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Conserved domains on  [gi|1278428263|gb|PIZ57586|]
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hypothetical protein COY28_00095 [Candidatus Woesearchaeota archaeon CG_4_10_14_0_2_um_filter_57_5]

Protein Classification

cation:proton antiporter( domain architecture ID 10008671)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to K(+) efflux antiporters that are involved in K(+) homeostasis and osmotic adjustment

CATH:  1.20.1530.20
Gene Ontology:  GO:0006812|GO:0015078|GO:0015297|GO:0016020|GO:1902600
PubMed:  9537504|12027219|16734752|12502567|17218973
TCDB:  2.A.37

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 1-524 4.21e-95

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 301.51  E-value: 4.21e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   1 MEPVFAGIAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVV 80
Cdd:COG4651     3 ETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGL-----------VADVELIEQLAEIGVILLLFGV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  81 GLEMEIRKINRVSLPSFLVALVPTVVIALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITG 160
Cdd:COG4651    72 GLEFSLKDLLAVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 161 TLLFQDFIAIIALAMLPGL---QQFSALLMLRSLLKGLALVLSIVAISDLVFAPMMRVAA--RSSELLFLMSLSVCFIAA 235
Cdd:COG4651   152 WLIVQDLAVVLMLVLLPALaggGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVArtRSRELFLLAVLAICLGVA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 236 SAAELAGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGMGLyqvpDWNLVWS-------FLAVVLILK 308
Cdd:COG4651   232 YLAALFGLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLF----DPSFLLEnplpvlaLLLIVLIGK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 309 PLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIYLLLRD 388
Cdd:COG4651   308 PLIAFLIVLALGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLER 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 389 RLFFLHRanLDKFDEFHTKKPFSAVLCGYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDR 468
Cdd:COG4651   388 RPPLAAR--LERDRPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLA 465

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1278428263 469 IFKFKPKVIISTVPDLDVNQLLIEQAEKSEHKVMLFVTASWIEDALRLYERGAHYV 524
Cdd:COG4651   466 ALLAAAAIAVVAIPAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEV 521
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 1-524 4.21e-95

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 301.51  E-value: 4.21e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   1 MEPVFAGIAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVV 80
Cdd:COG4651     3 ETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGL-----------VADVELIEQLAEIGVILLLFGV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  81 GLEMEIRKINRVSLPSFLVALVPTVVIALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITG 160
Cdd:COG4651    72 GLEFSLKDLLAVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 161 TLLFQDFIAIIALAMLPGL---QQFSALLMLRSLLKGLALVLSIVAISDLVFAPMMRVAA--RSSELLFLMSLSVCFIAA 235
Cdd:COG4651   152 WLIVQDLAVVLMLVLLPALaggGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVArtRSRELFLLAVLAICLGVA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 236 SAAELAGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGMGLyqvpDWNLVWS-------FLAVVLILK 308
Cdd:COG4651   232 YLAALFGLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLF----DPSFLLEnplpvlaLLLIVLIGK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 309 PLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIYLLLRD 388
Cdd:COG4651   308 PLIAFLIVLALGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLER 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 389 RLFFLHRanLDKFDEFHTKKPFSAVLCGYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDR 468
Cdd:COG4651   388 RPPLAAR--LERDRPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLA 465

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1278428263 469 IFKFKPKVIISTVPDLDVNQLLIEQAEKSEHKVMLFVTASWIEDALRLYERGAHYV 524
Cdd:COG4651   466 ALLAAAAIAVVAIPAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEV 521
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 8-370 1.04e-39

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 148.94  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   8 IAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFGRIFGIsylvhltdlsFLTDLSHIGVAFLLFVVGLEMEIR 87
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDE----------DLEVLSNLGLPPLLFLAGLELDLR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  88 KINRVSLPSFLVALVPTVVIALV--VIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQ 165
Cdd:pfam00999  71 ELRKNGGSILLLALLGVLIPFVLigLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 166 DFIAIIALAMLPGLQQF-SALLMLRSLLKGLALVLSIVAISDLVFAP----MMRVAARSSELLFLMSLSVCFIAASAAEL 240
Cdd:pfam00999 151 DGVAVVLLAVLLALAQGvGGGSDLGWLLLIFLVVAVGGLLLGLLIGWllrlITRFTDDDRELEVLLVLLLALLAALLAEA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 241 AGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRN-FFIILFYAALGMGLY----QVPDWNLVWSFLAVVLILKPLAMMLT 315
Cdd:pfam00999 231 LGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYgLFNPLFFVLVGLSLDlsslLLSVWILVLLALVAILLGRFLGVFLL 310

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1278428263 316 LDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFV 370
Cdd:pfam00999 311 LRLLGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVL 365
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 15-288 1.12e-34

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 132.00  E-value: 1.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  15 SALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVVGLEMEIRKINRVSL 94
Cdd:TIGR00932   4 AVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLGL-----------ISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  95 PSFLVALVPTVV-IALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQDFIAIIAL 173
Cdd:TIGR00932  73 AAFGVGVLQVLVpGVLLGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 174 AMLP----GLQQFSALLMLRSLLKGLALVLSIVAISDLVFAPMMRVA-ARSSELLFLMSLSVCFIAASAAELAGFSIEIG 248
Cdd:TIGR00932 153 ALLPllatSASTEHVALALLLLKVFLAFLLLVLLGRWLLRPVLRLTAeLRPSELFTAGSLLLMFGSAYFADLLGLSMALG 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1278428263 249 AFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGMGL 288
Cdd:TIGR00932 233 AFLAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMSV 272
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 33-496 7.26e-32

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 130.11  E-value: 7.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  33 YILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVVGLEMEIRKINRVSLPSFLVALVPTVVIALVVI 112
Cdd:PRK03562   35 YLIAGCIIGPWGLRL-----------VTDVESILHFAEFGVVLMLFVIGLELDPQRLWKLRRSIFGGGALQMVACGGLLG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 113 PLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQDFIAIIALAMLPGLQQFSALLMLRSL- 191
Cdd:PRK03562  104 LFCMLLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAIPLVAMIPLLAASGASTTLGAFa 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 192 ---LKGLALVLSIVAISDLVFAPMMRVAARSS--ELLFLMSLSVCFIAASAAELAGFSIEIGAFIAGLSLASLPYKPEIV 266
Cdd:PRK03562  184 lsaLKVAGALALVVLGGRYVTRPALRFVARSGlrEVFTAVALFLVFGFGLLMEEVGLSMALGAFLAGVLLASSEYRHALE 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 267 GRMLPVRNFFIILFYAALGMG-----LYQVPdWnLVWSFLAVVLILKPLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSL 341
Cdd:PRK03562  264 SDIEPFKGLLLGLFFIAVGMSidfgtLLENP-L-RILILLLGFLAIKIAMLWLLARPLGVPRKQRRWFAVLLGQGGEFAF 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 342 ILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIYLLLRdrlfflhrANLDKFDEFHTKKPfSAVLCGYNRTG 421
Cdd:PRK03562  342 VVFGAAQMANVLEPEWAKLLTLAVALSMAATPLLLVLLDRLEQSRT--------EEAREADEIDEQQP-RVIIAGFGRFG 412

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278428263 422 YGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDRIFKFKPKVIISTVPDLDVNQLLIEQAEK 496
Cdd:PRK03562  413 QIVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTSLQLVELVKE 487
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 1-524 4.21e-95

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 301.51  E-value: 4.21e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   1 MEPVFAGIAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVV 80
Cdd:COG4651     3 ETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGL-----------VADVELIEQLAEIGVILLLFGV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  81 GLEMEIRKINRVSLPSFLVALVPTVVIALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITG 160
Cdd:COG4651    72 GLEFSLKDLLAVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 161 TLLFQDFIAIIALAMLPGL---QQFSALLMLRSLLKGLALVLSIVAISDLVFAPMMRVAA--RSSELLFLMSLSVCFIAA 235
Cdd:COG4651   152 WLIVQDLAVVLMLVLLPALaggGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVArtRSRELFLLAVLAICLGVA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 236 SAAELAGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGMGLyqvpDWNLVWS-------FLAVVLILK 308
Cdd:COG4651   232 YLAALFGLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLF----DPSFLLEnplpvlaLLLIVLIGK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 309 PLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIYLLLRD 388
Cdd:COG4651   308 PLIAFLIVLALGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLER 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 389 RLFFLHRanLDKFDEFHTKKPFSAVLCGYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDR 468
Cdd:COG4651   388 RPPLAAR--LERDRPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLA 465

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1278428263 469 IFKFKPKVIISTVPDLDVNQLLIEQAEKSEHKVMLFVTASWIEDALRLYERGAHYV 524
Cdd:COG4651   466 ALLAAAAIAVVAIPAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEV 521
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 1-383 3.37e-68

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 225.41  E-value: 3.37e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   1 MEPVFAGIAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVV 80
Cdd:COG0475     2 LASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGL-----------IEDSEALELLAELGVVLLLFLI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  81 GLEMEIRKINRVSLPSFLVALVPTVVIALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITG 160
Cdd:COG0475    71 GLELDLKRLRKMGRRALGIGLLQVLLPFLLGFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 161 TLLFQDFIAIIALAMLPGLQQFSALL--MLRSLLKGLALVLSIVAISDLVFAPMMRVAAR--SSELLFLMSLSVCFIAAS 236
Cdd:COG0475   151 VALFDDIAAILLLALVPALAGGGSVAgsLLLALLKALLFLALLLLVGRYLLRRLFRLVARtrSRELFLLFALLLVLLAAA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 237 AAELAGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGMGLyqvpDWNLVWS-------FLAVVLILKP 309
Cdd:COG0475   231 LAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSL----DLSALLSnpllallLVLAAIVGKL 306

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1278428263 310 LAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIY 383
Cdd:COG0475   307 LGAYLAARLFGLSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRLA 380
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 8-370 1.04e-39

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 148.94  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   8 IAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFGRIFGIsylvhltdlsFLTDLSHIGVAFLLFVVGLEMEIR 87
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDE----------DLEVLSNLGLPPLLFLAGLELDLR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  88 KINRVSLPSFLVALVPTVVIALV--VIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQ 165
Cdd:pfam00999  71 ELRKNGGSILLLALLGVLIPFVLigLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 166 DFIAIIALAMLPGLQQF-SALLMLRSLLKGLALVLSIVAISDLVFAP----MMRVAARSSELLFLMSLSVCFIAASAAEL 240
Cdd:pfam00999 151 DGVAVVLLAVLLALAQGvGGGSDLGWLLLIFLVVAVGGLLLGLLIGWllrlITRFTDDDRELEVLLVLLLALLAALLAEA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 241 AGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRN-FFIILFYAALGMGLY----QVPDWNLVWSFLAVVLILKPLAMMLT 315
Cdd:pfam00999 231 LGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYgLFNPLFFVLVGLSLDlsslLLSVWILVLLALVAILLGRFLGVFLL 310

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1278428263 316 LDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFV 370
Cdd:pfam00999 311 LRLLGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVL 365
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 15-288 1.12e-34

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 132.00  E-value: 1.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  15 SALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVVGLEMEIRKINRVSL 94
Cdd:TIGR00932   4 AVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLGL-----------ISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  95 PSFLVALVPTVV-IALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQDFIAIIAL 173
Cdd:TIGR00932  73 AAFGVGVLQVLVpGVLLGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 174 AMLP----GLQQFSALLMLRSLLKGLALVLSIVAISDLVFAPMMRVA-ARSSELLFLMSLSVCFIAASAAELAGFSIEIG 248
Cdd:TIGR00932 153 ALLPllatSASTEHVALALLLLKVFLAFLLLVLLGRWLLRPVLRLTAeLRPSELFTAGSLLLMFGSAYFADLLGLSMALG 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1278428263 249 AFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGMGL 288
Cdd:TIGR00932 233 AFLAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMSV 272
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 33-496 7.26e-32

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 130.11  E-value: 7.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  33 YILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVVGLEMEIRKINRVSLPSFLVALVPTVVIALVVI 112
Cdd:PRK03562   35 YLIAGCIIGPWGLRL-----------VTDVESILHFAEFGVVLMLFVIGLELDPQRLWKLRRSIFGGGALQMVACGGLLG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 113 PLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQDFIAIIALAMLPGLQQFSALLMLRSL- 191
Cdd:PRK03562  104 LFCMLLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAIPLVAMIPLLAASGASTTLGAFa 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 192 ---LKGLALVLSIVAISDLVFAPMMRVAARSS--ELLFLMSLSVCFIAASAAELAGFSIEIGAFIAGLSLASLPYKPEIV 266
Cdd:PRK03562  184 lsaLKVAGALALVVLGGRYVTRPALRFVARSGlrEVFTAVALFLVFGFGLLMEEVGLSMALGAFLAGVLLASSEYRHALE 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 267 GRMLPVRNFFIILFYAALGMG-----LYQVPdWnLVWSFLAVVLILKPLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSL 341
Cdd:PRK03562  264 SDIEPFKGLLLGLFFIAVGMSidfgtLLENP-L-RILILLLGFLAIKIAMLWLLARPLGVPRKQRRWFAVLLGQGGEFAF 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 342 ILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIYLLLRdrlfflhrANLDKFDEFHTKKPfSAVLCGYNRTG 421
Cdd:PRK03562  342 VVFGAAQMANVLEPEWAKLLTLAVALSMAATPLLLVLLDRLEQSRT--------EEAREADEIDEQQP-RVIIAGFGRFG 412

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278428263 422 YGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDRIFKFKPKVIISTVPDLDVNQLLIEQAEK 496
Cdd:PRK03562  413 QIVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTSLQLVELVKE 487
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 3-526 7.34e-28

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 117.89  E-value: 7.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   3 PVFAGIAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFgrifgisylvhLTDLSFLTDLSHIGVAFLLFVVGL 82
Cdd:PRK10669    6 PLITTIVGGLVLAFILGMLANRLRISPLVGYLLAGVLAGPFTPGF-----------VADTKLAPELAELGVILLMFGVGL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  83 EMEIRKINRVSLPSFLVALVPTVVIALVVIPLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTL 162
Cdd:PRK10669   75 HFSLKDLMAVKSIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 163 LFQDFIAIIALAMLP--------GLQQFSALL--MLRSLLKGLA-LVLSIVAISDLVFAPMMRVAARSSELLFLMSLSVC 231
Cdd:PRK10669  155 IVEDLVMVLTLVLLPavagmmeqGDVGFATLAvdLGITIGKVIAfIAIMMLVGRRLVPWILARSAATGSRELFTLSVLAL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 232 F--IAASAAELAGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRNFFIILFYAALGM-----GLYQVPdwNLVWSFLAVV 304
Cdd:PRK10669  235 AlgIAFGAVELFDVSFALGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMlfdpmILIQQP--LAVLATLAII 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 305 LILKPLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILP--------ATYMVAITLVTLLTFVSSSYVI 376
Cdd:PRK10669  313 VFGKSLAAFFLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPqagqnlvlAGAILSIMLNPVLFTLLERYLA 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 377 RYANriylllrdrlffLHRANLDKFDEFHTKKPFS----AVLCGYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRHES 452
Cdd:PRK10669  393 KTET------------LEEQTLEEAIEEEKQIPVDicnhALLVGYGRVGSLLGEKLLAAGIPLVVIETSRTRVDELRERG 460

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1278428263 453 VPCIYGDLSDPEIVDRIFKFKPKVIISTVPDLDVNQLLIEQAEKSEHKVMLFVTASWIEDALRLYERGAHYVML 526
Cdd:PRK10669  461 IRAVLGNAANEEIMQLAHLDCARWLLLTIPNGYEAGEIVASAREKRPDIEIIARAHYDDEVAYITERGANQVVM 534
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 33-465 3.13e-25

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 110.12  E-value: 3.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  33 YILAGVLVGPLILAFgrIFGISYLVHLTDLsfltdlshiGVAFLLFVVGLEMEIRKINRVSLPSFLVALVPTVVIALVVI 112
Cdd:PRK03659   35 YLLAGIAIGPWGLGF--ISDVDEILHFSEL---------GVVFLMFIIGLELNPSKLWQLRRSIFGVGAAQVLLSAAVLA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 113 PLAMLTGLSATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHGRIITGTLLFQDFIAIIALAMLPGL--QQFSALLMLRS 190
Cdd:PRK03659  104 GLLMLTDFSWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALVPLLagSADEHFDWMKI 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 191 LLKGLALVLSIVAISDLVfAPMMRVAARSS--ELLFLMSLSVCFIAASAAELAGFSIEIGAFIAGLSLASLPYKPEIVGR 268
Cdd:PRK03659  184 GMKVLAFAGMLIGGRYLL-RPLFRFIAASGvrEVFTAAALLLVLGSALFMDALGLSMALGTFIAGVLLAESEYRHELEIA 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 269 MLPVRNFFIILFYAALGMG-----LYQVPDWNLVwSFLAVVLIlKPLAMMLtLDRLGFSRSTSFL--TGVnLAQTSEFSL 341
Cdd:PRK03659  263 IEPFKGLLLGLFFISVGMAlnlgvLYTHLLWVLI-SVVVLVAV-KGLVLYL-LARLYGLRSSERMqfAGV-LSQGGEFAF 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 342 ILVPIAIQANILPATYMVAITLVTLLTFVSSSYVIRYANRIYlllrdrlffLHRANLdkfDEFHTKKPF------SAVLC 415
Cdd:PRK03659  339 VLFSAASSQRLLQGDQMALLLVVVTLSMMTTPLLMKLIDKWL---------ARRLNG---PEEEDEKPWveddkpQVIIV 406

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1278428263 416 GYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEI 465
Cdd:PRK03659  407 GFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATQLEL 456
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
291-567 1.57e-15

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 77.08  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 291 VPDWNLVWSFLAVVLILKPLAMMLTLDRLGFSRSTSFLTGVNLAQTSEFSLILVPIAIQANILPATYMVAITLVTLLTFV 370
Cdd:COG1226    10 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLAALALAALLLLLLLAGGGGFFLLLLLAAAALLLLLLLAAALLLLLVLLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 371 SSSYVIRYANRIYLLLRDRLFFLHRANLDKFDEFHTkkpfSAVLCGYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRH 450
Cdd:COG1226    90 LLLLLLLLLALLLLLLALAAREEEAEAAEDAIDLEG----HVIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELRR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 451 ESVPCIYGDLSDPEIVDRIFKFKPKVIISTVPDLDVNQLLIEQAEKSEHKVMLFVTASWIEDALRLYERGAHYVMLPNLV 530
Cdd:COG1226   166 FGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRIVELARELNPDLKIIARARDREHAEELRQAGADEVVRETFE 245

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1278428263 531 AGDYLAGIV-HKHGKSHKHVHhlrkEHIKELKRRHRHA 567
Cdd:COG1226   246 SALQLARHAlEALGVPEEEAA----RAIQEFRRRDYER 279
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 413-527 9.51e-12

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 62.16  E-value: 9.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 413 VLCGYNRTGYGILKSFKEKKkEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDRIFKFKPKVIISTVPDLDVNQLLIE 492
Cdd:pfam02254   2 IIIGYGRVGRSLAEELSEGG-DVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILIVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1278428263 493 QAEKSEHKVMLFVTASWIEDALRLYERGAHYVMLP 527
Cdd:pfam02254  81 LARELNPDKKIIARANDPEHAELLRRLGADHVISP 115
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 8-333 2.49e-11

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 66.45  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   8 IAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPLILAFGRIFGISyLVHLTDLSFLTDLSHIGVAFLLFVVGLEMEIR 87
Cdd:PLN03159   48 LTLVVVTTRLLVFILKPFRQPRVISEILGGVILGPSVLGQSEVFANT-IFPLRSVMVLETMANLGLLYFLFLVGVEMDIS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  88 KINRVSLPSFLVAlvptvvIALVVIPLAMLTGLS------------ATAGAYLSLILSFSSTMVVLKLLSDRGELPTLHG 155
Cdd:PLN03159  127 VIRRTGKKALAIA------IAGMALPFCIGLAFSfifhqvsrnvhqGTFILFLGVALSVTAFPVLARILAEIKLINTELG 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 156 RIITGTLLFQDFIAIIALAMLPGLQQF--SALLMLRSLLKGLALVLSIVAISDLVFAPMMRVAARS---SELLFLMSLSV 230
Cdd:PLN03159  201 RIAMSAALVNDMCAWILLALAIALAENdsTSLASLWVLLSSVAFVLFCFYVVRPGIWWIIRRTPEGetfSEFYICLILTG 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 231 CFIAASAAELAGFSIEIGAFIAGLSLASLPY------KPE--IVGRMLPVrnFFIIlfyAALGMGLYQVPDwNLVWSFLA 302
Cdd:PLN03159  281 VMISGFITDAIGTHSVFGAFVFGLVIPNGPLgvtlieKLEdfVSGLLLPL--FFAI---SGLKTNVTKIQG-PATWGLLV 354

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1278428263 303 VVLILKPLAMMLTLDRLGFSRSTSFLTGVNL 333
Cdd:PLN03159  355 LVIIMASAGKIMGTIIIAFFYTMPFREGITL 385
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
1-320 1.02e-10

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 64.22  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   1 MEPVFAgIAAIIILSALFGYLMHRVRQPLLPAYILAGVLVGPlilafgrIFGISYLVHLTDLSFLTdlsHIGVAFLLFVV 80
Cdd:COG0025     1 MELLLL-ILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGP-------GLGLELDPELGDLEPLL---ELFLPPLLFEA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  81 GLEMEIRKINRVSLPSFLVALVPTVVIALVVIPLAM-LTGLSATAGAYLSLILSFSSTMVVLKLLSDRGeLPTLHGRIIT 159
Cdd:COG0025    70 ALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHwLLGLPLAAALLLGAILAPTDPVAVSPILRRLG-VPKRLRTILE 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 160 GTLLFQDFIAII----ALAMLpGLQQFSALLMLRSLLKGLALVLSIVAISDLVFAPMMRvAARSSELLFLMSLSVCFIAA 235
Cdd:COG0025   149 GESLLNDATALVlfvlALAAA-LGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLR-RLPDPLLEILLTLALPFLAY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 236 SAAELAGFSIEIGAFIAGLSLASLPYKPEIVGRMLPVRNFF-----------IILFYAALGMGLYQVPDWNLVWSFLAVV 304
Cdd:COG0025   227 LLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWetlefllnsllFVLLGAQLPLILLGALGLGGILLVLLAL 306

                         330
                  ....*....|....*.
gi 1278428263 305 LILKPLAMMLTLDRLG 320
Cdd:COG0025   307 LVVRPLWVFLSLALRG 322
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 413-543 1.03e-09

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 59.70  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 413 VLCGYNRTGYGILKSFKEKKKEILVVDYNPETIHRLRHESVPCIYGDLSDPEIVDRIFKFKPKVIISTVPDLDVNQLLIE 492
Cdd:COG0569    99 IIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDDEANILACL 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1278428263 493 QAeKSEHKVMLFVTASWIEDALRLYERGAHYVMLPNLVAGDYLAGIVHKHG 543
Cdd:COG0569   179 LA-KELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPG 228
Stt3 COG1287
Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, ...
 3-317 6.61e-03

Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440898 [Multi-domain]  Cd Length: 774  Bit Score: 39.39  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263   3 PVFAGIAAIIILSALFGYLMHRVR-----QPLLPAYILAGVLVGPLILAFGriFGISYLVHLTDLSFLTDlshIGVAFLL 77
Cdd:COG1287   224 VLFVGILALFALLQLLLDLLRGRSpeylaIVGAVSFAVAALLVLPFIPRLG--FSGTGLSLLQPLLALAL---AAGTVFL 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263  78 FVVGLEMEIRKINRVSLPSFLVALVPTVVIALVVIPlamltglsataGAYLSLILSFSStmvvlkllsdrgelptlhgRI 157
Cdd:COG1287   299 AWLARELERRDLPRLYYPAALVGLVAAGLALLAVLL-----------PRVLAALIPGLR-------------------RF 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 158 ITGTLLFqdfiAIIALAMLPGLQQfsallMLRSLlkGLALVLSIVAISDLVFAPMMRvaaRSSELLFLMSLSVCFIAASA 237
Cdd:COG1287   349 FGASALA----ATIAEAQPLTLSD-----LFSSF--GIAFFLALIGLLLLLYRPLRE---RRPELLFLLVWALFSIYAAF 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278428263 238 --AELAGFSIEIGAFIAGLSLASLPYKpeivgrmlpvrnffiILFYAALGMGLYQVPDWNLVWSFLAVVLILKPLAMMLT 315
Cdd:COG1287   415 tqVRFLYYLAVAVAILAAIGLGELLDR---------------LDLDKKKREAKKNINGVKILAVALIVLLLLIPLSASIA 479


                  ..
gi 1278428263 316 LD 317
Cdd:COG1287   480 LS 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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