O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates; similar to O-fucosyltransferases which are involved in glycan metabolism
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
186-508
1.02e-139
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
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Pssm-ID: 211385 Cd Length: 290 Bit Score: 406.57 E-value: 1.02e-139
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
186-508
1.02e-139
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Pssm-ID: 211385 Cd Length: 290 Bit Score: 406.57 E-value: 1.02e-139
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
186-503
6.16e-71
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.
Pssm-ID: 463023 [Multi-domain] Cd Length: 247 Bit Score: 227.95 E-value: 6.16e-71
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
186-508
1.02e-139
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Pssm-ID: 211385 Cd Length: 290 Bit Score: 406.57 E-value: 1.02e-139
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
186-503
6.16e-71
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.
Pssm-ID: 463023 [Multi-domain] Cd Length: 247 Bit Score: 227.95 E-value: 6.16e-71
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
320-505
3.10e-10
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Pssm-ID: 211383 Cd Length: 206 Bit Score: 60.12 E-value: 3.10e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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