|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-406 |
1.95e-54 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 184.30 E-value: 1.95e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 3 NKNTNNYAWVLVGLLWVVALLNYMDRQMLSTMKPAMQidiAELQ-SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWL 81
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQ---ADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 82 IVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATI 160
Cdd:COG2271 78 LAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPlLGWL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 161 ADKFSWQSTFHWFGIAGIIYSFvlilflrekkltdhemvsdkltikpslfkglgilftnISFWIILFYFAVPSLPGWAAK 240
Cdd:COG2271 158 LAAFGWRAAFLILGLPGLLLAL-------------------------------------LRFWLLALAYFLVYFALYGFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 241 NWLPTLFAQNLNIPMATAGPLSTItIAASSFLGVILGGILSDKWvqknLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVV 320
Cdd:COG2271 201 TWLPTYLVEVRGLSLAQAGLLLSL-PFLAGIVGSLLGGWLSDRL----GRRRKLVLAIGLLLAALALLLLALLPSPALAI 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 321 GAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMTGVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIVQL 400
Cdd:COG2271 276 ALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
....*.
gi 1272251015 401 YFLRPR 406
Cdd:COG2271 356 LLLRET 361
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-387 |
3.38e-48 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 168.95 E-value: 3.38e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 14 VGLLWVVALLNYMDRQMLSTMKPAMQ----IDIAELqsatnfGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVW 89
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQsdflIDDSLA------GLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 90 SAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGG-FGATIADKF-SWQ 167
Cdd:cd17328 75 SAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYvVGGLVAQATgGWR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 168 STFHWFGIAGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLF 247
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 248 AQNLNIPMATAGPLSTIT---IAASSFLGVILGGILSDKWVQKNLKGRIYTSAIGLALTIPsLLLLGFGHSLFHVVGAAI 324
Cdd:cd17328 235 LRAFGVGDLSSADVGLIFgaiTCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAP-FLFLALVLALSNLLLAWV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1272251015 325 CFGLGFGMFDANNMP---ILCQFVSARYRATAYGLMNMTGVFFGAFITDLL-GKSSDAGSLGKDFAM 387
Cdd:cd17328 314 LLFLGEFLLSLNWAPvfaILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLiGLISDLLRQNKDSPL 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-398 |
5.13e-42 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 151.57 E-value: 5.13e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 11 WVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAElqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWS 90
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGL--SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 91 AVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGG-FGATIADKFSWQST 169
Cdd:cd17319 80 LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFGWRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 170 FHWFGIAGIIYSFVLILFLRekkltdhemvsdkltikpslfkglgilftniSFWIILFYFAVPSLPGWAAKNWLPTLFAQ 249
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYLR-------------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 250 NLNIPMATAGPLSTItIAASSFLGVILGGILSDKWVQKNLKGRIytsAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLG 329
Cdd:cd17319 209 ARGFSLKQVGLLAAI-PFLAGAIGMILGGRLSDRLLRGARRLVI---IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 330 FGMFDANNMPILCQFVSARYRATAYGLMNMTGVFFGAFITDLLGKSSDA-GSLGKDFAMLAGIVVIALIV 398
Cdd:cd17319 285 IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALL 354
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-406 |
1.45e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 137.70 E-value: 1.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 8 NYAWVLVGLLWVVALLNYMDRQMLSTMKPAMQidiAELQ-SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSL 86
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLA---EEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 87 FVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGAT-IADKFS 165
Cdd:COG2223 78 LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPlLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 166 WQSTFHWFGIAGIIYSFVLILFLREKKltdhemvSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPT 245
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPP-------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 246 LFAQNLNIPMATAGPLSTITIAASSfLGVILGGILSDKWvqknlKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAIC 325
Cdd:COG2223 231 YLVDQFGLSAATAGLLAALFALLGA-LGRPLGGWLSDRI-----GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 326 FGLGFGMFDANNMPILCQFVSARYRATAYGLMNMTGVFFGAFITDLLGKSSDA-GSLGKDFAMLAGIVVIALIVqLYFLR 404
Cdd:COG2223 305 LGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVALVL-TLLLY 383
|
..
gi 1272251015 405 PR 406
Cdd:COG2223 384 RR 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-366 |
2.96e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 135.87 E-value: 2.96e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 6 TNNYAWVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGS 85
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG--ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 86 LFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKF 164
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLlGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 165 SWQSTFHWFGIAGIIYSFVLILFLREkkltdhemvsDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLP 244
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPE----------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 245 TLFAQNLNIPMATAGpLSTITIAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAI 324
Cdd:COG2814 232 LYLQEVLGLSASAAG-LLLALFGLGGVLGALLAGRLADRF------GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1272251015 325 CFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMTGVFFGA 366
Cdd:COG2814 305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
52-398 |
6.18e-33 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 127.31 E-value: 6.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 52 GYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFH 131
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 132 SPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFhWFGIAGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLF 210
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGpLLGGLLADALGYRAPF-LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 211 KGlgiLFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTItIAASSFLGVILGGILSDKWvqknlk 290
Cdd:cd17325 193 RL---LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA-QGLASALSQPPAGKLSDRI------ 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 291 GRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMT---GVFFGAF 367
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAfslGMVLGPL 342
|
330 340 350
....*....|....*....|....*....|.
gi 1272251015 368 ITDLLgksSDAGSLGKDFAMLAGIVVIALIV 398
Cdd:cd17325 343 LGGFL---YDAFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-367 |
1.59e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.74 E-value: 1.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 17 LWVVALLNYMDRQMLSTMKPAMQIDIAELqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLM 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGI-SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 97 GYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGG-FGATIADKFSWQSTfhwFGI 175
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPlLGGLLASLFGWRAA---FLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 176 AGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLpGWAAKNWLPtLFAQNLNIPM 255
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA-FFGLLTYLP-LYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 256 ATAGPLSTITIAASSFLGvILGGILSDKWvqkNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDA 335
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGR-LLLGRLSDRL---GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310
|
330 340 350
....*....|....*....|....*....|..
gi 1272251015 336 NNMPILCQFVSARYRATAYGLMNMTGVFFGAF 367
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-398 |
1.09e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.82 E-value: 1.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 17 LWVVALLNYMDRQMLSTMKPAMQIDIAElqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLM 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGL--SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 97 GYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGATIADKFSWQSTFHWFGIA 176
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 177 GIIYSFVLILFLREKKLTDHEMVSDKLTIKP-SLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPM 255
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSkSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 256 ATAGPLSTITIAAsSFLGVILGGILSDKwvqknLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDA 335
Cdd:cd06174 239 AVAGLLLSLFGLA-GALGSLLLGLLSDR-----LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1272251015 336 NNMPILCQFVSARYRATAYGLMNMTGVFFGAFITDLLGKSSDA-GSLGKDFAMLAGIVVIALIV 398
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
64-405 |
2.87e-21 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 94.56 E-value: 2.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 64 FMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIH 143
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 144 MTGLYMG----QALGGFGATIadkfSWQSTFHWFGIAGIIYSFVlILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFTN 219
Cdd:cd17473 130 SAAMSLGgvvfLLLGGALAEI----GWRAPFLVYLLALPVLILV-LLFLPEPARKSKSAASPGAATAAALPWKRVLPIYF 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 220 ISFWIILFYFAVPSLpgwaaknwLPTLFAQNLNIPMATAGplstiTIAASSFLGVILGGILSDKwvQKNLKGRIYTSAIG 299
Cdd:cd17473 205 LAFLAMLLFYVIPIQ--------LPFLLQERGGGSAALIG-----LALAIASLAGAIGALLFGR--LKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 300 LALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMtGVFFGAFITDLLGKSSDAG 379
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS-AFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|....*.
gi 1272251015 380 SLGKDFAMLAGIVVIALIVQLYFLRP 405
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-398 |
1.86e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 92.25 E-value: 1.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 20 VALLNYMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYA 99
Cdd:cd17474 7 ATLLAVLGVSIVDPILPAIAEALG--ASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 100 ETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADkFSWQSTFHWFGIAGI 178
Cdd:cd17474 85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLlGGLLAA-ISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 179 IYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFTNISFWIILF-YFAVpslpgwaaKNWLPTLFAQNLNIPMAT 257
Cdd:cd17474 164 VAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFlYFAF--------LTYLPFLLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 258 AGplstiTIAASSFLGVILGGILSDKWVQKNLkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANN 337
Cdd:cd17474 236 IG-----LLFAGWSVLLALGSLFVGRLLKKRF-GARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1272251015 338 MPILCQFVSARYRATAYGLMNM---TGVFFGAFITDLLGKSSDAGSLgkdFAMLAGIVVIALIV 398
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFvrfLGQAVGPLLFGLLLEIFGLSAP---FLVGAAIALAAAVL 370
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
14-365 |
1.93e-20 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 91.85 E-value: 1.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 14 VGLLWVVALLNYMDRQMLSTMKPAMQidiAELQ-SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAV 92
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMA---KEFGwSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 93 TFLMGYA--ETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGG-FGATIADKFSWQST 169
Cdd:cd17380 78 TLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGlIGPLLLEYYGWPSV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 170 FHWFGIAGIIYSFVLILFLRekkltdhemvsdkltikpslfkglgilftniSFWIILFYFAVPSLPGWAAKNWLPTLFAQ 249
Cdd:cd17380 158 FYFFGLLGLLWALVWLIYLP-------------------------------PVWAIIVAHFCMNWGFYILLSWLPTYFHE 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 250 NLnIPMATAGPLSTITIAASSFLGVIlGGILSDKWVQKNLKgRIYTSAI--GLALTIPSLLLLGFGHsLFHVVGAAICFG 327
Cdd:cd17380 207 VL-VPLAKGWVFNVVPWLVMFPSSNV-AGWLADHLISRGWT-VTSVRKLmqSIGFLGPALFLLLLSH-TDSFSLALLCMS 282
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1272251015 328 LGFGMFDANNMPILC--QFVSARYRATAYGLMNMTGVFFG 365
Cdd:cd17380 283 VALGLSAFSSSGVLVnhQDIAPNYAGIVFGISNTAGTIPG 322
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
47-409 |
2.92e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 91.86 E-value: 2.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSL 126
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 127 IADfHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEMVSDklti 205
Cdd:COG2807 131 IKR-WFPDRVGLMTGLYTAAMGLGAALAaGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA---- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 206 kpslfKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTlFAQNLNIPMATAGPLSTItIAASSFLGVILGGILSDKWv 285
Cdd:COG2807 206 -----ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPP-ILRDAGLSAATAGLLLSL-FQLAGIPGSLLVPLLADRL- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 286 qknlKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVgAAICFGLGFGM-FDANNMPILCQFVSARYRATAYGLMNMTGVFF 364
Cdd:COG2807 278 ----GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWL-WAVLLGLGQGGlFPLALTLIGLRARTPAEAAALSGMAQSVGYLL 352
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1272251015 365 GAFITDLLGKSSDA-GSLGKDFAMLAGIVVIALIVQLYFLRPRHND 409
Cdd:COG2807 353 AALGPLLVGALHDAtGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-332 |
3.73e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 91.07 E-value: 3.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSL 126
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 127 IADFHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREkkltdhemVSDKLTI 205
Cdd:cd17324 112 AADLVPPEKRGRAIGLVFSGLTLGLVLGrPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS--------LPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 206 KPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIpMATAGPLSTITIAASSFLGVILGGILSDKWV 285
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF-SSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1272251015 286 QKNLkgriytSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGM 332
Cdd:cd17324 263 RRAL------LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFA 303
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-397 |
3.10e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 88.38 E-value: 3.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 52 GYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFh 131
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 132 SPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEmvSDKLTIKPSLF 210
Cdd:cd17478 113 AGGRRGLAMSIFSVGGNLGFALGpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK--AAAKSSARSTL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 211 KGLGILFTNISFWIILFYFAVPSLPgwaakNWLPTLFAQNLNIPMATAGPLSTITIAASsfLGVILGGILSDKWvqknlk 290
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSLT-----TFLPFYLVQRGYSLVFAGLLLSLFLFAGA--IGTLIGGPLSDRF------ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 291 GRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAIcfgLGFGMFDAN-NMPILCQFVSARYRATAYGLMNMTGVFFGAFIT 369
Cdd:cd17478 258 GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVL---AGFLLFASFpVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGA 334
|
330 340
....*....|....*....|....*...
gi 1272251015 370 DLLGKSSDAGSLGKDFAMLAGIVVIALI 397
Cdd:cd17478 335 PVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-403 |
4.42e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.95 E-value: 4.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 17 LWVVALLNYMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLM 96
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLG--GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 97 GYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFhWFGI 175
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAlGLFLYQHLGFAVLF-IVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 176 AGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPS-LPGWAAknwlptlfaqnlNIP 254
Cdd:cd17489 158 VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTfLPLYAA------------ERG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 255 MATAGPLSTITIAASSFLGVILgGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFD 334
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFS-GKLSDRK------GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLF 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1272251015 335 ANNMPILCQFVSARYRATAYGLMNMT---GVFFGAFitdLLGKSSDAGSLGKDFAMLAGIVVIALIVQLYFL 403
Cdd:cd17489 299 PALQALAVDLVPPHRRGAANGTFFIFfdlGIGLGGL---LLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
64-368 |
7.57e-18 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 84.52 E-value: 7.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 64 FMSPVSGIIADKFNRKWLIVGSLFVWSAVT-FLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGI 142
Cdd:cd17370 49 LLRLFSGYLSDRTGKRKPLVILGYGLSALAkPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 143 HMTGLYMGQALGGFGATIA---DKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLgILFTN 219
Cdd:cd17370 129 HRALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAF-WLYLL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 220 ISFWIILFYFAVPSLPGWAAKNWLPTLFAqnlnipmatagPLSTITIAASSFLGVILGGILSDKWvqknlkGRIYTSAIG 299
Cdd:cd17370 208 AVALFALGNFSFAFLILRAQELGLSAALI-----------PLLYALFNLVYALAAYPAGRLSDRI------GRKKLLILG 270
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1272251015 300 LALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMT---GVFFGAFI 368
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVvgiGWLLASLI 342
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
14-406 |
1.00e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 78.01 E-value: 1.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 14 VGLLWVVALLNYMDRQMLSTMKPAMqidIAELQ-SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAV 92
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPAL---AQDWGlSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 93 TFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFH 171
Cdd:cd17365 78 TLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFlAAALIPAFGWRSVFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 172 WFGIAGIIYsfvlilflrekkltdhemvsdkltikpslfkgLGILFTNISFWIILFyfaVPSLPGWAAKNWLPTLFAQNl 251
Cdd:cd17365 158 LGGVPPLIL--------------------------------LPLLRGTLLLWVTFF---MGLLLVYLLNSWLPKLMVEA- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 252 NIPMATAGpLSTITIAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAIcFGLGFG 331
Cdd:cd17365 202 GYSLSQAL-TITLLLNIGGVIGSLLLGWLADRF------GPKRVLALFFALGAVSLALLGVSPASLVLLYVLV-FLAGAC 273
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1272251015 332 MFDANN-MPILC-QFVSARYRATAYGLMNMTGvFFGAFITDLLGKSSDAGSLGKD--FAMLAGIVVIALIVQLYFLRPR 406
Cdd:cd17365 274 VNGAQVgLYALAaRFYPTEVRATGVGWALGVG-RLGAILGPLLGGLLLAAGLGPEsvFLALAIPAALGALAVLLLRLRR 351
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-367 |
1.85e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 77.42 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 18 WVVALLNYMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMG 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIG--LSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 98 YAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQAL--GGFGATIADKFSWQSTFHWFGI 175
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLlpPLVLFGIAELYSWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 176 AGIIYSFVLILFLREKKLT-----DHEMVSDKLT----IKPSLFKGLGILFT----NISFWIILF-YFAVPSLPgWAAKN 241
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQScglppAEEMPNEEPDgdaeKKEEELTKKQIFLQyvllNKVLWYISLgYVFVYVVR-TGILD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 242 WLPTLFAQNLNIPMATAGpLSTITIAASSFLGVILGGILSDKWVQKNlkgRIYTSAIGLALTIPSLLLLGFGHSLFHVVG 321
Cdd:TIGR00881 238 WSPLYLTQEKGFSKEKAS-WAFTLYELGGLVGTLLAGWLSDKLFNGR---RGPLAVFFMALIIVSLLVYWLNPAANPLMD 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1272251015 322 AAICFGLGFGMFDANNM--PILCQFVSARYRATAYGLMNMTGVFFGAF 367
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLigVIASELAPKKAAGTAAGFVGFFAYLGGIL 361
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
47-402 |
1.91e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 77.27 E-value: 1.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSL 126
Cdd:cd17329 33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 127 IADFHSPKTRSLAIGIHMTGLYMGQALGGFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEmvsdklTIK 206
Cdd:cd17329 113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRA------AEK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 207 PSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTItiaaSSFLGVILGGILSdKWVQ 286
Cdd:cd17329 187 TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL----NALLIVLLQFPVA-RLVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 287 KnlKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMTGVFFGA 366
Cdd:cd17329 262 R--FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRA 339
|
330 340 350
....*....|....*....|....*....|....*.
gi 1272251015 367 FITDLLGKSSDAGSLGKDFAMLAGIVVIALIVQLYF 402
Cdd:cd17329 340 IGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
7-372 |
3.64e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 76.63 E-value: 3.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 7 NNYAWVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAeLQSATnFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSL 86
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWG-LDPVQ-LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 87 FVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFS 165
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFlAGWLIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 166 WQSTFHWFGIAGIIYSFVLILFLRE-----------------------------------KKLTDHEMVSDKLTIKPSLF 210
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFLPEsidflvskrpetvrrivnaiapqmqaeaqsalpeqKSTQGTKRSVFKALFQGKTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 211 KGLGILFTNISFWIILFYFAVpslpgwaakNWLPTLFAQnlnipmaTAGPLSTITIAASSF-----LGVILGGILSDKWV 285
Cdd:TIGR00895 250 RITVLLWLLYFMLLVGVYFLT---------NWLPKLMVE-------LGFSLSLAATGGALFnfggvIGSIIFGWLADRLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 286 QKN-----LKGRIYTSAIGLALTIPSLLLLgfghslfhvvgAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLM--- 357
Cdd:TIGR00895 314 PRVtalllLLGAVFAVLVGSTLFSPTLLLL-----------LGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAigi 382
|
410
....*....|....*
gi 1272251015 358 NMTGVFFGAFITDLL 372
Cdd:TIGR00895 383 GRLGAIIGPILAGYL 397
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
10-402 |
5.12e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 76.16 E-value: 5.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 10 AWVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVW 89
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFG--WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 90 SAVTFLMGYAETFNQIYWLRAVMGV--SEALYIPAGLSLIAdFHSPKTRSLAIGIHMTGLYMGQALGG-FGATIADKFSW 166
Cdd:cd17355 79 AAGLVLLALATSLWQLYLLWGLLGGggAGTLAAVAFATVAA-WWFERRRGLALGILTAGGGLGSLVFLpLGAALIEAFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 167 QSTFHWFGIAGIIYSFVLILFLReKKLTDHEMVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTL 246
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLLR-RRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 247 FAQNLNIPMATAGPLSTITIAAssFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHvvgAAICF 326
Cdd:cd17355 237 LADRGISPAAAAVALALIGLFN--IVGRLLSGWLGDRY------SPRRLLAASYALRALGLALLLLLPFPPL---ALLLF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 327 GLGFGMFDANNMPILCQFVSARYRATAYGLM-------NMTGVFFGAFITDLLgkSSDAGSLGKDFAMLAGIVVIALIVQ 399
Cdd:cd17355 306 AALFGLGWGATVPLTAALAARYFGARSYGTLfglvfapHQLGSALGPWLGGLL--YDRTGSYTAAWALAVALGLIAALLV 383
|
...
gi 1272251015 400 LYF 402
Cdd:cd17355 384 LPI 386
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-403 |
2.84e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 73.88 E-value: 2.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 22 LLNYMDRQMLSTMKPAMqidIAELQ-SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAE 100
Cdd:cd17371 9 ALDGFDLLLLGLVLPAL---IAEFGlDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 101 TFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIhmtgLYMGQALGGFGATIA---------DKFSWQSTFh 171
Cdd:cd17371 86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGY----VQSGWAVGWLLATLLaallfpllpPEIAWRVLF- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 172 WFGIAGIIysfvLILFLReKKLTDHEMVSDK----LTIKPSLFKGLGILFTNISFWIILFYFAVPSLPG-WAAKNWLPTL 246
Cdd:cd17371 161 LLGALPAL----LVLFIR-RFVKEPPQWQAAraarRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyYGITTWLPSY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 247 FAQNLNIPMATAGPLSTITIAASsFLGVILGGILSDKWVQKNLkgrIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICF 326
Cdd:cd17371 236 LTGERGLSFEGSAGYLVVTILGG-FLGYLAGGFLADRIGRRNN---FALFALGSAISILLYFFLPLSPTLILILGFPLGF 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1272251015 327 GLgFGMFDANnMPILCQFVSARYRATAYGLMNMTGVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIVQLYFL 403
Cdd:cd17371 312 FA-SGPFSGM-GAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-280 |
5.08e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.15 E-value: 5.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 11 WVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAElqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWS 90
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGA--SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 91 AVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQST 169
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGpLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 170 FhWFGIAGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQ 249
Cdd:COG0477 171 F-LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
|
250 260 270
....*....|....*....|....*....|.
gi 1272251015 250 NLNIPMATAGPLSTITIAASSFLGVILGGIL 280
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLL 280
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
47-403 |
8.65e-14 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 72.25 E-value: 8.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMA-IFLWIYGFMS-----PVsGIIADKFN-RKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALY 119
Cdd:cd17490 24 ESLGASLSMIgIILGAYGISQmllriPL-GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 120 IPAgLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGAT-IADKFSWQSTFhWFGIAGIIYSFVLILFLREKKLTDHem 198
Cdd:cd17490 103 VSF-TVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGlIAEHFGMRAPF-LLAALAGVLGFILSLFIKEERREKK-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 199 vsdkltIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNipmATAGPLSTITIAassFLGVILGG 278
Cdd:cd17490 179 ------PVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLG---ASSFQLGLLSII---YLLPNALA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 279 ILSDKWVQKNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMN 358
Cdd:cd17490 247 SLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQ 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1272251015 359 M---TGVFFGAFItdlLGKSSDAGSLGKDFAMLAGIVVIALIVQLYFL 403
Cdd:cd17490 327 AiyaLGMFLGPVL---VGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
47-398 |
1.56e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.49 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYA-----ETFNQIYWLRAVMGVSEALYIP 121
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 122 AGLSLIADFHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFhWFGIAGIIYSFVLILFLREKKltDHEMVS 200
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGpALGGLLVALLGPGGAF-AINALSFLLSALLLLFIRRPP--PAAPGE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 201 DKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGplstiTIAASSFLGVILGGIL 280
Cdd:cd06173 189 SSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG-----LLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 281 SDKWVQKnlKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMT 360
Cdd:cd06173 264 LGRLSKR--RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL 341
|
330 340 350
....*....|....*....|....*....|....*...
gi 1272251015 361 GVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIV 398
Cdd:cd06173 342 NSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
11-328 |
3.23e-13 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 70.38 E-value: 3.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 11 WVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWS 90
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIG--LSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 91 AVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGAT-IADKFSWQST 169
Cdd:cd17312 80 LANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAAsLASYYGWRAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 170 FHWFGIAGIIYSFVLILFLREkkltdhemvSDKLTIkpslFKGLGILFTNISFWIILFyfavpslpgwaaknWLPTLFAQ 249
Cdd:cd17312 160 FLVPGIVGLVVAIILFFFLRD---------SPPYVW----VLSLAYAFVYIVRYACLD--------------WGPLYLYE 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 250 NLNIPMATAGPLSTItIAASSFLGVILGGILSDKWVQKNlkgRIYTSAIGLALTIPSLLLLGF-GHSLFHVVGAAICFGL 328
Cdd:cd17312 213 VKGYSLIDAGWFSSL-YEVGGIAGTILAGLLSDKLFGGR---RAPIAVIYMLLMTLSLALFWFfPHNKLLSIVLLFLIGF 288
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-188 |
4.25e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.30 E-value: 4.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 13 LVGLLWVVALLNYMDRQMLSTMKPAMQIDIAELqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAV 92
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGL-SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 93 TFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFH 171
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLlGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 1272251015 172 WFGIAGIIYSFVLILFL 188
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-397 |
1.74e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.78 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKW-----LIVGSLFVWSAVTFLMGYAETFNQIYWL------RAVMGVS 115
Cdd:COG2211 44 SAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLiyalvtYLLLGLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 116 EALYIPAGLSLIAD-FHSPKTRSLAIGIHMTGLYMGQALGGFGATIADKF-------SWQSTFHWFGIAGIIYSFVLILF 187
Cdd:COG2211 124 YTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFG 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 188 LREKKLTDHEmvsdkltiKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTITIA 267
Cdd:COG2211 204 TKERPVPEEE--------KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 268 ASsFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGF--GHSLFHVVGAAICFGLGFGMFDANNMPILCQFV 345
Cdd:COG2211 276 AA-LLGAPLWPRLAKRF------GKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1272251015 346 SA-------RYRATAYGLMNMT-------GVFFGAFITDLLGKSSDAG-SLGKDFAMLAGIVVIALI 397
Cdd:COG2211 349 DYdewktgrRREGLYFGIFTFAiklgqalAGALAGLLLALFGYVAGAAqSPSALTGIRLLFFLLPAV 415
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
68-398 |
1.99e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.01 E-value: 1.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 68 VSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGL 147
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 148 YMGQALGGFGATI-----ADKFSWQSTFHWFGIAGIIysfvlILFLRekkltdhemvsdkltiKPSLFKGLGILFTNISF 222
Cdd:cd17316 135 ALGALLAALVASLlipllSGDWGWRILFLIGALPALL-----ALLLR----------------RRTLLLILLWFFISFGY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 223 WIILfyfavpslpgwaakNWLPTLFAQNLNIPMATAGPLSTItIAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLAL 302
Cdd:cd17316 194 YGLT--------------TFLPTYLQTVLGLSPATSSLYLLL-ISLGALVGALIAGLLSDRI------GRKKTLVIGLIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 303 TIPSLLLLGFGHSL-FHVVGAAICFGLGFGMFDANNMPI-LCQFVSARYRATAYGLMNMTGVFFGAFITDLLGK-SSDAG 379
Cdd:cd17316 253 SGILALPLFYLLSGsPTLLLLLLFILSFFVGGVWGALYAyLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALlLASTG 332
|
330
....*....|....*....
gi 1272251015 380 SLGKDFAMLAGIVVIALIV 398
Cdd:cd17316 333 GTGVPALILALLAIVALIV 351
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
45-398 |
3.88e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.26 E-value: 3.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 45 LQSATNFGYLMAIFLWiygfmspvsGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGL 124
Cdd:cd17475 36 LLSALNLGVAVSMLPA---------GWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 125 SLIADFHSPKTRSLAIGIHMTGLYMGQALGG-FGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEMVSdkl 203
Cdd:cd17475 107 RAIMRWFPPRERGLAMGIRQTGVPLGGALAAaLLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATES--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 204 tiKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTITIAASSfLGVILGGILSDK 283
Cdd:cd17475 184 --ASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGA-LGRIGLGRVSDR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 284 WVQKNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMnMTGVF 363
Cdd:cd17475 261 VFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLA-NTINF 339
|
330 340 350
....*....|....*....|....*....|....*..
gi 1272251015 364 FGAFITDLL--GKSSDAGSLGKDFAMLAGIVVIALIV 398
Cdd:cd17475 340 IGIAIGPPLfgLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
26-405 |
7.64e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 66.43 E-value: 7.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 26 MDRQMLSTMKPAMQ----IDIAELQSATNfGYLMAiflwiYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAET 101
Cdd:cd17321 10 LDVTIVNVALPTIArdlgASPSQLQWVVN-AYLLA-----FAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 102 FNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFHWFGIAGIIy 180
Cdd:cd17321 84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLlGGLLLELFGWRWIFLINVPIGLV- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 181 sfVLILflrekkltdhemvsdkltIKPSLFKGLGILFTNISFWIILFYfavpslpgwaaknwLPTLFAQNLNIPMATAGp 260
Cdd:cd17321 163 --ALLL------------------ARTFSGAVLAAFLLGAALGGLLFL--------------LPLYLQGVLGYSPLQAG- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 261 LSTITIAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGH---SLFHVVGAAICFGLGFGMFDANN 337
Cdd:cd17321 208 LALLPLALAMLVAAPLAGRLADRF------GPRLVLVAGLLLTAVGLLLLALLGadsSVWLLLPGLVLLGLGLGLFATPL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 338 MPILCQFVSARYRATAYGLMNMT------------GVFFGAFITDLLGKSSDAGSL---------GKDFAMLAGIVVIAL 396
Cdd:cd17321 282 TNAALSSVPKEKAGAASGILNTArqlggalgvallGALLTAGLSANLGDSGVAALLsaaaaafaaGFHLAFLVAAALALL 361
|
....*....
gi 1272251015 397 IVQLYFLRP 405
Cdd:cd17321 362 AALLALLLP 370
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
56-404 |
9.73e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.06 E-value: 9.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 56 AIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKT 135
Cdd:cd17323 41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 136 RSLAIGIHMTGLYMGQALGG-FGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTdhemvsdkltikpslfkglg 214
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPiIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIVLLL-------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 215 ILFTNISFWIILFYFAVpslpgwaaknwLPTLFAQNLNIPMATAGpLSTITIAASSFLGVILGGILSDKWVQKNLK---- 290
Cdd:cd17323 181 GLYVGLVYAILYLFLTA-----------FPYVFGEVYGFSPGEVG-LMYLPIGIGALIGSIIGGRLSDYYYRRLKKkngg 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 291 -----GRIYTSAIGLALTIPSLLLLGFGhSLFHV------VGAAIcFGLGFGM-FDANNMPILCQFVsaRYRATAYGLMN 358
Cdd:cd17323 249 kpepeARLPPAFIGAFLFPIGLFIFGWT-IYPHIhwivpiIGSAF-FGFGLMLiFQSSLTYLVDSYP--KYAASALAANT 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1272251015 359 MTGVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIVQLYFLR 404
Cdd:cd17323 325 LVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYK 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-409 |
1.80e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.26 E-value: 1.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 1 MQNKNTNNYAWVLVGLLWVVALLNYMDRQMLSTMKPAMQIDIAELqsatnfGYLMAIFLWIYGFMSPVSGIIADKFNRKW 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQA------GLLLFAFFLGYLLASLPAGRLIDRFGYKR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 81 LIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTR---SLAIGIHMTGLYMGQALGGFG 157
Cdd:COG0738 75 GLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 158 ATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEMVSDKLTIKPSLFKGLGILFtniSFWIILFYFAVpslpGW 237
Cdd:COG0738 155 ILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLL---GGLAIFLYVGA----EG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 238 AAKNWLPTLFAQNLNIPMATAGPLSTITiAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLF 317
Cdd:COG0738 228 AIGDWLPLYLKDVLGLSEATAALGLSLF-WGGMTIGRFLGGFLLKRF------GPVRLLRLSALLAAVGLLLALLAPGPW 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 318 HVVGAAICFGLGFGMFDANNMPILCQFVSaRYRATAYGLMNMTGVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALI 397
Cdd:COG0738 301 LALIGLALVGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
|
410
....*....|..
gi 1272251015 398 VQLYFLRPRHND 409
Cdd:COG0738 380 LALALKRKRRKK 391
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
52-402 |
2.22e-11 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 64.95 E-value: 2.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 52 GYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNqIYWL---RAVMGVSEALYIPAGLSLIA 128
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGG-YGALivlRILQGLAQGVTFPAMHALWA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 129 DFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFHWFGIAGIIYSFVLILFLrekkltdhemvsdkltikp 207
Cdd:cd17318 138 KWAPPLERSRLTSIAYSGSQFGTVIAMPlSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 208 slfkglgilftnISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTITIAASSFLGvILGGILSDKWVQK 287
Cdd:cd17318 199 ------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICS-IVGGYLADWLRSR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 288 NL--KGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAA--ICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMTGVF 363
Cdd:cd17318 266 GIlsTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVvfLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATI 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1272251015 364 FGaFITDLLGKS--SDAGSLG---KDFAMLAGIVVIALIVQLYF 402
Cdd:cd17318 346 AG-IISPLIVGAivKNDQTIGqwrIVFFISAAIYILGAIFYLIF 388
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
46-405 |
3.84e-11 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 64.38 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 46 QSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLM--GYAETFNQIYWLRAVMGVSEALYIPAG 123
Cdd:TIGR00894 73 WSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPAT 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 124 LSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF--GATIADKFSWQSTFHWFGIAGIIYSFVLILFLREK-KLTDHEMVS 200
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDpSIHPCISKF 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 201 DKLTIKPSLFKGLGI---------LFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTITIAA--- 268
Cdd:TIGR00894 233 EKKYINSSLQGQKGStrqslpikaIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFawl 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 269 -SSFLGVILGGILSDKWVQKNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVgAAICFGLGFGMFDANNMPILCQFVSA 347
Cdd:TIGR00894 313 cSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTI-IILTLANAVSSGPLAGVLINSLDLAP 391
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1272251015 348 RYRATAYGLMNMTGVFFGAFITDLLGKSSDAGSLG---KDFAMLAGIVVIALIVQLYFLRP 405
Cdd:TIGR00894 392 RFLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNvwlIVFLIMAFVNILCVIFYLIFGSA 452
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
11-359 |
4.71e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 64.19 E-value: 4.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 11 WVLVGLLWVVALLNYMDRQMLSTMKPA-MQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFN-RKWLIVgSLFV 88
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLK--LVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPpSKWLSV-FIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 89 WSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGAT-------IA 161
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYgvfkilgVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 162 DKFSWQSTFHWFGIAGIIYSFVLILFL------------REKKLTDHEMVSDKLTIKPSLFKGLGIL--FTNISFWIILF 227
Cdd:cd17327 161 GLAGWRWLFIIEGLITIIIGLVIFFWLpdnpskawflteEEKELAVERLRANQTGKGDQKFKWKQIKeaFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 228 YFAVPSLPGWAAKNWLPTLFAQNLNIPMATAgpLSTITIAASSFLGVILGGILSDKWvqknlKGRIYTSAIGLALTIPSL 307
Cdd:cd17327 241 FFFCSQITNNGISNFLPLILKSLGFYSLQTN--LLSVPIGALGAVSLLIAALLSDRF-----KKRGLFAIFACVLALVGS 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1272251015 308 LLLGFGHSLFHVVGAAICFGLGFGMfdanNMPILCQFVSA-----RYRATAYGLMNM 359
Cdd:cd17327 314 IILLAAPNPPGAYFAAYILGGGSYA----GFPILLSWISSncagyTKRATVLAIMLI 366
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
26-373 |
5.01e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 63.75 E-value: 5.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 26 MDRQMLSTMKPAMQ----IDIAELQSATNfGYLMAIflwiyGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAET 101
Cdd:cd17503 10 LDTTIVNVALPTIMgdlgASLDTVQWVIT-SYLLAL-----AIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 102 FNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFhWFGIAGIIY 180
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGpTLGGWLTDNLSWRWIF-YINLPIGIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 181 SFVLILFLREKKLTDHEMvsdkltikpslfkGLGILFTNISFwiiLFYFAVPSLpgwaaknwLPTLFAQNLNIPMATAGp 260
Cdd:cd17503 163 ALLLAPLLDLRLFKDRNF-------------TLGLLLSFLLG---LGLFGAMFL--------LPLYLQNVLGYSAFESG- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 261 LSTITIAASSFLGVILGGILSDKWVQKNLkgrIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPI 340
Cdd:cd17503 218 LVLAPGGLASAILSPLVGRLLDKFGPRLL---LLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTL 294
|
330 340 350
....*....|....*....|....*....|...
gi 1272251015 341 LCQFVSARYRATAYGLMNMTGVFFGAFITDLLG 373
Cdd:cd17503 295 ALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
53-398 |
8.68e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.90 E-value: 8.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 53 YLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHS 132
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 133 PKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEMVSDKltikpSLFK 211
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALApLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLS-----SLLR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 212 GLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGpLSTITIAASSFLGVILGGILSDKWVQKNLKG 291
Cdd:cd17320 193 AYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG-LLFALNAIALILGSLLNGRLVRRFGPRRLLR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 292 RIYTSAIGLALTIPSLLLLGFGHSLFHVVG-AAICFGLGFGMFDANNMPIlcqFVSARYRATAYGLMNMTGVFFGAFITD 370
Cdd:cd17320 272 LGLLLLLAAALVLLLAALLGGLSLWPLVAPlFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGFLQFLIGALAGA 348
|
330 340
....*....|....*....|....*...
gi 1272251015 371 LLGKSSDAGSLgkdfAMLAGIVVIALIV 398
Cdd:cd17320 349 LVGLLPNGTAL----PMGLLILVLGLLA 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-366 |
1.08e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.51 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 30 MLSTMKPAMQidiAELQ-SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWL 108
Cdd:cd17504 14 MLSPALPTIQ---REFGtSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 109 RAVMGVSEALyIPAGLSLIADFHSPKTRSLAIGIhMTGLYMGQALGGF--GATIADKFSWQSTFhWFGIAGIIYSFVLIL 186
Cdd:cd17504 91 RALQGIGGAV-FPLAFALVREEFPPERVPVAQGI-LSATFGIGAGIGLplGGWIVQHLGWRWIF-WTAAPVAVLLAALVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 187 FlrekkltdhemvsdkltIKPSLFKGLGILFTNISFWIILF-YFAVPSLpgwaaknwLPTLFAQNlnipmATAGPLSTIT 265
Cdd:cd17504 168 L-----------------IDLRLLRRRNVLLANITALLAGFgMFMVFQL--------LPQLLQLP-----TPTGFGLGIT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 266 IAASSFLGVILGGILSDKWVQKnLKGRI---YTSAIGLALTIPSLLLLGFGH-SLFHVVGAAICFGLGFGMFDANNMPIL 341
Cdd:cd17504 218 EAGLLLLPGALVMLIAGPLAGR-LIARVgprRVLLIGLVISAVGLLLLALLHsSLWALVVALLLIGIGLGLAFASLPNIV 296
|
330 340
....*....|....*....|....*
gi 1272251015 342 CQFVSARYRATAYGLMNMTGVFFGA 366
Cdd:cd17504 297 VESVPPDRTGIATGMNTVLRTIGSA 321
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
64-355 |
1.20e-09 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 59.51 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 64 FMSPVSGIIADKFN-RKWLIVGSLFVWSAvTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIAD-FHSPKTRSLAIG 141
Cdd:cd17384 46 ITNPIVGPLTNRIGySLPMFVGFVIMFIS-TLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASlYPDDKERGKAMG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 142 IHMTGLYMGQALG-GFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLREKKLTDHEMVSDKLTikpSLFKGLGILFTNI 220
Cdd:cd17384 125 IALGGLALGVLVGpPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTPWK---TLLKDPYILIAAG 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 221 SFWIILFYFAV--PSLPGWAAKNWLPTLFAQNLnipmatagplSTITIAASSFLGVILGGILSDKWvqknlkGRIYTSAI 298
Cdd:cd17384 202 AICFSNSGIAIlePCLPIWMMETMCPPKWQLGT----------AFLPDSIGYLIGTNLFGPLAHKI------GRWLCSLL 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1272251015 299 GLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYrATAYG 355
Cdd:cd17384 266 GMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRH-SSVYG 321
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
55-333 |
3.44e-09 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 58.78 E-value: 3.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 55 MAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAV---MGVSEALYIPAGLSLIADFH 131
Cdd:PRK08633 53 NALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFAVtflLGAQSAIYSPAKYGIIPELV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 132 SPKTRSLAIGIHMTGLYMGQALGGFGATI-------ADKFSWQSTFHWFGIAGIIYSFV-LILFLREKKL--TDHEMVSD 201
Cdd:PRK08633 133 GKENLSRANGLLEAFTIVAILAGTALFSFlfesvngNTPSEILGRIAPAGLVLLAVAVLgLIFAYRLPKVpaAAPEVFDK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 202 KLTIKPSLFKG-LGILFTNISFWI----ILFYFAVPSLpgwaAKNWLPTLFAQNLNIPMATAgplSTITIAASSfLGVIL 276
Cdd:PRK08633 213 KKYLFPKLLWRnLKLLRSDRVLWLaiigLSYFWFISQL----AQANFPAYAKEVLGLDNTFQ---VQYLLAASA-IGIGI 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1272251015 277 GGILSDKWVQKNLK-GRIYTSAIGLALtipSLLLLGFGHSLFHVVGAAICFGLGFGMF 333
Cdd:PRK08633 285 GSLLAGRLSGRHIElGLVPLGALGLAL---SLFLLPTAPSLASVLVLFFLFGFSAGLF 339
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
14-328 |
1.03e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 56.89 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 14 VGLLWVVALLNYMDRQMLST----MKPAMQIDIAELQ---SATNFGYLMAIFLwiygfmspvSGIIADKFNRKWLIVGSL 86
Cdd:PRK11551 17 IGLCFLVALLEGLDLQSAGVaaprMAQEFGLDVAQMGwafSAGILGLLPGALL---------GGRLADRIGRKRILIVSV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 87 FVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFS 165
Cdd:PRK11551 88 ALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALAsVIGVLAAGDAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 166 WQSTFHWFGIAGIIYSFVLILFLREKklTDHEMVSDKLTIKPSLFKGL---GILFTNISFWI------ILFYFAVpslpg 236
Cdd:PRK11551 168 WRHIFYVGGVGPLLLVPLLMRWLPES--RAFAQAAGAGKQRAPVLRALfgeGRATATLLLWIsyfftlIVLYFLL----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 237 waakNWLPTLF-AQNLNIPMATagpLSTITIAASSFLGVILGGILSDKWVQKNLKGRIYT------SAIGLALTIPSLLL 309
Cdd:PRK11551 241 ----NWLPSLLvGQGLSRSQAG---LVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAgilaslAALAAAPSFAGMLL 313
|
330
....*....|....*....
gi 1272251015 310 LGFGHSLFHVVGAAICFGL 328
Cdd:PRK11551 314 AGFAAGLFVVGGQSVLYAL 332
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
63-403 |
7.12e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 54.19 E-value: 7.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 63 GFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEAlYIPAGLSLIADfHSPKTRS-LAIG 141
Cdd:cd17391 50 AIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIAS-QTPKEKSgWALG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 142 IHMTGLYMGQALGGF-GATIADKFSWQSTFHWFGIAGIIYSFVLILFLRE--KKLTDHEMVSDKLTIKPSLFKGL--GIL 216
Cdd:cd17391 128 TLSTGVVAGTLIGPLlGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEdfKPVEKKKMVSTKEVWNSVPNPSLliSLF 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 217 FTNISFWIILFYFAvPSLpgwaaknwlpTLFAQNLNIPMATAGPLSTITIAASSFLGVILG---GILSDKWVQKNLkgri 293
Cdd:cd17391 208 VTTFIIQLANQSIE-PIL----------TLYIRQLMGDASNLAFISGLVFSATGVSSLLSAprlGKLGDRIGHHRI---- 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 294 ytsaIGLALTIPSLLLL--GFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLmNMTGVFFGAFITDL 371
Cdd:cd17391 273 ----LLGALLASALLYIpqAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGY-NQSFQYLGNVAGPL 347
|
330 340 350
....*....|....*....|....*....|....
gi 1272251015 372 LGkSSDAGSLGKD--FAMLAGIVVIALIVQLYFL 403
Cdd:cd17391 348 LG-SAIAAHFGYRavFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
17-367 |
5.45e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 51.03 E-value: 5.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 17 LWVVALLNYMDRQMLSTMKPAMqidIAELQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLM 96
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTI---VAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 97 GYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIhMTGLYMGQALGG--FGATIADKFSWQSTFhWFG 174
Cdd:cd17502 78 GLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGY-IGAVFGIASVAGplIGGAFTDHLSWRWCF-YIN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 175 IAGIIYSFVLilflrekkltdhemvsdkltIKPSLFKGLGILFTNISFWIILFYfavpslpgwaaknwLPTLFAQNLNIP 254
Cdd:cd17502 156 LPIGGLALAL--------------------LRTILLSSIFGFLFGGALFGLIYY--------------LPLYFQLVLGDS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 255 MATAGpLSTITIAASSFLGVILGGILSDKWvqKNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFD 334
Cdd:cd17502 202 ATKSG-VRLLPLIIGLVIGSIISGALISKT--GRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGF 278
|
330 340 350
....*....|....*....|....*....|....*..
gi 1272251015 335 ANNMPILCQFVSARYRATAYGLMN----MTGVFFGAF 367
Cdd:cd17502 279 QQPLVAVQNAVPPADVGVATATNTffrsLGGTLGVAI 315
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
47-192 |
5.82e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNR--KWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGL 124
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1272251015 125 SLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGA-TIADKFSWQSTFHWFGIAGIIYSFVLILFLREKK 192
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
46-404 |
1.13e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 50.24 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 46 QSATNFGYLMAIFLWIYGFMSPVSGIIADKFN-RKWLIVGSLFVwSAVTFLMGYAETFNQIYWLRAVM-GVSEALYIPAG 123
Cdd:cd17352 35 ESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGcRPVAIAGGLLA-ALGLLLSSFATSLWQLYLTYGVLgGLGLGLIYSPA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 124 LSLIADFHSpKTRSLAIGIHMTGLYMGQALGGFGAT-IADKFSWQSTFHWFGIAgIIYSFVLILFLRekkltdhemvsdK 202
Cdd:cd17352 114 IVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRyLLDNYGWRGALLILGGL-CLNLCVCGLLLR------------L 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 203 LTIKPSLFKGLGILFTNISFWIILFYFAvpslpgwaaknwlptLFAQNLNIPMATAGPLSTItIAASSFLGVILGGILSD 282
Cdd:cd17352 180 LKDPTFVLLALGVSFAMLGFFVPFVYLP---------------SYAKSLGIDESDAAFLLSI-IGISDIVGRILLGLLAD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 283 KwvqkNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMTGV 362
Cdd:cd17352 244 K----PRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1272251015 363 FFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIVQLYFLR 404
Cdd:cd17352 320 LAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-153 |
1.46e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.97 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 14 VGLLWVVALLNYMDRQMLSTMKPAMQIDIAELqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVT 93
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL-SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 94 FLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQAL 153
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
70-399 |
1.65e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.91 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 70 GIIADKFNRKWLIVGSLFVWSAVTFLMGYAETfnqIYWL---RAVMGvSEAlYIPAGLSLIADFHSPKTRSLAIGIhmTG 146
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATS---IYGLilgRALQG-SGA-ISSVVMALLADLTREENRTKAMAL--IG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 147 LYMGQALG---GFGATIADKFSWQSTFhWFGIAGIIYSFVLILFLR--EKKLTDHEMVSDKLTIK----PSLFKgLGILF 217
Cdd:cd17472 126 ASIGIAFAismVLGPLLAAHLGVSGLF-LITAILSLVSLLILLFFVpdPPKIVQISEKEKKKLKKllknKRLLR-LDFSI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 218 TNISFWIILFYFAVPslpgwaaknwlptLFAQNLNIPMATAGPLSTITIAASSFLGVILGgILSDKwvqKNLKGRIYTSA 297
Cdd:cd17472 204 FILHFVLMAFFYILP-------------LLLTQLGGGKGQLWKVYLPAILIGFILMVPFV-IYAEK---KGKMKQVFVSS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 298 IgLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMT---GVFFGAFITDLLGK 374
Cdd:cd17472 267 I-LLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSqflGSFLGGALGGLLWG 345
|
330 340
....*....|....*....|....*
gi 1272251015 375 SSDAGSLGKDFAMLAGIVVIALIVQ 399
Cdd:cd17472 346 LLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
54-186 |
2.35e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 54 LMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSP 133
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1272251015 134 KTRSLAIGIHMTGLYMGQALGGFGA-TIADKFSWQSTFhWFGIAGIIYSFVLIL 186
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAgYLWDLISPSAAF-LFSAVLALIALLLLL 371
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-397 |
3.41e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.78 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVM----GVSEALYIPA 122
Cdd:cd17345 36 SKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILlflnGWFQGMGWPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 123 GLSLIADFHSPKTRSLAIGI----HMTGLYMGQALGGFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLR--------- 189
Cdd:cd17345 116 SGRTMVHWFSKKERGTWTSIwnisHNVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKdtpeseglp 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 190 --------EKKLTDHEMVSDKLTIKPSLFKglgILFTNISFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPMATAGPL 261
Cdd:cd17345 196 pieeykgdYPEEADGEEEEQELSAWEIFVK---YVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 262 STI-TIAAssFLGVILGGILSDKWVQKNlkgRIYTSAIGLALTIpsLLLLGFGHSLFHVVGAAICFGLGFGMFdANNMPI 340
Cdd:cd17345 273 FSLfEWAA--IPGTLLAGWLSDKLFKGR---RAPTGIIFMILVI--VALIVYWLAPNVLVDLIALIALGFLIY-GPVMLI 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1272251015 341 LCQ---FVSARYRATAYGLMNMTGVFFGA-FITDLLGKSSDAGSLGKDFAMLAGIVVIALI 397
Cdd:cd17345 345 GLQaleLVPKKAAGTAAGLTGLFGYLGGSvLATALIGIIVDHFGWNGGFIVLLASCILAII 405
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
245-406 |
2.31e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 245 TLFAQNLNIPMATAGPLSTITiAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAI 324
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAY-ALGYALGALLLGPLSDRI------ERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 325 CFGLGFGMFDANNMPILCQFVSARYRATAYGLM-------NMTGVFFGAFITDLLGKSSdagslgkDFAMLAGIVVIALI 397
Cdd:cd17324 96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVfsgltlgLVLGRPLGGLLGQLLGWRA-------AFLAIAVLALLAAL 168
|
....*....
gi 1272251015 398 VQLYFLRPR 406
Cdd:cd17324 169 LLWRLLPSL 177
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
246-408 |
2.79e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.03 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 246 LFAQNLNIPMATAGPLSTITiAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAIC 325
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAY-ALAQLLFSPPAGRLSDRF------GRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 326 FGLGFGMFDANNMPILCQFVSARYRATAYGLMNM---TGVFFGAFITDLLgksSDAGSLGKDFAMLAGIVVIALIVQLYF 402
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaigLGFLIGPLLGGLL---ADALGYRAPFLVCAALALLALVLALLL 170
|
....*.
gi 1272251015 403 LRPRHN 408
Cdd:cd17325 171 LPEPRP 176
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
47-398 |
4.91e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 45.32 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFN-RKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIpAGLS 125
Cdd:cd17341 32 STSQIGLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGANFA-SGQP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 126 LIADFHSPKTRSLAIGIHMTGLYMGQALGGF--------GATIADKFSWQSTFHWFGIAGIIYSFVLILFLREkkLTDHe 197
Cdd:cd17341 111 WASFWFPKEKIGGAAGGIAGAGNMGVAVSQLlapliagaIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDD--LPTG- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 198 mVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSlpgwAAKNWLPTLFAQNLNIPMATAGPLSTITIAASSFLGVIlG 277
Cdd:cd17341 188 -KASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFV----GFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPA-G 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 278 GILSDKWvqknlKGRIYTSAIGLALTIPSLLLLGFGH----SLFHVVGAAICFGLGFGMfdANNM-PILCQFVSARYRAT 352
Cdd:cd17341 262 GWLSDRF-----GGRRRLWWLFIVMTIGAALLSLSLPtsgtNLVLFLALFVALGLGAGA--GNGSvFRMVPFIFRRELGA 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1272251015 353 AYGLMNMTGVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIV 398
Cdd:cd17341 335 VTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTL 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
243-408 |
6.24e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 243 LPTLFAQNLNIPMATAGPLSTITIAASsFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGA 322
Cdd:pfam07690 19 LPLLLAEDLGISPTEIGLLLTLFSLGY-ALAQPLAGRLSDRF------GRRRVLLIGLLLFALGLLLLLFASSLWLLLVL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 323 AICFGLGFGMFDANNMPILCQFVSARYRATAYGLMNMT---GVFFGAFITDLLGKSSDAGSLgkdfAMLAGIVVIALIVQ 399
Cdd:pfam07690 92 RVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGfglGAALGPLLGGLLASLFGWRAA----FLILAILSLLAAVL 167
|
....*....
gi 1272251015 400 LYFLRPRHN 408
Cdd:pfam07690 168 LLLPRPPPE 176
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-185 |
8.12e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 16 LLWVVALLNYMDRQMLSTMKPAMQIDIAELqSATNFGYLMAIFLWIYGFMSPVSGIIADK-FNRKWLIVGSLFVWSAVTF 94
Cdd:cd06174 207 LLLLAIFLVNLAYYSFSTLLPLFLLDLGGL-SVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 95 LMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGG--FGATIADKFSWQSTFHW 172
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPllAGFLLAATFGLTGAFLV 365
|
170
....*....|...
gi 1272251015 173 FGIAGIIYSFVLI 185
Cdd:cd06174 366 LAVLLLLAAILLL 378
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-402 |
9.05e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.11 E-value: 9.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 17 LWVVALLNYMDRQMLSTMKPAMQIDIAEL-QSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFL 95
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLgASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 96 MGYAETFNQIYWLRAVMGVSEAlYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALG-GFGATIADKFSWQSTFHWFG 174
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGpALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 175 IAGIIYSFVLILFLRekkltdhemvsdklTIKPSLFKGLGILFTNISFWIILFYFAvPSLPGWAAKNwlptlfaqnlnip 254
Cdd:cd17330 160 ALALLNLVLVLFFLP--------------PLRRLLLVYFLIALAFAGLESVFSLFL-KDRFGFSPSQ------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 255 maTAGPLSTITIAASSFLGVILGgilsdkwVQKNLKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFD 334
Cdd:cd17330 212 --IGLLLALVGIAGILAQLLLIP-------RLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1272251015 335 ANNMPILCQFVSARYRATAYG-------LMNMTGVFFGAFITDLLGKSSdagslgkdFAMLAGIVVIALIVQLYF 402
Cdd:cd17330 283 PALSALLSKSVPSKEQGKAQGiiqslqsLARIIGPLLAGPLYSFLGPGV--------PFLLAAGLLLIALFLLSL 349
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
64-188 |
1.06e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 64 FMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIH 143
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLY 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1272251015 144 MTGLYMGQALGGFGATIADKFSWQstfhWFGIAGIIYSFVLILFL 188
Cdd:cd17477 126 STVLGLGFALGPLLLALVGTAGAL----PFLIAAVLLLLALVPLL 166
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
68-362 |
1.52e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 43.86 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 68 VSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGL 147
Cdd:cd17343 57 IGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSM 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 148 YMGQALGGFGAT-IADKFSWQSTFHWFGIAGIIYSFVLILFLRE------KKLTDHEMVSDKLTIKPSLFKGLGILFTNI 220
Cdd:cd17343 137 NLAGSLGPILATlLALSYGWRSTLSISGTVAVVMSVVCLLFIKNepsdvgLNNIEEEESKGKKKKSPRGESTLKELLLSP 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 221 SFWIILFYFAVPSLPGWAAKNWLPTLFAQNLNIPmATAGPLSTITIAASSFLGVILGGILSDKWVQKNlKGRIYTSAIGL 300
Cdd:cd17343 217 FLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQS-ALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKH-GSSSRGNPRMP 294
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1272251015 301 ALTIPSLLLLGFGHSLFHVVGAaicfglgfgmfDANNMPILCqfVSARYRATAYGLMNMTGV 362
Cdd:cd17343 295 LALVFMAGLTVSLHLFRVHITS-----------DSSELFILL--LGFLIGFSLYGPIAIFGV 343
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
46-191 |
1.54e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.76 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 46 QSATNF--GYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEAlYIPAG 123
Cdd:PRK09874 49 HSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNA 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 124 LSLIADfHSPKTRS-LAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFHWFGIAGIIYSFVLILFLREK 191
Cdd:PRK09874 128 NALIAT-QVPRNKSgWALGTLSTGGVSGALLGPLaGGLLADSYGLRPVFFITASVLFLCFLVTLFCIREN 196
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
47-402 |
2.53e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVM-GVSEALYIPAGLS 125
Cdd:cd17353 36 SLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLgGIGAGIGYITPVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 126 LIADFHSPKtRSLAIGIHMTGLYMGQALGGFGATIA-DKFSWQSTFHWFGIAGIIYSFVLILFLR---EKKLTDHEMVSD 201
Cdd:cd17353 116 TAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLiNTVGVPTTFLILGIIFLIIIVIGAFLIRdppKGWVPPGVDPLA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 202 KLTIKPSLFKGLGILFTNISFWIILFYFAVPSLPGWAAKNWLPTlFAQNLNIPMATAGPLSTITIAASSFLGVILGGILS 281
Cdd:cd17353 195 NNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKP-IGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 282 DKWvqknlkGRIYT-SAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAYGLMnMT 360
Cdd:cd17353 274 DKI------GRKNTlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YT 346
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1272251015 361 GVFFGAFITDLLGKSSD-AGSLGKDFAMLAGIVVIALIVQLYF 402
Cdd:cd17353 347 AKGVGGLIGPIIAAYVLyTGGYNAAFIIAAALSLVALALALLL 389
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
17-185 |
2.58e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 43.18 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 17 LWVVALLNYM---DRQMLSTMKPAMQIDIAElqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVT 93
Cdd:PRK10504 12 LWIVAFGFFMqslDTTIVNTALPSMAQSLGE--SPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 94 FLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFhSPKTRSLAIGIHMT-----GLYMGQALGGFGATIAdkfSWqs 168
Cdd:PRK10504 90 LFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKI-VPREQYMAAMTFVTlpgqvGPLLGPALGGLLVEYA---SW-- 163
|
170 180
....*....|....*....|....
gi 1272251015 169 tfHWF-------GIAGIIYSFVLI 185
Cdd:PRK10504 164 --HWIflinipvGIIGAIATLMLM 185
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
246-407 |
2.71e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 246 LFAQNLNIPMATAGPLSTITiAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAIC 325
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAY-LLGAALGAPLAGRLADRF------GRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 326 FGLGFGMFDANNMPILCQFVSARYRATAYGLMNMT---GVFFGAFITDLLGKSSDAGSLgkdFAMLAGIVVIALIVQLYF 402
Cdd:COG2814 108 QGLGAGALFPAALALIADLVPPERRGRALGLLGAGlglGPALGPLLGGLLADLFGWRWV---FLVNAVLALLALLLLLRL 184
|
....*
gi 1272251015 403 LRPRH 407
Cdd:COG2814 185 LPESR 189
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
46-309 |
3.56e-04 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 42.30 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 46 QSATNF-GYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYW------LRAVMGVSEAL 118
Cdd:cd17342 59 DDAALFlGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNkylyciLWVLNGLLQST 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 119 YIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLrekkltdhem 198
Cdd:cd17342 139 GWPCVVAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGL---------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 199 VSDKLTIKPSLFKGLGILFTNISFWIilfyfavpslpgwaaknWLPTLFAQNLNIPMATAGPLStITIAASSFLGVILGG 278
Cdd:cd17342 209 LSSPPGVIPYSLAYACLKLVNYSFFF-----------------WLPFYLSNNFHWKESEADQLS-IWYDVGGIIGGIVAG 270
|
250 260 270
....*....|....*....|....*....|.
gi 1272251015 279 ILSDKwvqknLKGRIYTSAIGLALTIPSLLL 309
Cdd:cd17342 271 YISDR-----MGSRSPVVVVMLLLAIPSLFV 296
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
51-309 |
3.65e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 42.30 E-value: 3.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 51 FGYLMAIFLWIYGFMSPVSGIIADKFN-RKWLIVGSLF--VWSAVtFLMGYAETFNQIYW---LRAVMGVSEALYIPAGL 124
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPlRYFLSFGMLLsgLFTAL-FGLGYYWNIHSLWYfvvVQILAGLFQSTGWPSVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 125 SLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGATIADKFSWQSTFHWFGIAGIIYSFVLILFLrekkltdheMVSDKLT 204
Cdd:cd17344 143 ACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFL---------VEHPPGV 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 205 IKPSLFkglgILFTNISFWIILFyfavpslpgwaaknWLPTLFAQNLNIPMATAGPLSTItIAASSFLGVILGGILSDKw 284
Cdd:cd17344 214 IEFSLC----LFFAKLVSYTFLY--------------WLPLYISNTAILSAKKAGDLSTL-FDVGGIVGGILAGYISDY- 273
|
250 260
....*....|....*....|....*
gi 1272251015 285 vqknLKGRIYTSAIGLALTIPSLLL 309
Cdd:cd17344 274 ----TGGRATTCAAMLILAAPMLFI 294
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-154 |
4.61e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 14 VGLLWVVALLNYMDRQMLSTMKPAMQIDIAElqSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRK---WLIVGSLFVWS 90
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGL--SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAA 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1272251015 91 AVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALG 154
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
11-179 |
5.51e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 11 WVLVGLLWVVALLNYMDRQMLSTMKPAMQIDiaELQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWS 90
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ--RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAA 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 91 AVTFLMGYAETFNQIYWLrAVMGVSEALYIPAGLSLIADFhSPKTRSLAIGIhMTGLYMGqaLGGFGAT----IADKFSW 166
Cdd:cd17478 272 PFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQEL-LPGNVGLASGL-MMGLSFG--LGGIGAPvlgaLADAFGL 346
|
170
....*....|...
gi 1272251015 167 QSTFHWFGIAGII 179
Cdd:cd17478 347 ESVLLILALLPLL 359
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
47-333 |
9.05e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.44 E-value: 9.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFN------RKWLIVGS-----LFVWSAVTFLMGYAETFNQIYWLRAVMGVS 115
Cdd:cd17332 33 SAAAAGTIFLVARIIDAINDPLMGYLIDRTRsrwgrfRPWLLWGAiplalLFVLLFTTPDGSGTGKLIYALITYILLDLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 116 EALYIPAGLSLIAD-FHSPKTRSLAIGIHMTGLYMGQALGGFGATI--------ADKFSWQSTFHWFGIAGIIYSFVLIL 186
Cdd:cd17332 113 YTLVNIPYTALIPElTDDPEERTSLTSWRMFFATIGGLLVTVLPPPlvayfgggNASRGYFLTALIIGIIGIILLLICFF 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 187 FLREKKLtdhemVSDKLTIKPSLFKGLGILFTNISF-WIILFYFAvpSLPGWAAKNWLPTLFAQNLNIPMATAGPLSTIt 265
Cdd:cd17332 193 GTRERVV-----PPEEEKSKLPLLKSLKALLKNRPFlILLLAYLL--YFLAFNIVNTVLVYYFKYVLGGRAELVLLLLL- 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 266 IAASSFLGVILGGILSDKWvqknlkGRIYTSAIGLALTIPSLLLLGF--GHSLFHVVGAAICFGLGFGMF 333
Cdd:cd17332 265 ILSGALLALLPWPPLKKRF------GKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGA 328
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
47-189 |
9.71e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.09 E-value: 9.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSL 126
Cdd:cd17476 31 SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMAL 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1272251015 127 IADFHSP-KTRSLAIGIHMTGLYMGQALGG-FGATIADKFSWQSTFHWFGIAGIIYSFVLILFLR 189
Cdd:cd17476 111 LGRTYPPgPRKNIVFSLFGATAPLGFALGGvFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTS 175
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
64-367 |
1.22e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.82 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 64 FMSPVSGII----ADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQI-YWL-------RAVMGVSEALYIPAGLSLIADFH 131
Cdd:cd17368 51 FMRPIGAIVlgayADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgIAApllvllaRLLQGFAAGGEVGGVTAYLVEAA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 132 SPKTRSLAIGIHMTGLYMGQALGG---------FGATIADKFSWQSTFhWFGIAGIIYSFVLILFLRE--------KKLT 194
Cdd:cd17368 131 PPGRRGFYTSWQSASQQVAIVAGAlvgyllsltLTAEALAEWGWRIPF-FIGLLIIPLGLWLRRSLEEteaflerkARPT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 195 DHEMVSDKLTIKPSLFKGLGILF-TNISFWIILFYFavpslpgwaaknwlPTLFAQNLNIPMATAgPLSTITIAASSFLG 273
Cdd:cd17368 210 RRELFALLANNRRIILLGMLLVAgSTVTFYFTTVYT--------------PTYAKTVLGLSARDS-FLVTLLAGVANFIW 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 274 VILGGILSDKWVQKNLkgrIYTSAIGLALTI-PSLLLLGFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRAT 352
Cdd:cd17368 275 APLGGALSDRIGRRPV---LLVITLAALVTLyPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRST 351
|
330
....*....|....*.
gi 1272251015 353 AYGLMNMTGV-FFGAF 367
Cdd:cd17368 352 GFSLVYALAVaIFGGF 367
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
132-367 |
2.73e-03 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 39.50 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 132 SPKTRSLAIGIHMTGLYMGQALGGFGA-TIADKFSWQSTFHWFGIAgIIYSFVLILFLREKKLTDHeMVSDKLTIKPSLF 210
Cdd:cd17486 121 EDKEQGAGAGVRVNGYRIGMLVAGAGAlYLADSLSWSAVYLIMAAL-MGPGILATLFAPEPPRTDP-PANSLSETVVAFF 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 211 KGLGILFTNISFWIILFYFAVPSLpGWAAKNWLPTLFAQNLNIPMATAGPLSTITIAASSFLGVILGGILSDKWvqkNLK 290
Cdd:cd17486 199 APFKDFFGQPGALLILAFILLYKL-GDAMLGAMATPFLLDLGFTKTEIGAVYKTVGLIATIVGGLLGGFLMSRL---GLK 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 291 GRIYTSAIGLALTIPSLLLL-GFGHSLFHVVGAAICFGLGFGMFDANNMPILCQFVSARYRATAY----GLMNMTGVFFG 365
Cdd:cd17486 275 RSLWLFGILQALSNLGFIYLaHAGPNLTLLVAAVAVENFGGGLGTTAFVAYLMSLCNGEFTATQYallsSLMALGRMVLG 354
|
..
gi 1272251015 366 AF 367
Cdd:cd17486 355 AP 356
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
25-191 |
3.90e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 39.31 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 25 YMDRQMLSTMKPAMQIDIAelQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGYAETFNQ 104
Cdd:cd17488 16 YLTRKSFNAAMPAMLADLG--LDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 105 IYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGF-GATIADKFSWQSTFHWFGIAGIIYSFV 183
Cdd:cd17488 94 FAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPIlTGFAALTYGWRAGMYVPGIIAILMGIV 173
|
....*...
gi 1272251015 184 LILFLREK 191
Cdd:cd17488 174 LCWRLRDR 181
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
47-398 |
5.46e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.72 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 47 SATNFGYLMAIFLWIYGFMSPVSGIIADKFN-RKWLIVGSLFVWSAVTFLMGYAEtfnQIYWLRA-VMGVSEALYIPAgl 124
Cdd:cd17335 30 SPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVA---QIFWLLLlLVILGAFFSAPV-- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 125 sliadfhSPKTRSLAIGI--HMTGLYMGQALGG---FGAT------IADKFSWQSTFHW-FGIAGIIYSFVLILFLREKk 192
Cdd:cd17335 105 -------VPLVDSITLQYlgEERERYGKQRLWGsigFGIAallvgiLIDRSSTYKNYTIaFYVFAVLMLLALLLALKFP- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 193 ltdhemVSDKLTIKPSLFKGLGILFTNISFWIILFYFAVPSLpGWAAKNWLPTLFAQNLNIPMATAGPLSTITIAASsfl 272
Cdd:cd17335 177 ------FRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGF-GHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSE--- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 273 gvILGGILSDKWVQKnlKGRIYTSAIGLALTIPSLLLLGFGHSLFHVVGAAICFGLGFGMFdannMPILCQFVSA----R 348
Cdd:cd17335 247 --IPFFFFSSRLIQR--FGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALV----WAAAVSYASAaappG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1272251015 349 YRATAYGLMNMT----GVFFGAFITDLLGKSSDAGSLGKDFAMLAGIVVIALIV 398
Cdd:cd17335 319 LRATAQGLLQGLyfglGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
133-375 |
6.32e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 133 PKTRSLAIGIHMTGLYMGQALGGFGATIA-DKFSWQSTFhWFGIAGIIYSFVLILFLREKKLTDHEMVSDKltiKPSLFK 211
Cdd:cd17485 123 PEERGLGNAAQVVGYKLGSLLGGGGLLWLyDLIGWQSLL-LSLAALYLLLLLPVLFLRELELPQQPPASER---GAALKA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 212 GLGILFTNISFWIILFYFAVPSLPGWAAKNWLPtLFAQNLNIPMATAGPLSTITIAASSFLGVILGGILSDKWvqknlkG 291
Cdd:cd17485 199 SLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLP-PFLVDRGFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRR------G 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 292 RIYTSAIG-----LALTIPSLLLLGFGHSLFHVVGAAICF-GLGFGMFDANNMPILCQFVSARYRATAYGLM-------N 358
Cdd:cd17485 272 RRRLLLLGgllrlLLLGLYTLLALGGSGLNWVLLLASLALlHLVGGMITTALFTLMMDCSQQAQAGTDYTLLatvevlgK 351
|
250
....*....|....*..
gi 1272251015 359 MTGVFFGAFITDLLGKS 375
Cdd:cd17485 352 LLFGSLAGFLADHLGYA 368
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
45-187 |
7.07e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.38 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 45 LQSATNFG-YLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVWSAVTFLMGyaeTFNQIYWLR---AVMGVSEALYI 120
Cdd:cd17313 276 YGAGVRMGaWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMA---LVHNVTVALvlfALGGIGWATIN 352
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1272251015 121 PAGLSLIADFHSPKTRS--LAIGIHMTGLYMGQALGGFGATIADKFSWQSTFHWFGIAGIIYSFVLILF 187
Cdd:cd17313 353 INPYPLVSDYHSESGRGqgTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
81-188 |
8.04e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 8.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 81 LIVGSLFVWSAVTFLMGYAETFNQIYWLRAVMGVSEALYIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGATI 160
Cdd:cd06180 66 LIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPA 145
|
90 100
....*....|....*....|....*...
gi 1272251015 161 ADKFSWQSTFHWFGIAGIIYSFVLILFL 188
Cdd:cd06180 146 GLGGGLSWRAGWLALALLSAVLLLLSFL 173
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
19-188 |
8.53e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.38 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 19 VVALLNYMDRQMLSTMKPAMQIDI-AELQSATNFGYLMAIFLWIYGFMSPVSGIIADKFNRKWLIVGSLFVwSAVTFLM- 96
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIvADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLL-GVVGSIVa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272251015 97 GYAETFNQIYWLRAVMGVSEALyIPAGLSLIADFHSPKTRSLAIGIHMTGLYMGQALGGFGA---TIADKFSWQSTFhWF 173
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAgalVEANAAGWRWIF-YI 157
|
170
....*....|....*
gi 1272251015 174 GIAGIIYSFVLILFL 188
Cdd:cd06179 158 NAIFNALALILLFFF 172
|
|
| |
