NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1278738497|gb|PJC36438|]
View 

MAG: hypothetical protein CO047_00045 [Piscirickettsiaceae bacterium CG_4_9_14_0_2_um_filter_44_546]

Protein Classification

HugZ family protein( domain architecture ID 11433526)

HugZ family protein of unknown function, similar to Nostoc sp. putative heme oxygenase (Alr5027)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HugZ COG0748
Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and ...
 1-171 6.43e-50

Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 440511 [Multi-domain]  Cd Length: 221  Bit Score: 160.13  E-value: 6.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497   1 MKPAVDQIADDFHTYIASFQSAILATVNQSATPDASYAP-ILQQNGHFYIFISELAQHTENLMTTPTASLLFIEPEEDAG 79
Cdd:COG0748     1 DEEADEEAAEEARTLLRSARSGALATLDADGYPFASYAPfALDDDGSPYILISGLAEHTRNLLADPRASLLLIEDESKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  80 NLFARKRATIQVVARPIArTDADWPGLLDAMQAQLGEMiSILRNLADFHLFELTPIKANFVKGFAQAYELEGDRLTAVQH 159
Cdd:COG0748    81 DPLARPRLTLQGRAERVE-DSEEWEAARARYLARFPKA-ALYADLPDFSLFRLTPERGRLVGGFGRAYWLSGEDLLGADA 158

                         170
                  ....*....|..
gi 1278738497 160 RQGAGHRRVEDD 171
Cdd:COG0748   159 AEAGAVEHMNDD 170
 
Name Accession Description Interval E-value
HugZ COG0748
Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and ...
 1-171 6.43e-50

Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and metabolism];


Pssm-ID: 440511 [Multi-domain]  Cd Length: 221  Bit Score: 160.13  E-value: 6.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497   1 MKPAVDQIADDFHTYIASFQSAILATVNQSATPDASYAP-ILQQNGHFYIFISELAQHTENLMTTPTASLLFIEPEEDAG 79
Cdd:COG0748     1 DEEADEEAAEEARTLLRSARSGALATLDADGYPFASYAPfALDDDGSPYILISGLAEHTRNLLADPRASLLLIEDESKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  80 NLFARKRATIQVVARPIArTDADWPGLLDAMQAQLGEMiSILRNLADFHLFELTPIKANFVKGFAQAYELEGDRLTAVQH 159
Cdd:COG0748    81 DPLARPRLTLQGRAERVE-DSEEWEAARARYLARFPKA-ALYADLPDFSLFRLTPERGRLVGGFGRAYWLSGEDLLGADA 158

                         170
                  ....*....|..
gi 1278738497 160 RQGAGHRRVEDD 171
Cdd:COG0748   159 AEAGAVEHMNDD 170
heme_ox_HugZ TIGR04109
heme oxygenase, HugZ family; Members of this protein family are HugZ, a class of heme ...
 3-159 1.74e-36

heme oxygenase, HugZ family; Members of this protein family are HugZ, a class of heme oxygenase that belongs to the PPOX family (pfam01243) and lacks homology to the HmuO family (pfam01126). Characterized members of this family include HP0318 from Helicobacter pylori and CJ1613c from Campylobacter jejuni. This enzyme releases iron during the conversion of heme to biliverdin.


Pssm-ID: 200360 [Multi-domain]  Cd Length: 243  Bit Score: 126.39  E-value: 1.74e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497   3 PAVDQIADDFhtyIASFQSAILATVNQSATPDASYAPILQQNGHFYIFISELAQHTENLMTTPT-ASLLFIEPEEDAGNL 81
Cdd:TIGR04109  82 AAVEEEINAF---IDSFKSVILSTLNANGEVVCSYAPFVSDGGDYYIYISEVSEHFANLKNNPNkVEVMFLEDESKAKSI 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  82 FARKRATIQVVARPIARtDADWPGLLDAMQAQLGEMISI--LRNLADFHLFELTPIKANFVKGFAQAYELEGDRLTAVQH 159
Cdd:TIGR04109 159 IARKRLRYKANARFLER-GAKFDEIFDKFQEKTGGEGGIktIRAMKDFHLVKLEFKKGRFVKGFGQAYDIDGGEITHVGQ 237
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 16-95 4.36e-08

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 48.40  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  16 IASFQSAILATVNQSATPDASYAPILQQNG--HFYIFISELAQHTENLMTTPTASLLFIEPEEDAGNLFarkRATIQVVA 93
Cdd:pfam01243   9 LAEPNAVVLATVDKDGRPNVRPVGLKYGFDtvGILFATNTDSRKARNLEENPRVALLFGDPELRRGVRI---EGTAEIVT 85


                  ..
gi 1278738497  94 RP 95
Cdd:pfam01243  86 DG 87
 
Name Accession Description Interval E-value
HugZ COG0748
Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and ...
 1-171 6.43e-50

Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and metabolism];


Pssm-ID: 440511 [Multi-domain]  Cd Length: 221  Bit Score: 160.13  E-value: 6.43e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497   1 MKPAVDQIADDFHTYIASFQSAILATVNQSATPDASYAP-ILQQNGHFYIFISELAQHTENLMTTPTASLLFIEPEEDAG 79
Cdd:COG0748     1 DEEADEEAAEEARTLLRSARSGALATLDADGYPFASYAPfALDDDGSPYILISGLAEHTRNLLADPRASLLLIEDESKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  80 NLFARKRATIQVVARPIArTDADWPGLLDAMQAQLGEMiSILRNLADFHLFELTPIKANFVKGFAQAYELEGDRLTAVQH 159
Cdd:COG0748    81 DPLARPRLTLQGRAERVE-DSEEWEAARARYLARFPKA-ALYADLPDFSLFRLTPERGRLVGGFGRAYWLSGEDLLGADA 158

                         170
                  ....*....|..
gi 1278738497 160 RQGAGHRRVEDD 171
Cdd:COG0748   159 AEAGAVEHMNDD 170
heme_ox_HugZ TIGR04109
heme oxygenase, HugZ family; Members of this protein family are HugZ, a class of heme ...
 3-159 1.74e-36

heme oxygenase, HugZ family; Members of this protein family are HugZ, a class of heme oxygenase that belongs to the PPOX family (pfam01243) and lacks homology to the HmuO family (pfam01126). Characterized members of this family include HP0318 from Helicobacter pylori and CJ1613c from Campylobacter jejuni. This enzyme releases iron during the conversion of heme to biliverdin.


Pssm-ID: 200360 [Multi-domain]  Cd Length: 243  Bit Score: 126.39  E-value: 1.74e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497   3 PAVDQIADDFhtyIASFQSAILATVNQSATPDASYAPILQQNGHFYIFISELAQHTENLMTTPT-ASLLFIEPEEDAGNL 81
Cdd:TIGR04109  82 AAVEEEINAF---IDSFKSVILSTLNANGEVVCSYAPFVSDGGDYYIYISEVSEHFANLKNNPNkVEVMFLEDESKAKSI 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  82 FARKRATIQVVARPIARtDADWPGLLDAMQAQLGEMISI--LRNLADFHLFELTPIKANFVKGFAQAYELEGDRLTAVQH 159
Cdd:TIGR04109 159 IARKRLRYKANARFLER-GAKFDEIFDKFQEKTGGEGGIktIRAMKDFHLVKLEFKKGRFVKGFGQAYDIDGGEITHVGQ 237
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 16-95 4.36e-08

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 48.40  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278738497  16 IASFQSAILATVNQSATPDASYAPILQQNG--HFYIFISELAQHTENLMTTPTASLLFIEPEEDAGNLFarkRATIQVVA 93
Cdd:pfam01243   9 LAEPNAVVLATVDKDGRPNVRPVGLKYGFDtvGILFATNTDSRKARNLEENPRVALLFGDPELRRGVRI---EGTAEIVT 85


                  ..
gi 1278738497  94 RP 95
Cdd:pfam01243  86 DG 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH