|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
348-1312 |
4.67e-152 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 477.89 E-value: 4.67e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 348 HELVPDMALDFPFELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGK 427
Cdd:COG4581 12 LEALADFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVER 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 428 F---DVGLLTGDVSLRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLS 504
Cdd:COG4581 92 FgaeNVGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 505 ATVPNTIEFADWIGRtkqkrihVTGTT------KRPVPLEHcifysgesykiceseiflshglkaakdaskkktsSVASG 578
Cdd:COG4581 172 ATVGNAEEFAEWLTR-------VRGETavvvseERPVPLEF----------------------------------HYLVT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 579 SHVgasvsndgarnrknesFSRSKQNKhsgsqnlgnfsgtswgnqkngdsqnnwgsRRSDASSWLLLINRLSKKSLLPVV 658
Cdd:COG4581 211 PRL----------------FPLFRVNP-----------------------------ELLRPPSRHEVIEELDRGGLLPAI 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 659 IFCFSKNRCDKSADSIYSIDLTSSSEKSEIRVFCDKAfsrlkGSDRTLPQIVRVQGLLHRGIGVHHAGLLPIVKEVVEML 738
Cdd:COG4581 246 VFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLFGKTLSRLLRRGIAVHHAGMLPKYRRLVEEL 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 739 FCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKIGTVIVMcrdeIPEEKDLK 818
Cdd:COG4581 321 FQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAGRRGIDTEGHVVVL----APEHDDPK 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 819 RV--IVGSAT-KLESQFRLTYIMILHLL-RVEELKVEDMLKRSFAEFHA---QKKLPEKQQLLMRKLAQPTRTVECIKGE 891
Cdd:COG4581 397 KFarLASARPePLRSSFRPSYNMVLNLLaRPGLERARELLEDSFAQFQAdrsVVGLARRARELERALAGVVERLACDLGD 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 892 paIEEYYDLY---AEAEKNSNQISEAVMQSSAIQQFLTPGRVVVVRSQSDKDhllavivkalpmanRQYIVLVLKpdspp 968
Cdd:COG4581 477 --LQEYFALRqplSPLEALERESPAYALDVVSVPEATLEDPRPVLLAQDRRA--------------RGEAAAAMK----- 535
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 969 vqssssddsdkkkedfpqgyfmvpkskrglendyyspstrkgsgvvnirlphagaaAGVSYEVRgvdakeflcvcnkkiq 1048
Cdd:COG4581 536 --------------------------------------------------------AAIEYDER---------------- 543
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 1049 lnpVRLLEDVnnvaysqtvqqlldiksdgkfppaldplkdlklkdvnlveaykgwtdlvlkMVANKCHGCiKLGEHLKLA 1128
Cdd:COG4581 544 ---MERLEEV---------------------------------------------------LRPHPLHEC-PLERAFELY 568
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 1129 SEIKKHKEEVNNlkfqmSDEALQQmpDFQGRIDVLKEIGCInADLVVQIKGRVACEMNSgeeliCTECLFENQLDDLEPE 1208
Cdd:COG4581 569 RETHPWVRDIEL-----RPKSVAR--DFDRFCELLREYGYL-DDLTLTSEGLLLRYLYD-----AAEALRQGVPDDLDPE 635
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 1209 EAVALMSAFVFQQR----NTSEPSLTPKLSMAKKRLYETAIRLGKLQAQFRLPVdceeyardnLKFGLVEvvyEWAKGTP 1284
Cdd:COG4581 636 ELAALISWLVEEVRrvdsSEWERLPSPANRRAFVLVNALFRRLELLERRHGLPE---------LDPGLAG---AWASGAD 703
|
970 980 990
....*....|....*....|....*....|....*
gi 1281027023 1285 FADICELTDVPEGMIVRTIVR-------LDETCRE 1312
Cdd:COG4581 704 LAEVLDATDLDAGDFVRWVRQvidpdpeLRRTARA 738
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
355-531 |
3.92e-106 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 333.08 E-value: 3.92e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 355 ALDFPFELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKF-DVGLL 433
Cdd:cd18027 2 AFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFgDVGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 434 TGDVSLRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTIEF 513
Cdd:cd18027 82 TGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVEF 161
|
170
....*....|....*...
gi 1281027023 514 ADWIGRTKQKRIHVTGTT 531
Cdd:cd18027 162 ADWIGRIKKKNIYVISTP 179
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
353-533 |
1.45e-89 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 288.57 E-value: 1.45e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 353 DMALDFPFELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKF-DVG 431
Cdd:cd18024 24 NPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIYTSPIKALSNQKYRELQEEFgDVG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 432 LLTGDVSLRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTI 511
Cdd:cd18024 104 LMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKVRYVFLSATIPNAR 183
|
170 180
....*....|....*....|..
gi 1281027023 512 EFADWIGRTKQKRIHVTGTTKR 533
Cdd:cd18024 184 QFAEWICKIHKQPCHVVYTDYR 205
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
349-870 |
2.39e-68 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 240.18 E-value: 2.39e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 349 ELVPDMALDF-----PFELDTFQKEAI-YHLEKGDSVFVAAHTSAGKTVVAEYAF--ALATKHctRAVYTAPIKTISNQK 420
Cdd:COG1204 5 ELPLEKVIEFlkergIEELYPPQAEALeAGLLEGKNLVVSAPTASGKTLIAELAIlkALLNGG--KALYIVPLRALASEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 421 YRDFCGKF-----DVGLLTGDVSLRPE----ASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVI 491
Cdd:COG1204 83 YREFKRDFeelgiKVGVSTGDYDSDDEwlgrYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEVLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 492 ---IMLPRHINIVLLSATVPNTIEFADWIGRTkqkrihVTGTTKRPVPLEHCIFYSGESYkiceseiFlshglkaakdas 568
Cdd:COG1204 163 arlRRLNPEAQIVALSATIGNAEEIAEWLDAE------LVKSDWRPVPLNEGVLYDGVLR-------F------------ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 569 kkktssvasgshvgasvsNDGARNRKNESFSRSKQNKHSGSQNLgNFSgtswgnqkngdsqnnwgSRRSDASSWLlliNR 648
Cdd:COG1204 218 ------------------DDGSRRSKDPTLALALDLLEEGGQVL-VFV-----------------SSRRDAESLA---KK 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 649 LSKKslLPVVIFCFSKNRCDKSADSIYSIDLTSSSEKSEIRvfcdkafsrlkgsdrtlpqivrvqgLLHRGIGVHHAGLL 728
Cdd:COG1204 259 LADE--LKRRLTPEEREELEELAEELLEVSEETHTNEKLAD-------------------------CLEKGVAFHHAGLP 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 729 PIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRqllPGEYTQMAGRAGRRGLDKIGTVIVMCR 808
Cdd:COG1204 312 SELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMVPIP---VLEFKQMAGRAGRPGYDPYGEAILVAK 388
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1281027023 809 DEIPEEKDLKRVIVGSATKLESQFRLTYIMILHLLRV-------EELKVEDMLKRSFAEFHAQKKLPEK 870
Cdd:COG1204 389 SSDEADELFERYILGEPEPIRSKLANESALRTHLLALiasgfanSREELLDFLENTFYAYQYDKGDLEE 457
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
1173-1341 |
1.95e-64 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 215.39 E-value: 1.95e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 1173 LVVQIKGRVACEMNSGEELICTECLFENQLDDLEPEEAVALMSAFVFQQRNTSEPSLTPKLSMAKKRLYETAirlgklqa 1252
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYLPSPELAEALRLLEEIA-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 1253 qFRLPVDCEeyardnLKFGLVEVVYEWAKGTPFADICELTDVPEGMIVRTIVRLDETCREFKNAAAIMGNSALHKKMETA 1332
Cdd:pfam08148 73 -HRIAVSRF------LDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEA 145
|
....*....
gi 1281027023 1333 SNAIKRDIV 1341
Cdd:pfam08148 146 IELIKRDIV 154
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
361-520 |
4.47e-54 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 186.70 E-value: 4.47e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 361 ELDTFQKEAIYHL-EKGDSVFVAAHTSAGKTVVAEYA-FALATKHCTRAVYTAPIKTISNQKYRDFCGKF-----DVGLL 433
Cdd:cd17921 1 LLNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAiLRALATSGGKAVYIAPTRALVNQKEADLRERFgplgkNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 434 TGDVSLR----PEASCLIMTTEILRSMLYRGAD-IIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPR---HINIVLLSA 505
Cdd:cd17921 81 TGDPSVNklllAEADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLRinkNARFVGLSA 160
|
170
....*....|....*
gi 1281027023 506 TVPNTIEFADWIGRT 520
Cdd:cd17921 161 TLPNAEDLAEWLGVE 175
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
851-1147 |
1.06e-47 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 171.69 E-value: 1.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 851 EDMLKRSFAEFHAQKKLPEKQQLLmRKLAQPTRTVEcIKGEPAIEEYYDLYAEAEKNSNQISEAVMQSSAIQQFLTPGRV 930
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKL-KELEKELASIK-IPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 931 VVVRSQSDKDHLLAVIVK--------ALPMANRQYIV---LVLKPDSPPVQSSSSDdsdkkkEDFPQGYFMVPKSKRGle 999
Cdd:pfam13234 79 VVVKDNGDQDFGWGVVVNfkkrkkngKAEPPQESYIVdvlLVLALVSSPEDLDKFN------DVNPEGFRPAPPGEKG-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 1000 ndyyspstrkgsgvvnirlphagaaagvSYEVRGVDAKEFLCVCNKKIQLnPVRLLEDVNNVAYSQTVQQLLDIKSDGkf 1079
Cdd:pfam13234 151 ----------------------------EMEVVPVPLSDIEAISSVRLKL-PKDLRPAEAREAVLKALQELKRRFPDG-- 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1281027023 1080 PPALDPLKDLKLKDVNLVEAYKGWTDLVLKMVANKCHGCIKLGEHLKLASEIKKHKEEVNNLKFQMSD 1147
Cdd:pfam13234 200 IPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHKSPRLEELYALYHEKVELQEEIKELKKEISD 267
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
643-808 |
1.34e-46 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 164.26 E-value: 1.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 643 LLLINRLSKKSLLPVVIFCFSKNRCDKSADSIysidltsssekseirvfcdkafsrlkgsdrtlpqivrvqgllhRGIGV 722
Cdd:cd18795 32 IVLLKIETVSEGKPVLVFCSSRKECEKTAKDL-------------------------------------------AGIAF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 723 HHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKIGT 802
Cdd:cd18795 69 HHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGE 148
|
....*.
gi 1281027023 803 VIVMCR 808
Cdd:cd18795 149 AIIMTK 154
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
366-813 |
8.70e-32 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 133.93 E-value: 8.70e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 366 QKEAIyhlEKG----DSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGK----FDVGLLTGDV 437
Cdd:PRK02362 28 QAEAV---EAGlldgKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEEFERFeelgVRVGISTGDY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 438 SLRPEA----SCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLpRHIN----IVLLSATVPN 509
Cdd:PRK02362 105 DSRDEWlgdnDIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAKL-RRLNpdlqVVALSATIGN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 510 TIEFADWIGRTKqkrihVTgTTKRPVPLEHCIFYsGESYKICESEIFLshglkaakdaskkktsSVASGSHVGASVS--- 586
Cdd:PRK02362 184 ADELADWLDAEL-----VD-SEWRPIDLREGVFY-GGAIHFDDSQREV----------------EVPSKDDTLNLVLdtl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 587 NDG------ARNRKN-ESFSRskqnkhsgsqnlgnfsgtswgnqkngdsqnnwgsRRSDASSwllliNRLSKKsllpvvi 659
Cdd:PRK02362 241 EEGgqclvfVSSRRNaEGFAK----------------------------------RAASALK-----KTLTAA------- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 660 fcfSKNRCDKSADSIYSIDLTSSSEKseirvfcdkafsrlkgsdrtLPQIVRvqgllhRGIGVHHAGLLPIVKEVVEMLF 739
Cdd:PRK02362 275 ---ERAELAELAEEIREVSDTETSKD--------------------LADCVA------KGAAFHHAGLSREHRELVEDAF 325
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1281027023 740 CRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLP-GEYTQMAGRAGRRGLDKIGTVIVMCR--DEIPE 813
Cdd:PRK02362 326 RDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGAGMQPIPvLEYHQMAGRAGRPGLDPYGEAVLLAKsyDELDE 402
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
375-869 |
3.39e-31 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 132.25 E-value: 3.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 375 KGDSVFVAAHTSAGKTVVAEYAFA-LATKHCTRAVYTAPIKTISNQKYRDFcgKF------DVGLLTGDVSLRPE----A 443
Cdd:PRK00254 38 EGKNLVLAIPTASGKTLVAEIVMVnKLLREGGKAVYLVPLKALAEEKYREF--KDweklglRVAMTTGDYDSTDEwlgkY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 444 SCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTIEFADWIGRTkqk 523
Cdd:PRK00254 116 DIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSATVGNAEELAEWLNAE--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 524 rihVTGTTKRPVPLEHCIFYSGesykicesEIFLSHGlkaakdaskkktssvasgshvgasvsndgarnrKNESFSrskq 603
Cdd:PRK00254 193 ---LVVSDWRPVKLRKGVFYQG--------FLFWEDG---------------------------------KIERFP---- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 604 nkhsgsqnlgnfsgtswgnqkngdsqNNWGSRRSDASswlllinRLSKKSLlpvvIFCFSKNRCDKSADSIySIDLTSSS 683
Cdd:PRK00254 225 --------------------------NSWESLVYDAV-------KKGKGAL----VFVNTRRSAEKEALEL-AKKIKRFL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 684 EKSEIRvfcdkAFSRLKGSDRTLPQIVRVQGLLHRGIGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPA-R 762
Cdd:PRK00254 267 TKPELR-----ALKELADSLEENPTNEKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAfR 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 763 TVVFDTLRKFD-GKEFRQLLpgEYTQMAGRAGRRGLDKIGTVIVMCRDEIPEEKdLKRVIVGSATKL------ESQFRLT 835
Cdd:PRK00254 342 VIIRDTKRYSNfGWEDIPVL--EIQQMMGRAGRPKYDEVGEAIIVATTEEPSKL-MERYIFGKPEKLfsmlsnESAFRSQ 418
|
490 500 510
....*....|....*....|....*....|....*
gi 1281027023 836 YIMILHLLRVEELK-VEDMLKRSFaeFHAQKKLPE 869
Cdd:PRK00254 419 VLALITNFGVSNFKeLVNFLERTF--YAHQRKDLY 451
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
360-801 |
6.36e-31 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 130.77 E-value: 6.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 360 FELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGLLT----G 435
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEELSRLRSLGMRVkisiG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 436 DVSLRPE----ASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLpRHIN----IVLLSATV 507
Cdd:PRK01172 101 DYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLETVLSSA-RYVNpdarILALSATV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 508 PNTIEFADWIGRTKQKrihvtgTTKRPVPLEHCIFYsgesykicESEIFLShglkaakdaskkktssvasgshvgasvsn 587
Cdd:PRK01172 180 SNANELAQWLNASLIK------SNFRPVPLKLGILY--------RKRLILD----------------------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 588 dgarnrknesfsrskqnkhsgsqnlgnfsgtswgnqkngdsqnnwGSRRSDASswlllINRLSKKSLL---PVVIFCFSK 664
Cdd:PRK01172 217 ---------------------------------------------GYERSQVD-----INSLIKETVNdggQVLVFVSSR 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 665 NRCDKSADSIYSI-----DLTSSSEKSEirvfcdkafsrlkGSDRTLPQIVRvqgllhRGIGVHHAGLLPIVKEVVEMLF 739
Cdd:PRK01172 247 KNAEDYAEMLIQHfpefnDFKVSSENNN-------------VYDDSLNEMLP------HGVAFHHAGLSNEQRRFIEEMF 307
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1281027023 740 CRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLDKIG 801
Cdd:PRK01172 308 RNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYG 369
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
366-512 |
6.62e-29 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 113.88 E-value: 6.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 366 QKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHC---TRAVYTAPIKTISNQKYRDFCGKFD-----VGLLTGDV 437
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLdngPQALVLAPTRELAEQIYEELKKLGKglglkVASLLGGD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 438 SLRPEAS------CLIMTTEILRSMLYRgADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIVLLSATVPNTI 511
Cdd:pfam00270 84 SRKEQLEklkgpdILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLPRNL 162
|
.
gi 1281027023 512 E 512
Cdd:pfam00270 163 E 163
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
366-518 |
1.51e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 113.58 E-value: 1.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 366 QKEAIYH-LEKGDSVFVAAHTSAGKTVVAEYA---FALATKhctRAVYTAPIKTISNQKYRDFCGK----FDVGLLTGDV 437
Cdd:cd18028 6 QAEAVRAgLLKGENLLISIPTASGKTLIAEMAmvnTLLEGG---KALYLVPLRALASEKYEEFKKLeeigLKVGISTGDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 438 SLRPE----ASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWeEVIIMLPRHIN----IVLLSATVPN 509
Cdd:cd18028 83 DEDDEwlgdYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTL-ESIVARLRRLNpntqIIGLSATIGN 161
|
....*....
gi 1281027023 510 TIEFADWIG 518
Cdd:cd18028 162 PDELAEWLN 170
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
358-536 |
5.26e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.81 E-value: 5.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 358 FPFELDTFQKEAIYHLEKGD-SVFVAAHTSAGKTVVAEYAF--ALATKHCTRAVYTAPIKTISNQKYRDF------CGKF 428
Cdd:smart00487 5 GFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPAleALKRGKGGRVLVLVPTRELAEQWAEELkklgpsLGLK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 429 DVGLLTGDVS-------LRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPRHINIV 501
Cdd:smart00487 85 VVGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLL 164
|
170 180 190
....*....|....*....|....*....|....*
gi 1281027023 502 LLSATVPNTIEFADWIGRTKQKRIHVTGTTKRPVP 536
Cdd:smart00487 165 LLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIE 199
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
363-526 |
2.70e-25 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 104.76 E-value: 2.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 363 DTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRA--VYTAPIKTISNQKYRDFCGKFD----------V 430
Cdd:cd18025 3 DAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLRESDDGvvVYVAPTKALVNQVVAEVYARFSkkyppsgkslW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 431 GLLTGDVSLRPEASCLIMTT--EILRSMLY--RGADIIRDIEWVIFDEVHYVNDVERGVVWEEVIIMLPrhINIVLLSAT 506
Cdd:cd18025 83 GVFTRDYRHNNPMNCQVLITvpECLEILLLspHNASWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLLIP--CPFLALSAT 160
|
170 180
....*....|....*....|
gi 1281027023 507 VPNTIEFADWIGRTKQKRIH 526
Cdd:cd18025 161 IGNPQKFHEWLQSVQRARKA 180
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
366-534 |
6.28e-21 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 92.42 E-value: 6.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 366 QKEAIYHLEKGD-SVFVAAHTSAGKTVVAEYAFA-------LATKHCTRAVYTAPIKTISNQKYRDFCGKFD-----VGL 432
Cdd:cd18023 6 QSEVFPDLLYSDkNFVVSAPTGSGKTVLFELAILrllkernPLPWGNRKVVYIAPIKALCSEKYDDWKEKFGplglsCAE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 433 LTGDV---SLRPEASC-LIMTT-EILRSMLYRGAD---IIRDIEWVIFDEVHYVNDvERGVVWEEVI-----------IM 493
Cdd:cd18023 86 LTGDTemdDTFEIQDAdIILTTpEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEVVVsrmktlsssseLR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1281027023 494 LPRHINI--VLLSATVPNTIEFADWIGrTKQKRIHVTGTTKRP 534
Cdd:cd18023 165 GSTVRPMrfVAVSATIPNIEDLAEWLG-DNPAGCFSFGESFRP 206
|
|
| Ski2_N |
pfam17911 |
Ski2 N-terminal region; This region is the N-terminal extended region found in the Ski2 ... |
78-225 |
4.62e-20 |
|
Ski2 N-terminal region; This region is the N-terminal extended region found in the Ski2 protein. The Ski complex is a conserved multiprotein assembly required for the cytoplasmic functions of the exosome, including RNA turnover, surveillance, and interference. Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry.
Pssm-ID: 465562 Cd Length: 134 Bit Score: 87.72 E-value: 4.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 78 EKVGRQWDFDWFEMAKVSLDPSQPRSVvvptwvLPFERtkkDGTTGGTWEPCSV-QVDVSELNveAQESGSQPRVPGPAK 156
Cdd:pfam17911 1 DKAQRHWDRDKDYKSLLKIPPSPSRTT------LRFKR---DGLEGKIVGYKEVsLVEISNAT--AKNSLSLNRKPGPKS 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1281027023 157 DFVRGSINNRPFRPGGLDDSQSVDrilPDAASNGEWvQEILNGGRAQFVPPILKQGLDLGDLKEYPNSW 225
Cdd:pfam17911 70 DFVRGSSSNLPFAPGGLDEEVLKD---SEGVDSGLK-RLHRDEGGLLDVPPGFSRGLDFGEDEETDDDE 134
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
377-522 |
2.85e-16 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 78.45 E-value: 2.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 377 DSVFVAAHTSAGKTVVAEYAF--ALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGL------LTGDVS--LR-PEASC 445
Cdd:cd18021 20 DNVFVGAPTGSGKTVCAELALlrHWRQNPKGRAVYIAPMQELVDARYKDWRAKFGPLLgkkvvkLTGETStdLKlLAKSD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 446 LIMTT----EILrSMLYRGADIIRDIEWVIFDEVHYVNDVErGVVWEEVI-------IMLPRHINIVLLSATVPNTIEFA 514
Cdd:cd18021 100 VILATpeqwDVL-SRRWKQRKNVQSVELFIADELHLIGGEN-GPVYEVVVsrmryisSQLEKPIRIVGLSSSLANARDVG 177
|
....*...
gi 1281027023 515 DWIGRTKQ 522
Cdd:cd18021 178 EWLGASKS 185
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
369-518 |
9.20e-15 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 73.95 E-value: 9.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 369 AIYHLEkgDSVFVAAHTSAGKTVVAEYAF--ALATKHCTRAVYTAPIKTISNQKYRDFCGKFDVGL------LTGDVSLR 440
Cdd:cd18022 12 TLYHTD--NNVLLGAPTGSGKTIAAELAMfrAFNKYPGSKVVYIAPLKALVRERVDDWKKRFEEKLgkkvveLTGDVTPD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 441 PE----ASCLIMTTE----ILRSMLYRGadIIRDIEWVIFDEVHYVNDvERGVVWeEVII----MLPRH----INIVLLS 504
Cdd:cd18022 90 MKaladADIIITTPEkwdgISRSWQTRE--YVQQVSLIIIDEIHLLGS-DRGPVL-EVIVsrmnYISSQtekpVRLVGLS 165
|
170
....*....|....
gi 1281027023 505 ATVPNTIEFADWIG 518
Cdd:cd18022 166 TALANAGDLANWLG 179
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
373-806 |
1.94e-13 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 75.31 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 373 LEKGDSVFVAAHTSAGKTVVAEYA---FALATKhcTRAVYTAPIKTISNQKYRDFCGKFDVGLltgDVSLR--------- 440
Cdd:COG1202 222 LLEGKDQLVVSATATGKTLIGELAgikNALEGK--GKMLFLVPLVALANQKYEDFKDRYGDGL---DVSIRvgasrirdd 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 441 -----PEASCLIMTTEILRSMLYRGADIiRDIEWVIFDEVHYVNDVERGVVWEEVIIMLpRHI----NIVLLSATVPNTI 511
Cdd:COG1202 297 gtrfdPNADIIVGTYEGIDHALRTGRDL-GDIGTVVIDEVHMLEDPERGHRLDGLIARL-KYYcpgaQWIYLSATVGNPE 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 512 EFAdwigrtKQKRIHVTGTTKRPVPLE-HCIFysgesykiceseiflshglkaakdaskkktssvasgshvgasvsndgA 590
Cdd:COG1202 375 ELA------KKLGAKLVEYEERPVPLErHLTF-----------------------------------------------A 401
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 591 RNRknesfsrskqnkhsgsqnlgnfsgtswgnQKNGdsqnnwgsrrsdasswllLINRLSKKSLLPV---------VIFC 661
Cdd:COG1202 402 DGR-----------------------------EKIR------------------IINKLVKREFDTKsskgyrgqtIIFT 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 662 FSKNRCDKSADSIysidltsssekseirvfcdkafsrlkgsdrtlpqivrvqgllhrGIGV--HHAGLLPIVKEVVEMLF 739
Cdd:COG1202 435 NSRRRCHEIARAL--------------------------------------------GYKAapYHAGLDYGERKKVERRF 470
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1281027023 740 CRGVIKVLFSTETFAMGVNAPARTVVFDTLRKfdGKEFrqLLPGEYTQMAGRAGRRGLDKIGTVIVM 806
Cdd:COG1202 471 ADQELAAVVTTAALAAGVDFPASQVIFDSLAM--GIEW--LSVQEFHQMLGRAGRPDYHDRGKVYLL 533
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
745-806 |
5.24e-13 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 67.58 E-value: 5.24e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1281027023 745 KVLFSTETFAMGVNAPARTVVFDTLRKFDGKEFRQLLPGEYTQMAGRAGRRGLD-KIGTVIVM 806
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSHfPEGEVTTL 134
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
716-796 |
5.02e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.00 E-value: 5.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 716 LHRGIGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAP-ARTVVFDTLRKFdgkefrqllPGEYTQMAGRAGR 794
Cdd:smart00490 10 LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLPWS---------PASYIQRIGRAGR 80
|
..
gi 1281027023 795 RG 796
Cdd:smart00490 81 AG 82
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
376-506 |
1.99e-11 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 63.19 E-value: 1.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 376 GDSVFVAAHTSAGKTVVAE-YAFALATKHCTRAVYTAPIKTISNQKYRDFCGKFD----VGLLTGDVSL-------RPEA 443
Cdd:cd00046 1 GENVLITAPTGSGKTLAALlAALLLLLKKGKKVLVLVPTKALALQTAERLRELFGpgirVAVLVGGSSAeereknkLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1281027023 444 SCLIMTTE-ILRSMLYRGADIIRDIEWVIFDEVHYVNDVERGVVweeviIMLPRHIN-------IVLLSAT 506
Cdd:cd00046 81 DIIIATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGAL-----ILDLAVRKaglknaqVILLSAT 146
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
364-514 |
8.60e-11 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 62.22 E-value: 8.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 364 TFQKEAIYHLEKGDSVFVAAHTSAGKTVvaeyAF------ALATKHCTRAVYTAPIKTISN---QKYRDF----CGKFDV 430
Cdd:cd17923 3 SHQAEAIEAARAGRSVVVTTGTASGKSL----CYqlpileALLRDPGSRALYLYPTKALAQdqlRSLRELleqlGLGIRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 431 GLLTGDVS-------LRPEASCLIMTTEILRSMLYRGAD----IIRDIEWVIFDEVHYVndveRGVVWEEVIIMLPR--- 496
Cdd:cd17923 79 ATYDGDTPreerraiIRNPPRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTY----RGVFGSHVALLLRRlrr 154
|
170 180
....*....|....*....|....*
gi 1281027023 497 -------HINIVLLSATVPNTIEFA 514
Cdd:cd17923 155 lcrrygaDPQFILTSATIGNPAEHA 179
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
353-506 |
4.70e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 60.81 E-value: 4.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 353 DMALDFPFELDTFQKEAIYHL------EKGDSVFVAAhTSAGKTVVAeYAFALATKHCTRAVYTAPIKTISNQKYRDFCG 426
Cdd:COG1061 72 DEASGTSFELRPYQQEALEALlaalerGGGRGLVVAP-TGTGKTVLA-LALAAELLRGKRVLVLVPRRELLEQWAEELRR 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 427 KFDVGLLTGDvSLRPEASCLIMTTEILRSMLYRgADIIRDIEWVIFDEVHYVndveRGVVWEEVIIMLPRHInIVLLSAT 506
Cdd:COG1061 150 FLGDPLAGGG-KKDSDAPITVATYQSLARRAHL-DELGDRFGLVIIDEAHHA----GAPSYRRILEAFPAAY-RLGLTAT 222
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
376-517 |
1.37e-08 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 55.67 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 376 GDSVFVAAHTSAGKTvvaEYAF-----ALATKHC--TRAVYTAPIKTISNQKYR---DFCGKFD----VGLLTGDVS--- 438
Cdd:cd17922 1 GRNVLIAAPTGSGKT---EAAFlpalsSLADEPEkgVQVLYISPLKALINDQERrleEPLDEIDleipVAVRHGDTSqse 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 439 ----LRPEASCLIMTTEILRSML-YRGAD-IIRDIEWVIFDEVHYVNDVERGV-------VWEEVIIMLPRHINivlLSA 505
Cdd:cd17922 78 kakqLKNPPGILITTPESLELLLvNKKLReLFAGLRYVVVDEIHALLGSKRGVqlellleRLRKLTGRPLRRIG---LSA 154
|
170
....*....|..
gi 1281027023 506 TVPNTIEFADWI 517
Cdd:cd17922 155 TLGNLEEAAAFL 166
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
366-517 |
5.18e-08 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 54.53 E-value: 5.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 366 QKEAIYH--LEKGDSVFVAAHTSAGKTVVAEyAFALATKHCTR--AVYTAPIKTISNQKYRDFCGKF-DVGLL------- 433
Cdd:cd18026 21 QKECLSLpgLLEGRNLVYSLPTSGGKTLVAE-ILMLKRLLERRkkALFVLPYVSIVQEKVDALSPLFeELGFRvegyagn 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 434 --TGDVSLRPEASCLIMTTEILRSMLYRG--ADIIRDIEWVIFDEVHYVNDVERGVVWE----EVIIMLPRHINIVLLSA 505
Cdd:cd18026 100 kgRSPPKRRKSLSVAVCTIEKANSLVNSLieEGRLDELGLVVVDELHMLGDGHRGALLEllltKLLYAAQKNIQIVGMSA 179
|
170
....*....|..
gi 1281027023 506 TVPNTIEFADWI 517
Cdd:cd18026 180 TLPNLEELASWL 191
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
364-514 |
2.37e-07 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 55.23 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 364 TFQKEAIYHLEKGDSVFVAAHTSAGKTvvaeYAF------ALATKHCTRAVYTAPIKTISN---QKYRDFCGKFDVGL-- 432
Cdd:COG1205 59 SHQAEAIEAARAGKNVVIATPTASGKS----LAYllpvleALLEDPGATALYLYPTKALARdqlRRLRELAEALGLGVrv 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 433 --LTGDVS------LRPEASCLIMTTEIL-RSMLYRG---ADIIRDIEWVIFDEVH-YvndveRGV----V-WeeVI--- 491
Cdd:COG1205 135 atYDGDTPpeerrwIREHPDIVLTNPDMLhYGLLPHHtrwARFFRNLRYVVIDEAHtY-----RGVfgshVaN--VLrrl 207
|
170 180
....*....|....*....|....*....
gi 1281027023 492 --IMlpRHIN----IVLLSATVPNTIEFA 514
Cdd:COG1205 208 rrIC--RHYGsdpqFILASATIGNPAEHA 234
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
720-796 |
5.74e-07 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 49.52 E-value: 5.74e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1281027023 720 IGVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAPARTVVFDTLRKFDgkefrqllPGEYTQMAGRAGRRG 796
Cdd:pfam00271 41 VARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPWN--------PASYIQRIGRAGRAG 109
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
368-526 |
6.18e-07 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 51.66 E-value: 6.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 368 EAIYHLEkgDSVFVAAHTSAGKTVVAEYAFaLATKHCT------------RAVYTAPIKTISNQKYRDFCGKFD-----V 430
Cdd:cd18020 11 PVAYKTN--ENMLICAPTGAGKTNIAMLTI-LHEIRQHvnqggvikkddfKIVYIAPMKALAAEMVEKFSKRLAplgikV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 431 GLLTGDVSLRP---EASCLIMTTEILRSMLYRGA----DIIRDIEWVIFDEVHYVNDvERGVVWEEVIIMLPRH------ 497
Cdd:cd18020 88 KELTGDMQLTKkeiAETQIIVTTPEKWDVVTRKSsgdvALSQLVRLLIIDEVHLLHD-DRGPVIESLVARTLRQvestqs 166
|
170 180 190
....*....|....*....|....*....|
gi 1281027023 498 -INIVLLSATVPNTIEFADWIGRTKQKRIH 526
Cdd:cd18020 167 mIRIVGLSATLPNYLDVADFLRVNPYKGLF 196
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
365-506 |
1.96e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 48.84 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 365 FQKEAI----YHLEKGDSVFVAAhTSAGKTVVAEYAFALATKHctRAVYTAPIKTISNQ---KYRDFCGKFDVGLLTGDV 437
Cdd:cd17926 4 YQEEALeawlAHKNNRRGILVLP-TGSGKTLTALALIAYLKEL--RTLIVVPTDALLDQwkeRFEDFLGDSSIGLIGGGK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 438 S-LRPEASCLIMTTEILRSMLYRGADIIRDIEWVIFDEVHYVNdverGVVWEEVIIMLPRHiNIVLLSAT 506
Cdd:cd17926 81 KkDFDDANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHHLP----AKTFSEILKELNAK-YRLGLTAT 145
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
373-509 |
9.80e-06 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 48.14 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 373 LEKGDSVFVAAHTSAGKTVVAeyafaLAT------KHCTRA----------VYTAPIKTISNQKYRDFCGKFD-----VG 431
Cdd:cd18019 30 FETDENLLLCAPTGAGKTNVA-----LLTilreigKHRNPDgtinldafkiVYIAPMKALVQEMVGNFSKRLApygitVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 432 LLTGDVSLRPEAsclIMTTEILRSMLYRGADIIRD---------IEWVIFDEVHYVNDvERGVVWEEVIIMLPRHIN--- 499
Cdd:cd18019 105 ELTGDQQLTKEQ---ISETQIIVTTPEKWDIITRKsgdrtytqlVRLIIIDEIHLLHD-DRGPVLESIVARTIRQIEqtq 180
|
170
....*....|....
gi 1281027023 500 ----IVLLSATVPN 509
Cdd:cd18019 181 eyvrLVGLSATLPN 194
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
381-518 |
4.97e-05 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 48.00 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 381 VAAHTSAGKTVVA----------EYAFALATKH---CTRAVYTAPIKT---------------ISNQKYR--DFCGKFDV 430
Cdd:PRK09751 1 VIAPTGSGKTLAAflyaldrlfrEGGEDTREAHkrkTSRILYISPIKAlgtdvqrnlqiplkgIADERRRrgETEVNLRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 431 GLLTGDVS-------LRPEASCLIMTTEILRSMLY-RGADIIRDIEWVIFDEVHYVNDVERG----VVWEEVIIMLPRHI 498
Cdd:PRK09751 81 GIRTGDTPaqersklTRNPPDILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHTSA 160
|
170 180
....*....|....*....|
gi 1281027023 499 NIVLLSATVPNTIEFADWIG 518
Cdd:PRK09751 161 QRIGLSATVRSASDVAAFLG 180
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
365-524 |
5.10e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 47.79 E-value: 5.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 365 FQKEAIYHLEKGDSVFVAAHTSAGKT------VVAEYAF---ALATKHCTRAVYTAPIKTISN--------------QKY 421
Cdd:COG1201 28 PQREAWPAIAAGESTLLIAPTGSGKTlaaflpALDELARrprPGELPDGLRVLYISPLKALANdiernlrapleeigEAA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 422 RDFCGKFDVGLLTGDVS-------LR--PEasCLIMTTEILRSMLY--RGADIIRDIEWVIFDEVHYVNDVERGvvweeV 490
Cdd:COG1201 108 GLPLPEIRVGVRTGDTPaserqrqRRrpPH--ILITTPESLALLLTspDARELLRGVRTVIVDEIHALAGSKRG-----V 180
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1281027023 491 IIML---------PRHINIVLLSATVPNTIEFADWIGRTKQKR 524
Cdd:COG1201 181 HLALslerlralaPRPLQRIGLSATVGPLEEVARFLVGYEDPR 223
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
349-514 |
5.25e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 45.48 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 349 ELVPDMALDFPFELDTFQKEAI------YHLEKGDSVFVAAHTSAGKTVVAEYAFALATKHCTRAVYTAPIKTISNQKY- 421
Cdd:cd17918 3 ALIQELCKSLPFSLTKDQAQAIkdiekdLHSPEPMDRLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYe 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 422 --RDFCGKFDVGLLTGDV--SLRPEASCLIMTTEILRSmlyrgADIIRDIEWVIFDEVHYVndverGVVWEEVIIMLpRH 497
Cdd:cd17918 83 eaRKFLPFINVELVTGGTkaQILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNL-GA 151
|
170
....*....|....*...
gi 1281027023 498 INIVLLSAT-VPNTIEFA 514
Cdd:cd17918 152 THFLEATATpIPRTLALA 169
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
685-797 |
1.52e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 46.24 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 685 KSEIrVFCDkafSRLKGSDRTlpqiVRVQGllhRGIGV--HHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAP-A 761
Cdd:PRK11057 237 KSGI-IYCN---SRAKVEDTA----ARLQS---RGISAaaYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPnV 305
|
90 100 110
....*....|....*....|....*....|....*..
gi 1281027023 762 RTVV-FDTLRKFDgkefrqllpgEYTQMAGRAGRRGL 797
Cdd:PRK11057 306 RFVVhFDIPRNIE----------SYYQETGRAGRDGL 332
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
360-476 |
4.70e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 42.85 E-value: 4.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 360 FELDTFQKEAIYHLEKGDSVFVAAHTSAGKTVVAEYAfalATKHC---------TRAVYTAP-IKTISNQK---YRDFCG 426
Cdd:cd18036 1 LELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYI---CRHHLekrrsagekGRVVVLVNkVPLVEQQLekfFKYFRK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1281027023 427 KFDVGLLTGD----VSLRPEA---SCLIMTTEILRSMLYRGADIIR----DIEWVIFDEVH 476
Cdd:cd18036 78 GYKVTGLSGDsshkVSFGQIVkasDVIICTPQILINNLLSGREEERvylsDFSLLIFDECH 138
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
711-797 |
8.30e-04 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 41.04 E-value: 8.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 711 RVQGLLHR-GI--GVHHAGLLPIVKEVVEMLFCRGVIKVLFSTETFAMGVNAP-ARTVVFDTLRK-FDGkefrqllpgeY 785
Cdd:cd18794 45 QVAARLQSkGIsaAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPdVRFVIHYSLPKsMES----------Y 114
|
90
....*....|..
gi 1281027023 786 TQMAGRAGRRGL 797
Cdd:cd18794 115 YQESGRAGRDGL 126
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
366-512 |
6.25e-03 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 40.52 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 366 QKEAIYHLEKGDSVFVAAHTSAGKTVvaeyAFAL--------ATKHCTRAVYTAP-----------IKTISnqKYRDfcg 426
Cdd:COG0513 29 QAQAIPLILAGRDVLGQAQTGTGKTA----AFLLpllqrldpSRPRAPQALILAPtrelalqvaeeLRKLA--KYLG--- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281027023 427 kFDVGLLTGDVSLRPEasclimtteilRSMLYRGADII------------------RDIEWVIFDEVH------YVNDVE 482
Cdd:COG0513 100 -LRVATVYGGVSIGRQ-----------IRALKRGVDIVvatpgrlldliergaldlSGVETLVLDEADrmldmgFIEDIE 167
|
170 180 190
....*....|....*....|....*....|.
gi 1281027023 483 RgvvweevII-MLPRHINIVLLSATVPNTIE 512
Cdd:COG0513 168 R-------ILkLLPKERQTLLFSATMPPEIR 191
|
|
| |
