NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1278648220|gb|PJB54645|]
View 

MAG: lipoyl(octanoyl) transferase [Bdellovibrio sp. CG_4_9_14_3_um_filter_39_7]

Protein Classification

lipoyl(octanoyl) transferase LipB( domain architecture ID 10001066)

lipoyl(octanoyl) transferase LipB catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 1-204 1.31e-75

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


:

Pssm-ID: 440090  Cd Length: 211  Bit Score: 226.53  E-value: 1.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYQTQLENVEAVRAG-AEDTLIVCSHPPIVTLGKKTQAdEHQFWTGQT--LQIERGGRSTYHGPNQV 77
Cdd:COG0321     4 LIIRDLGLVDYEEAWAAQRRLTAARVAGdTPDELWLLEHPPVYTLGRSGKP-EHLLAPGGIpvVQTDRGGQITYHGPGQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  78 IIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPRKIASIGIAVKRWVTYHGLALNLEH 157
Cdd:COG0321    83 VGYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGA-----PGVWVDGRKIAAIGLRVRRGVTYHGFALNVNP 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1278648220 158 DPLAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQLCQILIQRFQ 204
Cdd:COG0321   158 DLSPFSRIVPCGIADLGVTSLSDELGRPVTMEEVAEALIRHFAEVFG 204
 
Name Accession Description Interval E-value
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 1-204 1.31e-75

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


Pssm-ID: 440090  Cd Length: 211  Bit Score: 226.53  E-value: 1.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYQTQLENVEAVRAG-AEDTLIVCSHPPIVTLGKKTQAdEHQFWTGQT--LQIERGGRSTYHGPNQV 77
Cdd:COG0321     4 LIIRDLGLVDYEEAWAAQRRLTAARVAGdTPDELWLLEHPPVYTLGRSGKP-EHLLAPGGIpvVQTDRGGQITYHGPGQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  78 IIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPRKIASIGIAVKRWVTYHGLALNLEH 157
Cdd:COG0321    83 VGYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGA-----PGVWVDGRKIAAIGLRVRRGVTYHGFALNVNP 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1278648220 158 DPLAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQLCQILIQRFQ 204
Cdd:COG0321   158 DLSPFSRIVPCGIADLGVTSLSDELGRPVTMEEVAEALIRHFAEVFG 204
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 2-203 2.90e-74

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


Pssm-ID: 319743  Cd Length: 199  Bit Score: 222.37  E-value: 2.90e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   2 KILNLGLLPYQSVYQTQLENVEAVRAG-AEDTLIVCSHPPIVTLGKKTQADEHQFWTGQTL-QIERGGRSTYHGPNQVII 79
Cdd:cd16444     1 IVRDLGLIPYEEAWELQKRLVAERIAGeTPDTLWLLEHPPVYTLGRRGKPENLLNNGGIPVvRTDRGGQVTYHGPGQLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  80 YPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPRKIASIGIAVKRWVTYHGLALNLEHDP 159
Cdd:cd16444    81 YPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGA-----PGVWVGDRKIASIGIRVRRGVTYHGLALNVNTDL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1278648220 160 LAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQLCQILIQRF 203
Cdd:cd16444   156 SPFNRINPCGIKGKGVTSLSDLGGREVDMEEVKQKLVEEFAKIF 199
PRK14342 PRK14342
lipoyl(octanoyl) transferase LipB;
1-203 5.19e-42

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237681  Cd Length: 213  Bit Score: 140.79  E-value: 5.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYQTQLENVEAVRAGAEDTLIVCSHPPIVTLGkktQA--DEHQFWTGQT--LQIERGGRSTYHGPNQ 76
Cdd:PRK14342    6 LIVRQLGLQPYEPVWQAMQEFTDTRDEETPDEIWLVEHPPVFTQG---QAgkPEHILNPGDIpvVQSDRGGQVTYHGPGQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  77 VIIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnPdltGIWVGPRKIASIGIAVKRWVTYHGLALNLE 156
Cdd:PRK14342   83 LVMYVLLDLKRLKLGVRQLVTAIEQTVINTLAEYGIEAHAKPDA--P---GVYVDGKKIASLGLRIRRGCSFHGLALNVN 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1278648220 157 HDPLAFQGINPCGKDSSIMTSLeQEIGQKVERSSFEAQLCQILIQRF 203
Cdd:PRK14342  158 MDLSPFLRINPCGYAGLEMTQL-SDLGGPATVDEVAPRLLAELLALL 203
lipB TIGR00214
lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the ...
 30-180 1.88e-39

lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process). [Protein fate, Protein modification and repair]


Pssm-ID: 272964  Cd Length: 184  Bit Score: 133.38  E-value: 1.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  30 EDTLIVCSHPPIVTLGKKTQADEHQFWT----GQTLQIERGGRSTYHGPNQVIIYPILNLNRYQQNLSGFLEAMENSMIE 105
Cdd:TIGR00214  12 LDEIMLVEHYPVYTQGQAGKTEHLLFDPdippAEVVQSERGGQVTYHGPGQQVMYVILDLKRFQLDVRWLVTQLEQTVII 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278648220 106 VLKQFDLQatGNPdrgNPDLTGIWVGPRKIASIGIAVKRWVTYHGLALNLEHDPLAFQGINPCGKDSSIMTSLEQ 180
Cdd:TIGR00214  92 TLAELGIE--GEP---IADATGVWVEGKKVASLGIRVRRGCTFHGLALNINMDLSPFSHINPCGYAGREMGSLNQ 161
 
Name Accession Description Interval E-value
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 1-204 1.31e-75

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


Pssm-ID: 440090  Cd Length: 211  Bit Score: 226.53  E-value: 1.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYQTQLENVEAVRAG-AEDTLIVCSHPPIVTLGKKTQAdEHQFWTGQT--LQIERGGRSTYHGPNQV 77
Cdd:COG0321     4 LIIRDLGLVDYEEAWAAQRRLTAARVAGdTPDELWLLEHPPVYTLGRSGKP-EHLLAPGGIpvVQTDRGGQITYHGPGQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  78 IIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPRKIASIGIAVKRWVTYHGLALNLEH 157
Cdd:COG0321    83 VGYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGA-----PGVWVDGRKIAAIGLRVRRGVTYHGFALNVNP 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1278648220 158 DPLAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQLCQILIQRFQ 204
Cdd:COG0321   158 DLSPFSRIVPCGIADLGVTSLSDELGRPVTMEEVAEALIRHFAEVFG 204
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 2-203 2.90e-74

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


Pssm-ID: 319743  Cd Length: 199  Bit Score: 222.37  E-value: 2.90e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   2 KILNLGLLPYQSVYQTQLENVEAVRAG-AEDTLIVCSHPPIVTLGKKTQADEHQFWTGQTL-QIERGGRSTYHGPNQVII 79
Cdd:cd16444     1 IVRDLGLIPYEEAWELQKRLVAERIAGeTPDTLWLLEHPPVYTLGRRGKPENLLNNGGIPVvRTDRGGQVTYHGPGQLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  80 YPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPRKIASIGIAVKRWVTYHGLALNLEHDP 159
Cdd:cd16444    81 YPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGA-----PGVWVGDRKIASIGIRVRRGVTYHGLALNVNTDL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1278648220 160 LAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQLCQILIQRF 203
Cdd:cd16444   156 SPFNRINPCGIKGKGVTSLSDLGGREVDMEEVKQKLVEEFAKIF 199
PRK14342 PRK14342
lipoyl(octanoyl) transferase LipB;
1-203 5.19e-42

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237681  Cd Length: 213  Bit Score: 140.79  E-value: 5.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYQTQLENVEAVRAGAEDTLIVCSHPPIVTLGkktQA--DEHQFWTGQT--LQIERGGRSTYHGPNQ 76
Cdd:PRK14342    6 LIVRQLGLQPYEPVWQAMQEFTDTRDEETPDEIWLVEHPPVFTQG---QAgkPEHILNPGDIpvVQSDRGGQVTYHGPGQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  77 VIIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnPdltGIWVGPRKIASIGIAVKRWVTYHGLALNLE 156
Cdd:PRK14342   83 LVMYVLLDLKRLKLGVRQLVTAIEQTVINTLAEYGIEAHAKPDA--P---GVYVDGKKIASLGLRIRRGCSFHGLALNVN 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1278648220 157 HDPLAFQGINPCGKDSSIMTSLeQEIGQKVERSSFEAQLCQILIQRF 203
Cdd:PRK14342  158 MDLSPFLRINPCGYAGLEMTQL-SDLGGPATVDEVAPRLLAELLALL 203
PRK14341 PRK14341
lipoyl(octanoyl) transferase LipB;
7-205 6.53e-42

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237680  Cd Length: 213  Bit Score: 140.81  E-value: 6.53e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   7 GLLPYQSVYQTQLENVEAVRAGAEDTLI-VCSHPPIVTLGKKTQADE----HQFWTGQTlqiERGGRSTYHGPNQVIIYP 81
Cdd:PRK14341   11 GLVPYPEALAFMEARVAAIAAGTADELVwLLEHPPLYTAGTSAKAEDlldpDRFPVYET---GRGGQYTYHGPGQRVAYV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  82 ILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWV--------GPRKIASIGIAVKRWVTYHGLAL 153
Cdd:PRK14341   88 MLDLKRRRRDVRAFVAALEEWIIATLAAFNIRGERREDR-----VGVWVrrpdkgsgAEDKIAAIGVRLRRWVSFHGISI 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1278648220 154 NLEHDPLAFQGINPCGKDSSIMTSLeQEIGQKVERSSFEAqlcqILIQRFQE 205
Cdd:PRK14341  163 NVEPDLSHFSGIVPCGISEHGVTSL-VDLGLPVTMDDVDA----ALKKAFEK 209
PRK14345 PRK14345
lipoyl(octanoyl) transferase LipB;
3-199 3.85e-40

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 184638  Cd Length: 234  Bit Score: 136.65  E-value: 3.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   3 ILNLGLLPYQSVYQTQLENVEAVRAG-AEDTLIVCSHPPIVTLGKKTQADEHQFWTGQTLQIERGGRSTYHGPNQVIIYP 81
Cdd:PRK14345   14 VRRLGLVDYQEAWDLQRELADARVAGeGPDTLLLLEHPAVYTAGKRTEPHERPTDGTPVVDVDRGGKITWHGPGQLVGYP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  82 ILNLN------RYQQNLsgfleamENSMIEVLKQFDLQATGNPDRgnpdlTGIWV-----GP-RKIASIGIAVKRWVTYH 149
Cdd:PRK14345   94 IIKLAepldvvDYVRRL-------EEALIAVCADLGLNAGRVDGR-----SGVWVpadggRPdRKIAAIGIRVSRGVTMH 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1278648220 150 GLALNLEHDPLAFQGINPCGKDSSIMTSLEQEIGQKVE----RSSFEAQLCQIL 199
Cdd:PRK14345  162 GFALNCDNDLAAFDAIVPCGISDAGVTTLSAELGRTVTvaevVDPVAAALCDAL 215
lipB TIGR00214
lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the ...
 30-180 1.88e-39

lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process). [Protein fate, Protein modification and repair]


Pssm-ID: 272964  Cd Length: 184  Bit Score: 133.38  E-value: 1.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  30 EDTLIVCSHPPIVTLGKKTQADEHQFWT----GQTLQIERGGRSTYHGPNQVIIYPILNLNRYQQNLSGFLEAMENSMIE 105
Cdd:TIGR00214  12 LDEIMLVEHYPVYTQGQAGKTEHLLFDPdippAEVVQSERGGQVTYHGPGQQVMYVILDLKRFQLDVRWLVTQLEQTVII 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278648220 106 VLKQFDLQatGNPdrgNPDLTGIWVGPRKIASIGIAVKRWVTYHGLALNLEHDPLAFQGINPCGKDSSIMTSLEQ 180
Cdd:TIGR00214  92 TLAELGIE--GEP---IADATGVWVEGKKVASLGIRVRRGCTFHGLALNINMDLSPFSHINPCGYAGREMGSLNQ 161
PRK14348 PRK14348
lipoyl(octanoyl) transferase LipB;
8-199 1.32e-33

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172824  Cd Length: 221  Bit Score: 119.74  E-value: 1.32e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   8 LLPYQSVYQTQLENVEA-VRAGA-----EDTLIVCSHPPIVTLGKKTQAD-----EHQFWT-GQTL-QIERGGRSTYHGP 74
Cdd:PRK14348   10 LIPYSEAWSRQTEWFDAlVHAKQngesyENRIIFCEHPHVYTLGRSGKENnmllgEEQLKTiGATLyHIDRGGDITYHGP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  75 NQVIIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQAtGNPDRGnpdlTGIWVG-----PRKIASIGIAVKRWVTYH 149
Cdd:PRK14348   90 GQLVCYPILNLEEFGLGLKEYVHLLEEAVIRVCASYGVVA-GRLEKA----TGVWLEgdtsrARKICAIGVRSSHYVTMH 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1278648220 150 GLALNLEHDPLAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQL-CQIL 199
Cdd:PRK14348  165 GLALNVNTDLRYFSYIHPCGFIDKGVTSLQQELGHSIDMAEVKERLgRELL 215
PRK14344 PRK14344
lipoyl(octanoyl) transferase LipB;
12-178 6.38e-33

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237683  Cd Length: 223  Bit Score: 117.86  E-value: 6.38e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  12 QSVYQTQL----ENVEAVRAGaedtlivcSHPPIVTLGKKTQADEHQFWTGQT----LQIERGGRSTYHGPNQVIIYPIL 83
Cdd:PRK14344   36 QKEWQQALiedpSNPQAVWLL--------EHQLCYTLGRGASEDNLLFSLNNPpadvFRIDRGGEVTHHMPGQLVTYLVL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  84 NLNRYQQNLSGFLEAMENSMIEVLKQFDLQAtgnpdRGNPDLTGIWVGPRKIASIGIAVKRWVTYHGLALNLEHDPLAFQ 163
Cdd:PRK14344  108 DLRRFNKDLNWYLRQLEQVLIDVLADLGIDG-----ERLDGLTGVWIGNKKVASIGIGCRRWITQHGFSLNVDCDLEGFN 182

                         170
                  ....*....|....*
gi 1278648220 164 GINPCGKDSSIMTSL 178
Cdd:PRK14344  183 KIVPCGLEGCQVGRL 197
PRK14347 PRK14347
lipoyl(octanoyl) transferase LipB;
65-192 1.72e-29

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172823  Cd Length: 209  Bit Score: 108.48  E-value: 1.72e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  65 RGGRSTYHGPNQVIIYPILNL---NRYQqNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPR-----KIA 136
Cdd:PRK14347   69 RGGKFTFHGPGQRVIYPILNLaspNRHK-DLKLYIKMLEEWIINSLNYFGIKAYIIKDK-----VGIWVKVRkdefaKIA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1278648220 137 SIGIAVKRWVTYHGLALNLEHDPLAFQGINPCGKDSSIMTSLEQeIGQKVERSSFE 192
Cdd:PRK14347  143 AIGVRVRKWVTYHGVAINISTDLSKFSGIIPCGLENSLVTSLNQ-LGIHVEMSEFD 197
PRK14343 PRK14343
lipoyl(octanoyl) transferase LipB;
1-169 3.37e-28

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237682  Cd Length: 235  Bit Score: 106.03  E-value: 3.37e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYqtqlenvEAVRA-----GAE--DTLIVCSHPPIVTLGkktQAD--EHQFWTGQTL---QIERGGR 68
Cdd:PRK14343   15 VTVRWRGREPYEACF-------DAMRAftdarTADtpDEIWLVEHPPVYTLG---QAGdpAHLLVADSGIplvKVDRGGQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  69 STYHGPNQVIIYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQATGNPdrGNPdltGIWV--GPR---KIASIGIAVK 143
Cdd:PRK14343   85 ITYHGPGQVVAYLLLDLRRRKLMVRELVTRIEQAVIDTLAAYNLASERKA--GAP---GIYVasGPHqgaKIAALGLKIR 159

                         170       180
                  ....*....|....*....|....*.
gi 1278648220 144 RWVTYHGLALNLEHDPLAFQGINPCG 169
Cdd:PRK14343  160 NGCSYHGLSLNVKMDLRPFLAINPCG 185
PRK14346 PRK14346
lipoyl(octanoyl) transferase LipB;
1-169 5.89e-28

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237684  Cd Length: 230  Bit Score: 105.22  E-value: 5.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   1 MKILNLGLLPYQSVYQTQLENVEAVRAGAEDTLIVCSHPPIVTLGKKTQADeHQFWTGQ--TLQIERGGRSTYHGPNQVI 78
Cdd:PRK14346    3 MDRRMLGRVDYLATVQAMQAFTAERTPETPDELWICEHPPVYTQGLAGKAD-HVLNPGDipVVATNRGGQVTYHGPGQVV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  79 IYPILNLNRYQQNLSGFLEAMENSMIEVLKQFDLQA----------------------TGNPD-RGNPDLTGIWVGPRKI 135
Cdd:PRK14346   82 AYPLIDLRRAGYFVKEYVYRIEEAVIRTLAHFGVTGhrvagapgiyvrlddpfshaalPQRPQkRGGGAPQPPFRGLGKI 161

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1278648220 136 ASIGIAVKRWVTYHGLALNLEHDPLAFQGINPCG 169
Cdd:PRK14346  162 AALGIKVSRHCTYHGVALNVAMDLEPFSRINPCG 195
PRK14349 PRK14349
lipoyl(octanoyl) transferase LipB;
11-169 3.53e-26

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172825  Cd Length: 220  Bit Score: 100.43  E-value: 3.53e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  11 YQSVYQTQLENVEAVRAGAEDTLIVCSHPPIVTLGKKTQAdEHQFWTGQ--TLQIERGGRSTYHGPNQVIIYPILNLNRY 88
Cdd:PRK14349   11 YASVWDAMKAFTAARGPGTADEIWLCEHAPVYTLGQAGRP-EHLLNPGLipVVHCDRGGQVTYHGPGQVLAYTLFDLRRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  89 QQNLSGFLEAMENSMIEVLKQFDL-QATGNPdrGNPdltGIWV-GP----RKIASIGIAVKRWVTYHGLALNLEHDPLAF 162
Cdd:PRK14349   90 GLYVREYVDMLEQATLATLRELGLeQACRKP--GAP---GIYVpQPggelAKIAALGVKVRNGYAYHGLALNIDMDLSPF 164


                  ....*..
gi 1278648220 163 QGINPCG 169
Cdd:PRK14349  165 LGINPCG 171
BPL_LplA_LipB cd16435
biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), ...
 3-197 1.53e-24

biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), lipoate-protein ligase A (LplA) and octanoyl-[acyl carrier protein]-protein acyltransferase (LipB). Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LplA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes.


Pssm-ID: 319740  Cd Length: 198  Bit Score: 95.30  E-value: 1.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220   3 ILNLGLLPYQSVYQTQLENVEAVRAGAEDTLIVCSHPPIVTLGKKTQADEHQF---WTGQTLQI---ERGGRSTYHGPNQ 76
Cdd:cd16435     2 VEVLDSVDYESAWAAQEKSLRENVSNQSSTLLLWEHPTTVTLGRLDRELPHLElakKIERGYELvvrNRGGRAVSHDPGQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648220  77 VIIYPILNLNRyQQNLSGFLEAMENSMIEVLKQFDLQATGNPDRgnpdlTGIWVGPRKIASIGIAVKRWVTYHGLALNLE 156
Cdd:cd16435    82 LVFSPVIGPNV-EFMISKFNLIIEEGIRDAIADFGQSAEVKWGR-----NDLWIDNRKVCGIAVRVVKEAIFHGIALNLN 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1278648220 157 HDPLAFQGINPCGKDSSIMTSLEQEIGQKVERSSFEAQLCQ 197
Cdd:cd16435   156 QDLENFTEIIPCGYKPERVTSLSLELGRKVTVEQVLERVLA 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH