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Conserved domains on  [gi|1279776319|ref|XP_022940892|]
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WD repeat-containing protein 44-like [Cucurbita moschata]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
433-754 3.23e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 3.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 510
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGA-VTSVafSPD----- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 511 ekkrrGRSSISrksASLENVIvpeTVFGLSE-KPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLKIF 588
Cdd:COG2319   174 -----GKLLAS---GSDDGTV---RLWDLATgKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 589 S-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSCRLYSTSENK 666
Cdd:COG2319   243 TgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 667 MQQkseinlqnkKKKSSHKKITGFQFAPgSSSEVLITSADSRVRV--VDGVDLVYRFKGFRNTNSqiSACLSSNGRYVIS 744
Cdd:COG2319   322 LLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLAS 389

                         330
                  ....*....|
gi 1279776319 745 ASEDSHVYIW 754
Cdd:COG2319   390 GSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
433-754 3.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 3.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 510
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGA-VTSVafSPD----- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 511 ekkrrGRSSISrksASLENVIvpeTVFGLSE-KPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLKIF 588
Cdd:COG2319   174 -----GKLLAS---GSDDGTV---RLWDLATgKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 589 S-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSCRLYSTSENK 666
Cdd:COG2319   243 TgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 667 MQQkseinlqnkKKKSSHKKITGFQFAPgSSSEVLITSADSRVRV--VDGVDLVYRFKGFRNTNSqiSACLSSNGRYVIS 744
Cdd:COG2319   322 LLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLAS 389

                         330
                  ....*....|
gi 1279776319 745 ASEDSHVYIW 754
Cdd:COG2319   390 GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 432-755 2.90e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 2.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 432 SQEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTAnespeptslspnvdsHHE 511
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--------------ETGELLRTLKG---------------HTG 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 512 KKRRGRSSISRK---SASLENVIvpeTVFGL-SEKPVCSFEGHLDVVLDLSWSKSQHLLSSSM-DKTVRLWHLSSKSCLK 586
Cdd:cd00200    53 PVRDVAASADGTylaSGSSDKTI---RLWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLT 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 587 IF-SHSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSCRLYSTSE 664
Cdd:cd00200   130 TLrGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 665 NKMQQkseinlqnkKKKSSHKKITGFQFAPGSSsevLITSA--DSRVRV--VDGVDLVYRFKGfrNTNSQISACLSSNGR 740
Cdd:cd00200   209 GKCLG---------TLRGHENGVNSVAFSPDGY---LLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTSLAWSPDGK 274

                         330
                  ....*....|....*
gi 1279776319 741 YVISASEDSHVYIWK 755
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-466 3.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1279776319  433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 466
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
433-466 1.86e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 466
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 543-625 9.08e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 9.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 543 PVCSFEGHLDVVLDLSWSK--SQHLLSSSMDKTVRLWHLSS--------KSCLKIFS-HSDYVTCIQFNPIDdrYFI--S 609
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMN--YYImcS 143

                          90
                  ....*....|....*.
gi 1279776319 610 GSLDAKVRIWSIPDRQ 625
Cdd:PTZ00420  144 SGFDSFVNIWDIENEK 159
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
433-754 3.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 3.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 510
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGA-VTSVafSPD----- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 511 ekkrrGRSSISrksASLENVIvpeTVFGLSE-KPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLKIF 588
Cdd:COG2319   174 -----GKLLAS---GSDDGTV---RLWDLATgKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 589 S-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSCRLYSTSENK 666
Cdd:COG2319   243 TgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 667 MQQkseinlqnkKKKSSHKKITGFQFAPgSSSEVLITSADSRVRV--VDGVDLVYRFKGFRNTNSqiSACLSSNGRYVIS 744
Cdd:COG2319   322 LLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLAS 389

                         330
                  ....*....|
gi 1279776319 745 ASEDSHVYIW 754
Cdd:COG2319   390 GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 432-755 2.90e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 2.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 432 SQEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTAnespeptslspnvdsHHE 511
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--------------ETGELLRTLKG---------------HTG 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 512 KKRRGRSSISRK---SASLENVIvpeTVFGL-SEKPVCSFEGHLDVVLDLSWSKSQHLLSSSM-DKTVRLWHLSSKSCLK 586
Cdd:cd00200    53 PVRDVAASADGTylaSGSSDKTI---RLWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLT 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 587 IF-SHSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSCRLYSTSE 664
Cdd:cd00200   130 TLrGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 665 NKMQQkseinlqnkKKKSSHKKITGFQFAPGSSsevLITSA--DSRVRV--VDGVDLVYRFKGfrNTNSQISACLSSNGR 740
Cdd:cd00200   209 GKCLG---------TLRGHENGVNSVAFSPDGY---LLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTSLAWSPDGK 274

                         330
                  ....*....|....*
gi 1279776319 741 YVISASEDSHVYIWK 755
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
433-663 1.12e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 510
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGS-VRSVafSPD----- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 511 ekkrrGRSSISrksASLENVIvpeTVFGLSE-KPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLWHLSSKSCLKIF 588
Cdd:COG2319   258 -----GRLLAS---GSADGTV---RLWDLATgELLRTLTGHSGGVNSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTL 326

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1279776319 589 S-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHE-MVTAACYTPDGKGALVGSYKGSCRLYSTS 663
Cdd:COG2319   327 TgHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
540-754 6.11e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 6.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 540 SEKPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLWHLSSKSCLKIFS-HSDYVTCIQFNPiDDRYFISGSLDAKVR 617
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVAFSPdGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 618 IWSIPDRQVVDWSDLHE-MVTAACYTPDGKGALVGSYKGSCRLYSTSENKMQQKSEinlqnkkkkSSHKKITGFQFAPGS 696
Cdd:COG2319   188 LWDLATGKLLRTLTGHTgAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT---------GHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 697 SSeVLITSADSRVRV--VDGVDLVYRFKGfrNTNSQISACLSSNGRYVISASEDSHVYIW 754
Cdd:COG2319   259 RL-LASGSADGTVRLwdLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
433-623 5.42e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 5.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 510
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL--------------ATGELLRTLTGHSGG-VNSVafSPD----- 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 511 ekkrrGRSSISrksASLENVIvpeTVFGLSE-KPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLKIF 588
Cdd:COG2319   300 -----GKLLAS---GSDDGTV---RLWDLATgKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTL 368

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1279776319 589 S-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPD 623
Cdd:COG2319   369 TgHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 543-754 2.79e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 2.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 543 PVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCL--------------------KIFS------------ 589
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLrtlkghtgpvrdvaasadgtYLASgssdktirlwdl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 590 -----------HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSC 657
Cdd:cd00200    81 etgecvrtltgHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 658 RLYSTSENKMQQKSEINlqnkkkkssHKKITGFQFAPgSSSEVLITSADSRVRVVD--GVDLVYRFKGFrnTNSQISACL 735
Cdd:cd00200   160 KLWDLRTGKCVATLTGH---------TGEVNSVAFSP-DGEKLLSSSSDGTIKLWDlsTGKCLGTLRGH--ENGVNSVAF 227

                         250
                  ....*....|....*....
gi 1279776319 736 SSNGRYVISASEDSHVYIW 754
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
549-754 5.44e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 5.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 549 GHLDVVLDLSWSKSQHLLSSSMDKTVRLWHLSSKSCLKIFS-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVV 627
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 628 DWSDLHE-MVTAACYTPDGKGALVGSYKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITGFQFAPGSSSeVLITSAD 706
Cdd:COG2319   114 RTLTGHTgAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---------TLTGHSGAVTSVAFSPDGKL-LASGSDD 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1279776319 707 SRVRV--VDGVDLVYRFKGfrNTNSQISACLSSNGRYVISASEDSHVYIW 754
Cdd:COG2319   184 GTVRLwdLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-466 3.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1279776319  433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 466
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 581-620 4.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 4.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1279776319  581 SKSCLKIFS-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWS 620
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 540-578 1.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.45e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1279776319  540 SEKPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLWH 578
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
433-466 1.86e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1279776319 433 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 466
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
582-620 3.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 3.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1279776319 582 KSCLKIFS-HSDYVTCIQFNPiDDRYFISGSLDAKVRIWS 620
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
542-577 4.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1279776319 542 KPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLW 577
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 543-625 9.08e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 9.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279776319 543 PVCSFEGHLDVVLDLSWSK--SQHLLSSSMDKTVRLWHLSS--------KSCLKIFS-HSDYVTCIQFNPIDdrYFI--S 609
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMN--YYImcS 143

                          90
                  ....*....|....*.
gi 1279776319 610 GSLDAKVRIWSIPDRQ 625
Cdd:PTZ00420  144 SGFDSFVNIWDIENEK 159
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-477 1.24e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1279776319 425 ELSALYKSQEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVVESEKKGEL 477
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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