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Conserved domains on  [gi|1273811296|gb|ATQ39681|]
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NADH dehydrogenase subunit I, partial (mitochondrion) [Betiscoides sp. B27_bo_85]

Protein Classification

complex I subunit 1 family protein( domain architecture ID 103)

complex I subunit 1 family protein similar to NADH dehydrogenase subunit 1, which is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

EC:  7.1.1.-
Gene Ontology:  GO:0016655|GO:0016020
PubMed:  23417064|24059520
SCOP:  4005664

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK06076 super family cl00469
NADH-quinone oxidoreductase subunit NuoH;
6-93 3.07e-39

NADH-quinone oxidoreductase subunit NuoH;


The actual alignment was detected with superfamily member MTH00193:

Pssm-ID: 469782  Cd Length: 306  Bit Score: 131.82  E-value: 3.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00193   81 LFLSLLIW 88
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-93 3.07e-39

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 131.82  E-value: 3.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00193   81 LFLSLLIW 88
NADHdh pfam00146
NADH dehydrogenase;
14-93 1.11e-19

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 80.21  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296  14 VLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLMISLFIW 93
Cdd:pfam00146   3 LLLLVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAF 82
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-93 1.96e-19

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 80.17  E-value: 1.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   5 DLFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVF 84
Cdd:COG1005     7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86


                  ....*....
gi 1273811296  85 SLMISLFIW 93
Cdd:COG1005    87 AFIPALLAF 95
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-93 3.07e-39

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 131.82  E-value: 3.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00193   81 LFLSLLIW 88
ND1 MTH00225
NADH dehydrogenase subunit 1; Provisional
 8-93 2.00e-32

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214465  Cd Length: 305  Bit Score: 113.98  E-value: 2.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   8 MF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLM 87
Cdd:MTH00225    2 SFLLKFLIMLICLLLSVAFYTLLERKVLGYIQLRKGPNKVGLMGLPQPFADALKLFTKEQTKPQLSNKLPYYIAPILSLI 81


                  ....*.
gi 1273811296  88 ISLFIW 93
Cdd:MTH00225   82 LSLILW 87
ND1 MTH00143
NADH dehydrogenase subunit 1; Provisional
 7-93 6.93e-31

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177201  Cd Length: 307  Bit Score: 109.96  E-value: 6.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   7 FMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSL 86
Cdd:MTH00143    1 LVSLLSSVFTYLCVLLAVAFFTLLERKGLGYFQIRKGPNKVGLMGLPQPLADAVKLFTKEFVKPTMSNKFPFFLAPCLSL 80


                  ....*..
gi 1273811296  87 MISLFIW 93
Cdd:MTH00143   81 ILALLLW 87
ND1 MTH00195
NADH dehydrogenase subunit 1; Provisional
 6-93 4.51e-25

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214452  Cd Length: 307  Bit Score: 94.81  E-value: 4.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00195    1 WMISVIHFLIQIVPVLLAVAFFTLLERKILGYIQLRKGPNKVGPYGLLQPIADAVKLFIKEPVKPSTSSLWLFFFAPVLA 80


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00195   81 LALALILW 88
ND1 MTH00111
NADH dehydrogenase subunit 1; Provisional
 6-93 4.61e-25

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214422  Cd Length: 323  Bit Score: 94.96  E-value: 4.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00111    4 LLLNLINPLLYIIPILIAVAFLTLLERKILGYMQLRKGPNIVGPFGLLQPIADGVKLFIKEPIRPSTSSPILFTLTPILA 83


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00111   84 LLLALTIW 91
ND1 MTH00104
NADH dehydrogenase subunit 1; Provisional
 8-93 8.81e-25

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177166  Cd Length: 318  Bit Score: 94.31  E-value: 8.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   8 MF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLM 87
Cdd:MTH00104    1 MFMINILLLIIPILLAVAFLTLVERKVLGYMQLRKGPNIVGPYGLLQPFADAMKLFTKEPLRPLTSSTTMFIIAPILALT 80


                  ....*.
gi 1273811296  88 ISLFIW 93
Cdd:MTH00104   81 LALTMW 86
ND1 MTH00071
NADH dehydrogenase subunit 1; Provisional
 6-93 3.13e-24

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214418  Cd Length: 322  Bit Score: 92.76  E-value: 3.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00071    4 LISLIINPLLYIIPVLLAVAFLTLVERKVLGYMQLRKGPNIVGPMGLLQPIADGLKLFIKEPIRPSTSSQILFILMPTMA 83


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00071   84 LTLALIIW 91
ND1 MTH00218
NADH dehydrogenase subunit 1; Provisional
 11-93 4.11e-24

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214463  Cd Length: 311  Bit Score: 92.28  E-value: 4.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296  11 LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLMISL 90
Cdd:MTH00218    6 INLLLYILPVLLAVAFLTLLERKVLGYMQLRKGPNVVGPYGLLQPIADGVKLFIKEPIRPSTSSPFLFLLAPILALTLAL 85


                  ...
gi 1273811296  91 FIW 93
Cdd:MTH00218   86 LLW 88
ND1 MTH00134
NADH dehydrogenase subunit 1; Provisional
 2-93 6.00e-24

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177192  Cd Length: 324  Bit Score: 91.98  E-value: 6.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   2 MLYDLFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF* 81
Cdd:MTH00134    1 MLSTLITHIINPLAYIVPVLLAVAFLTLLERKVLGYMQLRKGPNIVGPYGLLQPIADGVKLFIKEPVRPSTSSPFLFLAT 80

                          90
                  ....*....|..
gi 1273811296  82 PVFSLMISLFIW 93
Cdd:MTH00134   81 PMLALTLALTLW 92
ND1 MTH00216
NADH dehydrogenase subunit 1; Provisional
 2-93 1.58e-22

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 164761  Cd Length: 327  Bit Score: 88.25  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   2 MLYDLFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF* 81
Cdd:MTH00216    1 MMVFIIFYLIKILIIIVPLLIAVAYLTLAERKVLGYMQARKGPNVVGVYGLLQPFADGVKLFTKEMVIPHHANLFVYIVA 80

                          90
                  ....*....|..
gi 1273811296  82 PVFSLMISLFIW 93
Cdd:MTH00216   81 PVLSFTLALIVW 92
ND1 MTH00040
NADH dehydrogenase subunit 1; Validated
 4-93 2.14e-22

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 214409  Cd Length: 323  Bit Score: 88.11  E-value: 2.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   4 YDLFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PV 83
Cdd:MTH00040    1 MSVILFLINLLSFIVPVLLAVAFLTLVERKVLGYMQFRKGPNVVGPYGLLQPFADGLKLFIKETLKPSNASPYLFFFSPV 80

                          90
                  ....*....|
gi 1273811296  84 FSLMISLFIW 93
Cdd:MTH00040   81 LFLFLALLLW 90
ND1 MTH00010
NADH dehydrogenase subunit 1; Validated
 9-93 2.53e-22

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 164586  Cd Length: 311  Bit Score: 87.53  E-value: 2.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   9 F*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLMI 88
Cdd:MTH00010    5 FFISILLSYVMALLAMAFYTLLERKALGYFQLRKGPNKVGLAGIPQPFADAIKLFTKEQTKPSPANITPFLGAPMMSLIL 84


                  ....*
gi 1273811296  89 SLFIW 93
Cdd:MTH00010   85 ALLLW 89
ND1 MTH00054
NADH dehydrogenase subunit 1; Provisional
 6-93 2.55e-20

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177127  Cd Length: 324  Bit Score: 82.47  E-value: 2.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:MTH00054    1 MGIIIIKILAILVPLLISIAYLTLAERKVLGYIQCRKGPNVVGVYGLLQPLADGLKLFTKEIIIPNHANIFIYIMAPILS 80


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:MTH00054   81 LTLAFIAW 88
NADHdh pfam00146
NADH dehydrogenase;
14-93 1.11e-19

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 80.21  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296  14 VLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLMISLFIW 93
Cdd:pfam00146   3 LLLLVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAF 82
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-93 1.96e-19

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 80.17  E-value: 1.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   5 DLFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVF 84
Cdd:COG1005     7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86


                  ....*....
gi 1273811296  85 SLMISLFIW 93
Cdd:COG1005    87 AFIPALLAF 95
ND1 MTH00029
NADH dehydrogenase subunit 1; Provisional
 1-93 1.95e-16

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177108  Cd Length: 343  Bit Score: 71.97  E-value: 1.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   1 MMLYDLFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF 80
Cdd:MTH00029    1 MTIYSYITVTIKLLIIFVPLLLSVAYLTLAERKVLGLMQNRKGPAIVGPWGLVQPIADGVKLLTKELIIPSQANKFLYYI 80

                          90
                  ....*....|...
gi 1273811296  81 *PVFSLMISLFIW 93
Cdd:MTH00029   81 APIISFTLAILAW 93
ND1 MTH00090
NADH dehydrogenase subunit 1; Provisional
 12-93 3.44e-16

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177153  Cd Length: 284  Bit Score: 70.70  E-value: 3.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296  12 NFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFSLMISLF 91
Cdd:MTH00090    1 MLLLMMIFILQAIAFITLYERHLLGSSQNRLGPNKVSFMGVLQALLDGVKLLKKEQMLPLNSSDLSFLLVPGVSFVVMYL 80


                  ..
gi 1273811296  92 IW 93
Cdd:MTH00090   81 EW 82
PRK06076 PRK06076
NADH-quinone oxidoreductase subunit NuoH;
6-93 1.61e-15

NADH-quinone oxidoreductase subunit NuoH;


Pssm-ID: 235692  Cd Length: 322  Bit Score: 69.45  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811296   6 LFMF*LNFVLLIICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICKEQPIPIMSNYLLYYF*PVFS 85
Cdd:PRK06076    9 LLLILLKAVVILVVVLLCVAFLIWFERKVLARMQLRYGPNRVGPFGLLQLVADGIKLLFKEDIIPAGADKVLFLLAPVIA 88


                  ....*...
gi 1273811296  86 LMISLFIW 93
Cdd:PRK06076   89 FIPAFLAW 96
ND1 MTH00058
NADH dehydrogenase subunit 1; Provisional
 7-65 3.43e-12

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177130  Cd Length: 293  Bit Score: 59.94  E-value: 3.43e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1273811296   7 FMF*LNFVLLIICVLIsVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLICK 65
Cdd:MTH00058    2 FGLVSGLEGLLIILLL-VAFFILGERKILGYIQLRKGPNKVGIVGLLQSFADLLKLVVK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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