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Conserved domains on  [gi|12805629|gb|AAH02295|]
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Deoxyhypusine hydroxylase/monooxygenase [Mus musculus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.110
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
24-129 1.22e-13

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 66.58  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629  24 RFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDTSqePMVRHEAGEALGAIGNPEV 103
Cdd:COG1413  33 RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDED--PEVRRAAAEALGRLGDPAA 110

                        90       100
                ....*....|....*....|....*.
gi 12805629 104 LGLLKQYSTDPVVEVAETCQLAVGRL 129
Cdd:COG1413 111 VPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
155-278 4.68e-12

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 4.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629 155 AEQDVGRLREALLDEARPLfeRYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLarTT 234
Cdd:COG1413  14 DPAAVPALIAALADEDPDV--RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAAL--KD 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12805629 235 ESPMVRHECAEALGAIARPACLAALREHIEDPEQVVRESCEVAL 278
Cdd:COG1413  90 EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
24-129 1.22e-13

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 66.58  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629  24 RFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDTSqePMVRHEAGEALGAIGNPEV 103
Cdd:COG1413  33 RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDED--PEVRRAAAEALGRLGDPAA 110

                        90       100
                ....*....|....*....|....*.
gi 12805629 104 LGLLKQYSTDPVVEVAETCQLAVGRL 129
Cdd:COG1413 111 VPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
155-278 4.68e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 4.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629 155 AEQDVGRLREALLDEARPLfeRYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLarTT 234
Cdd:COG1413  14 DPAAVPALIAALADEDPDV--RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAAL--KD 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12805629 235 ESPMVRHECAEALGAIARPACLAALREHIEDPEQVVRESCEVAL 278
Cdd:COG1413  90 EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 48-118 7.09e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 49.26  E-value: 7.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12805629    48 EDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDTSqePMVRHEAGEALGAIGNPEVLGLLKQYSTDPVVEV 118
Cdd:pfam13646  10 RDPDPEVRAAAIRALGRIGDPEAVPALLELLKDED--PAVRRAAAEALGKIGDPEALPALLELLRDDDDDV 78
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 207-278 4.55e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.95  E-value: 4.55e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12805629   207 RHEVGYVLGQLQHEAAVPGLAATLarTTESPMVRHECAEALGAIARPACLAALREHI-EDPEQVVRESCEVAL 278
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELL--KDEDPAVRRAAAEALGKIGDPEALPALLELLrDDDDDVVRAAAAEAL 87
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 237-266 5.55e-05

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 5.55e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 12805629    237 PMVRHECAEALGAIARPACLAALREHIEDP 266
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 85-114 9.95e-04

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 35.85  E-value: 9.95e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 12805629     85 PMVRHEAGEALGAIGNPEVLGLLKQYSTDP 114
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
24-129 1.22e-13

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 66.58  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629  24 RFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDTSqePMVRHEAGEALGAIGNPEV 103
Cdd:COG1413  33 RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDED--PEVRRAAAEALGRLGDPAA 110

                        90       100
                ....*....|....*....|....*.
gi 12805629 104 LGLLKQYSTDPVVEVAETCQLAVGRL 129
Cdd:COG1413 111 VPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
155-278 4.68e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 4.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629 155 AEQDVGRLREALLDEARPLfeRYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLarTT 234
Cdd:COG1413  14 DPAAVPALIAALADEDPDV--RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAAL--KD 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12805629 235 ESPMVRHECAEALGAIARPACLAALREHIEDPEQVVRESCEVAL 278
Cdd:COG1413  90 EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
24-130 1.05e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.18  E-value: 1.05e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629  24 RFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDTSqePMVRHEAGEALGAIGNPEV 103
Cdd:COG1413   2 RRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPD--PEVRAAAAEALGRIGDPEA 79

                        90       100
                ....*....|....*....|....*..
gi 12805629 104 LGLLKQYSTDPVVEVAETCQLAVGRLE 130
Cdd:COG1413  80 VPALIAALKDEDPEVRRAAAEALGRLG 106
HEAT COG1413
HEAT repeat [General function prediction only];
176-278 8.99e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.79  E-value: 8.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629 176 RYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLArtTESPMVRHECAEALGAIARPAC 255
Cdd:COG1413   2 RRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK--DPDPEVRAAAAEALGRIGDPEA 79

                        90       100
                ....*....|....*....|...
gi 12805629 256 LAALREHIEDPEQVVRESCEVAL 278
Cdd:COG1413  80 VPALIAALKDEDPEVRRAAAEAL 102
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 48-118 7.09e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 49.26  E-value: 7.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12805629    48 EDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDTSqePMVRHEAGEALGAIGNPEVLGLLKQYSTDPVVEV 118
Cdd:pfam13646  10 RDPDPEVRAAAIRALGRIGDPEAVPALLELLKDED--PAVRRAAAEALGKIGDPEALPALLELLRDDDDDV 78
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 207-278 4.55e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.95  E-value: 4.55e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12805629   207 RHEVGYVLGQLQHEAAVPGLAATLarTTESPMVRHECAEALGAIARPACLAALREHI-EDPEQVVRESCEVAL 278
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELL--KDEDPAVRRAAAEALGKIGDPEALPALLELLrDDDDDVVRAAAAEAL 87
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 24-96 6.41e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.56  E-value: 6.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12805629    24 RFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDVRAIPVLVGVLQDtSQEPMVRHEAGEALG 96
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRD-DDDDVVRAAAAEALA 88
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 237-266 5.55e-05

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 5.55e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 12805629    237 PMVRHECAEALGAIARPACLAALREHIEDP 266
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 162-248 2.50e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 39.24  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12805629   162 LREALLDEARPLFeRYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAAtLARTTESPMVRH 241
Cdd:pfam13646   4 LLQALLRDPDPEV-RAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLE-LLRDDDDDVVRA 81


                  ....*..
gi 12805629   242 ECAEALG 248
Cdd:pfam13646  82 AAAEALA 88
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 85-114 9.95e-04

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 35.85  E-value: 9.95e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 12805629     85 PMVRHEAGEALGAIGNPEVLGLLKQYSTDP 114
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 223-271 8.30e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.01  E-value: 8.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 12805629   223 VPGLAATLARTtESPMVRHECAEALGAIARPACLAALREHIEDPEQVVR 271
Cdd:pfam13646   1 LPALLQALLRD-PDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVR 48
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 52-81 9.55e-03

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 33.16  E-value: 9.55e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 12805629     52 ALLKHELAYCLGQMRDVRAIPVLVGVLQDT 81
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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