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Conserved domains on  [gi|1278639238|gb|PJB46838|]
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TetR family transcriptional regulator [Comamonadaceae bacterium CG_4_9_14_3_um_filter_60_33]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
23-182 2.58e-27

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 102.28  E-value: 2.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  23 SRRKSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRENMSSRFAEWNDEFDrfEGST 102
Cdd:COG1309     1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALA--AEDP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238 103 RDMLRHCLFSWWERLgtTKASGIPKLMMSEAQNFPELASFYQHEVmqpaHALIQRILKRGVARGEFRPMDVTYGAYLVMA 182
Cdd:COG1309    79 RERLRALLRAYLEFL--AENPALARLLLAEAAELPELRAALRALL----RRLRALLAELLRAGGLLADVDPDALARALLA 152
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
23-182 2.58e-27

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 102.28  E-value: 2.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  23 SRRKSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRENMSSRFAEWNDEFDrfEGST 102
Cdd:COG1309     1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALA--AEDP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238 103 RDMLRHCLFSWWERLgtTKASGIPKLMMSEAQNFPELASFYQHEVmqpaHALIQRILKRGVARGEFRPMDVTYGAYLVMA 182
Cdd:COG1309    79 RERLRALLRAYLEFL--AENPALARLLLAEAAELPELRAALRALL----RRLRALLAELLRAGGLLADVDPDALARALLA 152
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
33-79 3.78e-18

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 75.14  E-value: 3.78e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1278639238  33 LLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAV 79
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
21-82 7.54e-14

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 68.03  E-value: 7.54e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1278639238  21 RRSRRKSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRE 82
Cdd:PRK15008   11 KRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQ 72
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
33-170 1.24e-12

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 64.15  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  33 LLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRENMSSRFAEWnDEFDRFEGSTRDMLRHCLFS 112
Cdd:NF041196   11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAV-EPQRAGGGSKLQELVDLTHV 89
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278639238 113 WWERLGT---TKASGipKLMMSEAQNFPELASFYQHevmqpAHALIQRILKRGVARGEFRP 170
Cdd:NF041196   90 LARRLRTdpvVRAGV--RLSIEQAAIGAGLPTPYRE-----WIDLVAELLAEARAAGELLP 143
PDI_b_family cd02981
Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of ...
32-74 6.16e-03

Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI, calsequestrin and other PDI-related proteins like ERp72, ERp57, ERp44 and PDIR. PDI, ERp57 (or ERp60), ERp72 and PDIR are all oxidases, catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER. They also exhibit reductase activity in acting as isomerases to correct any non-native disulfide bonds, as well as chaperone activity to prevent protein aggregation and facilitate the folding of newly synthesized proteins. These proteins contain multiple copies of a redox active TRX (a) domain containing a CXXC motif, and one or more redox inactive TRX-like (b) domains. The molecular structure of PDI is abb'a'. Also included in this family is the PDI-related protein ERp27, which contains only redox-inactive TRX-like (b and b') domains. The redox inactive b domains are implicated in substrate recognition.


Pssm-ID: 239279  Cd Length: 97  Bit Score: 35.01  E-value: 6.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1278639238  32 ELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEE 74
Cdd:cd02981    35 TFEKVAESLRDDYGFGHTSDKEVAKKLKVKPGSVVLFKPFEEE 77
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
23-182 2.58e-27

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 102.28  E-value: 2.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  23 SRRKSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRENMSSRFAEWNDEFDrfEGST 102
Cdd:COG1309     1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALA--AEDP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238 103 RDMLRHCLFSWWERLgtTKASGIPKLMMSEAQNFPELASFYQHEVmqpaHALIQRILKRGVARGEFRPMDVTYGAYLVMA 182
Cdd:COG1309    79 RERLRALLRAYLEFL--AENPALARLLLAEAAELPELRAALRALL----RRLRALLAELLRAGGLLADVDPDALARALLA 152
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
33-79 3.78e-18

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 75.14  E-value: 3.78e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1278639238  33 LLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAV 79
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
21-82 7.54e-14

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 68.03  E-value: 7.54e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1278639238  21 RRSRRKSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRE 82
Cdd:PRK15008   11 KRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQ 72
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
33-170 1.24e-12

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 64.15  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  33 LLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVRENMSSRFAEWnDEFDRFEGSTRDMLRHCLFS 112
Cdd:NF041196   11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAV-EPQRAGGGSKLQELVDLTHV 89
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278639238 113 WWERLGT---TKASGipKLMMSEAQNFPELASFYQHevmqpAHALIQRILKRGVARGEFRP 170
Cdd:NF041196   90 LARRLRTdpvVRAGV--RLSIEQAAIGAGLPTPYRE-----WIDLVAELLAEARAAGELLP 143
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
21-107 4.83e-11

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 59.95  E-value: 4.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  21 RRSRRKSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAVVR---ENMSSRFAEWNDEFDR 97
Cdd:COG3226     1 PRRRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFErlaEREAARLRALLAAADD 80
                          90
                  ....*....|
gi 1278639238  98 FEGSTRDMLR 107
Cdd:COG3226    81 LEDAAEALAD 90
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
100-192 2.31e-08

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 50.65  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238 100 GSTRDMLRHCLFSWWERLGTTKASGIPKLMMSEAQNFPELASFYQHEVMQPAHALIQRILKRGVARGEFRP-MDVTYGAY 178
Cdd:pfam16859   5 GSLRGDLRALLRALARALTSPRGGALLRALIAAAQRDPELAAALRERFLEPRRAALRAVLERAVARGELRPdADPDLVLD 84
                          90
                  ....*....|....
gi 1278639238 179 LVMAPMLFLALWQH 192
Cdd:pfam16859  85 LLFGPLYYRLLLTG 98
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
15-159 2.24e-06

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 46.97  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  15 LPNAQPRRSRRKSARPgELLAAALDLFVEKGFAATrVEEVAARAGVSKGTLFLYFPSKEELFKAVVR---ENMSSRFAEW 91
Cdd:PRK11552    1 MMNNPAMTTRGEQAKQ-QLIAAALAQFGEYGLHAT-TRDIAAQAGQNIAAITYYFGSKEDLYLAVAQwiaDFIGEQFRPH 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278639238  92 NDEFDRFEGST-------RDMLRHCLFSwWERLGTTKASGIPKLMMSEAQNFPELASFYQHE-VMQPAHALIQRIL 159
Cdd:PRK11552   79 AEEAERLFAQPapdraaiRELILRACLN-MIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEqVISPLHSHLTRLI 153
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
32-94 7.10e-05

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 42.42  E-value: 7.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  32 ELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAV------VRENMSSRFA-EWNDE 94
Cdd:PRK09975   15 ELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMwlqqppLRELIQEHLTaGLEHD 84
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
26-172 8.68e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 42.00  E-value: 8.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278639238  26 KSARPGELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELfKAVVrenmssrFAEWNDEFDRFEGSTRDM 105
Cdd:PRK14996    6 RDERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSAGEL-KALA-------FIHLIRQLLDAEQVPQTA 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1278639238 106 lrhclfSWWER----LGTTKASGIPKLMM-SEAQ----NFPELASFYQhEVMQPAHALIQRILKRGVARGEFRPMD 172
Cdd:PRK14996   78 ------SWRERlhamLGSEDGRFEPYIRLwREAQiladRDPEIKDAYL-LTMQMWHQETVAIIEQGKAAGEFRSTS 146
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
33-79 1.22e-04

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 41.92  E-value: 1.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1278639238  33 LLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEELFKAV 79
Cdd:PRK10668   16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
TetR_C_7 pfam14246
AefR-like transcriptional repressor, C-terminal domain; This family comprises the C-terminal ...
128-191 2.12e-04

AefR-like transcriptional repressor, C-terminal domain; This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.


Pssm-ID: 433807  Cd Length: 119  Bit Score: 39.85  E-value: 2.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1278639238 128 LMMSEAQNFPELASFYQHEVMQPAHALIQRILKRGVARGEFRPMDVTYGAYLVMA--------PMLFLALWQ 191
Cdd:pfam14246  25 LVIAEAERFPELGRAFYEAGPGRGLEALADYLEAAVAAGRLRIDDPELAAEQFLGllkgflfwPRLFGGDPP 96
PDI_b_family cd02981
Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of ...
32-74 6.16e-03

Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI, calsequestrin and other PDI-related proteins like ERp72, ERp57, ERp44 and PDIR. PDI, ERp57 (or ERp60), ERp72 and PDIR are all oxidases, catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER. They also exhibit reductase activity in acting as isomerases to correct any non-native disulfide bonds, as well as chaperone activity to prevent protein aggregation and facilitate the folding of newly synthesized proteins. These proteins contain multiple copies of a redox active TRX (a) domain containing a CXXC motif, and one or more redox inactive TRX-like (b) domains. The molecular structure of PDI is abb'a'. Also included in this family is the PDI-related protein ERp27, which contains only redox-inactive TRX-like (b and b') domains. The redox inactive b domains are implicated in substrate recognition.


Pssm-ID: 239279  Cd Length: 97  Bit Score: 35.01  E-value: 6.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1278639238  32 ELLAAALDLFVEKGFAATRVEEVAARAGVSKGTLFLYFPSKEE 74
Cdd:cd02981    35 TFEKVAESLRDDYGFGHTSDKEVAKKLKVKPGSVVLFKPFEEE 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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