RrF2 family transcriptional regulator similar to Desulfovibrio vulgaris regulatory protein Rrf2, iron-sulfur cluster assembly regulator IscR, and nitric oxide-responsive regulator NsrR
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
4-132
3.20e-45
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 396591 [Multi-domain] Cd Length: 131 Bit Score: 145.77 E-value: 3.20e-45
Rrf2 family protein; This model represents a superfamily of probable transcriptional ...
3-133
8.52e-42
Rrf2 family protein; This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General]
Pssm-ID: 273242 Cd Length: 132 Bit Score: 136.99 E-value: 8.52e-42
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
24-67
2.13e-03
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.
Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 35.74 E-value: 2.13e-03
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
4-132
3.20e-45
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 396591 [Multi-domain] Cd Length: 131 Bit Score: 145.77 E-value: 3.20e-45
Rrf2 family protein; This model represents a superfamily of probable transcriptional ...
3-133
8.52e-42
Rrf2 family protein; This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General]
Pssm-ID: 273242 Cd Length: 132 Bit Score: 136.99 E-value: 8.52e-42
iron-sulfur cluster assembly transcription factor IscR; This model describes IscR, an ...
2-132
5.04e-40
iron-sulfur cluster assembly transcription factor IscR; This model describes IscR, an iron-sulfur binding transcription factor of the ISC iron-sulfur cluster assembly system. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Regulatory functions, DNA interactions]
Pssm-ID: 273927 Cd Length: 135 Bit Score: 132.50 E-value: 5.04e-40
FeS assembly SUF system regulator, gammaproteobacterial; The SUF system is an oxygen-resistant ...
1-131
4.90e-21
FeS assembly SUF system regulator, gammaproteobacterial; The SUF system is an oxygen-resistant iron-sulfur cluster assembly system found in both aerobes and facultative anaerobes. Its presence appears to be a marker of oxygen tolerance; strict anaerobes and microaerophiles tend to have different FeS cluster biosynthesis systems. Members of this protein family belong to the rrf2 family of transcriptional regulators and are found, typically, as the first gene of a SUF operon. It is found only in a subset of genomes that encode the SUF system, including the genus Xanthomonas. The conserved location suggests an autoregulatory role. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Regulatory functions, DNA interactions]
Pssm-ID: 131989 [Multi-domain] Cd Length: 130 Bit Score: 83.70 E-value: 4.90e-21
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
24-67
2.13e-03
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.
Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 35.74 E-value: 2.13e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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