|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
4-705 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1191.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 4 FDKPYDPKEVEDKIYRLWEKSGYFNPDklPDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPG 83
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKAD--PDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 84 TDHAGIATQNVVEKDLKKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLH 163
Cdd:COG0525 81 TDHAGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 164 YHKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKSKLWFIKY-----SPDITVATTRPETMLGDTAVAVHPNDKRYKNL 238
Cdd:COG0525 161 LYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYpladgSGYIVVATTRPETMLGDTAVAVHPEDERYKHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 239 IGEKVILPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTVLQARE 318
Cdd:COG0525 241 IGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGK-YRGLDRFEARK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 319 KVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNNIKD 398
Cdd:COG0525 320 AIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIKFVPERWEKTYFHWMENIRD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 399 WCISRQIWWGHRLPVY--KNLEIYVGDNPP--------KDYIQIPDVLDTWFSSALWPFATLGWPKRTADLKEFYPTQIL 468
Cdd:COG0525 400 WCISRQLWWGHRIPAWycPDGEVYVARTEPeacakagsVNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 469 VTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDI 548
Cdd:COG0525 480 VTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDI 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 549 RWSEEHVVAGQKFCNKIWNSARFALLQILNSIITKQIPRgsfqisktiKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQ 628
Cdd:COG0525 560 KFDEERVEGYRNFANKLWNASRFVLMNLEGFDPGLDPDP---------EELSLADRWILSRLNKTIAEVTEALEKYRFDE 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 629 ALHKLYEFFWHNFCDKYIEISKKQMA--DDKLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLP-IKNKKMLMIEKW 705
Cdd:COG0525 631 AAQALYDFVWNEFCDWYLELAKPRLYggDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPpRKEGESIMLAPW 710
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-705 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1160.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 1 MKRFDKPYDPKEVEDKIYRLWEKSGYFNPDklpDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLW 80
Cdd:PRK05729 2 MMELPKTYDPKEVEAKWYQKWEEKGYFKPD---DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 81 LPGTDHAGIATQNVVEKDLKKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKET 160
Cdd:PRK05729 79 LPGTDHAGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 161 FLHYHKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKSKLWFIKY-----SPDITVATTRPETMLGDTAVAVHPNDKRY 235
Cdd:PRK05729 159 FVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYpladgSDYLVVATTRPETMLGDTAVAVNPEDERY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 236 KNLIGEKVILPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTVLQ 315
Cdd:PRK05729 239 KHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGE-YQGLDRFE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 316 AREKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNN 395
Cdd:PRK05729 318 ARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEIKFVPERWEKTYFHWMEN 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 396 IKDWCISRQIWWGHRLPVY--KNLEIYVGDNPPKD-----YIQIPDVLDTWFSSALWPFATLGWPKRTADLKEFYPTQIL 468
Cdd:PRK05729 398 IQDWCISRQLWWGHRIPAWydEDGEVYVGREEPEArekalLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 469 VTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDI 548
Cdd:PRK05729 478 VTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 549 RWSEEHVVAGQKFCNKIWNSARFALLQILNSIITKQIPRGSFqisktikpkTTADKKILNQLTKIKKSTEKDLDNYRFGQ 628
Cdd:PRK05729 558 RFDEERVEGYRNFANKLWNASRFVLMNLEGADVGELPDPEEL---------SLADRWILSRLNRTVAEVTEALDKYRFDE 628
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1277893524 629 ALHKLYEFFWHNFCDKYIEISKKQMADDKlQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLPIKN-KKMLMIEKW 705
Cdd:PRK05729 629 AARALYEFIWNEFCDWYLELAKPVLQEAA-KRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGiEESIMLAPW 705
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
4-695 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 944.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 4 FDKPYDPKEVEDKIYRLWEKSGYFNPDklPDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPG 83
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPD--GNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 84 TDHAGIATQNVVEKDLKKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLH 163
Cdd:TIGR00422 79 TDHAGIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 164 YHKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKSKLWFIKY------SPDITVATTRPETMLGDTAVAVHPNDKRYKN 237
Cdd:TIGR00422 159 LYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYplangsKDYLVVATTRPETMFGDTAVAVHPEDERYKH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 238 LIGEKVILPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTVLQAR 317
Cdd:TIGR00422 239 LIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGK-YQGLTRFEAR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 318 EKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNNIK 397
Cdd:TIGR00422 318 KKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGEIKFVPKRMEKRYLNWLRNIK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 398 DWCISRQIWWGHRLPVY---KNLEIYVGDN-----------PPKDYIQIPDVLDTWFSSALWPFATLGWPKRTADLKEFY 463
Cdd:TIGR00422 398 DWCISRQLIWGHRIPVWyckECGEVYVAKEeplpddktntgPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFY 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 464 PTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAM 543
Cdd:TIGR00422 478 PTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVT 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 544 GNQDIRWSEEHVVAGQKFCNKIWNSARFALLQILNSIItkqiprgsfqISKTIKPKTTADKKILNQLTKIKKSTEKDLDN 623
Cdd:TIGR00422 558 PGDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLE----------LSGGEEKLSLADRWILSKLNRTIKEVRKALDK 627
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1277893524 624 YRFGQALHKLYEFFWHNFCDKYIEISKKQMADD--KLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLPIK 695
Cdd:TIGR00422 628 YRFAEAAKALYEFIWNDFCDWYIELVKYRLYNGneAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG 701
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
6-695 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 822.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 6 KPYDPKEVEDKIYRLWEKSGYFNPDKLPDKKgKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTD 85
Cdd:PRK14900 17 KGYEHREVEARWYPFWQERGYFHGDEHDRTR-PPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 86 HAGIATQNVVEKDLKK-QGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHY 164
Cdd:PRK14900 96 HAGIATQMIVEKELKKtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 165 HKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKS-KLWFIKY-----SPDITVATTRPETMLGDTAVAVHPNDKRYKNL 238
Cdd:PRK14900 176 HEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQgELWSFAYpladgSGEIVVATTRPETMLGDTAVAVHPLDPRYMAL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 239 IGEKVILPIQNRKIAIIADKR-VDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTVLQAR 317
Cdd:PRK14900 256 HGKKVRHPITGRTFPIVADAIlVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGP-LAGLDRFEAR 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 318 EKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNNIK 397
Cdd:PRK14900 335 KEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQGRTRFIPEQWTNTYMAWMRNIH 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 398 DWCISRQIWWGHRLPVY--KNLEIYVGDNPP--------KDYIQIPDVLDTWFSSALWPFATLGWPKRTADLKEFYPTQI 467
Cdd:PRK14900 415 DWCISRQLWWGHQIPAWycPDGHVTVARETPeacstcgkAELRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSV 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 468 LVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQD 547
Cdd:PRK14900 495 METGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRD 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 548 IRWSEEHVVAGQKFCNKIWNSARFALLQILNSIITKQIPrgsfqiskTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFG 627
Cdd:PRK14900 575 IKLAKERIEGYRAFANKLWNASRFALMNLSGYQERGEDP--------ARLARTPADRWILARLQRAVNETVEALEAFRFN 646
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 628 QALHKLYEFFWHNFCDKYIEISKKQMADDKLQK--NTQEILIYILLSSLKLLHPFMPFITEEIYQQLPIK 695
Cdd:PRK14900 647 DAANAVYAFVWHELCDWYIELAKEALASEDPEArrSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQ 716
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
8-702 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 785.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 8 YDPKEVEDKIYRLWEKSGYFNP--DKLPDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTD 85
Cdd:PTZ00419 28 YDPKEVESGWYEWWEKSGFFKPaeDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTD 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 86 HAGIATQNVVEKDL-KKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHY 164
Cdd:PTZ00419 108 HAGIATQVVVEKKLmKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 165 HKKGWIYQAERVINWCIRCGTSLSDLEVELKD----TKSK------------LWFIKY------SPDITVATTRPETMLG 222
Cdd:PTZ00419 188 YEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEiekpTKITipgydkkvevgvLWHFAYpledsgQEEIVVATTRIETMLG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 223 DTAVAVHPNDKRYKNLIGEKVILP-IQNRKIAIIADKR-VDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKM 300
Cdd:PTZ00419 268 DVAVAVHPKDERYKKLHGKELIHPfIPDRKIPIIADDElVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKI 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 301 SEQAGKnFEGLTVLQAREKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSGKVKF 380
Cdd:PTZ00419 348 NENGGE-FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNGELKI 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 381 HPKRWEKIYFNWLNNIKDWCISRQIWWGHRLPVYK-----------NLEIYV-GDN--------------PPKDY--IQI 432
Cdd:PTZ00419 427 IPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRviskgpetdpsDEEPWVvARSeeealekakkkfglSEEDFelEQD 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 433 PDVLDTWFSSALWPFATLGWPKRTADLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRM 512
Cdd:PTZ00419 507 EDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKM 586
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 513 SKSLGTGVDPMDLIS-------------------------------------RYGADAVRFGLIWQAMGNQDIRWSEEHV 555
Cdd:PTZ00419 587 SKSKGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLAYTQQGRNINLDINRV 666
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 556 VAGQKFCNKIWNSARFALLQILNsiiTKQIPRgSFQISKTIKPKTTA-DKKILNQLTKIKKSTEKDLDNYRFGQALHKLY 634
Cdd:PTZ00419 667 VGYRHFCNKLWNAVKFALMKLLK---DFNLPN-STLFKPNNVESLPWeDKWILHRLNVAIKEVTEGFKEYDFSEATQATY 742
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1277893524 635 EFFWHNFCDKYIEISKKQMA--DDKLQKN-TQEILIYILLSSLKLLHPFMPFITEEIYQQLPIKNKKMLMI 702
Cdd:PTZ00419 743 NFWLYELCDVYLELIKPRLSkqSDGERKQhAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKSESI 813
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
14-705 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 689.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 14 EDKIYRLWEKSGYFNPDKlpDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQN 93
Cdd:PLN02943 66 EERIYNWWESQGYFKPNF--DRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 94 VVEKDLKKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQA 173
Cdd:PLN02943 144 VVEKMLASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 174 ERVINWCIRCGTSLSDLEVELKDTKSKLWFIKY-----SPD-ITVATTRPETMLGDTAVAVHPNDKRYKNLIGEKVILPI 247
Cdd:PLN02943 224 SYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYrvaggSEDfLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPM 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 248 Q-NRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAgknfeGLTVLQAREKVVQGLEK 326
Cdd:PLN02943 304 TyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVA-----GLYWFEAREKLWSDLEE 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 327 QGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNNIKDWCISRQIW 406
Cdd:PLN02943 379 TGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLW 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 407 WGHRLPVYknleIYVGDNPPKDYI-----------------------QIPDVLDTWFSSALWPFATLGWPKRTA-DLKEF 462
Cdd:PLN02943 459 WGHRIPVW----YIVGKDCEEDYIvarsaeealekarekygkdveiyQDPDVLDTWFSSALWPFSTLGWPDVSAeDFKKF 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 463 YPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQA 542
Cdd:PLN02943 535 YPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGT 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 543 MGnQDIRWSEEHVVAGQKFCNKIWNSARFALLQILNSIIT---KQIPRGSFQISKTIKPKTTADKKILNQLTKIKKSTEK 619
Cdd:PLN02943 615 AG-QDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSDTsawEHILACKFDKEESLLSLPLPECWVVSKLHELIDSVTT 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 620 DLDNYRFGQALHKLYEFFWHNFCDKYIEISKKQM---ADDKLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLPIKn 696
Cdd:PLN02943 694 SYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLyhsGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYR- 772
|
....*....
gi 1277893524 697 KKMLMIEKW 705
Cdd:PLN02943 773 KEALIVSPW 781
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
6-693 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 622.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 6 KPYDPKEVEDKIYRLWEKSGYFNPDKLPDKKgkTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTD 85
Cdd:PLN02381 98 KQYSPSAVEKSWYAWWEKSGYFGADAKSSKP--PFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 86 HAGIATQNVVEKDL-KKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHY 164
Cdd:PLN02381 176 HAGIATQVVVEKKLmRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 165 HKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKSK----------------LWFIKYS-----PDITVATTRPETMLGD 223
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERtllkvpgydkpvefgvLTSFAYPlegglGEIVVATTRIETMLGD 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 224 TAVAVHPNDKRYKNLIGEKVILPIQNRKIAIIADKR-VDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSE 302
Cdd:PLN02381 336 TAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAIlVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINS 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 303 QAGKNFEGLTVLQAREKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKSG---KVK 379
Cdd:PLN02381 416 NGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGenkKLE 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 380 FHPKRWEKIYFNWLNNIKDWCISRQIWWGHRLPVY---------KNLEIY-----VGDN------------PPK--DYIQ 431
Cdd:PLN02381 496 FIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWyvtleddqlKELGSYndhwvVARNesdalleasqkfPGKkfELSQ 575
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 432 IPDVLDTWFSSALWPFATLGWPKRTADLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKR 511
Cdd:PLN02381 576 DPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRK 655
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 512 MSKSLGTGVDPMDL-------------------------------------ISRYGADAVRFGLIWQAMGNQDIRWSEEH 554
Cdd:PLN02381 656 MSKSLGNVIDPLEVingisleglhkrleegnldpkelvvakegqkkdfpngIAECGTDALRFALVSYTAQSDKINLDILR 735
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 555 VVAGQKFCNKIWNSARFALLQILNSIITKQiprgsfQISKTIKPKTTadKKILNQLTKIKKSTEKDLDNYRFGQALHKLY 634
Cdd:PLN02381 736 VVGYRQWCNKLWNAVRFAMSKLGDDYTPPA------TLSVETMPFSC--KWILSVLNKAISKTVSSLDAYEFSDAASTVY 807
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1277893524 635 EFFWHNFCDKYIEISKKQMADDK-----LQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLP 693
Cdd:PLN02381 808 SWWQYQFCDVFIEAIKPYFAGDNpefasERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLP 871
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
16-551 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 600.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 16 KIYRLWEKSGYFNPDKLPDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVV 95
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 96 EKDL-KKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQAE 174
Cdd:pfam00133 81 EKKLgIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 175 RVINWCIRCGTSLSDLEVELKDTKSKLWFIKYSPD------ITVATTRPETMLGDTAVAVHPN----------------- 231
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLAddegasLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeall 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 232 --------------DKRYKNLIGEKVILPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQD 297
Cdd:pfam00133 241 kslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 298 GKMSEQAGkNFEGLTVLQAREKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKsgK 377
Cdd:pfam00133 321 GTFTEEAP-DFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE--K 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 378 VKFHPKRWEKIYFNWLNNIKDWCISRQIWWGHRLPVY----------------------------KNLEIYVGD---NPP 426
Cdd:pfam00133 398 VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWvskdteevvcrgelfelvagrfeeegsiKWLHREAKDklgYGK 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 427 KDYIQIPDVLDTWFSSALWPFATLGWPKRTA-DLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATIL 505
Cdd:pfam00133 478 GTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTeEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVR 557
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 1277893524 506 TKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGnQDIRWS 551
Cdd:pfam00133 558 DEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYG-RDINLS 602
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-692 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 575.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 1 MKRFDKPYDPKEVEDKIYRLWEKSGYFNPDklPDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLW 80
Cdd:PRK13208 3 MPELPKKYDPEELEEKWQKIWEEEGTYKFD--PDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 81 LPGTDHAGIATQNVVEKdlkKQGISRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKET 160
Cdd:PRK13208 81 PQGWDDNGLPTERKVEK---YYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 161 FLHYHKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKSKLWFIKYSP----DITVATTRPETMLGDTAVAVHPNDKRYK 236
Cdd:PRK13208 158 FLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVedgeEIEIATTRPELLPACVAVVVHPDDERYK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 237 NLIGEKVILPIQNRKIAIIADKRVDPKFGTGAIKVTpahSF---TDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTV 313
Cdd:PRK13208 238 HLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMIC---TFgdkTDVTWWRELNLPTRIIIDEDGRMTEAAGK-LAGLTI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 314 LQAREKVVQGLEKQGLIKKVEDYNNYVGHCYRCGTVIEPIPSLQWFLKMNELANTAIQAVKsgKVKFHPKRWEKIYFNWL 393
Cdd:PRK13208 314 EEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK--EINWYPEHMRVRLENWI 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 394 NNIK-DWCISRQ--------IWW----GH-------RLPVYKNLEIYVGDNPPK----DYIQIPDVLDTWFSSALWPFAT 449
Cdd:PRK13208 392 EGLNwDWCISRQryfgtpipVWYckdcGHpilpdeeDLPVDPTKDEPPGYKCPQcgspGFEGETDVMDTWATSSITPLIV 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 450 LGWPKRTADLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRY 529
Cdd:PRK13208 472 TGWERDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 530 GADAVRFgliWQAMGNQ--DIRWSEEHVVAGQKFCNKIWNSARFALlqilnsiitkQIPRGSFQISKTIkpKTTADKKIL 607
Cdd:PRK13208 552 GADAVRY---WAASARLgsDTPFDEKQVKIGRRLLTKLWNASRFVL----------HFSADPEPDKAEV--LEPLDRWIL 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 608 NQLTK-IKKSTEkDLDNYRFGQALHKLYEFFWHNFCDKYIEISKKQ---MADDKLQKNTQEILIYILLSSLKLLHPFMPF 683
Cdd:PRK13208 617 AKLAKvVEKATE-ALENYDFAKALEEIESFFWHVFCDDYLELVKSRaygEDEEEEQKSARYTLYTVLDTLLRLLAPFLPF 695
|
....*....
gi 1277893524 684 ITEEIYQQL 692
Cdd:PRK13208 696 ITEEVWSWL 704
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
38-550 |
2.21e-178 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 513.33 E-value: 2.21e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 38 KTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVVEKDLKKQGISRHDLGREKLIEK 117
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 118 IWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQAERVINWCIRCGTSLSDLEVelkdt 197
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 198 ksklwfikyspditvattrpetmlgdtavavhpndkryknligekvilpiqnrkiaiiadkrvdpkfgtgaikvtpahsf 277
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 278 tdfeigqehnleiikvigqdgkmseqagknfegltvlqarekvvqglekqglikkvedynnyvghCYRCGTVIEPIPSLQ 357
Cdd:cd00817 156 -----------------------------------------------------------------CSRSGDVIEPLLKPQ 170
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 358 WFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNNIKDWCISRQIWWGHRLPVYKNLE---IYVG------------ 422
Cdd:cd00817 171 WFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDgghWVVAreedeaidkaap 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 423 ----DNPPKDYIQIPDVLDTWFSSALWPFATLGWPKRTADLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDV 498
Cdd:cd00817 251 eacvPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEV 330
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1277893524 499 IIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDIRW 550
Cdd:cd00817 331 YLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-693 |
1.05e-102 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 335.13 E-value: 1.05e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 4 FDKPYDPKEVEDKIYRLWEKSGYFnpDKLPDKK--GKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWL 81
Cdd:COG0060 12 FPMRANLPKREPEILKFWEENDIY--EKSREARagRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 82 PGTD-HaGIATQNVVEKDLKKQGISRHDLGREKLIEK--------IWEWKEkygyiildQFKKLGCSMDWSRTRFTMDSD 152
Cdd:COG0060 90 PGWDcH-GLPIELKVEKELGIKKKDIEKVGIAEFREKcreyalkyVDEQRE--------DFKRLGVWGDWDNPYLTMDPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 153 YQEAVKETFLHYHKKGWIYQAERVINWCIRCGTSLSDLEVELKDTKsklwfikySPDITVA------------------- 213
Cdd:COG0060 161 YEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVT--------SPSIYVKfpvkdekalllledaylvi 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 214 -TTRPETMLGDTAVAVHP----------NDKRY---KNLIGE----------KVI-------------------LPIQNR 250
Cdd:COG0060 233 wTTTPWTLPANLAVAVHPdidyvlvevtGGERLilaEALVEAvlkelgiedyEVLatfkgaeleglryehpfyyVVGYDR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 251 KIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTVLQAREKVVQGLEKQGLI 330
Cdd:COG0060 313 AHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPL-FAGLFVKDANPAIIEDLKERGAL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 331 KKVEDYN-NYvGHCYRCGTviePI---PSLQWFLKMNELANTAIQAVKsgKVKFHPKRWEKIYFNWLNNIKDWCISRQIW 406
Cdd:COG0060 392 LAREKIThSY-PHCWRCKT---PLiyrATPQWFISMDKLRDRALEAIE--KVNWIPEWGEGRFGNMLENRPDWCISRQRY 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 407 WGHRLPVYKN-------------------LE--------------IYVGD---NP--PKDYIQIPDVLDTWFSSALWPFA 448
Cdd:COG0060 466 WGVPIPIWVCedcgelhrteevigsvaelLEeegadawfeldlhrPFLDEtlkCPkcGGTMRRVPDVLDVWFDSGSMHFA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 449 TL------GWPkrtADL-KE--------FYpTQilvtardiinLWVARMIFsglkftKKEPFKDVIIHATILTKEGKRMS 513
Cdd:COG0060 546 VLenreelHFP---ADFyLEgsdqtrgwFY-SS----------LLTSTALF------GRAPYKNVLTHGFVLDEDGRKMS 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 514 KSLGTGVDPMDLISRYGADAVRFGLIWQAMGNqDIRWSEEHVVAGQKFCNKIWNSARFaLLQILNSiitkqiprgsfqis 593
Cdd:COG0060 606 KSLGNVVDPQEVIDKYGADILRLWVASSDYWG-DLRFSDEILKEVRDVYRRLRNTYRF-LLANLDD-------------- 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 594 ktIKPKTTA---------DKKILNQLTKIKKSTEKDLDNYRFGQALHKLyeffwHNFCDK-----YIEISKKQM----AD 655
Cdd:COG0060 670 --FDPAEDAvpyedlpelDRWILSRLNELIKEVTEAYDNYDFHRAYRAL-----HNFCVEdlsnwYLDISKDRLyteaAD 742
|
810 820 830
....*....|....*....|....*....|....*...
gi 1277893524 656 DKLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLP 693
Cdd:COG0060 743 SLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLP 780
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
39-550 |
2.16e-67 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 224.22 E-value: 2.16e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 39 TFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVVEKDLKKQGISRHdlgREKLIEKI 118
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW---IEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 119 WEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQAERVInwcircgtslsdlevelkdtk 198
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV--------------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 199 sklwfikyspditvattrpetmlgdtavavhpndkryknligekvilpiqnrkiaiiadkrvdpkfgtgaikvtpahsft 278
Cdd:cd00668 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 279 dfeigqehnleiikvigqdgkmseqagknfegltvlqarekvvqglekqglikkvedynnyvghcyrcgtviepIPSLQW 358
Cdd:cd00668 137 --------------------------------------------------------------------------RITEQW 142
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 359 FLKMNELANTAIQAVKSGKvkFHPKRWEKIYFNWLNNIKDWCISRQIWWGHRLPvyknleiyvgdnppkdyiqiPDVLDT 438
Cdd:cd00668 143 FFDMPKFKEKLLKALRRGK--IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP--------------------EDVFDV 200
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 439 WFSSALWPFATLGWPKRTADLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGT 518
Cdd:cd00668 201 WFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGN 280
|
490 500 510
....*....|....*....|....*....|..
gi 1277893524 519 GVDPMDLISRYGADAVRFGLIWQAMGNQDIRW 550
Cdd:cd00668 281 VIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
14-698 |
3.61e-54 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 201.15 E-value: 3.61e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 14 EDKIYRLWEKSGYFnpDKLPDKK-GKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQ 92
Cdd:PLN02843 9 EPEIQKLWEENQVY--KRVSDRNnGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 93 NVVEKDLKKQgiSRHDLGREKLIEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQ 172
Cdd:PLN02843 87 LKVLQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 173 AERVINWCIRCGTSLSDLEVELKDT-KSKLWFIKYS----------------PDITVA--TTRPETMLGDTAVAVhpNDK 233
Cdd:PLN02843 165 GRKPVHWSPSSRTALAEAELEYPEGhVSKSIYVAFPvvspsetspeeleeflPGLSLAiwTTTPWTMPANAAVAV--NDK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 234 -------------------RYKNLIGEKVILPIQNRKIAIIAD--KRVDPKF---------------------------- 264
Cdd:PLN02843 243 lqysvvevqsfsedestsgGNKKKRPGNVLKEQQKLFLIVATDlvPALEAKWgvklvvlktfpgsdlegcryihplynre 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 265 --------------GTGAIKVTPAHSFTDFEIGQEHNLEIIKVIGQDGKMSEQAGKnFEGLTVL-QAREKVVQGLEKQGL 329
Cdd:PLN02843 323 spvviggdyittesGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLgEGNAAVVEALDEAGS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 330 IKKVEDYNNYVGHCYRCGTviepiPSL-----QWFLKMNELANTAIQAVKsgKVKFHPKRWEKIYFNWLNNIKDWCISRQ 404
Cdd:PLN02843 402 LLMEEAYGHKYPYDWRTKK-----PTIfrateQWFASVEGFRQAALDAID--KVKWIPAQGENRIRAMVSGRSDWCISRQ 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 405 IWWGHRLPVYKNLE----------------------------IYVGD-NPPK------DYIQIPDVLDTWFSS-ALWPfa 448
Cdd:PLN02843 475 RTWGVPIPVFYHVEtkeplmneetiahvksivaqkgsdawwyMDVEDlLPEKyrdkasDYEKGTDTMDVWFDSgSSWA-- 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 449 tlGWPKRTADLKefYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLIS- 527
Cdd:PLN02843 553 --GVLGSREGLS--YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEg 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 528 --------RYGADAVRfglIWQA---------MGNQDIRWSEEhvvagqkFCNKIWNSARFALLQI-----LNSIITKQI 585
Cdd:PLN02843 629 gknqkqepAYGADVLR---LWVAsvdytgdvlIGPQILKQMSD-------IYRKLRGTLRYLLGNLhdwkpDNAVPYEDL 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 586 PrgsfqisktikpktTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEFFWHNFCDKYIEISKKQM----ADDKLQKN 661
Cdd:PLN02843 699 P--------------SIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLyvggTTSFTRRS 764
|
810 820 830
....*....|....*....|....*....|....*..
gi 1277893524 662 TQEILIYILLSSLKLLHPFMPFITEEIYQQLPIKNKK 698
Cdd:PLN02843 765 CQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDG 801
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
550-692 |
3.73e-47 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 163.11 E-value: 3.73e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 550 WSEEHVVAGQKFCNKIWNSARFALLQIlnsiitkqipRGSFQISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQA 629
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNL----------EDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEA 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1277893524 630 LHKLYEFFWHNFCDKYIEISKKQMA--DDKLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQL 692
Cdd:cd07962 71 ATALYEFFWNDFCDWYLELVKPRLYgeDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
5-705 |
7.57e-47 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 178.32 E-value: 7.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 5 DKPYDPKEVEDKIYRLWEKSGYFNPDKLPDKKgK-----TFsivvPPPnvTGSLHLGHALNATIQDILIRKKRMEGYKTL 79
Cdd:COG0495 2 QERYNPKEIEKKWQKYWEENGTFKADEDSSKP-KyyvldMF----PYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 80 ----W----LP--------GTdHAGIAT-QNVveKDLKKQgisrhdlgrekliekiwewkekygyiildqFKKLGCSMDW 142
Cdd:COG0495 75 hpmgWdafgLPaenaaiknGV-HPAEWTyENI--ANMRRQ------------------------------LKRLGLSYDW 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 143 SRTRFTMDSDYqeaVKET---FLHYHKKGWIYQAERVINWCIRCGTSL------------SDLEVELKDTKSklWFIK-- 205
Cdd:COG0495 122 SREIATCDPEY---YKWTqwiFLQLYEKGLAYRKEAPVNWCPVDQTVLaneqvidgrcwrCGAPVEKKELPQ--WFLKit 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 206 -YS-------------PD----------------------------ITVATTRPETMLGDTAVAV---HP---------N 231
Cdd:COG0495 197 dYAdellddldkldgwPEkvktmqrnwigrsegaevdfpvegsdekITVFTTRPDTLFGATFMVLapeHPlvkelatpeQ 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 232 DKRYKNLI-----------------------GEKVILPIQNRKIAI-IADkrvdpkF-----GTGAIKVTPAHSFTDFEI 282
Cdd:COG0495 277 NAAVAAFIeeakkkseiertsetkektgvftGLYAINPLTGEKIPIwIAD------YvlmdyGTGAVMAVPAHDQRDFEF 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 283 GQEHNLEIIKVI----GQDGKMSEQA----GK--N---FEGLTVLQAREKVVQGLEKQGLIKKvedynnyvghcyrcgtv 349
Cdd:COG0495 351 AKKYGLPIKQVIapedGDDPDILEEAytgdGVliNsgeFDGLDSEEAKEAIIEWLEEKGLGKR----------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 350 iepipslqwflkmnelantaiqavksgKVKFHpkrwekiyfnwlnnIKDWCISRQIWWG------H------------RL 411
Cdd:COG0495 414 ---------------------------KVNYR--------------LRDWLISRQRYWGepipiiHcedcgvvpvpedQL 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 412 PV--YKNLEI-YVGDNP------------PKD---YIQIPDVLDTWF-SSalWPFAtlgwpkRTADLKefYPTQILvtAR 472
Cdd:COG0495 453 PVelPEDVDFdPTGGSPlarapewvnvtcPKCggpARRETDTMDTFVdSS--WYYL------RYTDPH--NDEAPF--DP 520
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 473 DIINLW--V----------------ARmiFsglkFTK----------KEPFK---------DVIIHATILTKEGKrMSKS 515
Cdd:COG0495 521 EAANYWlpVdqyiggiehailhllyAR--F----FTKvlrdlglvsfDEPFKrlltqgmvlEVGKDGVVIGGIEK-MSKS 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 516 LGTGVDPMDLISRYGADAVR----FgliwqaMG--NQDIRWSEEHVVAGQKFCNKIWNsarfallqilnsIITKQIPRGS 589
Cdd:COG0495 594 KGNVVDPDEIIEKYGADTLRlfemF------AGppERDLEWSDSGVEGAYRFLNRVWR------------LVVDEAEALK 655
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 590 FQISKTikpkTTADKKILNQLTK-IKKSTEkDLDNYRFGQALHKLYEFFwhNFCDKYIEiskKQMADDKLQKNTQEILIy 668
Cdd:COG0495 656 LDVADL----SEADKELRRALHKtIKKVTE-DIERLRFNTAIAALMELV--NALYKAKD---SGEADRAVLREALETLV- 724
|
890 900 910
....*....|....*....|....*....|....*..
gi 1277893524 669 illsslKLLHPFMPFITEEIYQQLpiKNKKMLMIEKW 705
Cdd:COG0495 725 ------LLLAPFAPHIAEELWERL--GHEGSVADAPW 753
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
10-692 |
9.26e-45 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 172.99 E-value: 9.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 10 PKEvEDKIYRLWEKSGYFNpDKLPDKKGK-TFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAG 88
Cdd:PLN02882 11 PKQ-EEKILSLWSEIDAFK-TQLKRTEGLpEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 89 IATQNVVEKDLkkqGISRHD----LGREKLIEK--------IWEWkEKygyiildQFKKLGCSMDWSRTRFTMDSDYQEA 156
Cdd:PLN02882 89 LPVEYEIDKKL---GIKRRDdvlkMGIDKYNEEcrsivtrySKEW-EK-------TVTRTGRWIDFENDYKTMDPKFMES 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 157 VKETFLHYHKKGWIYQAERVINWCIRCGTSLSDLEVEL--KDTKSklwfikysPDITVA---------------TTRPET 219
Cdd:PLN02882 158 VWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLnyKDVSD--------PAVMVSfpivgdpdnasfvawTTTPWT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 220 MLGDTAVAVHPN-----------DKRY--------------------------------------KNLIGEK------VI 244
Cdd:PLN02882 230 LPSNLALCVNPNftyvkvrnkytGKVYivaesrlsalptakpkskkgskpenaaegyevlakvpgSSLVGKKyeplfdYF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 245 LPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFEIGQEHNL-----EIIKVIGQDGKMSEQAGkNFEGLTVLQAREK 319
Cdd:PLN02882 310 SEFSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKVT-DFSGRYVKDADKD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 320 VVQGLEKQG-LIKKVEDYNNYvGHCYRCGT--VIEPIPSlqWFLKMNELANtaiQAVKSGK----VKFHPKrwEKIYFNW 392
Cdd:PLN02882 389 IIAAIKAKGrLVKSGSITHSY-PFCWRSDTplIYRAVPS--WFVKVEEIKD---RLLENNKqtywVPDYVK--EKRFHNW 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 393 LNNIKDWCISRQIWWGHRLPVYKN---LEIYVGDNPPK-----------------DYIQIP--------------DVLDT 438
Cdd:PLN02882 461 LENARDWAVSRSRFWGTPLPIWISddgEEVVVIGSIAEleklsgvkvtdlhrhfiDHITIPssrgpefgvlrrvdDVFDC 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 439 WFSSALWPFATLGWPKRTADLKEF-YPTQILVTARDIINLWV-ARMIFSGLKFtKKEPFKDVIIHATILTKEGKRMSKSL 516
Cdd:PLN02882 541 WFESGSMPYAYIHYPFENKELFEKnFPADFVAEGLDQTRGWFyTLMVLSTALF-DKPAFKNLICNGLVLAEDGKKMSKSL 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 517 GTGVDPMDLISRYGADAVRFGLIwqamgN------QDIRWSEEHVVAGQKFCNKIW-NSARFALLQILNSIITKQIPRGS 589
Cdd:PLN02882 620 KNYPDPNEVIDKYGADALRLYLI-----NspvvraEPLRFKEEGVFGVVKDVFLPWyNAYRFLVQNAKRLEVEGGAPFVP 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 590 FQISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEFFwHNFCDKYIEISKKQM-----ADDklQKNTQE 664
Cdd:PLN02882 695 LDLAKLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLkgrtgEED--CRTALS 771
|
810 820
....*....|....*....|....*...
gi 1277893524 665 ILIYILLSSLKLLHPFMPFITEEIYQQL 692
Cdd:PLN02882 772 TLYNVLLTSCKVMAPFTPFFTEVLYQNL 799
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
12-692 |
1.40e-44 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 172.46 E-value: 1.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 12 EVEDKIYRLWEKSGYFNPDKLPDKKGKTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIAT 91
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 92 QNVVEK--------DLKKQGISRHDlgrekliEKIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLH 163
Cdd:PTZ00427 156 EYEIEKenninkkeDILKMGIDVYN-------EKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 164 YHKKGWIYQAERVINWCIRCGTSLSDLEVEL--KDTKS--------------------------KLWFIKYSP------- 208
Cdd:PTZ00427 229 LYKNNYVYKSFKVMPYSCKCNTPISNFELNLnyKDTPDpsiiisfvlcsdfpkveeecnieedkQLLGEKYSVlynnkre 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 209 -------------------DITVATTRPETMLGDTAVAVHPN-------------------------------------- 231
Cdd:PTZ00427 309 nsnngnnnstnnvcyaqhsEILAWTTTPWTLPSNLALCVNEHftylrihhvksnrvvivgecrlewimkelkwnvedlki 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 232 ----------DKRYKNLIG---EKviLPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDFE-------IGQEHNLeII 291
Cdd:PTZ00427 389 vnrfkgkelkGLRYKPLFTnfyEK--YNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRvckkngvIDPEKNI-FI 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 292 KVIGQDGKMSEQAgKNFEGLTVLQAREKVVQGLEKQGLIKKvedyNNYVGH----CYRCGT--VIEPIPSlqWFLKmneL 365
Cdd:PTZ00427 466 DPLDANGYFTNEV-EEVQNLYIKEADNVIKKKLKNENRLLS----NNTIVHsypfCWRSDTplIYRAIPA--WFIR---V 535
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 366 ANTAIQAVKSGKVKF----HPKrwEKIYFNWLNNIKDWCISRQIWWGHRLPVY--------------KNLEIYVG----- 422
Cdd:PTZ00427 536 SNSTNELVKNNETTYwipaHIK--EKKFHNWIKDAKDWCISRNRYWGTPIPIWadekmetvicvesiKHLEELSGvknin 613
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 423 ------------DNPP-KDYIQ---IPDVLDTWFSSALWPFATLGWPKRTA--DLKEFYPTQILVTARDIINLWV-ARMI 483
Cdd:PTZ00427 614 dlhrhfidhieiKNPKgKTYPKlkrIPEVFDCWFESGSMPYAKVHYPFSTEkeDFHKIFPADFIAEGLDQTRGWFyTLLV 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 484 FSGLKFTKKePFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQ-AMGNQDIRWSEEHVVAGQK-F 561
Cdd:PTZ00427 694 ISTLLFDKA-PFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSvAVRAENLKFQEKGVNEVVKsF 772
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 562 CNKIWNSARFALLQILNSIITKQIpRGSFQISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEFFwHNF 641
Cdd:PTZ00427 773 ILPFYHSFRFFSQEVTRYECLNKK-QFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENL 850
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 1277893524 642 CDKYIEISKKQMADDKLQKNTQEILIyILLSSLKL----LHPFMPFITEEIYQQL 692
Cdd:PTZ00427 851 TNWYIRLNRDRMRGSLGEENCLQSLC-TTYRTLHLftvlMAPFTPFITEYIYQQL 904
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
38-549 |
1.98e-43 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 159.70 E-value: 1.98e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 38 KTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVVEKDLKKQGIS-RHDLGREKLIE 116
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKdIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 117 KIWEWKEKYGYIILDQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQAERVINWcircgtslsdlevelkd 196
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 197 tksklwfikysPDItvattrpetmlgdtavavhpndkryknligekvilpiqnrkiaiiadkrvdpkfgtgaIKVTPahs 276
Cdd:cd00818 144 -----------PLI----------------------------------------------------------YRATP--- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 277 ftdfeigqehnleiikvigqdgkmseqagknfegltvlqarekvvqglekqglikkvedynnyvghcyrcgtviepipsl 356
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 357 QWFLKMNELANTAIQAVKsgKVKFHPKRWEKIYFNWLNNIKDWCISRQIWWGHRLPVYknleiYVGDNPPKDYIQIPDVL 436
Cdd:cd00818 152 QWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVW-----YCEDCGEVLVRRVPDVL 224
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 437 DTWFSSALWPFATLGWPKRTADLKEFYPTQILVTARDIINLWVARMIFSGLKFTKKEPFKDVIIHATILTKEGKRMSKSL 516
Cdd:cd00818 225 DVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSL 304
|
490 500 510
....*....|....*....|....*....|...
gi 1277893524 517 GTGVDPMDLISRYGADAVRFGLIWQAMGNQDIR 549
Cdd:cd00818 305 GNYVDPQEVVDKYGADALRLWVASSDVYAEDLR 337
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
53-705 |
1.06e-42 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 166.20 E-value: 1.06e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 53 LHLGHALNATIQDILIRKKRMEGYKTLWlP------GTDHAGIATQnvvekdlkkqgISRHDlgrEKLIekiWEWKEKYG 126
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PmafhvtGTPILGIAER-----------IARGD---PETI---ELYKSLYG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 127 YI--ILDQF------------------KKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQAERVINWCIRCGTS 186
Cdd:PRK12300 63 IPeeELEKFkdpeyiveyfseeakedmKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 187 lsdleVELKDTKS-------KLWFIKYSPD----ITVATTRPETMLGDTAVAVHPN---------DKRY----------- 235
Cdd:PRK12300 143 -----VGDHDLLDgeepeivEYTLIKFEESedliLPAATLRPETIFGVTNLWVNPDatyvkaevdGEKWivskeaaekls 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 236 --------------KNLIGEKVILPIQNRKIAIIADKRVDPKFGTGAIKVTPAHSFTDF----EIGQEHNL----EIIKV 293
Cdd:PRK12300 218 fqdrdveiieeikgSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldviEPIPL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 294 I--------------------GQD------------------GKMSEQAGKnFEGLTVLQAREKVVQGLEKQGLIKKVED 335
Cdd:PRK12300 298 IevegygefpakevveklgikSQEdpeleeatkevyraefhkGVLKENTGE-YAGKPVREAREKITKDLIEKGIADIMYE 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 336 YNNYVGHCyRCGT-VIEPIPSLQWFLKMN-----ELANTAIqavksGKVKFHPKRWEKIYFNWLNNIKDWCISRQIWWGH 409
Cdd:PRK12300 377 FSNRPVYC-RCGTeCVVKVVKDQWFIDYSdpewkELAHKAL-----DNMEIIPEEYRKEFENTIDWLKDRACARRRGLGT 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 410 RLPVYKN--LE------IY-----------VGDNPPKDYiqIPDVLDTWF---SSALWPFATLGWPKrtADLKE------ 461
Cdd:PRK12300 451 RLPWDEEwiIEslsdstIYmayytiahkirEYGIKPEQL--TPEFFDYVFlgkGDPEEVSKKTGIPK--EILEEmreefl 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 462 -FYPTQILVTARDII-----------------NLWVARMIFSGLkftkkepfkdVIIhatiltkEGKRMSKSLGTGVDPM 523
Cdd:PRK12300 527 yWYPVDWRHSGKDLIpnhltffifnhvaifpeEKWPRGIVVNGF----------VLL-------EGKKMSKSKGNVIPLR 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 524 DLISRYGADAVRFGLIWQAMGNQDIRWSEEHVVAGQKFCNKIWNsarfallqilnsIITKQIPRGSfqisktIKPKTTAD 603
Cdd:PRK12300 590 KAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYE------------LAKELIEIGG------EEELRFID 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 604 KKILNQLTKIKKSTEKDLDNYRFGQALHKLYeFFWHNFCDKYIEISKkqmaddklqKNTQEILIYILLSSLKLLHPFMPF 683
Cdd:PRK12300 652 KWLLSRLNRIIKETTEAMESFQTRDAVQEAF-YELLNDLRWYLRRVG---------EANNKVLREVLEIWIRLLAPFTPH 721
|
810 820
....*....|....*....|..
gi 1277893524 684 ITEEIYQQLpiKNKKMLMIEKW 705
Cdd:PRK12300 722 LAEELWHKL--GGEGFVSLEKW 741
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
12-705 |
2.79e-34 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 140.34 E-value: 2.79e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 12 EVEDKIYRLWEKSGYF-NPDKLPDKKGKTFSI-VVPPPNVTGsLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGI 89
Cdd:PLN02563 84 EIEPKWQRYWEENRTFrTPDDVDTSKPKFYVLdMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 90 -ATQNVVEKDLKKQGISRHDLGREKLiekiwewkekygyiildQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKG 168
Cdd:PLN02563 163 pAEQYAIETGTHPKITTLKNIARFRS-----------------QLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 169 WIYQAERVINWCIRCGTSLSDLEVelKDTKS------------KLWFIKYS---------------PD------------ 209
Cdd:PLN02563 226 LAYQAEVPVNWCPALGTVLANEEV--VDGLSergghpvirkpmRQWMLKITayadrlledlddldwPEsikemqrnwigr 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 210 ---------------------ITVATTRPETMLGDTAVAVHP---------------NDKRYKNLIGEKVIL-------- 245
Cdd:PLN02563 304 segaeldfsvldgegkerdekITVYTTRPDTLFGATYLVVAPehpllsslttaeqkeAVEEYVDAASRKSDLertelqke 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 246 ------------PIQNRKIAI-IADkRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIG--------------QDG 298
Cdd:PLN02563 384 ktgvftgsyainPATGEAIPIwVAD-YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpadgneddaekaytGEG 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 299 KM--SEQAGKNFEGLTVLQAREKVVQGLEKQGLIKKvedynnyvghcyrcgtviepipslqwflkmnelantaiqavksg 376
Cdd:PLN02563 463 VIvnSSSSGLDINGLSSKEAAKKVIEWLEETGNGKK-------------------------------------------- 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 377 KVKFhpkrwekiyfnwlnNIKDWCISRQIWWGHRLPVY---------------KNLEIYVGDN--------PP----KDY 429
Cdd:PLN02563 499 KVNY--------------KLRDWLFARQRYWGEPIPVVfledsgepvpvpesdLPLTLPELDDftptgtgePPlakaVSW 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 430 IQIPDVLD-TWFS---SALWPFATLGW-------PKRTADL----KEFY--PTQILVTARD--IINLWVARM---IFSGL 487
Cdd:PLN02563 565 VNTVDPSSgKPARretNTMPQWAGSCWyylrfmdPKNSNALvdkeKEKYwmPVDLYVGGAEhaVLHLLYARFwhkVLYDI 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 488 KFTK-KEPFKDVIIHATIL-------------------------------------TKEGK-----------------RM 512
Cdd:PLN02563 645 GVVStKEPFQCLVNQGMILgeveytafkdsdgeyvsadtadrlgelqqekipeekvIKSGDsfvlkddpsirliarahKM 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 513 SKSLGTGVDPMDLISRYGADAVRfgLIWQAMGN-QDIR-WSEEHVVAGQKFCNKIWnsarfallqilNSIITKQIPRGSF 590
Cdd:PLN02563 725 SKSRGNVVNPDDVVSEYGADSLR--LYEMFMGPlRDSKtWSTSGVEGVHRFLGRTW-----------RLVVGAPLPDGSF 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 591 QiSKTIKPKTTADKKILNQLTK-IKKSTEkDLDNYRFGQALHKLYEFFWHNFcdkyieiskkqmaddKLQKNTQEILIYI 669
Cdd:PLN02563 792 R-DGTVVTDEEPSLEQLRLLHKcIAKVTE-EIESTRFNTAISAMMEFTNAAY---------------KWDKVPREAIEPF 854
|
890 900 910
....*....|....*....|....*....|....*.
gi 1277893524 670 LLsslkLLHPFMPFITEEIYQQLpiKNKKMLMIEKW 705
Cdd:PLN02563 855 VL----LLSPYAPHLAEELWFRL--GHSNSLAYEPW 884
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
38-692 |
9.60e-31 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 127.15 E-value: 9.60e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 38 KTFSIVVPPPNVTGSLHLGHALnATIQ-DILIRKKRMEGYKTLWLPGTD-HaGIAtqnvVEKDLKKQGISRhdlgrEKLI 115
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLY-TYIPaDILARYQRLRGHDVLFVTGTDeH-GTK----IELAAEKEGITP-----QELV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 116 EKIWEwkekygyIILDQFKKLGCSMD-WSRTrftMDSDYQEAVKETFLHYHKKGWIYqaERVIN--WCIRCGTSLSDlev 192
Cdd:COG0143 70 DRIHA-------EFKELFEKLGISFDnFIRT---TSPEHKELVQEIFQRLYDNGDIY--KGEYEgwYCPECERFLPD--- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 193 elkdtksklwfikyspditvattrpetmlgdtavavhpndkRYknligekvilpiqnrkiaiiadkrVD---PKFGTGai 269
Cdd:COG0143 135 -----------------------------------------RY------------------------VEgtcPKCGAE-- 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 270 kvtpahsftdfeigqehnleiikviGQDGKMSEQAGKNFEGLTVLQAREKVvqglekqglikkvedynnyvghcyrCGTV 349
Cdd:COG0143 148 -------------------------DAYGDQCENCGATLEPTELINPRSAI-------------------------SGAP 177
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 350 IEPIPSLQWFLKMNELA---------NTAIQAVKSGKVKfhpkrwekiyfNWLNN-IKDWCISRQIWWGHRLPVYKNLEI 419
Cdd:COG0143 178 PELREEEHYFFRLSKYQdrllewieeNPDIQPEVRNEVL-----------SWLKEgLQDLSISRDFDWGIPVPGDPGKVF 246
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 420 YVgdnppkdyiqipdvldtWFsSALWPF--ATLGWPKRT---ADLKEFYP----TQILVTARDIIN----LWVARMIFSG 486
Cdd:COG0143 247 YV-----------------WF-DALIGYisATKGYADDRglpEDFEKYWPapdtELVHFIGKDIIRfhaiIWPAMLMAAG 308
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 487 LKftkkePFKDVIIHAtILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDIRWSEEHVVA------GQK 560
Cdd:COG0143 309 LP-----LPKKVFAHG-FLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDFVArvnsdlAND 382
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 561 FCNkiwnsarfaLLQILNSIITK----QIPrgsfqiskTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEF 636
Cdd:COG0143 383 LGN---------LASRTLSMIHKyfdgKVP--------EPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMAL 445
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1277893524 637 FwhNFCDKYIEISK-----KQMADDKLQKntqeiLIYILLSSLK----LLHPFMPFITEEIYQQL 692
Cdd:COG0143 446 A--RAANKYIDETApwklaKDEDPERLAT-----VLYTLLEALRilaiLLKPFLPETAEKILEQL 503
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
603-705 |
3.98e-30 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 115.58 E-value: 3.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 603 DKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEFFWHNFCDKYIEISKKQMADDKLQKNTQEILIYILLSSLKLLHPFMP 682
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100
....*....|....*....|...
gi 1277893524 683 FITEEIYQqlpiknKKMLMIEKW 705
Cdd:pfam08264 81 FITEELWQ------KESIHLAPW 97
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
40-692 |
5.96e-28 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 118.63 E-value: 5.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 40 FSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVVEkdlkKQGISrhdlgREKLIEKIW 119
Cdd:TIGR00398 1 ILITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAE----QEGLT-----PKELVDKYH 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 120 EwkekygyIILDQFKKLGCSMDwsrtRF--TMDSDYQEAVKETFLHYHKKGWIYQAERVINWCIRCGTSLSDlevelkdt 197
Cdd:TIGR00398 72 E-------EFKDDWKWLNISFD----RFirTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPD-------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 198 ksklwfikyspditvattrpetmlgdtavavhpndkRYKNLIGEKvilpiqnrkiaiiadkrvdpkfgtgaikvtpahsf 277
Cdd:TIGR00398 133 ------------------------------------RYVEGTCPK----------------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 278 tdfeigqehnleiIKVIGQDGKMSEQAGKNFEGLTVLQARekvvqglekqglikkvedynnyvghCYRCGTVIEPIPSLQ 357
Cdd:TIGR00398 142 -------------CGSEDARGDHCEVCGRHLEPTELINPR-------------------------CKICGAKPELRDSEH 183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 358 WFLKMNELANTAIQAVKSGKV-KFHPKRWEKIYFNWLNN-IKDWCISRQI-WWGHRLPVYKNLEIYVgdnppkdyiqipd 434
Cdd:TIGR00398 184 YFFRLSAFEKELEEWIRKNPEsGSPASNVKNKAQNWLKGgLKDLAITRDLvYWGIPVPNDPNKVVYV------------- 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 435 vldtWFSsalwpfATLGW-------PKRTADLKEFYPTQ-----ILVTARDIIN----LWVARMIFSGLKFtkkepFKDV 498
Cdd:TIGR00398 251 ----WFD------ALIGYisslgilSGDTEDWKKWWNNDedaelIHFIGKDIVRfhtiYWPAMLMGLGLPL-----PTQV 315
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 499 IIHAtILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDIRWSEEhvvagqKFCNKIWNSARFALLQILN 578
Cdd:TIGR00398 316 FSHG-YLTVEGGKMSKSLGNVVDPSDLLARFGADILRYYLLKERPLGKDGDFSWE------DFVERVNADLANKLGNLLN 388
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 579 SIITKQIPRGSFQIsKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALhklyEFFWH--NFCDKYIEISK--KQMA 654
Cdd:TIGR00398 389 RTLGFIKKYFNGVL-PSEDITDEEDKKLLKLINEALEQIDEAIESFEFRKAL----REIMKlaDRGNKYIDENKpwELFK 463
|
650 660 670
....*....|....*....|....*....|....*...
gi 1277893524 655 DDKLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQL 692
Cdd:TIGR00398 464 QSPRLKELLAVCSMLIRVLSILLYPIMPKLSEKILKFL 501
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
42-557 |
1.01e-25 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 109.69 E-value: 1.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 42 IVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVVEKdlkkQGISRHDLGrekliekiwew 121
Cdd:pfam09334 3 VTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK----EGITPEELV----------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 122 kEKYGYIILDQFKKLGCSMD-WSRTRftmDSDYQEAVKETFLHYHKKGWIYQAERVINWCIRCGTSLSDlevelkdtksk 200
Cdd:pfam09334 68 -DRYHEIHREDFKKFNISFDdYGRTT---SERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPD----------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 201 lwfikyspditvattrpetmlgdtavavhpndkRYknligekvilpiqnrkiaiiadkrvdpkfgtgaIKVTPAHSFTDf 280
Cdd:pfam09334 133 ---------------------------------RY---------------------------------VEGTCPHCGSE- 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 281 eigqehnleiikviGQDGKMSEQAGKNFEGLTVLQARekvvqglekqglikkvedynnyvghCYRCGTVIEPIPSLQWFL 360
Cdd:pfam09334 146 --------------DARGDQCENCGRHLEPTELINPK-------------------------CVICGTTPEVKETEHYFF 186
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 361 KMNELANTAIQAVKSGkVKFHPKRWEKIYFNWLNN-IKDWCISRQIWWGHRLPVYKNLEIYVGDNPPKDYIQipdvldtw 439
Cdd:pfam09334 187 DLSKFQDKLREWIEEN-NPEWPENVKNMVLEWLKEgLKDRAISRDLDWGIPVPGAEGKVFYVWLDAPIGYIS-------- 257
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 440 fssalwpfATLGWPKRTADLKEFYPTQ-----ILVTARDIIN----LWVARMIFSGLKFTKKepfkdviIHAT-ILTKEG 509
Cdd:pfam09334 258 --------ATKELSGNEEKWKEWWPNDpdtelVHFIGKDIIYfhtiFWPAMLLGAGYRLPTT-------VFAHgYLTYEG 322
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1277893524 510 KRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDIRWSEEHVVA 557
Cdd:pfam09334 323 GKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWEDFVE 370
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
38-692 |
8.44e-25 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 108.82 E-value: 8.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 38 KTFSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTD-HagiatQNVVEKDLKKQGISRHDLGRE--KL 114
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRKAEEAGISPQELADRnsAA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 115 IEKIWEwkekygyiildqfkKLGCSMD-WSRTrftMDSDYQEAVKETFLHYHKKGWIYQAERVINWCIRCGTSLSDLEVe 193
Cdd:PRK11893 76 FKRLWE--------------ALNISYDdFIRT---TDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESEL- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 194 lkdtksklwfikyspditvattrpetmlgdtavavhpndkryknligekvilpIQNRKIAIIADKRVDPKfgtgaikvtp 273
Cdd:PRK11893 138 -----------------------------------------------------IEDGYRCPPTGAPVEWV---------- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 274 ahsftdfeigQEHNLEIikvigqdgKMSEQAgknfegltvlqarEKVVQGLEKQglikkvedynnyvghcyrcgtviepi 353
Cdd:PRK11893 155 ----------EEESYFF--------RLSKYQ-------------DKLLELYEAN-------------------------- 177
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 354 pslQWFLKmnelantaiqavksgkvkfhPKRWEKIYFNWLNN-IKDWCISRQ-IWWGHRLPVYKNLEIYVgdnppkdyiq 431
Cdd:PRK11893 178 ---PDFIQ--------------------PASRRNEVISFVKSgLKDLSISRTnFDWGIPVPGDPKHVIYV---------- 224
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 432 ipdvldtWFSsALWPFAT-LGWP----KRTADLKEFYPTQILVTARDIINL----WVARMIFSGLKFTKKepfkdVIIHA 502
Cdd:PRK11893 225 -------WFD-ALTNYLTaLGYPddeeLLAELFNKYWPADVHLIGKDILRFhavyWPAFLMAAGLPLPKR-----VFAHG 291
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 503 tILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQDIRWSEEHVVA--GQKFCNKIWNsarfaLLQILNSI 580
Cdd:PRK11893 292 -FLTLDGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINriNADLANDLGN-----LAQRTLSM 365
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 581 ITKQiprgSFQISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLyeffWH--NFCDKYIEISKK-QMADDK 657
Cdd:PRK11893 366 IAKN----FDGKVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAI----LAlvRAANKYIDEQAPwSLAKTD 437
|
650 660 670
....*....|....*....|....*....|....*....
gi 1277893524 658 LQKntQEILIYILLSSLK----LLHPFMPFITEEIYQQL 692
Cdd:PRK11893 438 PER--LATVLYTLLEVLRgiavLLQPVMPELAAKILDQL 474
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
396-705 |
2.55e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 92.56 E-value: 2.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 396 IKDWCISRQ-IWWGHRLPVYKNLEIYVgdnppkdyiqipdvldtWFSsALWPFAT-LGWPKRTADL-KEFYPTQILVTAR 472
Cdd:PRK12267 201 LEDLSISRTsFDWGIPVPFDPKHVVYV-----------------WID-ALLNYITaLGYGSDDDELfKKFWPADVHLVGK 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 473 DIIN----LWVArMIFS-GLkftkkEPFKDVIIHATILTKEGKrMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQD 547
Cdd:PRK12267 263 DILRfhaiYWPI-MLMAlGL-----PLPKKVFAHGWWLMKDGK-MSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSD 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 548 IRWSEEHVVagQKF----CNKIWNsarfaLLQILNSIITK----QIPrgsfqiskTIKPKTTADKKILNQLTKIKKSTEK 619
Cdd:PRK12267 336 GDFSPEALV--ERInsdlANDLGN-----LLNRTVAMINKyfdgEIP--------APGNVTEFDEELIALAEETLKNYEE 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 620 DLDNYRFGQALHKLYEFFwhNFCDKYI----------EISKKQMADDklqkntqeiLIYILLSSLK----LLHPFMPFIT 685
Cdd:PRK12267 401 LMEELQFSRALEEVWKLI--SRANKYIdetapwvlakDEGKKERLAT---------VMYHLAESLRkvavLLSPFMPETS 469
|
330 340
....*....|....*....|..
gi 1277893524 686 EEIYQQL--PIKNKKMLMIEKW 705
Cdd:PRK12267 470 KKIFEQLglEEELTSWESLLEW 491
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
318-547 |
1.41e-17 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 84.12 E-value: 1.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 318 EKVVQGLEKQGLIKKVEdynnYVG-HCYRCGTVI-EPIPSLQWFLKMNELANTAIQAVKSGKVKFHPKRWEKIYFNWLNN 395
Cdd:cd00814 102 QEFFKKLYENGYIYEGE----YEGlYCVSCERFLpEWREEEHYFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWLKE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 396 -IKDWCISRQIW-WGHRLPVYKNLEIYVGDNPPKDYIQIpdvldTWFSSALWPFATLGWPKRTADlkefyptqILVTARD 473
Cdd:cd00814 178 gLKDLSITRDLFdWGIPVPLDPGKVIYVWFDALIGYISA-----TGYYNEEWGNSWWWKDGWPEL--------VHFIGKD 244
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1277893524 474 IIN----LWVARMIFSGLKFTKKepfkdviIHAT-ILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIWQAMGNQD 547
Cdd:cd00814 245 IIRfhaiYWPAMLLGAGLPLPTR-------IVAHgYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
40-207 |
1.73e-17 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 83.84 E-value: 1.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 40 FSIVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGIATQNVVEKdlkkqgISRHdlgREKLIEK-I 118
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK------IGRD---PEDWTEYnI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 119 WEWKEkygyiildQFKKLGCSMDWSRTRFTMDSDYQEAVKETFLHYHKKGWIYQAERVINWCIrcgtslsdleveLKDTk 198
Cdd:cd00812 73 KKMKE--------QLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCK------------LLDQ- 131
|
....*....
gi 1277893524 199 sklWFIKYS 207
Cdd:cd00812 132 ---WFLKYS 137
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
564-698 |
6.34e-12 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 64.85 E-value: 6.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 564 KIWNSARFaLLQILNSiitkqiprgsFQISKTIKPK---TTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLyeffwHN 640
Cdd:cd07960 15 KIRNTFRF-LLGNLND----------FDPAKDAVPYeelLELDRYALHRLNELIKEVREAYENYEFHKVYQAL-----NN 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1277893524 641 FCDK-----YIEISKKQM----ADDKLQKNTQEILIYILLSSLKLLHPFMPFITEEIYQQLPIKNKK 698
Cdd:cd07960 79 FCTVdlsafYLDIIKDRLycdaKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKE 145
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
560-692 |
2.33e-11 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 62.95 E-value: 2.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 560 KFCNKIWNSARFALLQIlnsIITKQIPRgsfQISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEFF-- 637
Cdd:cd07961 12 KVLLPLWNAYRFFVTYA---NLDGFDPG---KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFIde 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1277893524 638 ---WhnfcdkYIEISKK-----QMADDKLQknTQEILIYILLSSLKLLHPFMPFITEEIYQQL 692
Cdd:cd07961 86 ltnW------YIRRNRKrfwgeEGDDDKLA--AYATLYEVLLTLSRLMAPFTPFITEEIYQNL 140
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
209-325 |
1.49e-08 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 54.86 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 209 DITVATTRPETMLGDTAVAV---HP-------NDKRYKNLI-----------------------GEKVILPIQNRKIAI- 254
Cdd:pfam13603 22 KIEVFTTRPDTLMGVTFVALapeHPlveklaeKNPEVAAFIeeckntseiertsetkekegvftGLYAIHPITGEKIPIw 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 255 IADkRVDPKFGTGAIKVTPAHSFTDFEIGQEHNLEIIKVIG-----QDGKMSEQA----GK-----NFEGLTVLQAREKV 320
Cdd:pfam13603 102 IAN-FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQpedgdLDLDIMTEAyteeGIlvnsgEFDGLDSEEAKEAI 180
|
....*
gi 1277893524 321 VQGLE 325
Cdd:pfam13603 181 IKKLE 185
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
391-556 |
1.76e-08 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 57.80 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 391 NWLNN-IKDWCISRQIW-WGHRLPVYKNLEIYVgdnppkdyiqipdvldtWFSSALWPFATLGWPKRTADLKEF----YP 464
Cdd:PLN02224 259 SWIKSgLRDFSISRALVdWGIPVPDDDKQTIYV-----------------WFDALLGYISALTEDNKQQNLETAvsfgWP 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 465 TQILVTARDIINL----WVARMIFSGLKFTKkepfkdVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLIW 540
Cdd:PLN02224 322 ASLHLIGKDILRFhavyWPAMLMSAGLELPK------MVFGHGFLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFLR 395
|
170
....*....|....*.
gi 1277893524 541 QAMGNQDIRWSEEHVV 556
Cdd:PLN02224 396 EVEFGNDGDYSEDRFI 411
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
550-692 |
3.36e-08 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 52.22 E-value: 3.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 550 WSEEHVVAGQKFCNKIWNsarfallqilnsIITKQIPRGSFQisKTIKPKTTADKKILNQLTK-IKKSTEkDLDNYRFGQ 628
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWR------------LVTELAEALAAP--AAAAELSEEDKELRRKLHKtIKKVTE-DIERLRFNT 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1277893524 629 ALHKLYEFFwhNFCDKYIeisKKQMADDKLQKNTQEILiyillssLKLLHPFMPFITEEIYQQL 692
Cdd:cd07958 66 AIAALMELV--NALYKYK---KKDAQHAAVLREALETL-------VLLLAPFAPHIAEELWEEL 117
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
594-692 |
4.03e-08 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 52.49 E-value: 4.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 594 KTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHKLYEFFwhNFCDKYIEISK-----KQMADDKLQKntqeiLIY 668
Cdd:cd07957 29 PEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA--RAANKYIDETApwklaKEEDPERLAT-----VLY 101
|
90 100
....*....|....*....|....*...
gi 1277893524 669 ILLSSLK----LLHPFMPFITEEIYQQL 692
Cdd:cd07957 102 VLLELLRilaiLLSPFMPETAEKILDQL 129
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
592-692 |
4.12e-08 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 51.82 E-value: 4.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 592 ISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALHK-LYEFFwhNFCDKYIEISKKQMaddklqknTQEILIYIL 670
Cdd:cd07959 26 TEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEgLYELQ--NDLDWYRERGGAGM--------NKDLLRRFI 95
|
90 100
....*....|....*....|..
gi 1277893524 671 LSSLKLLHPFMPFITEEIYQQL 692
Cdd:cd07959 96 EVWTRLLAPFAPHLAEEIWHEL 117
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
47-189 |
6.13e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 49.38 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 47 PNVTGSLHLGHALnATIQ-DILIRKKRMEGYKTLWLPGTDHAGIATQnvvekdLK--KQGISrhdlgREKLIEKIWEwke 123
Cdd:PRK00133 11 PYANGPIHLGHLV-EYIQaDIWVRYQRMRGHEVLFVCADDAHGTPIM------LKaeKEGIT-----PEELIARYHA--- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 124 kygyIILDQFKKLGCSMD-WSRTrftmDSDY-QEAVKETFLHYHKKGWIYqaERVIN--WCIRCGTSLSD 189
Cdd:PRK00133 76 ----EHKRDFAGFGISFDnYGST----HSEEnRELAQEIYLKLKENGYIY--EKTIEqlYDPEKGMFLPD 135
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
47-168 |
1.72e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 43.32 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 47 PNVTGSLHLGHALNATIQDILIRKKRMEGYKTLwlpgtdhagiaTQNVVekdlkkqgisrHDLGR--EKLIEKIWEWKEK 124
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT-----------REYYI-----------NDWGRqiGLLILSLEKWRKL 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1277893524 125 YGYII---LDQFKKLGCSMDwsrtRFTMDSDYQ-------EAVKETFLHYHKKG 168
Cdd:cd00671 67 VEESIkadLETYGRLDVRFD----VWFGESSYLglmgkvvELLEELGLLYEEDG 116
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
552-681 |
2.79e-04 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 40.95 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 552 EEHVVAGQKFCNKIWNSARFALLQIlnsiitkqiprGSFQISKTIKPKTTADKKILNQLTKIKKSTEKDLDNYRFGQALH 631
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKAL-----------GGTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQ 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1277893524 632 KLYEFFWHNfcDKYIEISKKQMADDKLQKNTQEILIYILLSSLKLLHPFM 681
Cdd:cd07375 70 ELFKFTNEL--NWYLDELKPALQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-164 |
1.00e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 40.16 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277893524 42 IVVPPPNVTGSLHLGHALNATIQDILIRKKRMEGYKTLWLPGTDHAGiatQNVVEKDLKKQGISRHDlgREKLIEKIwew 121
Cdd:cd00802 1 TTFSGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAG---GLIGDPANKKGENAKAF--VERWIERI--- 72
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1277893524 122 KEKYGYIILdqfkklgCSMDWSRtRFTMDSDYQEAVKETFLHY 164
Cdd:cd00802 73 KEDVEYMFL-------QAADFLL-LYETECDIHLGGSDQLGHI 107
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
493-539 |
1.90e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 40.25 E-value: 1.90e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1277893524 493 EPFKDVIIHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRFGLI 539
Cdd:cd00672 156 KPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALL 202
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
12-58 |
2.94e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 41.21 E-value: 2.94e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1277893524 12 EVEDKIYRLWEKSGYF--NPDKLPDKKGKTFSIVVPPPNVTGSLHLGHA 58
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFeaEAGDEPPKPGEKFFGNFPYPYMNGLLHLGHA 65
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
500-536 |
5.63e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 39.70 E-value: 5.63e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1277893524 500 IHATILTKEGKRMSKSLGTGVDPMDLISRYGADAVRF 536
Cdd:COG0215 254 MHNGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRF 290
|
|
| |
