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Conserved domains on  [gi|1279817386|ref|XP_022962361|]
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F-box/kelch-repeat protein At1g23390-like isoform X2 [Cucurbita moschata]

Protein Classification

F-box protein( domain architecture ID 10644568)

F-box protein may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
114-229 1.89e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.08  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 114 SASRFAFSMDPLHLNWEVAAP-PIGWRPDPVVAAVGNHIVVAGsgAYCGIQDDDTIPP-LEIYDTTTGTWEWCDSMPTEL 191
Cdd:COG3055    35 SASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFG--GFTGANPSSTPLNdVYVYDPATNTWTKLAPMPTPR 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1279817386 192 MDSAAstwlsvAADQNKMYV-----SVKRSGVTYSFDPRTKTW 229
Cdd:COG3055   113 GGATA------LLLDGKIYVvggwdDGGNVAWVEVYDPATGTW 149
FBOX smart00256
A Receptor for Ubiquitination Targets;
13-42 1.68e-03

A Receptor for Ubiquitination Targets;


:

Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.68e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1279817386   13 DILEEIISHVPLVDLVSANSVASSWRSAIS 42
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLID 33
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
114-229 1.89e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.08  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 114 SASRFAFSMDPLHLNWEVAAP-PIGWRPDPVVAAVGNHIVVAGsgAYCGIQDDDTIPP-LEIYDTTTGTWEWCDSMPTEL 191
Cdd:COG3055    35 SASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFG--GFTGANPSSTPLNdVYVYDPATNTWTKLAPMPTPR 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1279817386 192 MDSAAstwlsvAADQNKMYV-----SVKRSGVTYSFDPRTKTW 229
Cdd:COG3055   113 GGATA------LLLDGKIYVvggwdDGGNVAWVEVYDPATGTW 149
FBOX smart00256
A Receptor for Ubiquitination Targets;
13-42 1.68e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.68e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1279817386   13 DILEEIISHVPLVDLVSANSVASSWRSAIS 42
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLID 33
PHA03098 PHA03098
kelch-like protein; Provisional
 129-229 4.30e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.98  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 129 WEVAAPPIGWRPDPVVAAVGNHIVVAGsgaycGIQDDDT-IPPLEIYDTTTGTWEWCDSMPTELMDSaastwlSVAADQN 207
Cdd:PHA03098  370 WREEPPLIFPRYNPCVVNVNNLIYVIG-----GISKNDElLKTVECFSLNTNKWSKGSPLPISHYGG------CAIYHDG 438

                          90       100       110
                  ....*....|....*....|....*....|
gi 1279817386 208 KMYVS--------VKRSGVTYSFDPRTKTW 229
Cdd:PHA03098  439 KIYVIggisyidnIKVYNIVESYNPVTNKW 468
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 13-49 4.84e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.44  E-value: 4.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1279817386  13 DILEEIISHVPLVDLVSANSVASSWRSAISTSLLRLN 49
Cdd:pfam00646   7 DLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
114-229 1.89e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.08  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 114 SASRFAFSMDPLHLNWEVAAP-PIGWRPDPVVAAVGNHIVVAGsgAYCGIQDDDTIPP-LEIYDTTTGTWEWCDSMPTEL 191
Cdd:COG3055    35 SASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFG--GFTGANPSSTPLNdVYVYDPATNTWTKLAPMPTPR 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1279817386 192 MDSAAstwlsvAADQNKMYV-----SVKRSGVTYSFDPRTKTW 229
Cdd:COG3055   113 GGATA------LLLDGKIYVvggwdDGGNVAWVEVYDPATGTW 149
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
143-229 1.98e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.08  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 143 VVAAVGNHIVVAGsgaycGIQDDDTIPPLEIYDTTTGTWEWCDSMPTELMDSAAstwlsVAADQNKMYV---------SV 213
Cdd:COG3055    17 AAALLDGKVYVAG-----GLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAA-----AVAQDGKLYVfggftganpSS 86

                          90
                  ....*....|....*.
gi 1279817386 214 KRSGVTYSFDPRTKTW 229
Cdd:COG3055    87 TPLNDVYVYDPATNTW 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
129-211 6.69e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 40.91  E-value: 6.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 129 WEVAAPPIGWRPDPVVAAVGNHIVVAGsgaycGIQDDDTIPPLEIYDTTTGTWEWCDSMPTELMDSAAstwlsVAADQNK 208
Cdd:COG3055   102 WTKLAPMPTPRGGATALLLDGKIYVVG-----GWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAA-----AVLPDGK 171


                  ...
gi 1279817386 209 MYV 211
Cdd:COG3055   172 ILV 174
FBOX smart00256
A Receptor for Ubiquitination Targets;
13-42 1.68e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.68e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1279817386   13 DILEEIISHVPLVDLVSANSVASSWRSAIS 42
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLID 33
PHA03098 PHA03098
kelch-like protein; Provisional
 129-229 4.30e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.98  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279817386 129 WEVAAPPIGWRPDPVVAAVGNHIVVAGsgaycGIQDDDT-IPPLEIYDTTTGTWEWCDSMPTELMDSaastwlSVAADQN 207
Cdd:PHA03098  370 WREEPPLIFPRYNPCVVNVNNLIYVIG-----GISKNDElLKTVECFSLNTNKWSKGSPLPISHYGG------CAIYHDG 438

                          90       100       110
                  ....*....|....*....|....*....|
gi 1279817386 208 KMYVS--------VKRSGVTYSFDPRTKTW 229
Cdd:PHA03098  439 KIYVIggisyidnIKVYNIVESYNPVTNKW 468
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 13-49 4.84e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.44  E-value: 4.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1279817386  13 DILEEIISHVPLVDLVSANSVASSWRSAISTSLLRLN 49
Cdd:pfam00646   7 DLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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