|
Name |
Accession |
Description |
Interval |
E-value |
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-403 |
1.91e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 92.25 E-value: 1.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 10 YPMLFLSFMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVA 89
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 90 TGLLLLSYAPNAFTLFFAYLILRAFGQMGFGLfATTSISRLFY-ERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFV 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAV-GIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 169 SMKIVSATVVIFFIPFIFLVlpkipthVESPPQSIEKQSELKWSWRETFKnNKRSILLMISLAFIPFSVTALFFQQATLA 248
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFL-------RDPPAGAAAAAKASLRDQLEALR-DPRFWLLSLLYFGTFGSFIGFSSWLPPYL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 249 -DERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKE-LHGYFIYMMFLGLSVSLS 326
Cdd:COG2223 233 vDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278648217 327 GMLRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYGVHLQSLLLSLAVFSLVNFALITFIQRSFKKA 403
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
15-370 |
1.48e-19 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 89.64 E-value: 1.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 15 LSFMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLL 94
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 95 LSYAPNAFTLFFAYLILRAFGQ-MGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLG---AFVSM 170
Cdd:cd17355 85 LALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwrtALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 171 KIVSATVVIFFIPFIFLVLPKIPTHVESPPqsieKQSELKWSWRETFKnNKRSILLMISLAFIPFSVTALFFQQATLADE 250
Cdd:cd17355 165 ALLALLVLVPVLLLLRRRPADLALRAYDDA----SPASPGSTLKEALR-SASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 251 RGWTLVQLARGFWFYSACLIVGNFTWGPLVDRF-RAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGML 329
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYsPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1278648217 330 RHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALD 370
Cdd:cd17355 320 TAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYD 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-402 |
2.26e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.83 E-value: 2.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 5 KLIRDYPMLFLSFMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTL 84
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 85 TFAVATGLLLLSYAPNAFTLFFAYLILrAFGQMGFGLFATTSISRLFY-ERRGKAISVLGIGRSLAEGVLPNLGAILATS 163
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLL-GLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 164 LGafvsmkiVSATVVIFFIPFIFLVLPKIpthvesppqsiekqselkwswretfknnkrsILLMISLAFIPFSVTALFFQ 243
Cdd:COG2271 161 FG-------WRAAFLILGLPGLLLALLRF-------------------------------WLLALAYFLVYFALYGFLTW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 244 QAT-LADERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRF--RAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLG 320
Cdd:COG2271 203 LPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 321 LSVSLSGMLRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYGvHLQSLLLSLAVFSLVNFALITFIQRSF 400
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLLRET 361
|
..
gi 1278648217 401 KK 402
Cdd:COG2271 362 RK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-362 |
1.00e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 71.68 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 17 FMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLS 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 97 YAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKIVSat 176
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 177 vVIFFIPFIFLVLPKIPTHVESPPQSIEKQSELKWSWRETFKNnkRSILLMISLAFIPFSVTALFFQQATLADERGWTLV 256
Cdd:pfam07690 159 -ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD--PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 257 QLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITI---KELHGYFIYMMFLGLSVSLSGMLRHTL 333
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 1278648217 334 YAELFGVLQLGRIKGMDGNILIIGTSLGP 362
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-360 |
5.16e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.62 E-value: 5.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 3 MLKLIRDYPMLFLSFMGVAFFSGIGQTFFLSIYnADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLL 82
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPAL-PLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 83 TLTFAVATGLLLLSYAPNAFTLFFAYLILrAFGQMGFGLFATTSISRLF-YERRGKAISVLGIGRSLAEGVLPNLGAILA 161
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQ-GLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 162 TSLGAFVSMKIVSATVVIFFIPFIFLVlpkipthvesPPQSIEKQSELKWSWRETFKNNKRSILLMISLAFIPFSVTALF 241
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLL----------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 242 FQQATLADERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGL 321
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 1278648217 322 SVSLSGMLRHTLYAELFGVLQLGRIKGMDGNILIIGTSL 360
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
38-398 |
9.36e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.97 E-value: 9.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 38 DLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLSYAPNAFTLFFAYLILRAFGQM 117
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 118 GFGLFATTsISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKIVSATVVIFFIPFIFLVLPKIPTHVE 197
Cdd:COG2807 123 GNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 198 SPPqsiekqselKWSWRETFKnNKRSILLMISLAFIPFSVTALFFQQATLADERGWTLVQLARGFWFYSACLIVGNFTWG 277
Cdd:COG2807 202 APA---------AASLRSLWR-SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 278 PLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGMLRHTLYAELFG-VLQLGRIKGMDGNILII 356
Cdd:COG2807 272 LLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYL 351
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1278648217 357 GTSLGPLLSGLALDYGVHLQSLLLSLAVFSLVNFALITFIQR 398
Cdd:COG2807 352 LAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-396 |
4.30e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.71 E-value: 4.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 14 FLSFMGVAFFSGIGqTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLL 93
Cdd:cd06173 1 FRLLWLAQLLSALG-DWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 94 LLSYAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFY-----ERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFV 168
Cdd:cd06173 80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPelvpkEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 169 SMkivSATVVIFFIPFIFLVLPKIPTHVESPPQSIEKQSELKWSWRETFKNNKRSILLMISLAFIPFSVTALFFQQATLA 248
Cdd:cd06173 160 AF---AINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 249 DERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGM 328
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1278648217 329 LRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDyGVHLQSLLLSLAVFSLVNFALITFI 396
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD-ALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-392 |
1.02e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.75 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 32 LSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWnGRRYLLTLTFAVATGLLLLSYAPNAFTLFFAYLIL 111
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 112 RAFGQMGFGLFATTSISRLFYER-RGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKIVSATVVIFFIPFIFLVLP 190
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 191 KIPTHVESPPQSIEKQSELKWSWRETFKNNKRSILLMISLAFIPFSVTALFFQQATLADERGWTLVQLARGFWFYSACLI 270
Cdd:cd06174 174 PDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 271 VGNFTWGPLVDRFRAI-NLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGMLRHTLYAELFGVLQLGRIKGM 349
Cdd:cd06174 254 LGSLLLGLLSDRLIGRkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1278648217 350 DGNILIIGTSLGPLLSGLALDYGVHLQSLLLSLAVFSLVNFAL 392
Cdd:cd06174 334 LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-396 |
1.90e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 15 LSFMGVAFFSGIGQTF-FLSIYnadlMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLL 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIpILPLY----AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 94 LLSYAPNAFTLFFAYLILrAFGQMGFGLFATTSISRLF-YERRGKAISVLGIGRSLAEGVLPNLGAILATSLGaFVSMKI 172
Cdd:cd17325 77 LFAFATSYWQLLLARFLQ-GLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 173 VSATVVIFFIPFIFLVLPKIPthveSPPQSIEKQSELKWSWRETFKNNKRSILLMISLAFIPFSVTALFFQQATLADER- 251
Cdd:cd17325 155 VCAALALLALVLALLLLPEPR----PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 252 GWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGMLRH 331
Cdd:cd17325 231 GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278648217 332 TLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYGvHLQSLLLSLAVFSLVNFALITFI 396
Cdd:cd17325 311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
39-283 |
2.02e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.64 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 39 LMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWnGRRYLLTLTFAV-ATGLLLLSYAPNaFTLFFAYLILRAFGQM 117
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRK-PRRYLLPLGPLLtGLGLSLLGFAPN-YWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 118 GFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFvsmkivsATVVIFFIPFIFLVLPKIPthVE 197
Cdd:cd17478 100 AFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGL-------GLLILLIIPGLAVALLLLR--LR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 198 SPPQSIEKQSELKWSWRETFKNNKRSILLMISLAF----IPFSVTALFfqqATLADERGWTLVQLARG-FWFYSAClIVG 272
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFlrswVLSSLTTFL---PFYLVQRGYSLVFAGLLlSLFLFAG-AIG 246
|
250
....*....|.
gi 1278648217 273 NFTWGPLVDRF 283
Cdd:cd17478 247 TLIGGPLSDRF 257
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-396 |
4.02e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 4.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 20 VAFFSGIGQTFFLSIYNAdLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLSYAP 99
Cdd:cd17474 7 ATLLAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 100 NaFTLFFAYLILRAFGQMGFGLFATTSISRLF-YERRGKAISVLGIGRSLAEGVLPNLGAILAtSLGAFVSMKIVSATVV 178
Cdd:cd17474 86 S-FALLLAGRALQGIGAAGLGPLALTLIGDLFeGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 179 IFFIPFIFLVlpkipthveSPPQSIEKQSELKWSWRETFKNNKRSILLMISLAFIPFSV--TALFFQQATLADERGWTLV 256
Cdd:cd17474 164 VAFLAILFLL---------PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLyfAFLTYLPFLLELLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 257 QLARGFWFYSACLIVGNFTWGPLVD-RFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGMLRHTLYA 335
Cdd:cd17474 235 IIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278648217 336 ELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYGvHLQSLLLSLAVFSLVNFALITFI 396
Cdd:cd17474 315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF-GLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
12-396 |
4.01e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.84 E-value: 4.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 12 MLFLSFMGVAFFSGIGQTFflSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATG 91
Cdd:cd17353 4 LVLLGAVLMHLILGYQYAW--SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 92 LLLLSYAPNAFTLFFAYLILrafGQMGFGLFATTSIS---RLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLG--- 165
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVL---GGIGAGIGYITPVStavKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGvpt 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 166 AFVSMKIVsATVVIFFIPFIFLVLPKIPTH-VESPPQSIEKQSELKWSWRETFKnNKRSILLMISLAFIPFSVTALFFQQ 244
Cdd:cd17353 159 TFLILGII-FLIIIVIGAFLIRDPPKGWVPpGVDPLANNAENSPRDYTPREMLR-TPTFWLLWLMFFLNATAGLMLIGQA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 245 ATLA-DERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLglsV 323
Cdd:cd17353 237 KPIGqEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVAL---I 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278648217 324 SLSGMLRHTLY----AELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLaLDYGVHLQSLLLSLAVFSLVNFALITFI 396
Cdd:cd17353 314 GFCYGGGFALFpaltADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
13-395 |
1.20e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 50.10 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 13 LFLSFMGVAFFSGIGQTFflSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGL 92
Cdd:cd17314 5 LYVSFLLSAMSTGFILSW--SLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 93 LLLSYAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKI 172
Cdd:cd17314 83 TYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 173 VSAtVVIFFIPFIFLVLPKIPTHVESPPQSIEKqselKWSWRETFKNNKRSILLMISLAFIPFSVTALFFQQATLADERG 252
Cdd:cd17314 163 LGI-LAAIVLSVVSLLGFKEPPDNQARLHVQKK----KTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 253 WTLVQLARGFW-FYSACLIVGNFTWGPLVDRFRA-INLYPFVMLPLLLGLTALITIKELH--GYFIYMMFLGLSVSLSGM 328
Cdd:cd17314 238 LDAPSFVTKLMsIYGLFNAFGRLLWGIVADFFGGrLSTLSILLTILGLGLCAFLFLLKMTpvGLVLTGSLLGFSYGGLFT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1278648217 329 LRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYGVHLQSLLLSLAVFSLVNFALITF 395
Cdd:cd17314 318 VYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLA 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-198 |
1.25e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 3 MLKLIRDYPMLFLSFM-GVAFFSGIGQTFFLSIYnadLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYL 81
Cdd:COG2223 198 QLEALRDPRFWLLSLLyFGTFGSFIGFSSWLPPY---LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 82 LTLTFAVATGLLLLSYAPNAFTLFF-AYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAIL 160
Cdd:COG2223 275 LIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
170 180 190
....*....|....*....|....*....|....*...
gi 1278648217 161 ATSLGAFVSMKIVSATVVIFFIPFIFLVLPKIPTHVES 198
Cdd:COG2223 355 LDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
17-283 |
1.77e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 17 FMGVAFFSGIGQTFFLSIynADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLS 96
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAM--PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 97 YAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKIVSAT 176
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 177 VVIFFIPFIFLVL------PKIPTHVESPPQSIEKQSELKWSWRETFKNNKRSILLMISLAFIPFSVTALFF-------- 242
Cdd:TIGR00881 159 IAIIVSLICFLLLrdspqsCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVvrtgildw 238
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1278648217 243 QQATLADERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRF 283
Cdd:TIGR00881 239 SPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKL 279
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
30-397 |
2.02e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.53 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 30 FFLSIYnadLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLSYAPNAFTLFFAYL 109
Cdd:cd17329 20 PFMAIY---LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 110 ILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMkIVSATVVIFFIPFIFLVL 189
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFL-AAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 190 PKIPTHVESPPQSIekqselKWSWReTFKNNKRSILLMISLAFIPFSVTALFFQQATLADERGWTLVQLARGFWFYSACL 269
Cdd:cd17329 176 ETRPKRRAAEKTEI------LRGYK-IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 270 IV-GNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGMLRHTLYAELFGVLQLGRIKG 348
Cdd:cd17329 249 IVlLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1278648217 349 MDGNILIIGTSLGPLLSGLALDYGvHLQSLLLSLAVFSLVNFALITFIQ 397
Cdd:cd17329 329 FYALAWGLGRAIGPLVGGLLLDLL-GPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
68-394 |
2.19e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 68 LGVMVDRWNGRRYLLTLTFAVATGLLLLSYAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRS 147
Cdd:cd17324 54 LGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 148 LAEGVLPNLGAILATSLGAFVSMKIVSATVVIFFIPFIFLvLPKIPTHVESPPQSIEkqselkwSWRETFKNNK-RSILL 226
Cdd:cd17324 134 LGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL-LPSLPPKKPGSLGLLS-------SLLLLLRNPRlRLAYL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 227 MISLA----FIPFSVTALFFQQATLADERGWTLVqlargFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTA 302
Cdd:cd17324 206 ITFLLfggfFALYTYLAPFLTDVPGFSSSAIIGL-----LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 303 LITIKELHGYFIYMMFLGLSVSLSGMLRHTLYAELFGVlQLGRIKGMDGNILIIGTSLGPLLSGLALDYGvHLQSLLLSL 382
Cdd:cd17324 281 TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVG 358
|
330
....*....|..
gi 1278648217 383 AVFSLVNFALIT 394
Cdd:cd17324 359 AALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-403 |
2.71e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.08 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 1 MNMLKLIRDYPMLFLSFMGVAFFSGIgqtffLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRY 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATAL-----WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 81 LLTLTFAVATGLLLLSYAPNaFTLFFAYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAIL 160
Cdd:COG0738 76 LLLGLLLMALGLLLFALAPS-YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 161 ATSLGAFVSMKIVSATVVIFFIPFIFLVLPKIPTHVESPPQSIEKQSELKWSWRetfknNKRSILLMISLAFIPFSVTAL 240
Cdd:COG0738 155 ILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLK-----NPRLLLGGLAIFLYVGAEGAI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 241 FFQQATLA-DERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFL 319
Cdd:COG0738 230 GDWLPLYLkDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 320 GLSVSLsgmlrhtLYAELFGVL--QLGRIKGMDGNIL----IIGTSLGPLLSGLALDYgVHLQSLLLSLAVFSLVNFALI 393
Cdd:COG0738 310 GLGLSL-------MFPTIFSLAldGLGKRTAAAVSAVlimgIVGGAIGPPLIGFLADA-FGLRAAFLVPLVCYLLILLLA 381
|
410
....*....|
gi 1278648217 394 TFIQRSFKKA 403
Cdd:COG0738 382 LALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-188 |
6.43e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 6.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 13 LFLSFMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGL 92
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 93 LLLSYAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKI 172
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 1278648217 173 VSATVVIFFIPFIFLV 188
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
17-207 |
2.02e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.39 E-value: 2.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 17 FMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLT-FAVATGLLLL 95
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLAlLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 96 SYAPNAFTLFFAYLILRAFGQMGFG-LFAttsISRLFYERRGK-----AISVLGIGRSLAEGVLPNLGAILATSLGAFVS 169
Cdd:cd17471 81 AFLRNYWVLLLVGVVLLSLGAAAFPqLFA---LAREYADRSSGrdatlFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 1278648217 170 MKIVSATVVIFFIPfIFLVLPKIPTHVESPPQSIEKQS 207
Cdd:cd17471 158 FLLAALLYLVVALL-VLFLLPSVKPPAQKATPASSLVK 194
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
13-393 |
5.67e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.92 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 13 LFLSFMGVAFFS-GIGQTFFLsiynadLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATG 91
Cdd:cd17475 1 ATLAQAAASLVAqGIPALAPF------LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 92 LLLLSYApNAFTLFFAYLILRAFGQMGFGLFATTSISRLF-YERRGKAISV----LGIGRSLAEGVLPnlgaILATSLGA 166
Cdd:cd17475 75 ALLMALV-GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFpPRERGLAMGIrqtgVPLGGALAAALLP----PLALHYGW 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 167 FVSMkIVSATVVIFFIPFIFLVLPKIPTHVESPPQSIEKQSELKWSWRetFKNNKRSILLMISLAFIPFSVtaLFFQQAT 246
Cdd:cd17475 150 RAAF-VVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLR--NRDVWLIAIAGALLVAPQFAL--LTFLLLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 247 LADERGWTLVQLArgfWFYSACLI---VGNFTWGPLVDRFRAINLYPFVMLPLLLGLTALITIKELHGY------FIYMM 317
Cdd:cd17475 225 LHDHLGLSVVAAG---ALLAVAQLggaLGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGtplwllVLLLI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278648217 318 FLGLSVSLSGMLRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYGVHLQSLLLSLAVFSLVNFALI 393
Cdd:cd17475 302 LLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-372 |
1.16e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 15 LSFMGVAFFSGIGQTFFLSIYNADLmqkiGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWN---GRR--YLL--TLTFA 87
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVL----GLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwGRRrpWILigAIPLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 88 VATGLLLLSYAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLF-----YERRGKAISVLGIGRSLAEGVLPNLGAILAT 162
Cdd:COG2211 93 LSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 163 SLGA------FVSMKIVSATVVIFFIPFIFLVlpkipthvESPPQSIEKQSELKWSWRETFKNNK-RSILLMISLAFIPF 235
Cdd:COG2211 173 AFGGdaalgyRLTALIFAVLGLLAFLLTFFGT--------KERPVPEEEKVSLKESLKALLKNRPfLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 236 SVTALFFQQAtLADERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRF--RAINLYPFVMLPLLLGLTALITIKELHGYF 313
Cdd:COG2211 245 ALVAALLLYY-FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgkKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278648217 314 IYMMFLGLSVSLSGMLRHTLYAEL-------FGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYG 372
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-371 |
1.51e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 12 MLFLSFMGVAFFSGIGQTFflSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATG 91
Cdd:cd17352 4 VVFASFLVNFFTDGILNSF--GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 92 LLLLSYAPNAFTLFFAYLILRAFGqMGFGLFAT-TSISRLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSM 170
Cdd:cd17352 82 LLLSSFATSLWQLYLTYGVLGGLG-LGLIYSPAiVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 171 KIVSATVVIFFIPFIFLVLPKIPTHVesppqsiekqselkwswretfknnkrsiLLMISLAFIPFSVTALFFQQATLADE 250
Cdd:cd17352 161 LILGGLCLNLCVCGLLLRLLKDPTFV----------------------------LLALGVSFAMLGFFVPFVYLPSYAKS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 251 RGWTLVQLARGFWFYSACLIVGNFTWGPLVDR--FRAINLYPFVMLPLLLGLTALITIKELHGYFIYMMFLGLSVSLSGM 328
Cdd:cd17352 213 LGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSS 292
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1278648217 329 LRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDY 371
Cdd:cd17352 293 LTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDY 335
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
38-283 |
4.60e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.23 E-value: 4.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 38 DLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLSYAPNA---FTLFFAYLILRAF 114
Cdd:cd17345 28 YLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSAtssVGLMFILLFLNGW 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 115 GQ-MGFGLFATTsISRLFYER-RGKAISVLGIGRSLAEGVLPNLGAILATSLGA--FVSMKIVSATVVIFFIPFIFLV-- 188
Cdd:cd17345 108 FQgMGWPPSGRT-MVHWFSKKeRGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDgwWRGAFIFPAIIAIIVAVIVLFLgk 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 189 -------LPKIPTHVESPP-QSIEKQSELKWSWRETFK----NNKRSILLMISLAFIPF------SVTALFfqqatLADE 250
Cdd:cd17345 187 dtpesegLPPIEEYKGDYPeEADGEEEEQELSAWEIFVkyvlKNKLLWYIAIANVFVYLvrygilDWAPTY-----LSEV 261
|
250 260 270
....*....|....*....|....*....|...
gi 1278648217 251 RGWTLVQLARGFWFYSACLIVGNFTWGPLVDRF 283
Cdd:cd17345 262 KGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL 294
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
59-284 |
7.32e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 7.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 59 LVGSFNLT------YLGVMVDRWNGRRYLLTLTFAVATGLLLLSYAPNaftlFFAYLILRAFGQMGFGLFATTS----IS 128
Cdd:cd17489 36 VVGLFTLAallarpFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS----VALLLVLRLIHGIGWGAFTTAAatlvAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 129 RLFYERRGKAISVLGIGRSLAEGVLPNLGAILATSLGaFVSMKIVSATVVIFFIPFIFLVLPKIPTHVESppqsiekQSE 208
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLALLLVFLVKDPPPVAAEE-------AEA 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278648217 209 LKWSWRETFknNKRSILLMISLAFIPFSVTALFFQQATLADERGWTLVQLArgFWFYSACLIVGNFTWGPLVDRFR 284
Cdd:cd17489 184 GTRAFRRLV--EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLF--FTVYAIALLLSRPFSGKLSDRKG 255
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-168 |
1.32e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.65 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 20 VAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLLLLSYAP 99
Cdd:cd17365 178 VTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSP 257
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278648217 100 NAFTLFFAYLILrafgqMGFGLFAT----TSISRLFYERRGKAISV---LGIGRslaegvlpnLGAILATSLGAFV 168
Cdd:cd17365 258 ASLVLLYVLVFL-----AGACVNGAqvglYALAARFYPTEVRATGVgwaLGVGR---------LGAILGPLLGGLL 319
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
4-189 |
4.41e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.52 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 4 LKLIRDYPMLFLSFMGVAFFSGIGQtFFLSIYNADLMQKIGLSRTQLSS-LYACATL---VGSfnltylgVMVDRWNGRR 79
Cdd:PRK08633 225 LKLLRSDRVLWLAIIGLSYFWFISQ-LAQANFPAYAKEVLGLDNTFQVQyLLAASAIgigIGS-------LLAGRLSGRH 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 80 YLLTL----TFAVATGLLLLSYAPNaftLFFAYLILRAFGQMGfGLFAT--TSISRLFYE--RRGKAISvlgigrslAEG 151
Cdd:PRK08633 297 IELGLvplgALGLALSLFLLPTAPS---LASVLVLFFLFGFSA-GLFIVplNALIQFRAPekELGKVLA--------ANN 364
|
170 180 190
....*....|....*....|....*....|....*...
gi 1278648217 152 VLPNLGAILATSLGAFVSMKIVSATVVIFFIPFIFLVL 189
Cdd:PRK08633 365 FLQNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIG 402
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-186 |
4.85e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 14 FLSFMGVAFFSGIGQTFFLSIYNADLMQKIGLSRTQLSSLYACATLVGSFNLTYLGVMVDRWNGRRYLLTLTFAVATGLL 93
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 94 LLSYAPNAFTLFFAYLILRAFGQMGFGLFATTSISRLFY-ERRGKAISVLGIGRSLAEGVLPNLGAILATSLGAFVSMKI 172
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364
|
170
....*....|....
gi 1278648217 173 VSATVVIFFIPFIF 186
Cdd:cd06174 365 VLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
224-395 |
9.46e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 37.65 E-value: 9.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 224 ILLMISLAFIPFSVTALFFQQATLADERGWTLVQLARGFWFYSACLIVGNFTWGPLVDRFRAINLYPFVMLPLLLGLTAL 303
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278648217 304 ITIKELHGYFIYMMFLGLSVSLSGMLRHTLYAELFGVLQLGRIKGMDGNILIIGTSLGPLLSGLALDYgVHLQSLLLSLA 383
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLVNA 171
|
170
....*....|..
gi 1278648217 384 VFSLVNFALITF 395
Cdd:COG2814 172 VLALLALLLLLR 183
|
|
| |
