|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
16-275 |
2.66e-112 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 324.56 E-value: 2.66e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSIQG----RPDEAQALRVIGASLDAGVAFIDSADVYCLDQtdighNERLIAKALKARGRtkSVTVATKGGLK 91
Cdd:cd19088 4 LGYGAMRLTGPGiwgpPADREEAIAVLRRALELGVNFIDTADSYGPDV-----NERLIAEALHPYPD--DVVIATKGGLV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 92 RPNGD-WTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEK 170
Cdd:cd19088 77 RTGPGwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 171 IARIESVQNRCSPYDREdyDDGLLAACEERGITFLPYGPVGGHRAHTRLldePLLASLAEKYEATPYTIVLAWHLAKSER 250
Cdd:cd19088 157 IVRIVSVQNRYNLANRD--DEGVLDYCEAAGIAFIPWFPLGGGDLAQPG---GLLAEVAARLGATPAQVALAWLLARSPV 231
|
250 260
....*....|....*....|....*
gi 1276968131 251 ILPIPGASKIASAEDSPKAALLDLE 275
Cdd:cd19088 232 MLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-283 |
3.57e-88 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 265.12 E-value: 3.57e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPLS-IQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRt 79
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTMTFGgPWGGVDEAEAIAILDAALDAGINFFDTADVYGP-----GRSEELLGEALKGRPR- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSN 159
Cdd:COG0667 75 DDVVIATKVGRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 160 VDLGELERAEKIA----RIESVQNRCSPYDReDYDDGLLAACEERGITFLPYGPVG----------------GHRAHTRL 219
Cdd:COG0667 155 YSAEQLRRALAIAeglpPIVAVQNEYSLLDR-SAEEELLPAARELGVGVLAYSPLAgglltgkyrrgatfpeGDRAATNF 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276968131 220 LDEPL----------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:COG0667 234 VQGYLternlalvdaLRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALD 307
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
3-282 |
5.30e-73 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 226.33 E-value: 5.30e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 3 TRELGRTGIRLFPIGLGGMPLS-IQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGRTKS 81
Cdd:cd19076 2 TRKLGTQGLEVSALGLGCMGMSaFYGPADEEESIATLHRALELGVTFLDTADMYGP-----GTNEELLGKALK--DRRDE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 82 VTVATKGGLKRPNGDWTR--DASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSN 159
Cdd:cd19076 75 VVIATKFGIVRDPGSGFRgvDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 160 VDLGELERAEKIARIESVQNRCSPYDReDYDDGLLAACEERGITFLPYGPVG------------------GHRAHTRLLD 221
Cdd:cd19076 155 ASADTIRRAHAVHPITAVQSEYSLWTR-DIEDEVLPTCRELGIGFVAYSPLGrgfltgaikspedlpeddFRRNNPRFQG 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 222 EPL---------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKI 282
Cdd:cd19076 234 ENFdknlklvekLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
10-283 |
3.82e-72 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 223.56 E-value: 3.82e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPLS--IQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGRTKSVTVATK 87
Cdd:cd19084 1 DLKVSRIGLGTWAIGgtWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGF-----GHSEEILGKALK--GRRDDVVIATK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 88 GGLkRPNGDW--TRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGEL 165
Cdd:cd19084 74 CGL-RWDGGKgvTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 166 ERAEKIARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGPVGG-----------------HRAHTRLLDEPL---- 224
Cdd:cd19084 153 EEARKYGPIVSLQPPYSMLEREIEEE-LLPYCRENGIGVLPYGPLAQglltgkykkeptfppddRRSRFPFFRGENfekn 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276968131 225 ------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19084 232 leivdkLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
15-266 |
3.57e-63 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 198.51 E-value: 3.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPLSiqGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRTKSVTVATKGGLKRPN 94
Cdd:cd06660 2 RLGLGTMTFG--GDGDEEEAFALLDAALEAGGNFFDTADVYGD-----GRSERLLGRWLKGRGNRDDVVIATKGGHPPGG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 GDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIAR- 173
Cdd:cd06660 75 DPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKa 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 174 -----IESVQNRCSPYDREDYDDGLLAACEERGITFLPYGPVGGHRAHtrlldepllaslaekyeatpytIVLAWHLAKS 248
Cdd:cd06660 155 hglpgFAAVQPQYSLLDRSPMEEELLDWAEENGLPLLAYSPLARGPAQ----------------------LALAWLLSQP 212
|
250
....*....|....*...
gi 1276968131 249 ERILPIPGASKIASAEDS 266
Cdd:cd06660 213 FVTVPIVGARSPEQLEEN 230
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-286 |
2.83e-62 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 198.30 E-value: 2.83e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSIQ-GRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKAR-GRTKSVTVATKGGlkRP 93
Cdd:pfam00248 1 IGLGTWQLGGGwGPISKEEALEALRAALEAGINFIDTAEVYGD-----GKSEELLGEALKDYpVKRDKVVIATKVP--DG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 94 NGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERA--EKI 171
Cdd:pfam00248 74 DGPWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKAltKGK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 172 ARIESVQNRCSPYDREDyDDGLLAACEERGITFLPYGPVGG----------HRAHTRLLDE-------------PLLASL 228
Cdd:pfam00248 154 IPIVAVQVEYNLLRRRQ-EEELLEYCKKNGIPLIAYSPLGGglltgkytrdPDKGPGERRRllkkgtplnlealEALEEI 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 229 AEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:pfam00248 233 AKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-283 |
1.14e-59 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 190.52 E-value: 1.14e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPL---SIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKALKARGRtKSVTVAT 86
Cdd:cd19072 1 GEEVPVLGLGTWGIgggMSKDYSDDKKAIEALRYAIELGINLIDTAEMY-----GGGHAEELVGKAIKGFDR-EDLFITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 87 KGglkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELE 166
Cdd:cd19072 75 KV--------SPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 167 RAEKIAR---IESVQNRCSPYDREDyDDGLLAACEERGITFLPYGPVG-GHRAHTRLLdePLLASLAEKYEATPYTIVLA 242
Cdd:cd19072 147 EAQSYLKkgpIVANQVEYNLFDREE-ESGLLPYCQKNGIAIIAYSPLEkGKLSNAKGS--PLLDEIAKKYGKTPAQIALN 223
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1276968131 243 WhLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19072 224 W-LISKPNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
5-283 |
1.74e-59 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 191.66 E-value: 1.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 5 ELGRTGIRLFPIGLGGMPLSIQGrpDEAQALRVIGASLDAGVAFIDSADVYCLDQTDI--GHNERLIAKALKARGRTKSV 82
Cdd:cd19081 1 PLGRTGLSVSPLCLGTMVFGWTA--DEETSFALLDAFVDAGGNFIDTADVYSAWVPGNagGESETIIGRWLKSRGKRDRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 83 TVATKGGlkRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDL 162
Cdd:cd19081 79 VIATKVG--FPMGPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 163 GELERAEKIA------RIESVQNRCSPYDREDYDDGLLAACEERGITFLPYGPVGG-------------------HRAHT 217
Cdd:cd19081 157 WRLQEALELSrqhglpRYVSLQPEYNLVDRESFEGELLPLCREEGIGVIPYSPLAGgfltgkyrseadlpgstrrGEAAK 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 218 RLLDEP------LLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19081 237 RYLNERglrildALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
9-283 |
1.07e-58 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 189.37 E-value: 1.07e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGGMPLSIQGRP-DEAQALRVIGASLDAGVAFIDSADVYCLDqtDIGHNERLIAKALKARGRTKS-VTVAT 86
Cdd:cd19077 1 NGKLVGPIGLGLMGLTWRPNPtPDEEAFETMKAALDAGSNLWNGGEFYGPP--DPHANLKLLARFFRKYPEYADkVVLSV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 87 KGGLKrpNGDWTRDASPAQLRAACEASLKALQS-DSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGEL 165
Cdd:cd19077 79 KGGLD--PDTLRPDGSPEAVRKSIENILRALGGtKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAETI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 166 ERAEKIARIESVQNRCSPYDREDYDDGLLAACEERGITFLPYGPVG-G----------------HRAHTRLLDE------ 222
Cdd:cd19077 157 RRAHAVHPIAAVEVEYSLFSREIEENGVLETCAELGIPIIAYSPLGrGlltgriksladipegdFRRHLDRFNGenfekn 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276968131 223 -PL---LASLAEKYEATPYTIVLAWHLAKS-ERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19077 237 lKLvdaLQELAEKKGCTPAQLALAWILAQSgPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
3-285 |
7.26e-57 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 184.93 E-value: 7.26e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 3 TRELGRTGIRLFPIGLG-----GMPLSIQgrPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARG 77
Cdd:cd19083 1 KVKLGKSDIDVNPIGLGtnavgGHNLYPN--LDEEEGKDLVREALDNGVNLLDTAFIYGL-----GRSEELVGEVLKEYN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 78 RTKsVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGL 157
Cdd:cd19083 74 RNE-VVIATKGAHKFGGDGSVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 158 SNVDLGELERAEKIARIESVQnrcSPYD--REDYDDGLLAACEERGITFLPYGPV------GGHRAHTRLLDEPL----- 224
Cdd:cd19083 153 SNFSLEQLKEANKDGYVDVLQ---GEYNllQREAEEDILPYCVENNISFIPYFPLasgllaGKYTKDTKFPDNDLrndkp 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276968131 225 ----------------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGL 285
Cdd:cd19083 230 lfkgerfsenldkvdkLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
15-283 |
1.16e-56 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 184.36 E-value: 1.16e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPLSiQGR---PDEAQALRVIGASLDAGVAFIDSADVYcldqtdiG--HNERLIAKALKarGRTKSVTVATKGG 89
Cdd:cd19078 6 AIGLGCMGMS-HGYgppPDKEEMIELIRKAVELGITFFDTAEVY-------GpyTNEELVGEALK--PFRDQVVIATKFG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 LKrPNGDWTR----DASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGEL 165
Cdd:cd19078 76 FK-IDGGKPGplglDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVETI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 166 ERAEKIARIESVQNRCSPYDREdYDDGLLAACEERGITFLPYGPVG-----------------------------GHRAH 216
Cdd:cd19078 155 RRAHAVCPVTAVQSEYSMMWRE-PEKEVLPTLEELGIGFVPFSPLGkgfltgkidentkfdegddraslprftpeALEAN 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276968131 217 TRLLDepLLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19078 234 QALVD--LLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIE 298
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
1-282 |
2.99e-55 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 181.10 E-value: 2.99e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPLSI--QGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALK-ARG 77
Cdd:cd19144 1 IPTRTLGRNGPSVPALGFGAMGLSAfyGPPKPDEERFAVLDAAFELGCTFWDTADIY-------GDSEELIGRWFKqNPG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 78 RTKSVTVATKGGLKR--PNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHI 155
Cdd:cd19144 74 KREKIFLATKFGIEKnvETGEYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 156 GLSNVDLGELERAEKIARIESVQNRCSPY--DREDYDDGLLAACEERGITFLPYGPVG---------------------- 211
Cdd:cd19144 154 GLSECSAETLRRAHAVHPIAAVQIEYSPFslDIERPEIGVLDTCRELGVAIVAYSPLGrgfltgairspddfeegdfrrm 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 212 -------GHRAHTRLLDEplLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKI 282
Cdd:cd19144 234 aprfqaeNFPKNLELVDK--IKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEI 309
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-285 |
3.62e-54 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 177.87 E-value: 3.62e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 6 LGRTGIRLFPIGLGGMPLSiQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGRTKSVTVA 85
Cdd:cd19102 1 LTTIGLGTWAIGGGGWGGG-WGPQDDRDSIAAIRAALDLGINWIDTAAVYGL-----GHSEEVVGRALK--GLRDRPIVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 86 TKGG-LKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGE 164
Cdd:cd19102 73 TKCGlLWDEEGRIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 165 LERAEKIARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGPVG-------------------GHRAHTRLLDEPLL 225
Cdd:cd19102 153 MKRCQAIHPIASLQPPYSLLRRGIEAE-ILPFCAEHGIGVIVYSPMQsglltgkmtpervaslpadDWRRRSPFFQEPNL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 226 A----------SLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGL 285
Cdd:cd19102 232 ArnlalvdalrPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
3-282 |
3.30e-53 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 175.31 E-value: 3.30e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 3 TRELGRTGIRLFPIGLGGMPLSIQGRPD--EAQALRVIGASLDAGVAFIDSADVYCLDQtdighNERLIAKALKARGRTK 80
Cdd:cd19145 2 RVKLGSQGLEVSAQGLGCMGLSGDYGAPkpEEEGIALIHHAFNSGVTFLDTSDIYGPNT-----NEVLLGKALKDGPREK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 sVTVATKGGLKRPNGDWTR-DASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSN 159
Cdd:cd19145 77 -VQLATKFGIHEIGGSGVEvRGDPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 160 VDLGELERAEKIARIESVQNRCSPYDReDYDDGLLAACEERGITFLPYGPVGG------------------HRAHTRLLD 221
Cdd:cd19145 156 ASADTIRRAHAVHPITAVQLEWSLWTR-DIEEEIIPTCRELGIGIVPYSPLGRgffagkakleellensdvRKSHPRFQG 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 222 EPL---------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKI 282
Cdd:cd19145 235 ENLeknkvlyerVEALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
3-283 |
4.95e-53 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 175.15 E-value: 4.95e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 3 TRELGRTGIRLFPIGLGGMPL---SIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGRT 79
Cdd:cd19149 1 YRKLGKSGIEASVIGLGTWAIgggPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGF-----GHSEEIVGKAIK--GRR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATKGGL-----------KRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQD 148
Cdd:cd19149 74 DKVVLATKCGLrwdreggsfffVRDGVTVYKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 149 EGKILHIGLSNVDLGELERAEKIARIESVQNRCSPYDREdYDDGLLAACEERGITFLPYGP-----------------VG 211
Cdd:cd19149 154 QGKIRAIGASNVSVEQIKEYVKAGQLDIIQEKYSMLDRG-IEKELLPYCKKNNIAFQAYSPleqglltgkitpdrefdAG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 212 GHRAH------------TRLLDEplLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDL 279
Cdd:cd19149 233 DARSGipwfspenrekvLALLEK--WKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLSAEDI 310
|
....
gi 1276968131 280 EKID 283
Cdd:cd19149 311 ATMR 314
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
15-283 |
1.27e-52 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 173.54 E-value: 1.27e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMplSIQGRP-----DEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGRTKSVTVATKGg 89
Cdd:cd19085 3 RLGLGCW--QFGGGYwwgdqDDEESIATIHAALDAGINFFDTAEAYGD-----GHSEEVLGKALK--GRRDDVVIATKV- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 lkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAE 169
Cdd:cd19085 73 -------SPDNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 170 KIARIESVQNRCSPYDREdYDDGLLAACEERGITFLPYGP-----------------VGGHRAHTRLLDEP--------- 223
Cdd:cd19085 146 DAGRIDSNQLPYNLLWRA-IEYEILPFCREHGIGVLAYSPlaqglltgkfssaedfpPGDARTRLFRHFEPgaeeetfea 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 224 --LLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19085 225 leKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERLD 286
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
16-269 |
3.19e-49 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 163.03 E-value: 3.19e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLS--IQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKALKARGrtKSVTVATKGGLK-R 92
Cdd:cd19086 6 IGFGTWGLGgdWWGDVDDAEAIRALRAALDLGINFFDTADVY-----GDGHSERLLGKALKGRR--DKVVIATKFGNRfD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 93 PNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVA-LEESVGELKKLQDEGKILHIGLSNVDLGELERAEKI 171
Cdd:cd19086 79 GGPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEVLdNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALRR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 172 ARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGPvgghrahtrlLDEPLLAS-LAEkyeatpytIVLAWHLAKSER 250
Cdd:cd19086 159 GGIDVVQVIYNLLDQRPEEE-LFPLAEEHGVGVIARVP----------LASGLLTGkLAQ--------AALRFILSHPAV 219
|
250
....*....|....*....
gi 1276968131 251 ILPIPGASKIASAEDSPKA 269
Cdd:cd19086 220 STVIPGARSPEQVEENAAA 238
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
10-286 |
3.32e-49 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 163.69 E-value: 3.32e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPLsiqgrpDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG-RTKSVTVATKg 88
Cdd:COG0656 2 GVEIPALGLGTWQL------PGEEAAAAVRTALEAGYRHIDTAAMY--------GNEEGVGEAIAASGvPREELFVTTK- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 gLkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAvdPA-VALEESVGELKKLQDEGKILHIGLSNVDLGELER 167
Cdd:COG0656 67 -V------WNDNHGYDDTLAAFEESLERLGLDYLDLYLIHW--PGpGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEE 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 168 AEKIARIESV--QNRCSPYDREDyddGLLAACEERGITFLPYGPVGghraHTRLLDEPLLASLAEKYEATPYTIVLAWHL 245
Cdd:COG0656 138 LLAETGVKPAvnQVELHPYLQQR---ELLAFCREHGIVVEAYSPLG----RGKLLDDPVLAEIAEKHGKTPAQVVLRWHL 210
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1276968131 246 AKSerILPIPGASKIASAEDSpkAALLDLE--PEDLEKIDGLN 286
Cdd:COG0656 211 QRG--VVVIPKSVTPERIREN--LDAFDFElsDEDMAAIDALD 249
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-285 |
6.57e-49 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 164.28 E-value: 6.57e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMplSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGRTK 80
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGTM--NFGGRTDEETSFAIMDRALDAGINFFDTADVYGG-----GRSEEIIGRWIA--GRRD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 SVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNV 160
Cdd:cd19087 72 DIVLATKVFGPMGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 161 ---DLGE-LERAEK--IARIESVQnrcSPY---DREDYDDgLLAACEERGITFLPYGPVGG---------------HRAH 216
Cdd:cd19087 152 aawQIAKaQGIAARrgLLRFVSEQ---PMYnllKRQAELE-ILPAARAYGLGVIPYSPLAGglltgkygkgkrpesGRLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 217 TRLLD-----EPLLASLAEKYEA-------TPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDG 284
Cdd:cd19087 228 ERARYqarygLEEYRDIAERFEAlaaeaglTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPELLAEIDE 307
|
.
gi 1276968131 285 L 285
Cdd:cd19087 308 L 308
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-283 |
5.03e-44 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 152.00 E-value: 5.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGM-------PLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKAL 73
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGTMtfgggggFFGAWGGVDQEEADRLVDIALDAGINFFDTADVY-----SEGESEEILGKAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 74 KARgRTKsVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKIL 153
Cdd:cd19091 76 KGR-RDD-VLIATKVRGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 154 HIGLSNVDLGELERAEKIA------RIESVQNRCSPYDReDYDDGLLAACEERGITFLPYGPVGG------------HRA 215
Cdd:cd19091 154 YIGVSNFSAWQIMKALGISerrglaRFVALQAYYSLLGR-DLEHELMPLALDQGVGLLVWSPLAGgllsgkyrrgqpAPE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 216 HTRL---------LDEPL-------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDL 279
Cdd:cd19091 233 GSRLrrtgfdfppVDRERgydvvdaLREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLSLTPEEI 312
|
....
gi 1276968131 280 EKID 283
Cdd:cd19091 313 ARLD 316
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
9-278 |
5.48e-42 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 145.78 E-value: 5.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGGMPLSIQGRPDEaQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKAR-GRTKSVTVATK 87
Cdd:cd19092 2 EGLEVSRLVLGCMRLADWGESAE-ELLSLIEAALELGITTFDHADIYGG-----GKCEELFGEALALNpGLREKIEIQTK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 88 GGLKRPNGDWTR-----DASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDL 162
Cdd:cd19092 76 CGIRLGDDPRPGrikhyDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 163 GELERAEKIARIESV--QNRCSPYDREDYDDGLLAACEERGITFLPYGPVGGHRAHT-------RLLDEplLASLAEKYE 233
Cdd:cd19092 156 SQIELLQSYLDQPLVtnQIELSLLHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFGgfderfqRLRAA--LEELAEEYG 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1276968131 234 ATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPED 278
Cdd:cd19092 234 VTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
16-283 |
6.61e-42 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 144.55 E-value: 6.61e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGmplsiqGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRT-KSVTVATKggLkrpn 94
Cdd:cd19071 4 IGLGT------YKLKPEETAEAVLAALEAGYRHIDTAAAY--------GNEAEVGEAIRESGVPrEELFITTK--L---- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 gdWTRDASPAQLRAACEASLKALQSDSITLYQLH------AVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERA 168
Cdd:cd19071 64 --WPTDHGYERVREALEESLKDLGLDYLDLYLIHwpvpgkEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEEL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 169 EKIARIE--SVQNRCSPYDredYDDGLLAACEERGITFLPYGPVGghRAHTRLLDEPLLASLAEKYEATPYTIVLAWHLA 246
Cdd:cd19071 142 LAAARIKpaVNQIELHPYL---QQKELVEFCKEHGIVVQAYSPLG--RGRRPLLDDPVLKEIAKKYGKTPAQVLLRWALQ 216
|
250 260 270
....*....|....*....|....*....|....*..
gi 1276968131 247 KseRILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19071 217 R--GVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
9-283 |
1.67e-41 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 143.93 E-value: 1.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLG--GMPLSIQGRPDEAQALRvigASLDAGVAFIDSADVYcldqTDiGHNERLIAKALkaRGRTKSVTVAT 86
Cdd:cd19138 7 DGTKVPALGQGtwYMGEDPAKRAQEIEALR---AGIDLGMTLIDTAEMY----GD-GGSEELVGEAI--RGRRDKVFLVS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 87 KgglkrpngDWTRDASPAQLRAACEASLKALQSDSITLYQLHAvDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELE 166
Cdd:cd19138 77 K--------VLPSNASRQGTVRACERSLRRLGTDYLDLYLLHW-RGGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDME 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 167 RAEKIARIE---------SVQNRCSPYDredyddgLLAACEERGITFLPYGPVG-GHRAHTRLLDEPLLASLAEKYEATP 236
Cdd:cd19138 148 ELWAVPGGGncaanqvlyNLGSRGIEYD-------LLPWCREHGVPVMAYSPLAqGGLLRRGLLENPTLKEIAARHGATP 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1276968131 237 YTIVLAWHLaKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19138 221 AQVALAWVL-RDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-209 |
3.37e-41 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 144.37 E-value: 3.37e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLG--GMPLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKALKARGRTKSVTVATK 87
Cdd:cd19148 1 DLPVSRIALGtwAIGGWMWGGTDEKEAIETIHKALDLGINLIDTAPVY-----GFGLSEEIVGKALKEYGKRDRVVIATK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 88 GGLK-RPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELE 166
Cdd:cd19148 76 VGLEwDEGGEVVRNSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQME 155
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1276968131 167 RAEKIARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGP 209
Cdd:cd19148 156 TFRKVAPLHTVQPPYNLFEREIEKD-VLPYARKHNIVTLAYGA 197
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
16-283 |
1.75e-40 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 140.48 E-value: 1.75e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSiqgrpdEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATKgglkrpn 94
Cdd:cd19073 4 LGLGTWQLR------GDDCANAVKEALELGYRHIDTAEIY--------NNEAEVGEAIAESGVPREdLFITTK------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 gDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIAR- 173
Cdd:cd19073 63 -VWRDHLRPEDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPl 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 174 -IESVQNRCSPYdreDYDDGLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKSerIL 252
Cdd:cd19073 142 pIAVNQVEFHPF---LYQAELLEYCRENDIVITAYSPL----ARGEVLRDPVIQEIAEKYDKTPAQVALRWLVQKG--IV 212
|
250 260 270
....*....|....*....|....*....|.
gi 1276968131 253 PIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19073 213 VIPKASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
6-280 |
4.69e-40 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 141.57 E-value: 4.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 6 LGRTGIRLFPIGLGGMPLsiqGRP-------DEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGR 78
Cdd:cd19079 5 LGNSGLKVSRLCLGCMSF---GDPkwrpwvlDEEESRPIIKRALDLGINFFDTANVYSG-----GASEEILGRALKEFAP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 79 TKSVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLS 158
Cdd:cd19079 77 RDEVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 159 NVDLGELERAEKIA------RIESVQNrcsPYD---REDYDDgLLAACEERGITFLPYGPV------------------- 210
Cdd:cd19079 157 SMYAWQFAKALHLAekngwtKFVSMQN---HYNllyREEERE-MIPLCEEEGIGVIPWSPLargrlarpwgdtterrrst 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276968131 211 ----GGHRAHTRLLDEPLLAS---LAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLE 280
Cdd:cd19079 233 tdtaKLKYDYFTEADKEIVDRveeVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIK 309
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-270 |
9.37e-40 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 140.16 E-value: 9.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSiqGRPDEAQALRVIGASLDAGVAFIDSADVYC--LDQTDIGHNERLIAKALKARGRTKSVTVATKGG--LK 91
Cdd:cd19752 3 LCLGTMYFG--TRTDEETSFAILDRYVAAGGNFLDTANNYAfwTEGGVGGESERLIGRWLKDRGNRDDVVIATKVGagPR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 92 RPNGDWT--RDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAE 169
Cdd:cd19752 81 DPDGGPEspEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLERAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 170 KIARIE------SVQNRCSpYDREDY----------DDGLLAACEERG-ITFLPYGPV--GGHRAHTRLLDEP------- 223
Cdd:cd19752 161 QIARQQgwaefsAIQQRHS-YLRPRPgadfgvqrivTDELLDYASSRPdLTLLAYSPLlsGAYTRPDRPLPEQydgpdsd 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1276968131 224 ----LLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAA 270
Cdd:cd19752 240 arlaVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAAL 290
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
15-283 |
1.04e-38 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 137.36 E-value: 1.04e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMP-----LSIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKALKARGRTKSVTVATK-G 88
Cdd:cd19093 4 PLGLGTWQwgdrlWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVY-----GTGRSERLLGRFLKELGDRDEVVIATKfA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 GLKrpngdWTRdaSPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGE-LKKLQDEGKILHIGLSNVDLGELER 167
Cdd:cd19093 79 PLP-----WRL--TRRSVVKALKASLERLGLDSIDLYQLHWPGPWYSQIEALMDgLADAVEEGLVRAVGVSNYSADQLRR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 168 A-EKIAR----IESVQNRCSPYDREDYDDGLLAACEERGITFLPY-------------------GPVGGHRAHTRLL-DE 222
Cdd:cd19093 152 AhKALKErgvpLASNQVEYSLLYRDPEQNGLLPACDELGITLIAYsplaqglltgkyspenpppGGRRRLFGRKNLEkVQ 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276968131 223 PLLASL---AEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19093 232 PLLDALeeiAEKYGKTPAQVALNWLIAKG--VVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-202 |
2.30e-37 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 132.71 E-value: 2.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPLSiqgrpdeAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKALKARGRtK 80
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFGGGGLP-------RESPELLRRALDLGINYFDTAEGY-----GNGNSEEIIGEALKGLRR-D 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 SVTVATKGGLKRPNGDwtrdasPAQLRAACEASLKALQSDSITLYQLHAVDPA---VALEESVGELKKLQDEGKILHIGL 157
Cdd:cd19105 68 KVFLATKASPRLDKKD------KAELLKSVEESLKRLQTDYIDIYQLHGVDTPeerLLNEELLEALEKLKKEGKVRFIGF 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1276968131 158 SNVDLGE--LERAEKIARIESVQNRCSPYDREDYDDGLLAACEERGI 202
Cdd:cd19105 142 STHDNMAevLQAAIESGWFDVIMVAYNFLNQPAELEEALAAAAEKGI 188
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
15-270 |
2.46e-37 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 133.83 E-value: 2.46e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPLsiQGRPDEAQALRVIGASLDAGVAFIDSADVYClDQTDIGHNERLIAKALKARGRTKSVTVATKGGLKRPN 94
Cdd:cd19082 2 RIVLGTADF--GTRIDEEEAFALLDAFVELGGNFIDTARVYG-DWVERGASERVIGEWLKSRGNRDKVVIATKGGHPDLE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 GDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIAR- 173
Cdd:cd19082 79 DMSRSRLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAYAKa 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 174 -----IESVQN-----RCSPYDREDY-----DDGLLAACEERGITFLPYGPVGG----HRAHTRLLDEPLLAS------- 227
Cdd:cd19082 159 hglpgFAASSPqwslaRPNEPPWPGPtlvamDEEMRAWHEENQLPVFAYSSQARgffsKRAAGGAEDDSELRRvyyseen 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 228 ---------LAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAA 270
Cdd:cd19082 239 ferlerakeLAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAA 290
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
8-285 |
2.70e-37 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 132.77 E-value: 2.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 8 RTGIRLFPIGLGGMPLsiQGRpdeaQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG--RTKsVTVA 85
Cdd:cd19140 3 VNGVRIPALGLGTYPL--TGE----ECTRAVEHALELGYRHIDTAQMY--------GNEAQVGEAIAASGvpRDE-LFLT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 86 TKGglkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGEL 165
Cdd:cd19140 68 TKV--------WPDNYSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 166 ERAEKIARIESVQNRC--SPY-DREDyddgLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLA 242
Cdd:cd19140 140 REAVELSEAPLFTNQVeyHPYlDQRK----LLDAAREHGIALTAYSPL----ARGEVLKDPVLQEIGRKHGKTPAQVALR 211
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1276968131 243 WHLAKsERILPIPGASKIASAEDSpkAALLD--LEPEDLEKIDGL 285
Cdd:cd19140 212 WLLQQ-EGVAAIPKATNPERLEEN--LDIFDftLSDEEMARIAAL 253
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
1-287 |
5.77e-37 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 132.79 E-value: 5.77e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRT----GIRLFPIGLGGMPLS---IQGRP-DEAQALRVIGASLDAGVAFIDSADVYCLDQTDighneRLIAKA 72
Cdd:PRK10376 1 MSTIMSSGTftlgGRSVNRLGYGAMQLAgpgVFGPPkDRDAAIAVLREAVALGVNHIDTSDFYGPHVTN-----QLIREA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 73 LKARGrtKSVTVATKGGLKR-PNGDWTRDASPAQLRAACEASLKALQSDSITLYQL------HAVDPAvALEESVGELKK 145
Cdd:PRK10376 76 LHPYP--DDLTIVTKVGARRgEDGSWLPAFSPAELRRAVHDNLRNLGLDVLDVVNLrlmgdgHGPAEG-SIEEPLTVLAE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 146 LQDEGKILHIGLSNVDLGELERAEKIARIESVQNRCSPYDREDydDGLLAACEERGITFLPYGPVGGHRAhtrlLDEPLL 225
Cdd:PRK10376 153 LQRQGLVRHIGLSNVTPTQVAEARKIAEIVCVQNHYNLAHRAD--DALIDALARDGIAYVPFFPLGGFTP----LQSSTL 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 226 ASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLNG 287
Cdd:PRK10376 227 SDVAASLGATPMQVALAWLLQRSPNILLIPGTSSVAHLRENLAAAELVLSEEVLAELDGIAR 288
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-221 |
9.22e-37 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 130.68 E-value: 9.22e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 3 TRELGRTGIRLFPIGLGGMPLsiqGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKarGRTKSV 82
Cdd:cd19100 1 YRRLGRTGLKVSRLGFGGGPL---GRLSQEEAAAIIRRALDLGINYFDTAPSY-------GDSEEKIGKALK--GRRDKV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 83 TVATKgglkrpNGDWTRDASPAQLraacEASLKALQSDSITLYQLHAVDPAVALEESVGE------LKKLQDEGKILHIG 156
Cdd:cd19100 69 FLATK------TGARDYEGAKRDL----ERSLKRLGTDYIDLYQLHAVDTEEDLDQVFGPggaleaLLEAKEEGKIRFIG 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 157 LSNVDLGELERAEKIARIESVQNRCSPYDRE--DYDDGLLAACEERGITFL---PYGpvGGHRAHTRLLD 221
Cdd:cd19100 139 ISGHSPEVLLRALETGEFDVVLFPINPAGDHidSFREELLPLAREKGVGVIamkVLA--GGRLLSGDPLD 206
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
10-283 |
1.08e-33 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 123.45 E-value: 1.08e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPLSIQGRPD---EAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRtKSVTVAT 86
Cdd:cd19137 1 GEKIPALGLGTWGIGGFLTPDysrDEEMVELLKTAIELGYTHIDTAEMYGG-----GHTEELVGKAIKDFPR-EDLFIVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 87 KgglkrpngDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELE 166
Cdd:cd19137 75 K--------VWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 167 RAEKIARIESVQNRC--SPYDREDYDDGLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLAWH 244
Cdd:cd19137 147 EAISKSQTPIVCNQVkyNLEDRDPERDGLLEYCQKNGITVVAYSPL----RRGLEKTNRTLEEIAKNYGKTIAQIALAWL 222
|
250 260 270
....*....|....*....|....*....|....*....
gi 1276968131 245 LAKsERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19137 223 IQK-PNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-285 |
4.80e-33 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 124.16 E-value: 4.80e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPLSiqgRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKarGRTK 80
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGMRLP---RKDEEEAEALIRRAIDNGINYIDTARGY-------GDSEEFLGKALK--GPRD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 SVTVATKgglkrpNGDWTRDasPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGE------LKKLQDEGKILH 154
Cdd:COG1453 69 KVILATK------LPPWVRD--PEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVLKPggaleaLEKAKAEGKIRH 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 155 IGLSNvdLGELERAEKIAR---IESVQNRCSPYDrEDYDDG--LLAACEERGItflpyG-----PVGGHrahtRLLDEPL 224
Cdd:COG1453 141 IGFST--HGSLEVIKEAIDtgdFDFVQLQYNYLD-QDNQAGeeALEAAAEKGI-----GviimkPLKGG----RLANPPE 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276968131 225 LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLD--LEPEDLEKIDGL 285
Cdd:COG1453 209 KLVELLCPPLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENLKTADNLepLTEEELAILERL 271
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
4-283 |
1.44e-30 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 116.16 E-value: 1.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 4 RELGRTGIRLFPIGLGGMPLSIQ--GRPDEAQALRVIGASLDAGVAFIDSADVYcldqTDiGHNERLIAKALKARgRTKS 81
Cdd:cd19080 1 RLLGRSGLRVSPLALGTMTFGTEwgWGADREEARAMFDAYVEAGGNFIDTANNY----TN-GTSERLLGEFIAGN-RDRI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 82 VtVATKGGLKRPNGDwtrdasPA-------QLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILH 154
Cdd:cd19080 75 V-LATKYTMNRRPGD------PNaggnhrkNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLY 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 155 IGLSNVDLGELERAEKIA------RIESVQNRCSPYDReDYDDGLLAACEERGITFLPYGPVGG---------------- 212
Cdd:cd19080 148 VGISDTPAWVVARANTLAelrgwsPFVALQIEYSLLER-TPERELLPMARALGLGVTPWSPLGGglltgkyqrgeegrag 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 213 ------------HRAHTRLLDEplLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLE 280
Cdd:cd19080 227 eakgvtvgfgklTERNWAIVDV--VAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLA 304
|
...
gi 1276968131 281 KID 283
Cdd:cd19080 305 RLD 307
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
15-234 |
4.48e-30 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 113.48 E-value: 4.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGM-PLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKARGRtKSVTVATKGGLKRP 93
Cdd:cd19095 2 VLGLGTSgIGRVWGVPSEAEAARLLNTALDLGINLIDTAPAY-------GRSEERLGRALAGLRR-DDLFIATKVGTHGE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 94 NGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNvDLGELERAEKIAR 173
Cdd:cd19095 74 GGRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSG-DGEELEAAIASGV 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276968131 174 IESVQNRCSPYDREdyDDGLLAACEERGITFLPYGPVGGHRAHTRLLDEPLLASLAEKYEA 234
Cdd:cd19095 153 FDVVQLPYNVLDRE--EEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYARRPEF 211
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
14-283 |
5.21e-30 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 115.36 E-value: 5.21e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 14 FPIGLGGMPLSIQGrpDEAQALRVIGASLDAGVAFIDSADVYCL---DQTDiGHNERLIAKALKARGRTKSVTVATK--- 87
Cdd:cd19094 2 SEICLGTMTWGEQN--TEAEAHEQLDYAFDEGVNFIDTAEMYPVppsPETQ-GRTEEIIGSWLKKKGNRDKVVLATKvag 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 88 --GGLKRPNGDWTRdASPAQLRAACEASLKALQSDSITLYQLHAVD------------------PAVALEESVGELKKLQ 147
Cdd:cd19094 79 pgEGITWPRGGGTR-LDRENIREAVEGSLKRLGTDYIDLYQLHWPDrytplfgggyytepseeeDSVSFEEQLEALGELV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 148 DEGKILHIGLSNvdlgE--------LERAEK--IARIESVQNRCSPYDREdYDDGLLAACEERGITFLPYGPVGG----- 212
Cdd:cd19094 158 KAGKIRHIGLSN----EtpwgvmkfLELAEQlgLPRIVSIQNPYSLLNRN-FEEGLAEACHRENVGLLAYSPLAGgvltg 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 213 -------HRAHTRLLDEPL----------------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKA 269
Cdd:cd19094 233 kyldgaaRPEGGRLNLFPGymaryrspqaleavaeYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATTLEQLKENIDA 312
|
330
....*....|....
gi 1276968131 270 ALLDLEPEDLEKID 283
Cdd:cd19094 313 FDVPLSDELLAEID 326
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
40-283 |
8.94e-30 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 113.10 E-value: 8.94e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 40 ASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG--RtKSVTVATK--GGLKRPngdwtrdaspaqlRAACEASLK 115
Cdd:cd19120 33 LALKAGFRHIDTAEMY--------GNEKEVGEALKESGvpR-EDLFITTKvsPGIKDP-------------REALRKSLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 116 ALQSDSITLYQLHAV----DPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARIESVQN--RCSPYDREDY 189
Cdd:cd19120 91 KLGVDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVNqiEFHPYLYPQQ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 190 DDgLLAACEERGITFLPYGPVG--GHRAHTRLldEPLLASLAEKYEATPYTIVLAWHLAKseRILPIPGASKIASAEDSP 267
Cdd:cd19120 171 PA-LLEYCREHGIVVSAYSPLSplTRDAGGPL--DPVLEKIAEKYGVTPAQVLLRWALQK--GIVVVTTSSKEERMKEYL 245
|
250
....*....|....*.
gi 1276968131 268 KAALLDLEPEDLEKID 283
Cdd:cd19120 246 EAFDFELTEEEVEEID 261
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
10-277 |
2.17e-29 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 113.07 E-value: 2.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMpLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRTKSVtVATKgg 89
Cdd:cd19074 1 GLKVSELSLGTW-LTFGGQVDDEDAKACVRKAYDLGINFFDTADVYAA-----GQAEEVLGKALKGWPRESYV-ISTK-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 LKRPNGDWTRDA--SPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELER 167
Cdd:cd19074 72 VFWPTGPGPNDRglSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 168 AEKIAR------IESVQNRCSPYDREdYDDGLLAACEERGITFLPYGP---------------VGGHRAHT--------- 217
Cdd:cd19074 152 AHDLARqfglipPVVEQPQYNMLWRE-IEEEVIPLCEKNGIGLVVWSPlaqglltgkyrdgipPPSRSRATdednrdkkr 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276968131 218 RLLDEPLLA------SLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPE 277
Cdd:cd19074 231 RLLTDENLEkvkklkPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-285 |
1.74e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 110.50 E-value: 1.74e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 30 DEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRtKSVTVATKgglKRPNGdwtRDASPAQLRAA 109
Cdd:cd19103 30 DEDTLKAVFDKAMAAGLNLWDTAAVYGM-----GASEKILGEFLKRYPR-EDYIISTK---FTPQI---AGQSADPVADM 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 110 CEASLKALQSDSITLYQLHavDPAvALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKI-----ARIESVQNRCSPY 184
Cdd:cd19103 98 LEGSLARLGTDYIDIYWIH--NPA-DVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEIlakagVSLSAVQNHYSLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 185 DREDYDDGLLAACEERGITFLPY-----------------GPVGGHRAHT--RLLDE-----PLLASLAEKYEATPYTIV 240
Cdd:cd19103 175 YRSSEEAGILDYCKENGITFFAYmvleqgalsgkydtkhpLPEGSGRAETynPLLPQleeltAVMAEIGAKHGASIAQVA 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1276968131 241 LAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGL 285
Cdd:cd19103 255 IAWAIAKG--TTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-202 |
3.77e-27 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 106.87 E-value: 3.77e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPL-SIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRt 79
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGASPLgGVFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQ-----GRSETVLGKALKGIPR- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPA----VALEESVGELKKLQDEGKILHI 155
Cdd:cd19163 75 DSYYLATKVGRYGLDPDKMFDFSAERITKSVEESLKRLGLDYIDIIQVHDIEFApsldQILNETLPALQKLKEEGKVRFI 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1276968131 156 GLSNVDLGELER-AEKIA-RIESVQ--NRCSPYDREdyDDGLLAACEERGI 202
Cdd:cd19163 155 GITGYPLDVLKEvLERSPvKIDTVLsyCHYTLNDTS--LLELLPFFKEKGV 203
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
9-253 |
3.88e-26 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 104.42 E-value: 3.88e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALK---ARGRTK--SVT 83
Cdd:cd19154 8 NGVKMPLIGLG----TWQSKGAEGIT--AVRTALKAGYRLIDTAFLY--------QNEEAIGEALAellEEGVVKreDLF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 84 VATKGglkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHA-------------------VDPAVALEESVGELK 144
Cdd:cd19154 74 ITTKL--------WTHEHAPEDVEEALRESLKKLQLEYVDLYLIHApaafkddegesgtmengmsIHDAVDVEDVWRGME 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 145 KLQDEGKILHIGLSNVDLGELERAEKIARIESVQNR--CSPY-DREDyddgLLAACEERGITFLPYGPVG--GHRAHTR- 218
Cdd:cd19154 146 KVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQveCHLYfPQKE----LVEFCKKHNISVTSYATLGspGRANFTKs 221
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1276968131 219 --------LLDEPLLASLAEKYEATPYTIVLAWHLAKSERILP 253
Cdd:cd19154 222 tgvspapnLLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIP 264
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
37-285 |
3.92e-25 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 100.51 E-value: 3.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 37 VIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG-RTKSVTVATKgglkrpngDWTRDASPAQLRAACEASLK 115
Cdd:cd19139 19 SVRTALELGYRHIDTAQIY--------DNEAAVGQAIAESGvPRDELFITTK--------IWIDNLSKDKLLPSLEESLE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 116 ALQSDSITLYQLH--AVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKI---ARIESVQNRCSPYDRedyD 190
Cdd:cd19139 83 KLRTDYVDLTLIHwpSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVvgaGAIATNQIELSPYLQ---N 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 191 DGLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSPKAA 270
Cdd:cd19139 160 RKLVAHCKQHGIHVTSYMTL----AYGKVLDDPVLAAIAERHGATPAQIALAWAMARG--YAVIPSSTKREHLRSNLLAL 233
|
250
....*....|....*
gi 1276968131 271 LLDLEPEDLEKIDGL 285
Cdd:cd19139 234 DLTLDADDMAAIAAL 248
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
15-277 |
6.74e-25 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 100.32 E-value: 6.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPL-SIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKARGRtKSVTVATK-GGLKR 92
Cdd:cd19090 2 ALGLGTAGLgGVFGGVDDDEAVATIRAALDLGINYIDTAPAY-------GDSEERLGLALAELPR-EPLVLSTKvGRLPE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 93 PNGDWTRDAspaqLRAACEASLKALQSDSITLYQLH-----AVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELER 167
Cdd:cd19090 74 DTADYSADR----VRRSVEESLERLGRDRIDLLMIHdpervPWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDLLRR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 168 AEKIARIESV--QNRCSPYDREDYDDgLLAACEERGITFL---PYG---PVGGHRAHTRLLDEPLLASLAEKYEAtpyti 239
Cdd:cd19090 150 AIETGDFDVVltANRYTLLDQSAADE-LLPAAARHGVGVInasPLGmglLAGRPPERVRYTYRWLSPELLDRAKR----- 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1276968131 240 VLAW---------HLA-----KSERI-LPIPGASKIASAEDSPKAALLDLEPE 277
Cdd:cd19090 224 LYELcdehgvplpALAlrfllRDPRIsTVLVGASSPEELEQNVAAAEGPLPEE 276
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
10-286 |
1.56e-24 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 98.88 E-value: 1.56e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPLsiqgrpDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATKg 88
Cdd:cd19132 4 GTQIPAIGFGTYPL------KGDEGVEAVVAALQAGYRLLDTAFNY--------ENEGAVGEAVRRSGVPREeLFVTTK- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 glkRPNGDWTRDASpaqlRAACEASLKALQSDSITLYQLHAVDPAVALE-ESVGELKKLQDEGKILHIGLSNVDLGELER 167
Cdd:cd19132 69 ---LPGRHHGYEEA----LRTIEESLYRLGLDYVDLYLIHWPNPSRDLYvEAWQALIEAREEGLVRSIGVSNFLPEHLDR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 168 -AEKIARIESV-QNRCSPY-DREDyddgLLAACEERGITFLPYGPVGghRAhTRLLDEPLLASLAEKYEATPYTIVLAWH 244
Cdd:cd19132 142 lIDETGVTPAVnQIELHPYfPQAE----QRAYHREHGIVTQSWSPLG--RG-SGLLDEPVIKAIAEKHGKTPAQVVLRWH 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1276968131 245 LAKSerILPIPGASkiasaedSPK-----AALLD--LEPEDLEKIDGLN 286
Cdd:cd19132 215 VQLG--VVPIPKSA-------NPErqrenLAIFDfeLSDEDMAAIAALD 254
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
27-283 |
7.07e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 98.05 E-value: 7.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 27 GRPDEAQALRVIGASLDAGVAFIDSADVYCLDQTDIGhneRLIAKALKARGRTKSVTVATKgglKRPNGDwTRDASPAQL 106
Cdd:cd19101 18 GIRDEDAAVRAMAAYVDAGLTTFDCADIYGPAEELIG---EFRKRLRRERDAADDVQIHTK---WVPDPG-ELTMTRAYV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 107 RAACEASLKALQSDSITLYQLHAVDPAV-ALEESVGELKKLQDEGKILHIGLSNVDLGELERA-EKIARIESVQNRCSPY 184
Cdd:cd19101 91 EAAIDRSLKRLGVDRLDLVQFHWWDYSDpGYLDAAKHLAELQEEGKIRHLGLTNFDTERLREIlDAGVPIVSNQVQYSLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 185 DREDyDDGLLAACEERGITFLPYGPVGG----------------------HRAHTRLLDE-----------PLLASLAEK 231
Cdd:cd19101 171 DRRP-ENGMAALCEDHGIKLLAYGTLAGgllsekylgvpeptgpaletrsLQKYKLMIDEwggwdlfqellRTLKAIADK 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 232 YEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19101 250 HGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFRLDDEDRAAID 301
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
18-212 |
2.44e-23 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 96.86 E-value: 2.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 18 LGGMPLSIQGRPDEAQALR-VIGASLDAGVAFIDSADVYCLDQTdighnERLIAKALKARgrtKSVTVATKGglkrpNGD 96
Cdd:cd19075 5 LGTMTFGSQGRFTTAEAAAeLLDAFLERGHTEIDTARVYPDGTS-----EELLGELGLGE---RGFKIDTKA-----NPG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 97 WTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIAR--- 173
Cdd:cd19075 72 VGGGLSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKeng 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1276968131 174 --IESV-QNRCSPYDReDYDDGLLAACEERGITFLPYGPVGG 212
Cdd:cd19075 152 wvLPTVyQGMYNAITR-QVETELFPCLRKLGIRFYAYSPLAG 192
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
29-243 |
3.42e-23 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 96.37 E-value: 3.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 29 PDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALK---ARG--RTKSVTVATKgglkrpngDWTRDASP 103
Cdd:cd19129 16 PDPSATRNAVKAALEAGFRHFDCAERY--------RNEAEVGEAMQevfKAGkiRREDLFVTTK--------LWNTNHRP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 104 AQLRAACEASLKALQSDSITLYQLHA--------------------VDPAVALEESVGELKKLQDEGKILHIGLSNVDLG 163
Cdd:cd19129 80 ERVKPAFEASLKRLQLDYLDLYLIHTpfafqpgdeqdprdangnviYDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 164 ELERAEKIARIES--VQNRCSPYDREdydDGLLAACEERGITFLPYGPVgGHRAHTRLLDEPLLASLAEKYEATPYTIVL 241
Cdd:cd19129 160 KLREIFEAARIKPavVQVESHPYLPE---WELLDFCKNHGIVLQAFAPL-GHGMEPKLLEDPVITAIARRVNKTPAQVLL 235
|
..
gi 1276968131 242 AW 243
Cdd:cd19129 236 AW 237
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
29-286 |
3.17e-22 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 92.84 E-value: 3.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 29 PDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKSVTVATKgglKRPNGDWTRDASpaqlRA 108
Cdd:cd19157 21 EEGSEVVNAVKTALKNGYRSIDTAAIY--------GNEEGVGKGIKESGIPREELFITS---KVWNADQGYDST----LK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 109 ACEASLKALQSDSITLYQLHAvdPAVAL-EESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARIESVQNR--CSPY- 184
Cdd:cd19157 86 AFEASLERLGLDYLDLYLIHW--PVKGKyKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQveFHPRl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 185 DREDyddgLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKiasaE 264
Cdd:cd19157 164 TQKE----LRDYCKKQGIQLEAWSPL----MQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNG--VVTIPKSIK----E 229
|
250 260
....*....|....*....|....*.
gi 1276968131 265 DSPK--AALLDLE--PEDLEKIDGLN 286
Cdd:cd19157 230 HRIIenADVFDFElsQEDMDKIDALN 255
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
9-286 |
3.27e-22 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 93.60 E-value: 3.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKArgrtksvTVATKG 88
Cdd:cd19106 3 TGQKMPLIGLG----TWKSKPGQVKA--AVKYALDAGYRHIDCAAVY--------GNEQEVGEALKE-------KVGPGK 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 GLKRPN-----GDWTRDASPAQLRAACEASLKALQSDSITLYQLH------------AVDP-------AVALEESVGELK 144
Cdd:cd19106 62 AVPREDlfvtsKLWNTKHHPEDVEPALRKTLKDLQLDYLDLYLIHwpyafergdnpfPKNPdgtirydSTHYKETWKAME 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 145 KLQDEGKILHIGLSNVDLGELERAEKIARIESV--QNRCSPYDREDyddGLLAACEERGITFLPYGPVGG-HRAHTR--- 218
Cdd:cd19106 142 KLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAvlQVECHPYLAQN---ELIAHCKARGLVVTAYSPLGSpDRPWAKpde 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276968131 219 --LLDEPLLASLAEKYEATPYTIVLAWHLAKseRILPIPGA---SKIASAEDspkaaLLD--LEPEDLEKIDGLN 286
Cdd:cd19106 219 pvLLEEPKVKALAKKYNKSPAQILLRWQVQR--GVVVIPKSvtpSRIKQNIQ-----VFDftLSPEEMKQLDALN 286
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
37-285 |
3.43e-22 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 92.77 E-value: 3.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 37 VIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG-RTKSVTVATKggLkrpngdWTRDASPAQLRAACEASLK 115
Cdd:cd19135 31 VVYALKECGYRHIDTAKRY--------GCEELLGKAIKESGvPREDLFLTTK--L------WPSDYGYESTKQAFEASLK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 116 ALQSDSITLYQLHAVDPAV-------ALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARI--ESVQNRCSPYDR 186
Cdd:cd19135 95 RLGVDYLDLYLLHWPDCPSsgknvkeTRAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVvpHVNQVEFHPFQN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 187 edyDDGLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDS 266
Cdd:cd19135 175 ---PVELIEYCRDNNIVFEGYCPL----AKGKALEEPTVTELAKKYQKTPAQILIRWSIQNG--VVTIPKSTKEERIKEN 245
|
250
....*....|....*....
gi 1276968131 267 PKAALLDLEPEDLEKIDGL 285
Cdd:cd19135 246 CQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
10-286 |
7.37e-22 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 91.73 E-value: 7.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPLsiqgrPDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATKG 88
Cdd:cd19126 6 GTRMPWLGLGVFQT-----PDGDETERAVQTALENGYRSIDTAAIY--------KNEEGVGEAIRESGVPREeLFVTTKL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 glkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAvALEESVGELKKLQDEGKILHIGLSNVDLGELERA 168
Cdd:cd19126 73 --------WNDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKD-KFIDTWKALEKLYASGKVKAIGVSNFQEHHLEEL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 169 EKIARIESVQNR--CSPY-DREDyddgLLAACEERGITFLPYGPVGGhrahTRLLDEPLLASLAEKYEATPYTIVLAWHL 245
Cdd:cd19126 144 LAHADVVPAVNQveFHPYlTQKE----LRGYCKSKGIVVEAWSPLGQ----GGLLSNPVLAAIGEKYGKSAAQVVLRWDI 215
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1276968131 246 AKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19126 216 QHG--VVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
16-243 |
8.55e-22 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 91.47 E-value: 8.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGM--PLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRtKSVTVATKGGlkrP 93
Cdd:cd19096 3 LGFGTMrlPESDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGG-----GKSEEILGEALKEGPR-EKFYLATKLP---P 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 94 NGDWTRDASPAQLraacEASLKALQSDSITLYQLHAV-----DPAVALEESVGELKKLQDEGKILHIGLS-NVDLGELER 167
Cdd:cd19096 74 WSVKSAEDFRRIL----EESLKRLGVDYIDFYLLHGLnspewLEKARKGGLLEFLEKAKKEGLIRHIGFSfHDSPELLKE 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276968131 168 AEKIARIESVQNRCSPYDRED-YDDGLLAACEERGITFLPYGPVGGHRahtRLLDEPLLASLAEKYEATPYTIVLAW 243
Cdd:cd19096 150 ILDSYDFDFVQLQYNYLDQENqAGRPGIEYAAKKGMGVIIMEPLKGGG---LANNPPEALAILCGAPLSPAEWALRF 223
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
30-285 |
1.01e-21 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 91.54 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 30 DEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGrtksvtvaTKGGLKRPngD-------WTRDAS 102
Cdd:cd19136 13 GEEEVRQAVDAALKAGYRLIDTASVY--------RNEADIGKALRDLL--------PKYGLSRE--DifitsklAPKDQG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 103 PAQLRAACEASLKALQSDSITLYQLH--------AVDPA-VALE-ESVGELKKLQDEGKILHIGLSNVDLGELERAEKIA 172
Cdd:cd19136 75 YEKARAACLGSLERLGTDYLDLYLIHwpgvqglkPSDPRnAELRrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 173 RIE-SV-QNRCSPYdREDYDdgLLAACEERGITFLPYGPVGghRAHTRLLDEPLLASLAEKYEATPYTIVLAWhlAKSER 250
Cdd:cd19136 155 EVPpAVnQVEFHPH-LVQKE--LLKFCKDHGIHLQAYSSLG--SGDLRLLEDPTVLAIAKKYGRTPAQVLLRW--ALQQG 227
|
250 260 270
....*....|....*....|....*....|....*
gi 1276968131 251 ILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGL 285
Cdd:cd19136 228 IGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
10-283 |
1.10e-21 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 92.58 E-value: 1.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPL-----SIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLDQTdighnERLIAKALKARGRTKSVTV 84
Cdd:cd19147 7 GIRVSPLILGAMSIgdawsGFMGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQS-----ETWIGEWMKSRKNRDQIVI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 85 ATK-------GGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGL 157
Cdd:cd19147 82 ATKfttdykaYEVGKGKAVNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 158 SNVDLGELERAEKIARIE-----SV-QNRCSPYDReDYDDGLLAACEERGITFLPYGPVGGHRAHTRLL-------DEPL 224
Cdd:cd19147 162 SDTPAWVVSAANYYATAHgktpfSVyQGRWNVLNR-DFERDIIPMARHFGMALAPWDVLGGGKFQSKKAveerkknGEGL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1276968131 225 -------------------LASLAEKYEATPYT-IVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19147 241 rsfvggteqtpeevkiseaLEKVAEEHGTESVTaIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
26-286 |
4.10e-21 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 89.74 E-value: 4.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 26 QGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATKgglkRPNGDWTRDASpa 104
Cdd:cd19131 19 QVSNDEAAS--AVREALEVGYRSIDTAAIY--------GNEEGVGKAIRASGVPREeLFITTK----LWNSDQGYDST-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 105 qlRAACEASLKALQSDSITLYQLHAVDPAVALE-ESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARIESVQNR--C 181
Cdd:cd19131 83 --LRAFDESLRKLGLDYVDLYLIHWPVPAQDKYvETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQieL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 182 SPYDREDyddGLLAACEERGITFLPYGPVGGhrahTRLLDEPLLASLAEKYEATPYTIVLAWHLAkSERILpIP---GAS 258
Cdd:cd19131 161 HPRFQQR---ELRAFHAKHGIQTESWSPLGQ----GGLLSDPVIGEIAEKHGKTPAQVVIRWHLQ-NGLVV-IPksvTPS 231
|
250 260 270
....*....|....*....|....*....|
gi 1276968131 259 KIASaedspKAALLD--LEPEDLEKIDGLN 286
Cdd:cd19131 232 RIAE-----NFDVFDfeLDADDMQAIAGLD 256
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
2-202 |
1.94e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 89.25 E-value: 1.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 2 NTRELGRTGIRLFPIGLGG---MPLSIQGRPDEAqaLRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKarGR 78
Cdd:cd19104 1 KYRRFGRTGLKVSELTFGGggiGGLMGRTTREEQ--IAAVRRALDLGINFFDTAPSYGD-----GKSEENLGRALK--GL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 79 TKSVTVATKGGLkrpnGDWTRDASPAQLRAACEASLKALQSDSITLYQLH----AVDPAVA-----------LEESVGEL 143
Cdd:cd19104 72 PAGPYITTKVRL----DPDDLGDIGGQIERSVEKSLKRLKRDSVDLLQLHnrigDERDKPVggtlsttdvlgLGGVADAF 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 144 KKLQDEGKILHIGLSNVDLGE-LERAEKIARIESVQN------------RCSPYDREDYdDGLLAACEERGI 202
Cdd:cd19104 148 ERLRSEGKIRFIGITGLGNPPaIRELLDSGKFDAVQVyynllnpsaaeaRPRGWSAQDY-GGIIDAAAEHGV 218
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
9-285 |
1.74e-19 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 86.01 E-value: 1.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDEAqALRVIgASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATK 87
Cdd:cd19117 10 TGAEIPAVGLG----TWQSKPNEV-AKAVE-AALKAGYRHIDTAAIY--------GNEEEVGQGIKDSGVPREeIFITTK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 88 gglkrPNGDWTRdaspaQLRAACEASLKALQSDSITLYQLH---------------------AVDPAVALEESVGELKKL 146
Cdd:cd19117 76 -----LWCTWHR-----RVEEALDQSLKKLGLDYVDLYLMHwpvpldpdgndflfkkddgtkDHEPDWDFIKTWELMQKL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 147 QDEGKILHIGLSNVDLGELER--AEKIARIESVQNRCS--PYDREDYddgLLAACEERGITFLPYGPVGGhrAHTRLLDE 222
Cdd:cd19117 146 PATGKVKAIGVSNFSIKNLEKllASPSAKIVPAVNQIElhPLLPQPK---LVDFCKSKGIHATAYSPLGS--TNAPLLKE 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276968131 223 PLLASLAEKYEATPYTIVLAWHLAKSERILPIP-GASKIASAEDspkaaLLDLEPEDLEKIDGL 285
Cdd:cd19117 221 PVIIKIAKKHGKTPAQVIISWGLQRGYSVLPKSvTPSRIESNFK-----LFTLSDEEFKEIDEL 279
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
10-286 |
3.00e-19 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 84.77 E-value: 3.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYCldqtdighNERLIAKALKARGRTKS-VTVATKG 88
Cdd:cd19127 6 GVEMPALGLG----VFQTPPEETAD--AVATALADGYRLIDTAAAYG--------NEREVGEGIRRSGVDRSdIFVTTKL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 glkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAV--ALEESVGELKKLQDEGKILHIGLSNVDLGELE 166
Cdd:cd19127 72 --------WISDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVPNDfdRTIQAYKALEKLLAEGRVRAIGVSNFTPEHLE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 167 RAekIARIESV----QNRCSPY-DREDyddgLLAACEERGITFLPYGPVGGHR--------AHTRLLDEPLLASLAEKYE 233
Cdd:cd19127 144 RL--IDATTVVpavnQVELHPYfSQKD----LRAFHRRLGIVTQAWSPIGGVMrygasgptGPGDVLQDPTITGLAEKYG 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 234 ATPYTIVLAWHLakSERILPIP---GASKIASAEDspkaaLLD--LEPEDLEKIDGLN 286
Cdd:cd19127 218 KTPAQIVLRWHL--QNGVSAIPksvHPERIAENID-----IFDfaLSAEDMAAIDALD 268
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-204 |
3.69e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 84.50 E-value: 3.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLG----GMPLSI---QGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKargRTKSVTVATKG 88
Cdd:cd19097 3 LALGtaqfGLDYGIankSGKPSEKEAKKILEYALKAGINTLDTAPAY-------GDSEKVLGKFLK---RLDKFKIITKL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 glkrPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHavDPAVAL---EESVGELKKLQDEGKILHIGLSNVDLGEL 165
Cdd:cd19097 73 ----PPLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLH--NPDDLLkhgGKLVEALLELKKEGLIRKIGVSVYSPEEL 146
|
170 180 190
....*....|....*....|....*....|....*....
gi 1276968131 166 ERAEKIARIESVQNRCSPYDREDYDDGLLAACEERGITF 204
Cdd:cd19097 147 EKALESFKIDIIQLPFNILDQRFLKSGLLAKLKKKGIEI 185
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
4-279 |
5.17e-19 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 85.00 E-value: 5.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 4 RELGRTGIRLFPIGLG-GMPLSIQGRPDEAQALrvIGASLDAGVAFIDSADVYCLDQtdiGHNERLIAKALK--ARGRTK 80
Cdd:cd19089 2 RRCGRSGLHLPAISLGlWHNFGDYTSPEEAREL--LRTAFDLGITHFDLANNYGPPP---GSAEENFGRILKrdLRPYRD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 SVTVATKGGLK---RPNGDWtrdASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGL 157
Cdd:cd19089 77 ELVISTKAGYGmwpGPYGDG---GSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 158 SNVDLGELERAEKI-----ARIESVQNRCSPYDREDyDDGLLAACEERGITFLPYGP-----------VGGHRAHTRLLD 221
Cdd:cd19089 154 SNYPGAKARRAIALlrelgVPLIIHQPRYSLLDRWA-EDGLLEVLEEAGIGFIAFSPlaqglltdkylNGIPPDSRRAAE 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276968131 222 EPL----------------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAA-LLDLEPEDL 279
Cdd:cd19089 233 SKFlteealtpekleqlrkLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALkNLDFSEEEL 307
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
10-283 |
2.11e-18 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 83.63 E-value: 2.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGGMPL-----SIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtDIGHNERLIAKALKARGRTKSVTV 84
Cdd:cd19146 8 GVRVSPLCLGAMSFgeawkSMMGECDKETAFKLLDAFYEQGGNFIDTANNY-----QGEESERWVGEWMASRGNRDEMVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 85 ATKGGLKRPNGDWTRDASPAQ------LRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLS 158
Cdd:cd19146 83 ATKYTTGYRRGGPIKIKSNYQgnhaksLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 159 N------VDLGELERAEKIARIESVQNRCSPYDReDYDDGLLAACEERGITFLPYGPVGGHRAHT--------------R 218
Cdd:cd19146 163 DtpawvvSKANAYARAHGLTQFVVYQGHWSAAFR-DFERDILPMCEAEGMALAPWGVLGQGQFRTeeefkrrgrsgrkgG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276968131 219 LLDEP------LLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKID 283
Cdd:cd19146 242 PQTEKerkvseKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIE 312
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
16-286 |
4.95e-18 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 82.07 E-value: 4.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGgmplSIQGRPDEAQalRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKArgrtksvtVATKGGLKRPN- 94
Cdd:cd19123 15 LGLG----TWKSKPGEVG--QAVKQALEAGYRHIDCAAIY--------GNEAEIGAALAE--------VFKEGKVKREDl 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 ----GDWTRDASPAQLRAACEASLKALQSDSITLYQLH---AVDPAV---------------ALEESVGELKKLQDEGKI 152
Cdd:cd19123 73 witsKLWNNSHAPEDVLPALEKTLADLQLDYLDLYLMHwpvALKKGVgfpesgedllslspiPLEDTWRAMEELVDKGLC 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 153 LHIGLSNVDLGELERAEKIARIESVQNRC--SPYDREDyddGLLAACEERGITFLPYGPVG-GHR-------AHTRLLDE 222
Cdd:cd19123 153 RHIGVSNFSVKKLEDLLATARIKPAVNQVelHPYLQQP---ELLAFCRDNGIHLTAYSPLGsGDRpaamkaeGEPVLLED 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276968131 223 PLLASLAEKYEATPYTIVLAWHLAKSERILPIPGASKiaSAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19123 230 PVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPE--RIQQNLEAAEVELDASDMATIAALD 291
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
9-253 |
6.33e-18 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 81.62 E-value: 6.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDE-AQALRvigASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKSVT---- 83
Cdd:cd19125 7 TGAKIPAVGLG----TWQADPGVvGNAVK---TAIKEGYRHIDCAAIY--------GNEKEIGKALKKLFEDGVVKredl 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 84 -VATKgglkrpngDWTRDASPAQLRAACEASLKALQSDSITLYQLH--------AVDPAVA------LEESVGELKKLQD 148
Cdd:cd19125 72 fITSK--------LWCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHwpvrlkkgAHMPEPEevlppdIPSTWKAMEKLVD 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 149 EGKILHIGLSNVDLGELERAEKIARIE-SV-QNRCSPYDREDyddGLLAACEERGITFLPYGPVG---GHRAHTRLLDEP 223
Cdd:cd19125 144 SGKVRAIGVSNFSVKKLEDLLAVARVPpAVnQVECHPGWQQD---KLHEFCKSKGIHLSAYSPLGspgTTWVKKNVLKDP 220
|
250 260 270
....*....|....*....|....*....|
gi 1276968131 224 LLASLAEKYEATPYTIVLAWHLAKSERILP 253
Cdd:cd19125 221 IVTKVAEKLGKTPAQVALRWGLQRGTSVLP 250
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
12-286 |
6.46e-18 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 81.06 E-value: 6.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 12 RLFP-IGLGGMPLSiqgrpdEAQALRVIGASLDAGVAFIDSADVYCldqtdighNERLIAKALKARGRTKS-VTVATKGg 89
Cdd:cd19134 9 NTMPvIGLGVGELS------DDEAERSVSAALEAGYRLIDTAAAYG--------NEAAVGRAIAASGIPRGeLFVTTKL- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 lkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVA-LEESVGELKKLQDEGKILHIGLSNVDLGELERA 168
Cdd:cd19134 74 -------ATPDQGFTASQAACRASLERLGLDYVDLYLIHWPAGREGkYVDSWGGLMKLREEGLARSIGVSNFTAEHLENL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 169 EKIARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGPVGghraHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKS 248
Cdd:cd19134 147 IDLTFFTPAVNQIELHPLLNQAE-LRKVNAQHGIVTQAYSPLG----VGRLLDNPAVTAIAAAHGRTPAQVLLRWSLQLG 221
|
250 260 270
....*....|....*....|....*....|....*....
gi 1276968131 249 ERILP-IPGASKIASAEDSPKaalLDLEPEDLEKIDGLN 286
Cdd:cd19134 222 NVVISrSSNPERIASNLDVFD---FELTADHMDALDGLD 257
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
16-285 |
8.46e-18 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 81.03 E-value: 8.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGgmplSIQGRPDEA-QALRVigaSLDAGVAFIDSADVYcldqtdigHNERLIAKALKargrtksvTVATKGGLKRPN 94
Cdd:cd19128 4 LGFG----TYKITESESkEAVKN---AIKAGYRHIDCAYYY--------GNEAFIGIAFS--------EIFKDGGVKRED 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 -----GDWTRDASPAQLRAACEASLKALQSDSITLYQLH---AVDP----------------AVALEESVGELKKLQDEG 150
Cdd:cd19128 61 lfitsKLWPTMHQPENVKEQLLITLQDLQLEYLDLFLIHwplAFDMdtdgdprddnqiqslsKKPLEDTWRAMEQCVDEK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 151 KILHIGLSNVDLGELERAEKIARIESVQNR--CSPYDRedyDDGLLAACEERGITFLPYGPVGGHRAHTRL--LDEPLLA 226
Cdd:cd19128 141 LTKNIGVSNYSTKLLTDLLNYCKIKPFMNQieCHPYFQ---NDKLIKFCIENNIHVTAYRPLGGSYGDGNLtfLNDSELK 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 227 SLAEKYEATPYTIVLAWHLAK-SERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGL 285
Cdd:cd19128 218 ALATKYNTTPPQVIIAWHLQKwPKNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
29-286 |
1.43e-17 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 79.93 E-value: 1.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 29 PDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG-RTKSVTVATKgglkrpngDWTRDASPAQLR 107
Cdd:cd19133 20 PDPEECERAVLEAIKAGYRLIDTAAAY--------GNEEAVGRAIKKSGiPREELFITTK--------LWIQDAGYEKAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 108 AACEASLKALQSDSITLYQLHavDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARIESVQNR--CSPYD 185
Cdd:cd19133 84 KAFERSLKRLGLDYLDLYLIH--QPFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQieTHPFN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 186 REDyddGLLAACEERGITFLPYGPVGGHRAHtrLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAED 265
Cdd:cd19133 162 QQI---EAVEFLKKYGVQIEAWGPFAEGRNN--LFENPVLTEIAEKYGKSVAQVILRWLIQRG--IVVIPKSVRPERIAE 234
|
250 260
....*....|....*....|...
gi 1276968131 266 SpkAALLD--LEPEDLEKIDGLN 286
Cdd:cd19133 235 N--FDIFDfeLSDEDMEAIAALD 255
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
10-253 |
4.60e-17 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 79.08 E-value: 4.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALK-----ARGRTKSVTV 84
Cdd:cd19111 1 GFPMPVIGLG----TYQSPPEEVRA--AVDYALFVGYRHIDTALSY--------QNEKAIGEALKwwlknGKLKREEVFI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 85 ATKGglkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLH-------------AVDPAVALEESVGELKKLQDEGK 151
Cdd:cd19111 67 TTKL--------PPVYLEFKDTEKSLEKSLENLKLPYVDLYLIHhpcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGK 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 152 ILHIGLSNVDLGELERAEKIARI--ESVQNRCSPY--DREdyddgLLAACEERGITFLPYGPVGghrAHTR--------- 218
Cdd:cd19111 139 VKSIGLSNFNPRQINKILAYAKVkpSNLQLECHAYlqQRE-----LRKFCNKKNIVVTAYAPLG---SPGRanqslwpdq 210
|
250 260 270
....*....|....*....|....*....|....*..
gi 1276968131 219 --LLDEPLLASLAEKYEATPYTIVLAWHLAKSERILP 253
Cdd:cd19111 211 pdLLEDPTVLAIAKELDKTPAQVLLRFVLQRGTGVLP 247
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
16-211 |
6.12e-17 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 79.51 E-value: 6.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSIQGrpDEAQALRVIGASLDAGVAFIDSADVYCLD---QTDiGHNERLIAKALKARGRTKSVTVATK-GGLK 91
Cdd:PRK10625 16 LGLGTMTFGEQN--SEADAHAQLDYAVAQGINLIDVAEMYPVPprpETQ-GLTETYIGNWLAKRGSREKLIIASKvSGPS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 92 RPNGDWTRdasPAQ------LRAACEASLKALQSDSITLYQLH-----------------AVDPAVALEESVGELKKLQD 148
Cdd:PRK10625 93 RNNDKGIR---PNQaldrknIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklgyswtDSAPAVSLLETLDALAEQQR 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1276968131 149 EGKILHIGLSNVD----LGELERAEK--IARIESVQNRCSPYDREdYDDGLLAACEERGITFLPYGPVG 211
Cdd:PRK10625 170 AGKIRYIGVSNETafgvMRYLHLAEKhdLPRIVTIQNPYSLLNRS-FEVGLAEVSQYEGVELLAYSCLA 237
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
1-284 |
6.61e-17 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 79.18 E-value: 6.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMpLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRTK 80
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFGSW-VTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYAN-----GQSEEIMGQAIKELGWPR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 S-VTVATK----GGLKRPNgdwTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHI 155
Cdd:cd19143 75 SdYVVSTKifwgGGGPPPN---DRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 156 GLSNVDLGELERAEKIARIESV------QNRCSPYDRE----DYD-----------------DGLLAACEERGItflPYG 208
Cdd:cd19143 152 GTSEWSAQQIEEAHEIADRLGLippvmeQPQYNLFHRErvevEYAplyekyglgtttwsplaSGLLTGKYNNGI---PEG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 209 PVGGHRAHTRLLDEPL------------LASLAEKYEATPYTIVLAWhLAKSERILP-IPGASKIASAEDSPKA--ALLD 273
Cdd:cd19143 229 SRLALPGYEWLKDRKEelgqekiekvrkLKPIAEELGCSLAQLAIAW-CLKNPNVSTvITGATKVEQLEENLKAleVLPK 307
|
330
....*....|.
gi 1276968131 274 LEPEDLEKIDG 284
Cdd:cd19143 308 LTPEVMEKIEA 318
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
16-209 |
3.93e-16 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 76.63 E-value: 3.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRTKsVTVATKGG-LKRPN 94
Cdd:cd19162 3 LGLGAASLGNLARAGEDEAAATLDAAWDAGIRYFDTAPLYGL-----GLSERRLGAALARHPRAE-YVVSTKVGrLLEPG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 GDWTRDASPAQL-------RAACEASLKALQSDSITLYQLHAVDP--AVALEESVGELKKLQDEGKILHIGLSNVDLGEL 165
Cdd:cd19162 77 AAGRPAGADRRFdfsadgiRRSIEASLERLGLDRLDLVFLHDPDRhlLQALTDAFPALEELRAEGVVGAIGVGVTDWAAL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1276968131 166 ERAEKIARIESV--QNRCSPYDREDYDDgLLAACEERGITFLPYGP 209
Cdd:cd19162 157 LRAARRADVDVVmvAGRYTLLDRRAATE-LLPLCAAKGVAVVAAGV 201
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
10-286 |
9.03e-16 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 75.78 E-value: 9.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 10 GIRLFPIGLGgmplSIQGRPDEaQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALK---ARGRTK--SVTV 84
Cdd:cd19116 8 GNEIPAIALG----TWKLKDDE-GVRQAVKHAIEAGYRHIDTAYLY--------GNEAEVGEAIRekiAEGVVKreDLFI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 85 ATKggLkrpngdWTRDASPAQLRAACEASLKALQSDSITLYQLH----------------AVDPAVALEESVGELKKLQD 148
Cdd:cd19116 75 TTK--L------WNSYHEREQVEPALRESLKRLGLDYVDLYLIHwpvafkenndsesngdGSLSDIDYLETWRGMEDLVK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 149 EGKILHIGLSNVDLGELERAEKIARIESVQNR--CSP-YDREDyddgLLAACEERGITFLPYGPVG-----GHRAHTRLL 220
Cdd:cd19116 147 LGLTRSIGVSNFNSEQINRLLSNCNIKPAVNQieVHPtLTQEK----LVAYCQSNGIVVMAYSPFGrlvprGQTNPPPRL 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 221 DEPLLASLAEKYEATPYTIVLAWHLakSERILPIPGASKIASAEDSpkAALLD--LEPEDLEKIDGLN 286
Cdd:cd19116 223 DDPTLVAIAKKYGKTTAQIVLRYLI--DRGVVPIPKSSNKKRIKEN--IDIFDfqLTPEEVAALNSFN 286
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
29-286 |
1.88e-15 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 74.48 E-value: 1.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 29 PDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARG-RTKSVTVATKGglkrpngdWTRDASPAQLR 107
Cdd:cd19156 20 QDGAEAENAVKWAIEAGYRHIDTAAIY--------KNEEGVGQGIRESGvPREEVFVTTKL--------WNSDQGYESTL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 108 AACEASLKALQSDSITLYQLH------AVDPAVALEesvgelkKLQDEGKILHIGLSNVDLGELERAEKIARIESVQNRC 181
Cdd:cd19156 84 AAFEESLEKLGLDYVDLYLIHwpvkgkFKDTWKAFE-------KLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 182 SPYDREDYDDgLLAACEERGITFLPYGPVG-GHrahtrLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKI 260
Cdd:cd19156 157 ELHPLLTQEP-LRKFCKEKNIAVEAWSPLGqGK-----LLSNPVLKAIGKKYGKSAAQVIIRWDIQHG--IITIPKSVHE 228
|
250 260
....*....|....*....|....*.
gi 1276968131 261 ASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19156 229 ERIQENFDVFDFELTAEEIRQIDGLN 254
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
42-285 |
1.93e-15 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 74.29 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 42 LDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATKgglkrpngDWTRDASPAQLRAACEASLKALQSD 120
Cdd:PRK11172 26 LELGYRAIDTAQIY--------DNEAAVGQAIAESGVPRDeLFITTK--------IWIDNLAKDKLIPSLKESLQKLRTD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 121 SITLYQLH--AVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERAekIA-----RIESVQNRCSPY--DREdydd 191
Cdd:PRK11172 90 YVDLTLIHwpSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQA--IAavgaeNIATNQIELSPYlqNRK---- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 192 gLLAACEERGITFLPYGPVgghrAHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKSERIlpIPGASKIASAEDSPKAAL 271
Cdd:PRK11172 164 -VVAFAKEHGIHVTSYMTL----AYGKVLKDPVIARIAAKHNATPAQVILAWAMQLGYSV--IPSSTKRENLASNLLAQD 236
|
250
....*....|....
gi 1276968131 272 LDLEPEDLEKIDGL 285
Cdd:PRK11172 237 LQLDAEDMAAIAAL 250
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
37-286 |
2.92e-15 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 74.44 E-value: 2.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 37 VIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKSVT-----VATKgglkrpngDWTRDAspAQLRAACE 111
Cdd:cd19112 29 LILNAIKIGYRHFDCAADY--------KNEKEVGEALAEAFKTGLVKredlfITTK--------LWNSDH--GHVIEACK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 112 ASLKALQSDSITLYQLH-----------------------AVDPAVALEESVGELKKLQDEGKILHIGLSNVDLGELERA 168
Cdd:cd19112 91 DSLKKLQLDYLDLYLVHfpvatkhtgvgttgsalgedgvlDIDVTISLETTWHAMEKLVSAGLVRSIGISNYDIFLTRDC 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 169 EKIARIESVQNRCS--PYDREDyddGLLAACEERGITFLPYGPVGGHRAHTRL------LDEPLLASLAEKYEATPYTIV 240
Cdd:cd19112 171 LAYSKIKPAVNQIEthPYFQRD---SLVKFCQKHGISVTAHTPLGGAAANAEWfgsvspLDDPVLKDLAKKYGKSAAQIV 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1276968131 241 LAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19112 248 LRWGIQRN--TAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLD 291
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
32-286 |
5.24e-15 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 73.02 E-value: 5.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 32 AQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKS-VTVATKgglkrpngDWTRDASPAQLRAAC 110
Cdd:cd19130 23 ADTQRAVATALEVGYRHIDTAAIY--------GNEEGVGAAIAASGIPRDeLFVTTK--------LWNDRHDGDEPAAAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 111 EASLKALQSDSITLYQLHAVDPAVALEESVGE-LKKLQDEGKILHIGLSNVDLGELER-AEKIARIESV-QNRCSPY--D 185
Cdd:cd19130 87 AESLAKLGLDQVDLYLVHWPTPAAGNYVHTWEaMIELRAAGRTRSIGVSNFLPPHLERiVAATGVVPAVnQIELHPAyqQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 186 REDYDdgllaACEERGITFLPYGPVGghraHTRLLDEPLLASLAEKYEATPYTIVLAWHLAKSERIlpIPGASKIASAED 265
Cdd:cd19130 167 RTIRD-----WAQAHDVKIEAWSPLG----QGKLLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVV--FPKSVRRERMED 235
|
250 260
....*....|....*....|.
gi 1276968131 266 SPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19130 236 NLDVFDFDLTDTEIAAIDALD 256
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-231 |
1.24e-14 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 72.74 E-value: 1.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPLSIQGRPDEaQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRTKSVT-----VATKGG 89
Cdd:cd19099 5 SLGLGTYRGDSDDETDE-EYREALKAALDSGINVIDTAINYRG-----GRSERLIGKALRELIEKGGIKrdevvIVTKAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 -------------------LKRPNGDWTRDA------SPAQLRAACEASLKALQSDSITLYQLHavDPAVALEESVGE-- 142
Cdd:cd19099 79 yipgdgdeplrplkyleekLGRGLIDVADSAglrhciSPAYLEDQIERSLKRLGLDTIDLYLLH--NPEEQLLELGEEef 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 143 ----------LKKLQDEGKILHIGLS-------------NVDLGELERAEKIA-----RIESVQNRCSPYDRE------- 187
Cdd:cd19099 157 ydrleeafeaLEEAVAEGKIRYYGIStwdgfrappalpgHLSLEKLVAAAEEVggdnhHFKVIQLPLNLLEPEalteknt 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1276968131 188 --DYDDGLLAACEERGITFLPYGP-----VGGHRAHTRLLDEPLLASLAEK 231
Cdd:cd19099 237 vkGEALSLLEAAKELGLGVIASRPlnqgqLLGELRLADLLALPGGATLAQR 287
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
1-245 |
2.90e-14 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 71.73 E-value: 2.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPlSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLDQTdighnERLIAKALKARG-RT 79
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWS-TFSTAISEEQAEEIVTLAYENGINYFDTSDAFTSGQA-----ETELGRILKKKGwKR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATKggLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSN 159
Cdd:cd19142 75 SSYIVSTK--IYWSYGSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 160 VDLGELERAEKIARiesvQNRCSP-------YD---REDYDDGLLAACEERGITFLPYGPV------------------- 210
Cdd:cd19142 153 WSPVEIMEAFSIAR----QFNCPTpiceqseYHmfcREKMELYMPELYNKVGVGLITWSPLslgldpgiseetrrlvtkl 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1276968131 211 ------------------GGHRAHTRLLDeplLASLAEKYEATPYTIVLAWHL 245
Cdd:cd19142 229 sfksskykvgsdgngiheETRRASHKLRE---LSLIAERLGCDLTQLLIAWSL 278
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
9-285 |
5.92e-14 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 70.25 E-value: 5.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKArgrtksvtvATKG 88
Cdd:cd19121 8 TGASIPAVGLG----TWQAKAGEVKA--AVAHALKIGYRHIDGALCY--------QNEDEVGEGIKE---------AIAG 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 GLKRPN-----GDWTRDASPAQLraACEASLKALQSDSITLYQLH----------------------AVDPAVALEESVG 141
Cdd:cd19121 65 GVKREDlfvttKLWSTYHRRVEL--CLDRSLKSLGLDYVDLYLVHwpvllnpngnhdlfptlpdgsrDLDWDWNHVDTWK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 142 ELKKLQDEGKILHIGLSNVDLGELER----AEKIARIESVQNRcsPYDREDyddGLLAACEERGITFLPYGPVGGhrAHT 217
Cdd:cd19121 143 QMEKVLKTGKTKAIGVSNYSIPYLEEllkhATVVPAVNQVENH--PYLPQQ---ELVDFCKEKGILIEAYSPLGS--TGS 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 218 RLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSpkAALLDLEPEDLEKIDGL 285
Cdd:cd19121 216 PLISDEPVVEIAKKHNVGPGTVLISYQVARG--AVVLPKSVTPDRIKSN--LEIIDLDDEDMNKLNDI 279
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
16-286 |
6.61e-14 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 70.63 E-value: 6.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALK---ARGRTKS-----VTVATK 87
Cdd:cd19155 15 VGLG----TWQSSPEEIET--AVDTALEAGYRHIDTAYVY--------RNEAAIGNVLKkwiDSGKVKReelfiVTKLPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 88 GGLKRPNgdwtrdaspaqLRAACEASLKALQSDSITLYQLHA----------------------------VDPAVALEES 139
Cdd:cd19155 81 GGNRREK-----------VEKFLLKSLEKLQLDYVDLYLIHFpvgslskeddsgkldptgehkqdyttdlLDIWKAMEAQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 140 VgelkklqDEGKILHIGLSNVDLGELERAEKIARIE--SVQNRCSPYDREDyddGLLAACEERGITFLPYGPVGGHRAH- 216
Cdd:cd19155 150 V-------DQGLTRSIGLSNFNREQMARILKNARIKpaNLQVELHVYLQQK---DLVDFCSTHSITVTAYAPLGSPGAAh 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 217 ------------TRLLDEPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDG 284
Cdd:cd19155 220 fspgtgspsgssPDLLQDPVVKAIAERHGKSPAQVLLRWLMQRG--VVVIPKSTNAARIKENFQVFDFELTEADMAKLSS 297
|
..
gi 1276968131 285 LN 286
Cdd:cd19155 298 LD 299
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
16-286 |
7.90e-14 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 70.37 E-value: 7.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGgmplSIQGRPDE-AQALRVigaSLDAGVAFIDSADVYcldqtdigHNERLIAKALKAR-----GRTKSVTVATKgg 89
Cdd:cd19110 7 VGLG----TWKASPGEvTEAVKV---AIDAGYRHFDCAYLY--------HNESEVGAGIREKikegvVRREDLFIVSK-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 lkrpngDWTRDASPAQLRAACEASLKALQSDSITLYQLH------AVDPAVALEES----------VGELKKLQD---EG 150
Cdd:cd19110 70 ------LWCTCHKKSLVKTACTRSLKALKLNYLDLYLIHwpmgfkPGEPDLPLDRSgmvipsdtdfLDTWEAMEDlviEG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 151 KILHIGLSNVDLGELERA--EKIARIESVQNR--CSPYDREDyddGLLAACEERGITFLPYGPVGGHRAHTRLLDEPLLA 226
Cdd:cd19110 144 LVKNIGVSNFNHEQLERLlnKPGLRVKPVTNQieCHPYLTQK---KLISFCQSRNVSVTAYRPLGGSCEGVDLIDDPVIQ 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 227 SLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19110 221 RIAKKHGKSPAQILIRFQIQRN--VIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLD 278
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
16-245 |
8.03e-14 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 69.72 E-value: 8.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 16 IGLGGMPLSIQgrpdeaQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTK-SVTVATKgglkrpn 94
Cdd:PRK11565 18 LGLGVWQASNE------EVITAIHKALEVGYRSIDTAAIY--------KNEEGVGKALKEASVAReELFITTK------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 95 gDWTRDASPAqlRAACEASLKALQSDSITLYQLHAvdPAVALEESVG---ELKKLQDEGKILHIGLSNVDLGELER---- 167
Cdd:PRK11565 77 -LWNDDHKRP--REALEESLKKLQLDYVDLYLMHW--PVPAIDHYVEawkGMIELQKEGLIKSIGVCNFQIHHLQRlide 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 168 ---AEKIARIE---SVQNRcspydredyddGLLAACEERGITFLPYGPV--GGHRahtrLLDEPLLASLAEKYEATPYTI 239
Cdd:PRK11565 152 tgvTPVINQIElhpLMQQR-----------QLHAWNATHKIQTESWSPLaqGGKG----VFDQKVIRDLADKYGKTPAQI 216
|
....*.
gi 1276968131 240 VLAWHL 245
Cdd:PRK11565 217 VIRWHL 222
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
3-178 |
2.73e-13 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 68.72 E-value: 2.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 3 TRELGRTGIRLFPIGLGGMPLS--IQGRPDEAQALRVIGASLDAGVAFIDSADVYCLDQTdighnERLIAKALKARGRTK 80
Cdd:cd19153 2 GETLEIALGNVSPVGLGTAALGgvYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESS-----EAVLGKALAALQVPR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 S-VTVATKGGLKRPNG-DWTRDAspaqLRAACEASLKALQSDSITLYQLHAV---DPAVALEESVGELKKLQDEGKILHI 155
Cdd:cd19153 77 SsYTVATKVGRYRDSEfDYSAER----VRASVATSLERLHTTYLDVVYLHDIefvDYDTLVDEALPALRTLKDEGVIKRI 152
|
170 180
....*....|....*....|...
gi 1276968131 156 GLSNVDLGELERAEKIARIESVQ 178
Cdd:cd19153 153 GIAGYPLDTLTRATRRCSPGSLD 175
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
9-285 |
4.67e-13 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 67.91 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKargrtksvTVATKG 88
Cdd:cd19119 8 TGASIPALGLG----TASPHEDRAEVKEAVEAAIKEGYRHIDTAYAY--------ETEDFVGEAIK--------RAIDDG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 GLKRPNGDWTRDASPA---QLRAACEASLKALQSDSITLYQLHAVDPAVALEESVG------------------------ 141
Cdd:cd19119 68 SIKREELFITTKVWPTfydEVERSLDESLKALGLDYVDLLLVHWPVCFEKDSDDSGkpftpvnddgktryaasgdhitty 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 142 -ELKKLQDEGKILHIGLSNVDLGELERAEKIARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGPVGGHRAhtRLL 220
Cdd:cd19119 148 kQLEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMD-LRDFCFKHGILVTAYSPLGSHGA--PNL 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276968131 221 DEPLLASLAEKYEATPYTIVLAWHLakSERILPIPGASKIASAEDSPKAALLDlePEDLEKIDGL 285
Cdd:cd19119 225 KNPLVKKIAEKYNVSTGDILISYHV--RQGVIVLPKSLKPVRIVSNGKIVSLT--KEDLQKLDDI 285
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
4-280 |
7.26e-13 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 67.43 E-value: 7.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 4 RELGRTGIRLFPIGLGgMPLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldQTDIGHNERLIAKALKA--RGRTKS 81
Cdd:cd19151 3 NRCGRSGLKLPAISLG-LWHNFGDVDRYENSRAMLRRAFDLGITHFDLANNY---GPPPGSAEENFGRILKEdlKPYRDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 82 VTVATKGGLKR---PNGDWtrdASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLS 158
Cdd:cd19151 79 LIISTKAGYTMwpgPYGDW---GSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGIS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 159 NVDLGELERAEKIARIESV-----QNRCSPYDREdYDDGLLAACEERGITFLPYGPVGGHRAHTRLL------------D 221
Cdd:cd19151 156 NYPPEEAREAAAILKDLGTpclihQPKYSMFNRW-VEEGLLDVLEEEGIGCIAFSPLAQGLLTDRYLngipedsraakgS 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276968131 222 EPL---------------LASLAEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSpKAAL--LDLEPEDLE 280
Cdd:cd19151 235 SFLkpeqiteeklakvrrLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDA-VGALdnREFSEEELA 309
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
9-285 |
1.42e-12 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 66.28 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 9 TGIRLFPIGLGgmplSIQGRPDEAQAlrVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKArgrtksvTVATKG 88
Cdd:cd19118 3 TGNKIPAIGLG----TWQAEPGEVGA--AVKIALKAGYRHLDLAKVY--------QNQHEVGQALKE-------LLKEEP 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 89 GLKRpnGD-------WTRDASPAQLRAACEASLKALQSDSITLYQLH------------------------AVDPAVALE 137
Cdd:cd19118 62 GVKR--EDlfitsklWNNSHRPEYVEPALDDTLKELGLDYLDLYLIHwpvafkptgdlnpltavptnggevDLDLSVSLV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 138 ESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARIESVQNRCSPYDREDYDDgLLAACEERGITFLPYGPVGGHRA-H 216
Cdd:cd19118 140 DTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDE-LVDYCKSKNIHITAYSPLGNNLAgL 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 217 TRLLDEPLLASLAEKYEATPYTIVLAWHLAKSERILPIP-GASKIASAEDSpkaalLDLEPEDLEKIDGL 285
Cdd:cd19118 219 PLLVQHPEVKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSvTPSRIRSNFEQ-----VELSDDEFNAVTAL 283
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
41-286 |
2.33e-12 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 65.98 E-value: 2.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 41 SLDAGVAFIDSADVYcldqtdigHNERLIAKALK---ARGRTKSVTVATKGGLkrpngdWTRDASPAQLRAACEASLKAL 117
Cdd:cd19109 30 AIDTGYRHIDGAYIY--------QNEHEVGQAIRekiAEGKVKREDIFYCGKL------WNTCHPPELVRPTLERTLKVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 118 QSDSITLYQLH---AVDPAVA----------------LEESVGELKKLQDEGKILHIGLSNVDLGELE----RAEKIARI 174
Cdd:cd19109 96 QLDYVDLYIIEmpmAFKPGDEiyprdengkwlyhktnLCATWEALEACKDAGLVKSIGVSNFNRRQLElilnKPGLKHKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 175 ESVQNRCSPYDREDyddGLLAACEERGITFLPYGPVGGHRAHT-------RLLDEPLLASLAEKYEATPYTIVLAWHLAK 247
Cdd:cd19109 176 VSNQVECHPYFTQP---KLLEFCQQHDIVIVAYSPLGTCRDPIwvnvsspPLLEDPLLNSIGKKYNKTAAQVVLRFNIQR 252
|
250 260 270
....*....|....*....|....*....|....*....
gi 1276968131 248 SerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19109 253 G--VVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALN 289
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
15-158 |
5.59e-12 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 64.61 E-value: 5.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPLSIQGRPDEAQA--LRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKA------RgrtKSVTVAT 86
Cdd:cd19164 15 PLIFGAATFSYQYTTDPESIppVDIVRRALELGIRAFDTSPYY-------GPSEIILGRALKAlrdefpR---DTYFIIT 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276968131 87 KGGLKrpnGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDpAVALEE---SVGELKKLQDEGKILHIGLS 158
Cdd:cd19164 85 KVGRY---GPDDFDYSPEWIRASVERSLRRLHTDYLDLVYLHDVE-FVADEEvleALKELFKLKDEGKIRNVGIS 155
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
29-286 |
5.93e-12 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 64.56 E-value: 5.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 29 PDE---AQALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALkargRTKsvtvATKGGLKRPngD-------WT 98
Cdd:cd19108 21 PEEvpkSKALEATKLAIDAGFRHIDSAYLY--------QNEEEVGQAI----RSK----IADGTVKRE--DifytsklWC 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 99 RDASPAQLRAACEASLKALQSDSITLYQLH---AVDPAVAL--EESVGE--------------LKKLQDEGKILHIGLSN 159
Cdd:cd19108 83 TFHRPELVRPALEKSLKKLQLDYVDLYLIHfpvALKPGEELfpKDENGKlifdtvdlcatweaMEKCKDAGLAKSIGVSN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 160 VDLGELERaekI-----ARIESVQNR--CSPYDREDyddGLLAACEERGITFLPYGPVGGHRaHTR--------LLDEPL 224
Cdd:cd19108 163 FNRRQLEM---IlnkpgLKYKPVCNQveCHPYLNQS---KLLDFCKSKDIVLVAYSALGSQR-DKEwvdqnspvLLEDPV 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276968131 225 LASLAEKYEATPYTIVLAWH-------LAKS---ERIlpipgaskiasaEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19108 236 LCALAKKHKRTPALIALRYQlqrgvvvLAKSfneKRI------------KENLQVFEFQLTSEDMKALDGLN 295
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
109-286 |
3.58e-11 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 62.44 E-value: 3.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 109 ACEASLKALQSDSITLYQLH------AVDPAV------------------ALEESVGELKKLQDEGKILHIGLSNVDLGE 164
Cdd:cd19115 92 ICRKQLADWGIDYFDLFLIHfpialkYVDPAVryppgwfydgkkvefsnaPIQETWTAMEKLVDKGLARSIGVSNFSAQL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 165 LERAEKIARIE--SVQNRCSPYDREDyddGLLAACEERGITFLPY---GPVG-------GHRAHTRLLDEPLLASLAEKY 232
Cdd:cd19115 172 LMDLLRYARIRpaTLQIEHHPYLTQP---RLVKYAQKEGIAVTAYssfGPQSfleldlpGAKDTPPLFEHDVIKSIAEKH 248
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1276968131 233 EATPYTIVLAWhlAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19115 249 GKTPAQVLLRW--ATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALD 300
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
4-163 |
5.78e-11 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 62.10 E-value: 5.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 4 RELGRTGIRLFPIGLGGMPL-SIQGRPDEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHN--ERLIAKALKARGRTK 80
Cdd:PLN02587 2 RELGSTGLKVSSVGFGASPLgSVFGPVSEEDAIASVREAFRLGINFFDTSPYY-------GGTlsEKVLGKALKALGIPR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 81 -SVTVATKGGLKRPNGDWtrdaSPAQLRAACEASLKALQSDSITLYQLHAVDPAvALEESVGE----LKKLQDEGKILHI 155
Cdd:PLN02587 75 eKYVVSTKCGRYGEGFDF----SAERVTKSVDESLARLQLDYVDILHCHDIEFG-SLDQIVNEtipaLQKLKESGKVRFI 149
|
....*...
gi 1276968131 156 GLSNVDLG 163
Cdd:PLN02587 150 GITGLPLA 157
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
15-202 |
7.42e-11 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 61.47 E-value: 7.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPL-SIQGRPDEAQALRVIGASLDAGVAFIDSADVYCLdqtdiGHNERLIAKALKARGRTKSV--------TVA 85
Cdd:cd19152 2 KLGFGTAPLgNLYEAVSDEEAKATLVAAWDLGIRYFDTAPWYGA-----GLSEERLGAALRELGREDYVistkvgrlLVP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 86 TKGGLKRPNGDW--------TRDASPAQLRAACEASLKALQSDSITLYQLHAVDP-----------AVALEESVGELKKL 146
Cdd:cd19152 77 LQEVEPTFEPGFwnplpfdaVFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEdlagaesdehfAQAIKGAFRALEEL 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 147 QDEGKILHIGLSNVDLGELERAEKIARIESV--QNRCSPYDREDYDDgLLAACEERGI 202
Cdd:cd19152 157 REEGVIKAIGLGVNDWEVILRILEEADLDWVmlAGRYTLLDHSAARE-LLPECEKRGV 213
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-173 |
1.35e-09 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 58.07 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMpLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCldqtdIGHNERLIAKALKARG-RT 79
Cdd:cd19160 3 MKYRNLGKSGLRVSCLGLGTW-VTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYA-----AGKAERTLGNILKSKGwRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATK---GGlkrpNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIG 156
Cdd:cd19160 77 SSYVVTTKiywGG----QAETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWG 152
|
170
....*....|....*..
gi 1276968131 157 LSNVDLGELERAEKIAR 173
Cdd:cd19160 153 TSRWSAMEIMEAYSVAR 169
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
33-286 |
4.57e-09 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 56.27 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 33 QALRVIGASLDAGVAFIDSADVYcldqtdigHNERLIAKALKARGRTKSVtvatkgglKRPN-----GDWTRDASPAQLR 107
Cdd:cd19107 18 QVTEAVKVAIDAGYRHIDCAYVY--------QNENEVGEAIQEKIKEQVV--------KREDlfivsKLWCTFHEKGLVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 108 AACEASLKALQSDSITLYQLH--------------------------AVDPAVALEESVgelkklqDEGKILHIGLSNVD 161
Cdd:cd19107 82 GACQKTLSDLKLDYLDLYLIHwptgfkpgkelfpldesgnvipsdttFLDTWEAMEELV-------DEGLVKAIGVSNFN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 162 LGELER-------AEKIArieSVQNRCSPYDREDyddGLLAACEERGITFLPYGPVGG-HRAHTR-----LLDEPLLASL 228
Cdd:cd19107 155 HLQIERilnkpglKYKPA---VNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPLGSpDRPWAKpedpsLLEDPKIKEI 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1276968131 229 AEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19107 229 AAKHNKTTAQVLIRFPIQRN--LVVIPKSVTPERIAENFKVFDFELSSEDMATILSFN 284
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-173 |
2.64e-08 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 53.94 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMpLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCldqtdIGHNERLIAKALKARG-RT 79
Cdd:cd19158 1 QFYRNLGKSGLRVSCLGLGTW-VTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYA-----AGKAEVVLGNIIKKKGwRR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATK---GGlkrpNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIG 156
Cdd:cd19158 75 SSLVITTKifwGG----KAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWG 150
|
170
....*....|....*..
gi 1276968131 157 LSNVDLGELERAEKIAR 173
Cdd:cd19158 151 TSRWSSMEIMEAYSVAR 167
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
4-173 |
7.48e-08 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 52.45 E-value: 7.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 4 RELGRTGIRLFPIGLGGMpLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCldqtdIGHNERLIAKALKARG-RTKSV 82
Cdd:cd19141 3 RNLGKSGLRVSCLGLGTW-VTFGSQISDEVAEELVTLAYENGINLFDTAEVYA-----AGKAEIVLGKILKKKGwRRSSY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 83 TVATK---GGlkrpNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSN 159
Cdd:cd19141 77 VITTKifwGG----KAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSR 152
|
170
....*....|....
gi 1276968131 160 VDLGELERAEKIAR 173
Cdd:cd19141 153 WSAMEIMEAYSVAR 166
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
21-286 |
1.91e-07 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 51.40 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 21 MPLSIQG--RPDEAQALRVIGASLDAGVAFIDSADVYClDQTDIGHN-ERLIAKALKARgrtKSVTVATKgglkrpngDW 97
Cdd:cd19114 4 MPLVGFGtaKIKANETEEVIYNAIKVGYRLIDGALLYG-NEAEVGRGiRKAIQEGLVKR---EDLFIVTK--------LW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 98 TRDASPAQLRAACEASLKALQSDSITLYQLH------AVDPA-------------------VALEESVGELKKLQDEGKI 152
Cdd:cd19114 72 NNFHGKDHVREAFDRQLKDYGLDYIDLYLIHfpipaaYVDPAenypflwkdkelkkfpleqSPMQECWREMEKLVDAGLV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 153 LHIGLSNVDLGELERAEKIARIES--VQNRCSPYDREDYddgLLAACEERGITFLPYGPVGG--------HRAH-TRLLD 221
Cdd:cd19114 152 RNIGIANFNVQLILDLLTYAKIKPavLQIEHHPYLQQKR---LIDWAKKQGIQITAYSSFGNavytkvtkHLKHfTNLLE 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276968131 222 EPLLASLAEKYEATPYTIVLAWHLAKSerILPIPGASKIASAEDSPKAALLDLEPEDLEKIDGLN 286
Cdd:cd19114 229 HPVVKKLADKHKRDTGQVLLRWAVQRN--ITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELE 291
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
4-280 |
2.00e-07 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 51.30 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 4 RELGRTGIRLFPIGLGGMPLSIQGRPDEAQAlRVIGASLDAGVAFIDSADVYcldQTDIGHNERLIAKALKA--RGRTKS 81
Cdd:cd19150 3 RRCGKSGLKLPALSLGLWHNFGDDTPLETQR-AILRTAFDLGITHFDLANNY---GPPPGSAEENFGRILREdfAGYRDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 82 VTVATKGGLKR---PNGDWtrdASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLS 158
Cdd:cd19150 79 LIISTKAGYDMwpgPYGEW---GSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGIS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 159 NVDLGELERAEKIARIESV-----QNRCSPYDREDYDDGLLAACEERGITFLPYGPVG--------------GHRAH--- 216
Cdd:cd19150 156 SYSPERTREAAAILRELGTpllihQPSYNMLNRWVEESGLLDTLQELGVGCIAFTPLAqglltdkylngipeGSRASker 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276968131 217 ---TRLLDEPLLASL------AEKYEATPYTIVLAWHLAKSERILPIPGASKIASAEDSPKA-ALLDLEPEDLE 280
Cdd:cd19150 236 slsPKMLTEANLNSIralneiAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGAlDNLTFSADELA 309
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
97-283 |
2.50e-07 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 51.08 E-value: 2.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 97 WTRDASPAQLRAACEASLKALQSDSITLYQLHAvdPAVALEESVGELK-------------------------KLQDEGK 151
Cdd:cd19122 79 WNHLHEPEDVKWSIDNSLKNLKLDYIDLFLVHW--PIAAEKNDQRSPKlgpdgkyvilkdltenpeptwrameEIYESGK 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 152 ILHIGLSNVDLGELERAEKIARIESVQNRCS--PY--DREdyddgLLAACEERGITFLPYGPVGGHR----AHTRLLDEP 223
Cdd:cd19122 157 AKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEihPFlpNEE-----LVDYCFSNDILPEAYSPLGSQNqvpsTGERVSENP 231
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276968131 224 LLASLAEKYEATPYTIVLAWHLAKSERILPIPGA-SKIASAEDSPkaallDLEPEDLEKID 283
Cdd:cd19122 232 TLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTpSRIESNFKSI-----ELSDEDFEAIN 287
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
134-286 |
4.30e-07 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 50.14 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 134 VALEESVGELKKLQDEGKILHIGLSNVDLGELERAEKIARIESV--QNRCSPYDREDYddgLLAACEERGITFLPYGPVG 211
Cdd:cd19113 140 VPILDTWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAvlQIEHHPYLQQPK---LIEYAQKAGITITAYSSFG 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 212 GHR----AHTRLLDEPLL------ASLAEKYEATPYTIVLAWhlAKSERILPIPGASKIASAEDSPKAALLDLEPEDLEK 281
Cdd:cd19113 217 PQSfvelNQGRALNTPTLfehdtiKSIAAKHNKTPAQVLLRW--ATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEE 294
|
....*
gi 1276968131 282 IDGLN 286
Cdd:cd19113 295 IAKLD 299
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-173 |
5.60e-07 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 50.04 E-value: 5.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMpLSIQGRPDEAQALRVIGASLDAGVAFIDSADVYCldqtdIGHNERLIAKALKARG-RT 79
Cdd:cd19159 1 MKYRNLGKSGLRVSCLGLGTW-VTFGGQISDEVAERLMTIAYESGVNLFDTAEVYA-----AGKAEVILGSIIKKKGwRR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATK---GGlkrpNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIG 156
Cdd:cd19159 75 SSLVITTKlywGG----KAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWG 150
|
170
....*....|....*..
gi 1276968131 157 LSNVDLGELERAEKIAR 173
Cdd:cd19159 151 TSRWSAMEIMEAYSVAR 167
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-283 |
1.29e-06 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 49.22 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 1 MNTRELGRTGIRLFPIGLGGMPLSIQGRPDEAQAlRVIGASLDAGVAFIDSADVYCLDQTDIGHN-ERLIAKALKARgrT 79
Cdd:PRK09912 13 MQYRYCGKSGLRLPALSLGLWHNFGHVNALESQR-AILRKAFDLGITHFDLANNYGPPPGSAEENfGRLLREDFAAY--R 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 80 KSVTVATKGGLKRPNGDWTRDASPAQLRAACEASLKALQSDSITLYQLHAVDPAVALEESVGELKKLQDEGKILHIGLSN 159
Cdd:PRK09912 90 DELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 160 VD------LGELERAEKIARIESvQNRCSPYDREDYDDGLLAACEERGITFLPYGPVG--------------GHRAH--- 216
Cdd:PRK09912 170 YSpertqkMVELLREWKIPLLIH-QPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAqglltgkylngipqDSRMHreg 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 217 -------TRLLDEP------LLASLAEKYEATPYTIVLAWhLAKSERILPI-PGASKIASAEDSPKA-ALLDLEPEDLEK 281
Cdd:PRK09912 249 nkvrgltPKMLTEAnlnslrLLNEMAQQRGQSMAQMALSW-LLKDERVTSVlIGASRAEQLEENVQAlNNLTFSTEELAQ 327
|
..
gi 1276968131 282 ID 283
Cdd:PRK09912 328 ID 329
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
15-209 |
7.94e-04 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 40.39 E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 15 PIGLGGMPLSIQGRP-DEAQALRVIGASLDAGVAFIDSADVYcldqtdiGHN--ERLIAKALKARGRtKSVTVATKGG-- 89
Cdd:cd19161 2 ELGLGTAGLGNLYTAvSNADADATLDAAWDSGIRYFDTAPMY-------GHGlaEHRLGDFLREKPR-DEFVLSTKVGrl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 90 LK------RPNGDWTRDASPAQ----------LRAAcEASLKALQSDSITLYQLHAVDP------------AVALEESVG 141
Cdd:cd19161 74 LKparegsVPDPNGFVDPLPFEivydysydgiMRSF-EDSLQRLGLNRIDILYVHDIGVythgdrkerhhfAQLMSGGFK 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 142 ELKKLQDEGKILHIGLSNVDLGELERAEKIARIES--VQNRCSPYDReDYDDGLLAACEERGITFLPYGP 209
Cdd:cd19161 153 ALEELKKAGVIKAFGLGVNEVQICLEALDEADLDCflLAGRYSLLDQ-SAEEEFLPRCEQRGTSLVIGGV 221
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
31-173 |
1.37e-03 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 39.64 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276968131 31 EAQALRVIGASLDAGVAFIDSADVYcldqtdiGHNERLIAKALKARGRTK-SVTVATKGGLkRPNGDWTRDASP------ 103
Cdd:cd19098 34 RAHTHAVLDAAWAAGVRYFDAARSY-------GRAEEFLGSWLRSRNIAPdAVFVGSKWGY-TYTADWQVDAAVhevkdh 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276968131 104 --AQLRAACEASLKALqSDSITLYQLHAVDPAVAL---EESVGELKKLQDEGKILHIGLSNVDLGE-LERAEKIAR 173
Cdd:cd19098 106 slARLLKQWEETRSLL-GKHLDLYQIHSATLESGVledADVLAALAELKAEGVKIGLSLSGPQQAEtLRRALEIEI 180
|
|
| |
