49e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 374 ILKQEARIERLRIELNTEKAKLVIMKQEVADLEKNRLEKLADIEmekQLTMEIRHLRRQCKVLELDAPVILKQEARIERL 453
Cdd:COG4372    75 LEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELE---ELQKERQDLEQQRKQLEAQIAELQSEIAEREEE 151

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1285024735 454 RIELNTEKAKLvimKQEVADLEKNrLEKLADIEMEKQLTMEIRHLRRQCKVLELDGEA 511
Cdd:COG4372   152 LKELEEQLESL---QEELAALEQE-LQALSEAEAEQALDELLKEANRNAEKEEELAEA 205
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 370-500 6.75e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 39.95  E-value: 6.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  370 QPPVILKQEARIERLRIELNTEKAKLVIMKQEvADLEKNRLE----KLADIEMEKQLTMEIRHLRRQCKVLELDAPVILK 445
Cdd:TIGR00618  329 KRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDA-HEVATSIREiscqQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQR 407

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1285024735  446 QEARIERLRIELNTEKAKLVIMK-QEVADLEKNRLEKLADIEMEKQLTMEIRHLRR 500
Cdd:TIGR00618  408 EQATIDTRTSAFRDLQGQLAHAKkQQELQQRYAELCAAAITCTAQCEKLEKIHLQE 463
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
375-508 7.67e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.37  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 375 LKQEARIERLRIELNTekaklvIMKQEVADLEKNRLEKLADIEMEKQLTMEIRHLRRQCKVLELDAPVILKQ------EA 448
Cdd:COG4717   359 LEEELQLEELEQEIAA------LLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEAldeeelEE 432

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735 449 RIERLRIELNTEKAKLVIMKQEVADLEkNRLEKLADIEMEKQLTMEIRHLRRQCKVLELD 508
Cdd:COG4717   433 ELEELEEELEELEEELEELREELAELE-AELEQLEEDGELAELLQELEELKAELRELAEE 491
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 381-508 9.53e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.85  E-value: 9.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  381 IERLRIELNTEkakLVIMKQEVADLEKNrLEKLADI-----EMEKQLTMEIRHLRRQCKVLELDAPVILKqearieRLRI 455
Cdd:smart00787 142 LEGLKEGLDEN---LEGLKEDYKLLMKE-LELLNSIkpklrDRKDALEEELRQLKQLEDELEDCDPTELD------RAKE 211

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285024735  456 ELNTEKAKLVIMKQEVADLEKNRLEKLADIEMEKQL-------TMEIRHLRRQCKVLELD 508
Cdd:smart00787 212 KLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKkselnteIAEAEKKLEQCRGFTFK 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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