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Conserved domains on  [gi|12804513|gb|AAH01667|]
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Jumping translocation breakpoint [Homo sapiens]

Protein Classification

JTB domain-containing protein( domain architecture ID 10527183)

JTB domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JTB pfam05439
Jumping translocation breakpoint protein (JTB); This family contains several jumping ...
 37-143 2.41e-40

Jumping translocation breakpoint protein (JTB); This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the trans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex). JTB has also been implicated in prostatic carcinomas.


:

Pssm-ID: 398872  Cd Length: 110  Bit Score: 130.95  E-value: 2.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12804513    37 EKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTP--ECGPTGYVEKITCSSSKRNEFKSC-RSALMEQRLFWKFEGAV 113
Cdd:pfam05439   1 TKVFTIESNSTCWKHEEFEVVKECHPCSDFEIKSRSigVCIHTGYKEVLKCSKSGEIVTRSCdRVALLEEREFWKFEGFM 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 12804513   114 VCVALIFACLVIIRQRQLDRKALEKVRKQI 143
Cdd:pfam05439  81 FVIGTLSALVVVLRQRVLDRRAYMRVQRQI 110
 
Name Accession Description Interval E-value
JTB pfam05439
Jumping translocation breakpoint protein (JTB); This family contains several jumping ...
 37-143 2.41e-40

Jumping translocation breakpoint protein (JTB); This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the trans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex). JTB has also been implicated in prostatic carcinomas.


Pssm-ID: 398872  Cd Length: 110  Bit Score: 130.95  E-value: 2.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12804513    37 EKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTP--ECGPTGYVEKITCSSSKRNEFKSC-RSALMEQRLFWKFEGAV 113
Cdd:pfam05439   1 TKVFTIESNSTCWKHEEFEVVKECHPCSDFEIKSRSigVCIHTGYKEVLKCSKSGEIVTRSCdRVALLEEREFWKFEGFM 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 12804513   114 VCVALIFACLVIIRQRQLDRKALEKVRKQI 143
Cdd:pfam05439  81 FVIGTLSALVVVLRQRVLDRRAYMRVQRQI 110
 
Name Accession Description Interval E-value
JTB pfam05439
Jumping translocation breakpoint protein (JTB); This family contains several jumping ...
 37-143 2.41e-40

Jumping translocation breakpoint protein (JTB); This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the trans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex). JTB has also been implicated in prostatic carcinomas.


Pssm-ID: 398872  Cd Length: 110  Bit Score: 130.95  E-value: 2.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12804513    37 EKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTP--ECGPTGYVEKITCSSSKRNEFKSC-RSALMEQRLFWKFEGAV 113
Cdd:pfam05439   1 TKVFTIESNSTCWKHEEFEVVKECHPCSDFEIKSRSigVCIHTGYKEVLKCSKSGEIVTRSCdRVALLEEREFWKFEGFM 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 12804513   114 VCVALIFACLVIIRQRQLDRKALEKVRKQI 143
Cdd:pfam05439  81 FVIGTLSALVVVLRQRVLDRRAYMRVQRQI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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