NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|12758125|ref|NP_056139|]
View 

ribosomal RNA-processing protein 8 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11155561)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens ribosomal RNA-processing protein 8

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 242-456 1.45e-131

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


:

Pssm-ID: 398698  Cd Length: 214  Bit Score: 378.39  E-value: 1.45e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   242 MAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCR 321
Cdd:pfam05148   1 MKKRLDGGRFRMLNEKLYTGKGSRAGDLFKEDPDAFDLYHEGFNLQVKKWPVNPLDVIIRKLKRRPGNGVIADLGCGEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   322 LASSIRNP--VHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFED 399
Cdd:pfam05148  81 IAFRKREFenVHSFDLVAVNKRVIPCDMARVPLEDESVDVAVFCLSLMGTNIADFLKEANRILKNGGLLKIAEVRSRFPS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12758125   400 VRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTgpPLVGPKAQLsGLQLQPCLYKRR 456
Cdd:pfam05148 161 VGLFERAFTKLGFEVEHVDLSNAQFVLFEFQKT--SRVGPKRLL-GLKLVPCLYKKR 214
 
Name Accession Description Interval E-value
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 242-456 1.45e-131

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


Pssm-ID: 398698  Cd Length: 214  Bit Score: 378.39  E-value: 1.45e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   242 MAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCR 321
Cdd:pfam05148   1 MKKRLDGGRFRMLNEKLYTGKGSRAGDLFKEDPDAFDLYHEGFNLQVKKWPVNPLDVIIRKLKRRPGNGVIADLGCGEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   322 LASSIRNP--VHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFED 399
Cdd:pfam05148  81 IAFRKREFenVHSFDLVAVNKRVIPCDMARVPLEDESVDVAVFCLSLMGTNIADFLKEANRILKNGGLLKIAEVRSRFPS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12758125   400 VRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTgpPLVGPKAQLsGLQLQPCLYKRR 456
Cdd:pfam05148 161 VGLFERAFTKLGFEVEHVDLSNAQFVLFEFQKT--SRVGPKRLL-GLKLVPCLYKKR 214
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 297-413 1.29e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 67.71  E-value: 1.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 297 DRIARDLRQRPASlVVADFGCGDCRLASSIRNP---VHCFDL--------------ASLDPRVTVCDMAQVPLEDESVDV 359
Cdd:COG2226  12 EALLAALGLRPGA-RVLDLGCGTGRLALALAERgarVTGVDIspemlelareraaeAGLNVEFVVGDAEDLPFPDGSFDL 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12758125 360 AVFCLSLMG-TNIRDFLEEANRVLKPGGLLKVAEVSSRfeDVRTFLRAVTKLGFK 413
Cdd:COG2226  91 VISSFVLHHlPDPERALAEIARVLKPGGRLVVVDFSPP--DLAELEELLAEAGFE 143
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 312-388 3.09e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 3.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 312 VADFGCGD----CRLASSIRNPVHCFDL-------------ASLDPRVTV--CDMAQVPL-EDESVDVAVFCLSLMG--T 369
Cdd:cd02440   2 VLDLGCGTgalaLALASGPGARVTGVDIspvalelarkaaaALLADNVEVlkGDAEELPPeADESFDVIISDPPLHHlvE 81

                        90
                ....*....|....*....
gi 12758125 370 NIRDFLEEANRVLKPGGLL 388
Cdd:cd02440  82 DLARFLEEARRLLKPGGVL 100
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 305-418 1.33e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.22  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125  305 QRPASLVVADFGCGDCRLASsirnpvHCFDLASLDPRVT--VCDMAQVPLEDESVDvavfCLSlMGTNIRDF------LE 376
Cdd:PRK00216  74 GKTGEVVGLDFSEGMLAVGR------EKLRDLGLSGNVEfvQGDAEALPFPDNSFD----AVT-IAFGLRNVpdidkaLR 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 12758125  377 EANRVLKPGGLLKVAEVSSR----FEDVRTF--LRAVTKLGfKIVSKD 418
Cdd:PRK00216 143 EMYRVLKPGGRLVILEFSKPtnppLKKAYDFylFKVLPLIG-KLISKN 189
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 346-394 6.32e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 38.01  E-value: 6.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12758125   346 DMAQVPLEDESVDVAVfclslMGTNIRDF------LEEANRVLKPGGLLKVAEVS 394
Cdd:TIGR01934  96 DAEALPFEDNSFDAVT-----IAFGLRNVtdiqkaLREMYRVLKPGGRLVILEFS 145
 
Name Accession Description Interval E-value
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 242-456 1.45e-131

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


Pssm-ID: 398698  Cd Length: 214  Bit Score: 378.39  E-value: 1.45e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   242 MAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCR 321
Cdd:pfam05148   1 MKKRLDGGRFRMLNEKLYTGKGSRAGDLFKEDPDAFDLYHEGFNLQVKKWPVNPLDVIIRKLKRRPGNGVIADLGCGEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   322 LASSIRNP--VHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFED 399
Cdd:pfam05148  81 IAFRKREFenVHSFDLVAVNKRVIPCDMARVPLEDESVDVAVFCLSLMGTNIADFLKEANRILKNGGLLKIAEVRSRFPS 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12758125   400 VRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTgpPLVGPKAQLsGLQLQPCLYKRR 456
Cdd:pfam05148 161 VGLFERAFTKLGFEVEHVDLSNAQFVLFEFQKT--SRVGPKRLL-GLKLVPCLYKKR 214
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 297-413 1.29e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 67.71  E-value: 1.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 297 DRIARDLRQRPASlVVADFGCGDCRLASSIRNP---VHCFDL--------------ASLDPRVTVCDMAQVPLEDESVDV 359
Cdd:COG2226  12 EALLAALGLRPGA-RVLDLGCGTGRLALALAERgarVTGVDIspemlelareraaeAGLNVEFVVGDAEDLPFPDGSFDL 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12758125 360 AVFCLSLMG-TNIRDFLEEANRVLKPGGLLKVAEVSSRfeDVRTFLRAVTKLGFK 413
Cdd:COG2226  91 VISSFVLHHlPDPERALAEIARVLKPGGRLVVVDFSPP--DLAELEELLAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 312-386 9.03e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 58.34  E-value: 9.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   312 VADFGCGDCR----LASSIRNPVHCFDL------------ASLDPRVT--VCDMAQVPLEDESVDVAVFCLSLM---GTN 370
Cdd:pfam13649   1 VLDLGCGTGRltlaLARRGGARVTGVDLspemlerareraAEAGLNVEfvQGDAEDLPFPDGSFDLVVSSGVLHhlpDPD 80

                          90
                  ....*....|....*.
gi 12758125   371 IRDFLEEANRVLKPGG 386
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 314-388 2.25e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 57.29  E-value: 2.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   314 DFGCGDCRLASSIRNP---VHCFDLAS------------LDPRVTVCDMAQVPLEDESVDVAVFCLSLMG-TNIRDFLEE 377
Cdd:pfam08241   2 DVGCGTGLLTELLARLgarVTGVDISPemlelarekaprEGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHvEDPERALRE 81

                          90
                  ....*....|.
gi 12758125   378 ANRVLKPGGLL 388
Cdd:pfam08241  82 IARVLKPGGIL 92
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 297-388 1.72e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.41  E-value: 1.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 297 DRIARDLRQR-PASLVVADFGCGDCRLASSIRN---PVHCFDL------------ASLDPRVTVCDMAQVPLEDESVDVa 360
Cdd:COG2227  12 RRLAALLARLlPAGGRVLDVGCGTGRLALALARrgaDVTGVDIspealeiareraAELNVDFVQGDLEDLPLEDGSFDL- 90

                        90       100       110
                ....*....|....*....|....*....|
gi 12758125 361 VFCLSLMG--TNIRDFLEEANRVLKPGGLL 388
Cdd:COG2227  91 VICSEVLEhlPDPAALLRELARLLKPGGLL 120
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
292-407 1.42e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 54.23  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 292 PLQPVDRIARDLRQRPASLVVaDFGCGDCRLASSIRN---PVHCFDLA----------SLDPRVTVCDMAQVPLEDESVD 358
Cdd:COG4976  31 PALLAEELLARLPPGPFGRVL-DLGCGTGLLGEALRPrgyRLTGVDLSeemlakarekGVYDRLLVADLADLAEPDGRFD 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12758125 359 VAVFCLSLM-GTNIRDFLEEANRVLKPGGLL----KVAEVSSRFEDVRTFLRAV 407
Cdd:COG4976 110 LIVAADVLTyLGDLAAVFAGVARALKPGGLFifsvEDADGSGRYAHSLDYVRDL 163
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 339-417 1.04e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.79  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 339 DPRVTVCDMAQVPLEDESVDVAVF------CLSLMGTNIRD----FLEEANRVLKPGGllKVAEVSSRFEDvrtflRAVT 408
Cdd:COG1041  75 DADVIRGDARDLPLADESVDAIVTdppygrSSKISGEELLElyekALEEAARVLKPGG--RVVIVTPRDID-----ELLE 147


                ....*....
gi 12758125 409 KLGFKIVSK 417
Cdd:COG1041 148 EAGFKVLER 156
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 296-388 2.45e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 47.23  E-value: 2.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 296 VDRIARDLRQRPASLVVaDFGCGD----CRLASSIRNPVHCFDL--------------ASLDPRVTV--CDMAQVPlEDE 355
Cdd:COG2230  40 LDLILRKLGLKPGMRVL-DIGCGWgglaLYLARRYGVRVTGVTLspeqleyareraaeAGLADRVEVrlADYRDLP-ADG 117

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 12758125 356 SVD--VAVFCLSLMGT-NIRDFLEEANRVLKPGGLL 388
Cdd:COG2230 118 QFDaiVSIGMFEHVGPeNYPAYFAKVARLLKPGGRL 153
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 312-388 3.09e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 3.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 312 VADFGCGD----CRLASSIRNPVHCFDL-------------ASLDPRVTV--CDMAQVPL-EDESVDVAVFCLSLMG--T 369
Cdd:cd02440   2 VLDLGCGTgalaLALASGPGARVTGVDIspvalelarkaaaALLADNVEVlkGDAEELPPeADESFDVIISDPPLHHlvE 81

                        90
                ....*....|....*....
gi 12758125 370 NIRDFLEEANRVLKPGGLL 388
Cdd:cd02440  82 DLARFLEEARRLLKPGGVL 100
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 295-388 6.77e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.83  E-value: 6.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 295 PVDRIARDLRQRPASLVVADFGCGDCR----LASSIRNPVHCFDL--------------ASLDP-RVTVCDMAQ-VPLED 354
Cdd:COG0500  13 GLAALLALLERLPKGGRVLDLGCGTGRnllaLAARFGGRVIGIDLspeaialararaakAGLGNvEFLVADLAElDPLPA 92

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 12758125 355 ESVDVAVF--CLSLMGT-NIRDFLEEANRVLKPGGLL 388
Cdd:COG0500  93 ESFDLVVAfgVLHHLPPeEREALLRELARALKPGGVL 129
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
314-429 1.32e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 45.24  E-value: 1.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 314 DFGCGDCRLASSIRnpvhcFDLASLDPRVTVCDMAQ-VPLEDESVDvAVFC------LSLmgTNIRDFLEEANRVLKPGG 386
Cdd:COG4627   8 NIGCGPKRLPGWLN-----VDIVPAPGVDIVGDLTDpLPFPDNSVD-AIYSshvlehLDY--EEAPLALKECYRVLKPGG 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 12758125 387 LLKVAeVSSRFEDVRTFL---RAVTKLGFKIVSKDLTNSHFFLFDF 429
Cdd:COG4627  80 ILRIV-VPDLEHVARLYLaeyDAALDVAELRLAGPIDPLGIILGER 124
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 305-418 1.33e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.22  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125  305 QRPASLVVADFGCGDCRLASsirnpvHCFDLASLDPRVT--VCDMAQVPLEDESVDvavfCLSlMGTNIRDF------LE 376
Cdd:PRK00216  74 GKTGEVVGLDFSEGMLAVGR------EKLRDLGLSGNVEfvQGDAEALPFPDNSFD----AVT-IAFGLRNVpdidkaLR 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 12758125  377 EANRVLKPGGLLKVAEVSSR----FEDVRTF--LRAVTKLGfKIVSKD 418
Cdd:PRK00216 143 EMYRVLKPGGRLVILEFSKPtnppLKKAYDFylFKVLPLIG-KLISKN 189
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 314-388 9.20e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.50  E-value: 9.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125   314 DFGCGDCRLASSIRNPVHCFDLASLDP-----------------------RVTVCDMAQvpLEDESVDVAVFCLSLMGT- 369
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLEYTGLDIspaaleaarerlaalgllnavrvELFQLDLGE--LDPGSFDVVVASNVLHHLa 79

                          90
                  ....*....|....*....
gi 12758125   370 NIRDFLEEANRVLKPGGLL 388
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
312-388 1.61e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 37.88  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 312 VADFGCGDCRLASSI--RNP---VHCFDL--------ASLDPRVT--VCDMAQVPLEdESVDVAVFCLSLM-GTNIRDFL 375
Cdd:COG4106   5 VLDLGCGTGRLTALLaeRFPgarVTGVDLspemlaraRARLPNVRfvVADLRDLDPP-EPFDLVVSNAALHwLPDHAALL 83

                        90
                ....*....|...
gi 12758125 376 EEANRVLKPGGLL 388
Cdd:COG4106  84 ARLAAALAPGGVL 96
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 346-394 6.32e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 38.01  E-value: 6.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12758125   346 DMAQVPLEDESVDVAVfclslMGTNIRDF------LEEANRVLKPGGLLKVAEVS 394
Cdd:TIGR01934  96 DAEALPFEDNSFDAVT-----IAFGLRNVtdiqkaLREMYRVLKPGGRLVILEFS 145
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
352-435 7.61e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 37.98  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12758125 352 LEDESVDVAV----FCLSLMGTN-----------------IRDFLEEANRVLKPGGLLKVAeVSSRFedVRTFLRAVTKL 410
Cdd:COG0863  14 LPDESVDLIVtdppYNLGKKYGLgrreignelsfeeylefLREWLAECYRVLKPGGSLYVN-IGDRY--ISRLIAALRDA 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 12758125 411 GFKIVS---------------KDLTNSHFFLFDFQKTGPP 435
Cdd:COG0863  91 GFKLRNeiiwrkpngvpgpskRRFRNSHEYILWFTKGKKY 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH