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Conserved domains on  [gi|1273811318|gb|ATQ39692|]
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NADH dehydrogenase subunit I, partial (mitochondrion) [Betiscoides sp. B40_dh_74]

Protein Classification

complex I subunit 1 family protein( domain architecture ID 103)

complex I subunit 1 family protein similar to NADH dehydrogenase subunit 1, which is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

EC:  7.1.1.-
Gene Ontology:  GO:0016655|GO:0016020
PubMed:  23417064|24059520
SCOP:  4005664

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK06076 super family cl00469
NADH-quinone oxidoreductase subunit NuoH;
6-111 2.57e-38

NADH-quinone oxidoreductase subunit NuoH;


The actual alignment was detected with superfamily member MTH00193:

Pssm-ID: 469782  Cd Length: 306  Bit Score: 130.27  E-value: 2.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   6 LF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811318  86 LMISLFVWSIFPYLTYMCSFSYGFLF 111
Cdd:MTH00193   81 LFLSLLIWLIYPYLFNLISFNLGILF 106
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-111 2.57e-38

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 130.27  E-value: 2.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   6 LF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811318  86 LMISLFVWSIFPYLTYMCSFSYGFLF 111
Cdd:MTH00193   81 LFLSLLIWLIYPYLFNLISFNLGILF 106
NADHdh pfam00146
NADH dehydrogenase;
17-98 4.44e-17

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 74.05  E-value: 4.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:pfam00146   6 LVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAFAVI 85


                  ..
gi 1273811318  97 PY 98
Cdd:pfam00146  86 PF 87
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-98 1.41e-15

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 70.16  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   5 DLF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVF 84
Cdd:COG1005     7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86

                          90
                  ....*....|....
gi 1273811318  85 SLMISLFVWSIFPY 98
Cdd:COG1005    87 AFIPALLAFAVIPF 100
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-111 2.57e-38

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 130.27  E-value: 2.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   6 LF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811318  86 LMISLFVWSIFPYLTYMCSFSYGFLF 111
Cdd:MTH00193   81 LFLSLLIWLIYPYLFNLISFNLGILF 106
ND1 MTH00225
NADH dehydrogenase subunit 1; Provisional
 17-111 5.68e-32

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214465  Cd Length: 305  Bit Score: 113.59  E-value: 5.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00225   11 LICLLLSVAFYTLLERKVLGYIQLRKGPNKVGLMGLPQPFADALKLFTKEQTKPQLSNKLPYYIAPILSLILSLILWSLY 90

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00225   91 PSMFSIYSFKFGILF 105
ND1 MTH00143
NADH dehydrogenase subunit 1; Provisional
 18-111 2.72e-30

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177201  Cd Length: 307  Bit Score: 109.19  E-value: 2.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  18 ICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIFP 97
Cdd:MTH00143   12 LCVLLAVAFFTLLERKGLGYFQIRKGPNKVGLMGLPQPLADAVKLFTKEFVKPTMSNKFPFFLAPCLSLILALLLWQLYP 91

                          90
                  ....*....|....
gi 1273811318  98 YLTYMCSFSYGFLF 111
Cdd:MTH00143   92 SYFSSSYFGWGLLF 105
ND1 MTH00195
NADH dehydrogenase subunit 1; Provisional
 17-111 2.29e-23

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214452  Cd Length: 307  Bit Score: 90.96  E-value: 2.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00195   12 IVPVLLAVAFFTLLERKILGYIQLRKGPNKVGPYGLLQPIADAVKLFIKEPVKPSTSSLWLFFFAPVLALALALILWVPI 91

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00195   92 PSPFGFSSINLSVLF 106
ND1 MTH00111
NADH dehydrogenase subunit 1; Provisional
 17-111 1.59e-22

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214422  Cd Length: 323  Bit Score: 89.18  E-value: 1.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00111   15 IIPILIAVAFLTLLERKILGYMQLRKGPNIVGPFGLLQPIADGVKLFIKEPIRPSTSSPILFTLTPILALLLALTIWTPL 94

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00111   95 PMPFPLADLNLGLLF 109
ND1 MTH00071
NADH dehydrogenase subunit 1; Provisional
 17-111 2.53e-21

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214418  Cd Length: 322  Bit Score: 85.83  E-value: 2.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00071   15 IIPVLLAVAFLTLVERKVLGYMQLRKGPNIVGPMGLLQPIADGLKLFIKEPIRPSTSSQILFILMPTMALTLALIIWTPL 94

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00071   95 PMPNNLSNLNLGILF 109
ND1 MTH00216
NADH dehydrogenase subunit 1; Provisional
 2-98 3.97e-21

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 164761  Cd Length: 327  Bit Score: 85.56  E-value: 3.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   2 MLYDLF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFS 81
Cdd:MTH00216    1 MMVFIIFYLIKILIIIVPLLIAVAYLTLAERKVLGYMQARKGPNVVGVYGLLQPFADGVKLFTKEMVIPHHANLFVYIVA 80

                          90
                  ....*....|....*..
gi 1273811318  82 PVFSLMISLFVWSIFPY 98
Cdd:MTH00216   81 PVLSFTLALIVWGVIPY 97
ND1 MTH00218
NADH dehydrogenase subunit 1; Provisional
 17-111 6.92e-21

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214463  Cd Length: 311  Bit Score: 84.58  E-value: 6.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00218   12 ILPVLLAVAFLTLLERKVLGYMQLRKGPNVVGPYGLLQPIADGVKLFIKEPIRPSTSSPFLFLLAPILALTLALLLWMPL 91

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00218   92 PLPFSLINLNLGVLF 106
ND1 MTH00134
NADH dehydrogenase subunit 1; Provisional
 2-111 1.85e-20

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177192  Cd Length: 324  Bit Score: 83.50  E-value: 1.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   2 MLYDLF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFS 81
Cdd:MTH00134    1 MLSTLITHIINPLAYIVPVLLAVAFLTLLERKVLGYMQLRKGPNIVGPYGLLQPIADGVKLFIKEPVRPSTSSPFLFLAT 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1273811318  82 PVFSLMISLFVWSIFPYLTYMCSFSYGFLF 111
Cdd:MTH00134   81 PMLALTLALTLWAPMPMPYPVTDLNLGILF 110
ND1 MTH00010
NADH dehydrogenase subunit 1; Validated
 17-98 6.99e-20

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 164586  Cd Length: 311  Bit Score: 81.75  E-value: 6.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00010   13 YVMALLAMAFYTLLERKALGYFQLRKGPNKVGLAGIPQPFADAIKLFTKEQTKPSPANITPFLGAPMMSLILALLLWSLY 92


                  ..
gi 1273811318  97 PY 98
Cdd:MTH00010   93 PH 94
ND1 MTH00054
NADH dehydrogenase subunit 1; Provisional
 17-98 7.41e-20

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177127  Cd Length: 324  Bit Score: 82.08  E-value: 7.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00054   12 LVPLLISIAYLTLAERKVLGYIQCRKGPNVVGVYGLLQPLADGLKLFTKEIIIPNHANIFIYIMAPILSLTLAFIAWGVI 91


                  ..
gi 1273811318  97 PY 98
Cdd:MTH00054   92 PY 93
ND1 MTH00040
NADH dehydrogenase subunit 1; Validated
 17-97 1.83e-19

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 214409  Cd Length: 323  Bit Score: 80.79  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00040   14 IVPVLLAVAFLTLVERKVLGYMQFRKGPNVVGPYGLLQPFADGLKLFIKETLKPSNASPYLFFFSPVLFLFLALLLWSLI 93


                  .
gi 1273811318  97 P 97
Cdd:MTH00040   94 P 94
ND1 MTH00104
NADH dehydrogenase subunit 1; Provisional
 17-111 5.38e-19

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177166  Cd Length: 318  Bit Score: 79.67  E-value: 5.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00104   10 IIPILLAVAFLTLVERKVLGYMQLRKGPNIVGPYGLLQPFADAMKLFTKEPLRPLTSSTTMFIIAPILALTLALTMWIPL 89

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00104   90 PMPYPLINMNLGVLF 104
NADHdh pfam00146
NADH dehydrogenase;
17-98 4.44e-17

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 74.05  E-value: 4.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:pfam00146   6 LVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAFAVI 85


                  ..
gi 1273811318  97 PY 98
Cdd:pfam00146  86 PF 87
ND1 MTH00090
NADH dehydrogenase subunit 1; Provisional
 17-111 9.85e-16

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177153  Cd Length: 284  Bit Score: 70.31  E-value: 9.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:MTH00090    6 MIFILQAIAFITLYERHLLGSSQNRLGPNKVSFMGVLQALLDGVKLLKKEQMLPLNSSDLSFLLVPGVSFVVMYLEWFVL 85

                          90
                  ....*....|....*
gi 1273811318  97 PYLTYMCSFSYGFLF 111
Cdd:MTH00090   86 PYFFDFLSFEYSLLF 100
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-98 1.41e-15

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 70.16  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   5 DLF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVF 84
Cdd:COG1005     7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86

                          90
                  ....*....|....
gi 1273811318  85 SLMISLFVWSIFPY 98
Cdd:COG1005    87 AFIPALLAFAVIPF 100
ND1 MTH00029
NADH dehydrogenase subunit 1; Provisional
 1-95 1.75e-14

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177108  Cd Length: 343  Bit Score: 67.35  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318   1 MMLYDLF*********VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYF 80
Cdd:MTH00029    1 MTIYSYITVTIKLLIIFVPLLLSVAYLTLAERKVLGLMQNRKGPAIVGPWGLVQPIADGVKLLTKELIIPSQANKFLYYI 80

                          90
                  ....*....|....*
gi 1273811318  81 SPVFSLMISLFVWSI 95
Cdd:MTH00029   81 APIISFTLAILAWAI 95
PRK06076 PRK06076
NADH-quinone oxidoreductase subunit NuoH;
17-98 6.94e-13

NADH-quinone oxidoreductase subunit NuoH;


Pssm-ID: 235692  Cd Length: 322  Bit Score: 62.90  E-value: 6.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811318  17 VICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK****PIMSNYLLYYFSPVFSLMISLFVWSIF 96
Cdd:PRK06076   20 LVVVLLCVAFLIWFERKVLARMQLRYGPNRVGPFGLLQLVADGIKLLFKEDIIPAGADKVLFLLAPVIAFIPAFLAWAVI 99


                  ..
gi 1273811318  97 PY 98
Cdd:PRK06076  100 PF 101
ND1 MTH00058
NADH dehydrogenase subunit 1; Provisional
 18-65 4.53e-09

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177130  Cd Length: 293  Bit Score: 51.85  E-value: 4.53e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1273811318  18 ICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSETVKLICK 65
Cdd:MTH00058   12 LIILLLVAFFILGERKILGYIQLRKGPNKVGIVGLLQSFADLLKLVVK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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