NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|127590|sp|P01104|]
View 

RecName: Full=Transforming protein Myb

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 13851052)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a LMSTEN motif and Cmyb C-terminal domain

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 18-126 3.90e-30

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 120.47  E-value: 3.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590     18 ELNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKhLKG--RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRW 95
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 127590     96 AEIAKLLPGRTDNAVKNHWNSTMRRKVEQEG 126
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 197-242 2.06e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


:

Pssm-ID: 462332  Cd Length: 47  Bit Score: 80.69  E-value: 2.06e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 127590     197 NIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKGQQ 242
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Cmyb_C super family cl07814
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 327-370 1.76e-15

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


The actual alignment was detected with superfamily member pfam09316:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 73.16  E-value: 1.76e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 127590     327 QLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHKDQT 370
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQT 44
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 1-32 8.65e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 42.68  E-value: 8.65e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 127590       1 NRTDVQCQHRWQKVLNPELNKGPWTKEEDQRV 32
Cdd:pfam13921  29 RRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 18-126 3.90e-30

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 120.47  E-value: 3.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590     18 ELNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKhLKG--RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRW 95
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 127590     96 AEIAKLLPGRTDNAVKNHWNSTMRRKVEQEG 126
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 18-120 1.45e-29

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 119.51  E-value: 1.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590    18 ELNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 97
Cdd:COG5147  17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                        90       100
                ....*....|....*....|...
gi 127590    98 IAKLLPGRTDNAVKNHWNSTMRR 120
Cdd:COG5147  97 IADYKDRRTAQQCVERYVNTLED 119
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 197-242 2.06e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 80.69  E-value: 2.06e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 127590     197 NIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKGQQ 242
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 24-82 3.91e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.43  E-value: 3.91e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 127590      24 WTKEEDQRVIEHVQKYGPKrWSDIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDR 82
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
21-69 8.79e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 73.41  E-value: 8.79e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 127590       21 KGPWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCRERWHNHLNP 69
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 23-67 2.19e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 72.22  E-value: 2.19e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 127590    23 PWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCRERWHNHL 67
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 327-370 1.76e-15

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 73.16  E-value: 1.76e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 127590     327 QLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHKDQT 370
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQT 44
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 1-32 8.65e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 42.68  E-value: 8.65e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 127590       1 NRTDVQCQHRWQKVLNPELNKGPWTKEEDQRV 32
Cdd:pfam13921  29 RRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 18-126 3.90e-30

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 120.47  E-value: 3.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590     18 ELNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKhLKG--RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRW 95
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 127590     96 AEIAKLLPGRTDNAVKNHWNSTMRRKVEQEG 126
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 18-120 1.45e-29

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 119.51  E-value: 1.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590    18 ELNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 97
Cdd:COG5147  17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                        90       100
                ....*....|....*....|...
gi 127590    98 IAKLLPGRTDNAVKNHWNSTMRR 120
Cdd:COG5147  97 IADYKDRRTAQQCVERYVNTLED 119
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 19-133 3.95e-29

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 113.25  E-value: 3.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590     19 LNKGPWTKEEDQRVIEHVQKYGPKRWSDIAKHLKG-RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 97
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSL 102

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 127590     98 IAKLLPGRTDNAVKNHWNSTMRRKVEQEGYPQESSK 133
Cdd:PLN03212 103 IAGRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTHK 138
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 197-242 2.06e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 80.69  E-value: 2.06e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 127590     197 NIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKGQQ 242
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 24-82 3.91e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.43  E-value: 3.91e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 127590      24 WTKEEDQRVIEHVQKYGPKrWSDIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDR 82
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 73-116 5.32e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.08  E-value: 5.32e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 127590      73 KTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAVKNHWNS 116
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 21-67 6.69e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 73.69  E-value: 6.69e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 127590      21 KGPWTKEEDQRVIEHVQKYGpKRWSDIAKHLKGRIGKQCRERWHNHL 67
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
21-69 8.79e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 73.41  E-value: 8.79e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 127590       21 KGPWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCRERWHNHLNP 69
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 23-67 2.19e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 72.22  E-value: 2.19e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 127590    23 PWTKEEDQRVIEHVQKYGPKRWSDIAKHLKGRIGKQCRERWHNHL 67
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 327-370 1.76e-15

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 73.16  E-value: 1.76e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 127590     327 QLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHKDQT 370
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQT 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
73-120 3.60e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.09  E-value: 3.60e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 127590       73 KTSWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAVKNHWNSTMRR 120
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 75-115 6.27e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 6.27e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 127590    75 SWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAVKNHWN 115
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 76-130 1.49e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 56.16  E-value: 1.49e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 127590      76 WTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAVKNHWNSTMRRKVEQEGYPQE 130
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKE 55
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 2-120 1.03e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 56.72  E-value: 1.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590     2 RTDVQCQHRWQKVLNPELNKGPWTKEEDQRVIEHVQKYGPkRWSDIAKHLKGRIGKQCRERWHNHLNPEvKKTSWTEEED 81
Cdd:COG5147  53 STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGT-QWSTIADYKDRRTAQQCVERYVNTLEDL-SSTHDSKLQR 130

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 127590    82 RIIYQAHKRLGNRWAEIAKLLPGRTDNAVKNHWNSTMRR 120
Cdd:COG5147 131 RNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRLR 169
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 23-65 2.24e-08

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 49.87  E-value: 2.24e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 127590    23 PWTKEEDQRVIEHVQKYGPKRWSDIAKH---LKGRIGKQCRERWHN 65
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 17-63 2.03e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 47.30  E-value: 2.03e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 127590    17 PELNKGPWTKEEDQRVIeHVQKYGPKRWSDIAKhLKGRIGKQCRERW 63
Cdd:cd11659   1 PSIKKTEWTREEDEKLL-HLAKLLPTQWRTIAP-IVGRTAQQCLERY 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 1-32 8.65e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 42.68  E-value: 8.65e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 127590       1 NRTDVQCQHRWQKVLNPELNKGPWTKEEDQRV 32
Cdd:pfam13921  29 RRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 69-108 9.72e-06

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 42.68  E-value: 9.72e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 127590    69 PEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLpGRTDN 108
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 9-106 4.17e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 39.00  E-value: 4.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127590     9 HRWQKVLNPELNKGPWTKEEDQRVIEHVQKYGpKRWSDIAKhLKGRIGKQCRERWHNHLNP--EVKKTSWT-EEEDRII- 84
Cdd:COG5147 279 KHLRRKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDk 356

                        90       100
                ....*....|....*....|....*...
gi 127590    85 ------YQAHKRLGNRWAEIAKLLPGRT 106
Cdd:COG5147 357 vvnemrLEAQQSSRILWLLIAQNIRNRL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH