NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1281027864|ref|XP_022998350|]
View 

protein TOO MANY MOUTHS [Cucurbita maxima]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 152-402 1.96e-38

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 149.61  E-value: 1.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 152 VPSFLGQLgPSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIP-SLG- 229
Cdd:PLN00113  180 IPNSLTNL-TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPsSLGn 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 230 LDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLI 309
Cdd:PLN00113  259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 310 LKGNPMSCSISNDLF--------------------DGMLS---LMTLILSNMGFHGPIPRSLGRLPNLRVLHLDANYFNG 366
Cdd:PLN00113  339 LWSNKFSGEIPKNLGkhnnltvldlstnnltgeipEGLCSsgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSG 418

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1281027864 367 SIPSNFQDLRNLNDLRLNDNMLTGRIPLQKqmiWKM 402
Cdd:PLN00113  419 ELPSEFTKLPLVYFLDISNNNLQGRINSRK---WDM 451
PLN03150 super family cl31977
hypothetical protein; Provisional
 23-228 1.12e-05

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  23 SASFTVIMSDSGAPSALVDGPQSgFSLHNAAVRTDPAEQSAVYDIMSATGNP----WATqipDVCGGR---WHGIECMPD 95
Cdd:PLN03150  337 GRTLTIVLQPKKGTHAIINAIEV-FEIITAESKTLLEEVSALQTLKSSLGLPlrfgWNG---DPCVPQqhpWSGADCQFD 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  96 NHNLFHVVSlsfgSLSDDTafptcDPTRSTISPSLAKLPHLRTLFFYRCFTDNpqIVPSFLGQLgPSLQTLVLRENGLIG 175
Cdd:PLN03150  413 STKGKWFID----GLGLDN-----QGLRGFIPNDISKLRHLQSINLSGNSIRG--NIPPSLGSI-TSLEVLDLSYNSFNG 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1281027864 176 PIPSELTNLTRLKVLDLHGNNLNGSIPVGLN-RLVGLRSLDLSWNKLTGSIPSL 228
Cdd:PLN03150  481 SIPESLGQLTSLRILNLNGNSLSGRVPAALGgRLLHRASFNFTDNAGLCGIPGL 534
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-402 1.96e-38

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 149.61  E-value: 1.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 152 VPSFLGQLgPSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIP-SLG- 229
Cdd:PLN00113  180 IPNSLTNL-TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPsSLGn 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 230 LDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLI 309
Cdd:PLN00113  259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 310 LKGNPMSCSISNDLF--------------------DGMLS---LMTLILSNMGFHGPIPRSLGRLPNLRVLHLDANYFNG 366
Cdd:PLN00113  339 LWSNKFSGEIPKNLGkhnnltvldlstnnltgeipEGLCSsgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSG 418

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1281027864 367 SIPSNFQDLRNLNDLRLNDNMLTGRIPLQKqmiWKM 402
Cdd:PLN00113  419 ELPSEFTKLPLVYFLDISNNNLQGRINSRK---WDM 451
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-394 3.94e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 3.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 146 TDNPQIVPSFLGQLgPSLQTLVLRENgligpipSELTNLTRLKVLDLHGNNLNgSIPVGLNRLVGLRSLDLSWNKLTGSI 225
Cdd:COG4886    82 LSLLLLGLTDLGDL-TNLTELDLSGN-------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLP 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 226 PSLG-LDNLRILDLSQNLLTGlIPNRIVTCQSLIKLDLSRNSlIGVIQESITELKDLVLLDLSYNQIScPLPMSLQHLSS 304
Cdd:COG4886   153 EPLGnLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 305 LEVLILKGNPMScSISNdlFDGMLSLMTLILSNMGFHGpIPrSLGRLPNLRVLHLDANYFNGSIPSNFQDLRNLNDLRLN 384
Cdd:COG4886   230 LETLDLSNNQLT-DLPE--LGNLTNLEELDLSNNQLTD-LP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                         250
                  ....*....|
gi 1281027864 385 DNMLTGRIPL 394
Cdd:COG4886   305 LLLLNLLELL 314
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-316 3.55e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 3.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 161 PSLQTLVLRENgLIGPIPSeLTNLTRLKVLDLHGNNLNgSIPvGLNRLVGLRSLDLSWNKLTgSIPSL-GLDNLRILDLS 239
Cdd:cd21340    24 KNLKVLYLYDN-KITKIEN-LEFLTNLTHLYLQNNQIE-KIE-NLENLVNLKKLYLGGNRIS-VVEGLeNLTNLEELHIE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 240 -QNLLTG--LI--PNRIVT-CQSLIKLDLSRNSLigviqESITELKDLV---LLDLSYNQISC--PLPMSLQHLSSLEVL 308
Cdd:cd21340    99 nQRLPPGekLTfdPRSLAAlSNSLRVLNISGNNI-----DSLEPLAPLRnleQLDASNNQISDleELLDLLSSWPSLREL 173


                  ....*...
gi 1281027864 309 ILKGNPMS 316
Cdd:cd21340   174 DLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
232-291 1.39e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.39e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 232 NLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQI 291
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 23-228 1.12e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  23 SASFTVIMSDSGAPSALVDGPQSgFSLHNAAVRTDPAEQSAVYDIMSATGNP----WATqipDVCGGR---WHGIECMPD 95
Cdd:PLN03150  337 GRTLTIVLQPKKGTHAIINAIEV-FEIITAESKTLLEEVSALQTLKSSLGLPlrfgWNG---DPCVPQqhpWSGADCQFD 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  96 NHNLFHVVSlsfgSLSDDTafptcDPTRSTISPSLAKLPHLRTLFFYRCFTDNpqIVPSFLGQLgPSLQTLVLRENGLIG 175
Cdd:PLN03150  413 STKGKWFID----GLGLDN-----QGLRGFIPNDISKLRHLQSINLSGNSIRG--NIPPSLGSI-TSLEVLDLSYNSFNG 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1281027864 176 PIPSELTNLTRLKVLDLHGNNLNGSIPVGLN-RLVGLRSLDLSWNKLTGSIPSL 228
Cdd:PLN03150  481 SIPESLGQLTSLRILNLNGNSLSGRVPAALGgRLLHRASFNFTDNAGLCGIPGL 534
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-402 1.96e-38

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 149.61  E-value: 1.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 152 VPSFLGQLgPSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIP-SLG- 229
Cdd:PLN00113  180 IPNSLTNL-TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPsSLGn 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 230 LDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLI 309
Cdd:PLN00113  259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 310 LKGNPMSCSISNDLF--------------------DGMLS---LMTLILSNMGFHGPIPRSLGRLPNLRVLHLDANYFNG 366
Cdd:PLN00113  339 LWSNKFSGEIPKNLGkhnnltvldlstnnltgeipEGLCSsgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSG 418

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1281027864 367 SIPSNFQDLRNLNDLRLNDNMLTGRIPLQKqmiWKM 402
Cdd:PLN00113  419 ELPSEFTKLPLVYFLDISNNNLQGRINSRK---WDM 451
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-393 2.33e-36

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 143.45  E-value: 2.33e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  81 DVCggRWHGIECmpdnHNLFHVVSLSFGSLSddtafptcdpTRSTISPSLAKLPHLRTL--------------FFYRCFT 146
Cdd:PLN00113   56 DVC--LWQGITC----NNSSRVVSIDLSGKN----------ISGKISSAIFRLPYIQTInlsnnqlsgpipddIFTTSSS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 147 ------DNPQIVPSFLGQLGPSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNK 220
Cdd:PLN00113  120 lrylnlSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQ 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 221 LTGSIPS-LG-LDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMS 298
Cdd:PLN00113  200 LVGQIPReLGqMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPS 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 299 LQHLSSLEVLILKGNPMSCSISnDLFDGMLSLMTLILSNMGFHGPIPRSLGRLPNLRVLHLDANYFNGSIPSNFQDLRNL 378
Cdd:PLN00113  280 IFSLQKLISLDLSDNSLSGEIP-ELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         330
                  ....*....|....*
gi 1281027864 379 NDLRLNDNMLTGRIP 393
Cdd:PLN00113  359 TVLDLSTNNLTGEIP 373
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 175-413 1.04e-32

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 132.66  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 175 GPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLV-GLRSLDLSWNKLTGSIPSLGLDNLRILDLSQNLLTGLIPNRIVT 253
Cdd:PLN00113   83 GKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 254 CQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLILKGNPMSCSISNDLfDGMLSLMTL 333
Cdd:PLN00113  163 FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEI-GGLTSLNHL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 334 ILSNMGFHGPIPRSLGRLPNLRVLHLDANYFNGSIPSNFQDLRNLNDLRLNDNMLTGRIPlqkQMIWKMKKKLTLYNNSN 413
Cdd:PLN00113  242 DLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIP---ELVIQLQNLEILHLFSN 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 126-394 4.31e-31

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 127.66  E-value: 4.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 126 ISPSLAKLPHLRTLFFYRC--------------------FTDN--PQIVPSFLGQLgPSLQTLVLRENGLIGPIPSELTN 183
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNklsgpippsifslqklisldLSDNslSGEIPELVIQL-QNLEILHLFSNNFTGKIPVALTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 184 LTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIPSLGLD--NLRILDLSQNLLTGLIPNRIVTCQSLIKLD 261
Cdd:PLN00113  331 LPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSsgNLFKLILFSNSLEGEIPKSLGACRSLRRVR 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 262 LSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLILKGNPMSCSISnDLFdGMLSLMTLILSNMGFH 341
Cdd:PLN00113  411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP-DSF-GSKRLENLDLSRNQFS 488

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1281027864 342 GPIPRSLGRLPNLRVLHLDANYFNGSIPSNFQDLRNLNDLRLNDNMLTGRIPL 394
Cdd:PLN00113  489 GAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPA 541
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-370 1.66e-27

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.87  E-value: 1.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  97 HNLFHVVSLSFGSLSDDTAFPTCDptrstiSPSLAKLphlrtLFFYRCFTDNpqiVPSFLGQLGpSLQTLVLRENGLIGP 176
Cdd:PLN00113  355 HNNLTVLDLSTNNLTGEIPEGLCS------SGNLFKL-----ILFSNSLEGE---IPKSLGACR-SLRRVRLQDNSFSGE 419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 177 IPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIP-SLGLDNLRILDLSQNLLTGLIPNRIVTCQ 255
Cdd:PLN00113  420 LPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPdSFGSKRLENLDLSRNQFSGAVPRKLGSLS 499

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 256 SLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLILKGNPMScsisndlfdgmlslmtlil 335
Cdd:PLN00113  500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS------------------- 560

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1281027864 336 snmgfhGPIPRSLGRLPNLRVLHLDANYFNGSIPS 370
Cdd:PLN00113  561 ------GEIPKNLGNVESLVQVNISHNHLHGSLPS 589
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-394 3.94e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 3.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 146 TDNPQIVPSFLGQLgPSLQTLVLRENgligpipSELTNLTRLKVLDLHGNNLNgSIPVGLNRLVGLRSLDLSWNKLTGSI 225
Cdd:COG4886    82 LSLLLLGLTDLGDL-TNLTELDLSGN-------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLP 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 226 PSLG-LDNLRILDLSQNLLTGlIPNRIVTCQSLIKLDLSRNSlIGVIQESITELKDLVLLDLSYNQIScPLPMSLQHLSS 304
Cdd:COG4886   153 EPLGnLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 305 LEVLILKGNPMScSISNdlFDGMLSLMTLILSNMGFHGpIPrSLGRLPNLRVLHLDANYFNGSIPSNFQDLRNLNDLRLN 384
Cdd:COG4886   230 LETLDLSNNQLT-DLPE--LGNLTNLEELDLSNNQLTD-LP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                         250
                  ....*....|
gi 1281027864 385 DNMLTGRIPL 394
Cdd:COG4886   305 LLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-411 6.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 6.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 120 DPTRSTISPSLAKLPHLRTLFFYRCFTDNPQIVPSFLGQLGPSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNG 199
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 200 SIPVGLNRLVGLRSLDLSWNKltgsiPSLGLDNLRILDLSQNLLTGLiPNRIVTCQSLIKLDLSRNSlIGVIQESITELK 279
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQ-LTDLPEPLGNLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 280 DLVLLDLSYNQISCpLPMSLQHLSSLEVLILKGNPMScSISNDLFdGMLSLMTLILSNMGFHgPIPRSLGRLPNLRVLHL 359
Cdd:COG4886   160 NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLG-NLTNLEELDLSGNQLT-DLPEPLANLTNLETLDL 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1281027864 360 DANYFNgSIPSnFQDLRNLNDLRLNDNMLTGrIPLQKQMiwKMKKKLTLYNN 411
Cdd:COG4886   236 SNNQLT-DLPE-LGNLTNLEELDLSNNQLTD-LPPLANL--TNLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-304 1.49e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.68  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 124 STISPSLAKLPHLRTLFFYRCftdnpQI--VPSFLGQLgPSLQTLVLRENGlIGPIPSELTNLTRLKVLDLHGNNLNgSI 201
Cdd:COG4886   149 TDLPEPLGNLTNLKSLDLSNN-----QLtdLPEELGNL-TNLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGNQLT-DL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 202 PVGLNRLVGLRSLDLSWNKLTgSIPSLG-LDNLRILDLSQNLLTGLIPnrIVTCQSLIKLDLSRNSLIGVIQESITELKD 280
Cdd:COG4886   221 PEPLANLTNLETLDLSNNQLT-DLPELGnLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                         170       180
                  ....*....|....*....|....
gi 1281027864 281 LVLLDLSYNQISCPLPMSLQHLSS 304
Cdd:COG4886   298 LNSLLLLLLLLNLLELLILLLLLT 321
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-289 1.75e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 1.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 124 STISPSLAKLPHLRTLFFYRC-FTDnpqiVPSFLGQLgPSLQTLVLRENGlIGPIPSELTNLTRLKVLDLHGNNLNgSIP 202
Cdd:COG4886   172 TDLPEELGNLTNLKELDLSNNqITD----LPEPLGNL-TNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQLT-DLP 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 203 vGLNRLVGLRSLDLSWNKLTGSIPSLGLDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLV 282
Cdd:COG4886   245 -ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                  ....*..
gi 1281027864 283 LLDLSYN 289
Cdd:COG4886   324 LLLLLLL 330
PLN03150 PLN03150
hypothetical protein; Provisional
 166-248 2.44e-14

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 75.62  E-value: 2.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 166 LVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIP-SLG-LDNLRILDLSQNLL 243
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPeSLGqLTSLRILNLNGNSL 502


                  ....*
gi 1281027864 244 TGLIP 248
Cdd:PLN03150  503 SGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 225-316 5.58e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 64.84  E-value: 5.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 225 IPSLGLDNlrildlsqNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSS 304
Cdd:PLN03150  420 IDGLGLDN--------QGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTS 491

                          90
                  ....*....|..
gi 1281027864 305 LEVLILKGNPMS 316
Cdd:PLN03150  492 LRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 330-393 9.18e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 64.07  E-value: 9.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1281027864 330 LMTLILSNMGFHGPIPRSLGRLPNLRVLHLDANYFNGSIPSNFQDLRNLNDLRLNDNMLTGRIP 393
Cdd:PLN03150  444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 163-227 3.11e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 62.53  E-value: 3.11e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1281027864 163 LQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIPS 227
Cdd:PLN03150  444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPA 508
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-316 3.55e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 3.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 161 PSLQTLVLRENgLIGPIPSeLTNLTRLKVLDLHGNNLNgSIPvGLNRLVGLRSLDLSWNKLTgSIPSL-GLDNLRILDLS 239
Cdd:cd21340    24 KNLKVLYLYDN-KITKIEN-LEFLTNLTHLYLQNNQIE-KIE-NLENLVNLKKLYLGGNRIS-VVEGLeNLTNLEELHIE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 240 -QNLLTG--LI--PNRIVT-CQSLIKLDLSRNSLigviqESITELKDLV---LLDLSYNQISC--PLPMSLQHLSSLEVL 308
Cdd:cd21340    99 nQRLPPGekLTfdPRSLAAlSNSLRVLNISGNNI-----DSLEPLAPLRnleQLDASNNQISDleELLDLLSSWPSLREL 173


                  ....*...
gi 1281027864 309 ILKGNPMS 316
Cdd:cd21340   174 DLTGNPVC 181
PLN03150 PLN03150
hypothetical protein; Provisional
 214-299 9.89e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.44  E-value: 9.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 214 LDLSWNKLTGSIPS--LGLDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQI 291
Cdd:PLN03150  423 LGLDNQGLRGFIPNdiSKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                  ....*...
gi 1281027864 292 SCPLPMSL 299
Cdd:PLN03150  503 SGRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 126-337 4.52e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 126 ISPSLAKLPHLRTLFFYRCFT----DNPQIVPSFLGQlGPSLQTLVLRENGL----IGPIPSELTNLTrLKVLDLHGNNL 197
Cdd:cd00116    43 LASALRPQPSLKELCLSLNETgripRGLQSLLQGLTK-GCGLQELDLSDNALgpdgCGVLESLLRSSS-LQELKLNNNGL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 198 ngsipvglnrlvGLRSLDLswnkLTGSIPSLGLDnLRILDLSQNLLTG---------LIPNRivtcqSLIKLDLSRNSL- 267
Cdd:cd00116   121 ------------GDRGLRL----LAKGLKDLPPA-LEKLVLGRNRLEGascealakaLRANR-----DLKELNLANNGIg 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 268 ---IGVIQESITELKDLVLLDLSYNQISCP----LPMSLQHLSSLEVLILKGNPMSCSISNDLFDGML----SLMTLILS 336
Cdd:cd00116   179 dagIRALAEGLKANCNLEVLDLNNNGLTDEgasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLspniSLLTLSLS 258


                  .
gi 1281027864 337 N 337
Cdd:cd00116   259 C 259
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-229 1.33e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 152 VPSFLGQLgPSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTG-------- 223
Cdd:PLN00113  491 VPRKLGSL-SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGeipknlgn 569

                          90       100
                  ....*....|....*....|..
gi 1281027864 224 ----------------SIPSLG 229
Cdd:PLN00113  570 veslvqvnishnhlhgSLPSTG 591
LRR_8 pfam13855
Leucine rich repeat;
232-291 1.39e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.39e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 232 NLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQI 291
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
161-221 2.73e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.73e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1281027864 161 PSLQTLVLRENGLIGPIPSELTNLTRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKL 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 160-362 3.32e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 160 GPSLQTLVLRENGlIGP-----IPSELTNLTRLKVLDLHGNNLNGSIPVGL------NRLVglRSLDLSWNKLT--GSIp 226
Cdd:COG5238   207 NTTVTTLWLKRNP-IGDegaeiLAEALKGNKSLTTLDLSNNQIGDEGVIALaealknNTTV--ETLYLSGNQIGaeGAI- 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 227 SL-----GLDNLRILDLSQNLLTGlipnrivtcQSLIkldlsrnsligVIQESITELKDLVLLDLSYNQISC----PLPM 297
Cdd:COG5238   283 ALakalqGNTTLTSLDLSVNRIGD---------EGAI-----------ALAEGLQGNKTLHTLNLAYNGIGAqgaiALAK 342

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1281027864 298 SLQHLSSLEVLILKGNPMSCSisndlfdGMLSLMTLILSNmgfhgpiprslgrlPNLRVLHLDAN 362
Cdd:COG5238   343 ALQENTTLHSLDLSDNQIGDE-------GAIALAKYLEGN--------------TTLRELNLGKN 386
LRR_8 pfam13855
Leucine rich repeat;
255-315 5.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 5.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1281027864 255 QSLIKLDLSRNSLIGVIQESITELKDLVLLDLSYNQISCPLPMSLQHLSSLEVLILKGNPM 315
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 23-228 1.12e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  23 SASFTVIMSDSGAPSALVDGPQSgFSLHNAAVRTDPAEQSAVYDIMSATGNP----WATqipDVCGGR---WHGIECMPD 95
Cdd:PLN03150  337 GRTLTIVLQPKKGTHAIINAIEV-FEIITAESKTLLEEVSALQTLKSSLGLPlrfgWNG---DPCVPQqhpWSGADCQFD 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  96 NHNLFHVVSlsfgSLSDDTafptcDPTRSTISPSLAKLPHLRTLFFYRCFTDNpqIVPSFLGQLgPSLQTLVLRENGLIG 175
Cdd:PLN03150  413 STKGKWFID----GLGLDN-----QGLRGFIPNDISKLRHLQSINLSGNSIRG--NIPPSLGSI-TSLEVLDLSYNSFNG 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1281027864 176 PIPSELTNLTRLKVLDLHGNNLNGSIPVGLN-RLVGLRSLDLSWNKLTGSIPSL 228
Cdd:PLN03150  481 SIPESLGQLTSLRILNLNGNSLSGRVPAALGgRLLHRASFNFTDNAGLCGIPGL 534
LRR_8 pfam13855
Leucine rich repeat;
185-243 7.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1281027864 185 TRLKVLDLHGNNLNGSIPVGLNRLVGLRSLDLSWNKLTGSIP--SLGLDNLRILDLSQNLL 243
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
210-267 1.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 210 GLRSLDLSWNKLTGSIPS--LGLDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSL 267
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-289 1.75e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 124 STISPSLAKLPHLRTLFFYRC-FTDNPQivpsfLGQLgPSLQTLVLRENGLIGPipSELTNLTRLKVLDLHGNNLNGSIP 202
Cdd:COG4886   218 TDLPEPLANLTNLETLDLSNNqLTDLPE-----LGNL-TNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 203 VGLNRLVGLRSLDLSWNKLTGSIPSLGLDNLRILDLSQNLLTGLIPNRIVTCQSLIKLDLSRNSLIGVIQESITELKDLV 282
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369


                  ....*..
gi 1281027864 283 LLDLSYN 289
Cdd:COG4886   370 GLLGLLE 376
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
55-344 3.93e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864  55 RTDPAEQS----AVYDIMSA----------TGNPWATQIPDvcggrwhgieCMPDnhnlfHVVSLSFGSlSDDTAFPTCD 120
Cdd:PRK15387  178 RAAPAEESrgraAVVQKMRAclnngnavlnVGESGLTTLPD----------CLPA-----HITTLVIPD-NNLTSLPALP 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 121 PTRSTISPS---LAKLPHLRTLFFYRCFTDNP----QIVPSFLGQL-------------GPSLQTLVLRENGL--IGPIP 178
Cdd:PRK15387  242 PELRTLEVSgnqLTSLPVLPPGLLELSIFSNPlthlPALPSGLCKLwifgnqltslpvlPPGLQELSVSDNQLasLPALP 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 179 SELTNLTRlkvldlHGNNLNG--SIPVGL-------NRLVGLRSLD------LSWNKLTGSIPSLGlDNLRILDLSQNLL 243
Cdd:PRK15387  322 SELCKLWA------YNNQLTSlpTLPSGLqelsvsdNQLASLPTLPselyklWAYNNRLTSLPALP-SGLKELIVSGNRL 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 244 TGLIpnriVTCQSLIKLDLSRNSLIgviqeSITELKD-LVLLDLSYNQIScPLPMSLQHLSSLEVLILKGNPMScsisnd 322
Cdd:PRK15387  395 TSLP----VLPSELKELMVSGNRLT-----SLPMLPSgLLSLSVYRNQLT-RLPESLIHLSSETTVNLEGNPLS------ 458

                         330       340
                  ....*....|....*....|..
gi 1281027864 323 lfDGMLSLMTLILSNMGFHGPI 344
Cdd:PRK15387  459 --ERTLQALREITSAPGYSGPI 478
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 161-292 1.14e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 161 PSLQTLVLREN-----GLIGpIPSELTNLTRLKVLDLHGNNL--NGSIPVG--LNRLVGLRSLDLSWNKLTGS-----IP 226
Cdd:COG5238   236 KSLTTLDLSNNqigdeGVIA-LAEALKNNTTVETLYLSGNQIgaEGAIALAkaLQGNTTLTSLDLSVNRIGDEgaialAE 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 227 SL-GLDNLRILDLSQN---------LLTGLIPNRIVTcqsliKLDLSRNSL--IGVIQ--ESITELKDLVLLDLSYNQIS 292
Cdd:COG5238   315 GLqGNKTLHTLNLAYNgigaqgaiaLAKALQENTTLH-----SLDLSDNQIgdEGAIAlaKYLEGNTTLRELNLGKNNIG 389
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 159-261 4.77e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 159 LGPSLQTLVLRENGLigPIPSELTNLTRLKVLDLHGNNLNgsipvglnrlvglrsldlSWNKLTGSIPSLGldNLRILDL 238
Cdd:cd21340   118 LSNSLRVLNISGNNI--DSLEPLAPLRNLEQLDASNNQIS------------------DLEELLDLLSSWP--SLRELDL 175

                          90       100
                  ....*....|....*....|....*.
gi 1281027864 239 SQNLLTGLIPNR---IVTCQSLIKLD 261
Cdd:cd21340   176 TGNPVCKKPKYRdkiILASKSLEVLD 201
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 170-291 7.15e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 170 ENGLIGpIPSELTNLTRLKVLDLHGNNLNG----SIPVGLNRLVGLRSLDLSWNKLT--GSIPSL----GLDNLRILDLS 239
Cdd:COG5238   278 AEGAIA-LAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQGNKTLHTLNLAYNGIGaqGAIALAkalqENTTLHSLDLS 356

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027864 240 QNLLTG----LIPNRIVTCQSLIKLDLSRNSL--IGViQESITELK--DLVLLDLSYNQI 291
Cdd:COG5238   357 DNQIGDegaiALAKYLEGNTTLRELNLGKNNIgkQGA-EALIDALQtnRLHTLILDGNLI 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH