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Conserved domains on  [gi|1272249726|gb|ATP55136.1|]
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SusC/RagA family TonB-linked outer membrane protein [Pedobacter ginsengisoli]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 1000763)

SusC/RagA family TonB-linked outer membrane protein

Gene Ontology:  GO:0022857|GO:0009279

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC super family cl37378
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-1041 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


The actual alignment was detected with superfamily member TIGR04056:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 604.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   27 KITGTVTgNPDGETIPGASIIIKGKKSGTTTDGNGKFSLAADVNDVLSISYLGYATKEITITAATaTLNITLDVASNALS 106
Cdd:TIGR04056    2 TVTGVVV-DETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQK-NLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  107 EVVVTALGISKeKKSLGYAVQELKSKDIATAKETNLINSLAGKIAGVQTTNSQGDMG-SSRIIIRGETSISGNNQPLFVV 185
Cdd:TIGR04056   80 EVVVVGYGTQK-KKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGgDAEIWIRGISSFGGNNSPLYVI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  186 DGVPVDNsqnlgiagsrdfanTISDINSEDIESISVLKGPNAAALYGSRAAAGVILIKTKtgRGQKG-LGISVNSNTTFS 264
Cdd:TIGR04056  159 DGVPRDN--------------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTK--RGKEGkPKISYNAEFGFS 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  265 NLLTLPDYQNSFGQGTSGK-FSFVDGKGGGVNDGVDE--SWGPALDGRLIPQFNSKGvavpfiahpdnvKNFFETGYALN 341
Cdd:TIGR04056  223 TPTRLPEMLNAYEYAELYNeALLNRGSSPPDIYTDEEieAYRNGLDPDLYPNTDWQD------------EIFKRTAFNQR 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  342 NGIAIAGSGEKQDVRFSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNADNLPASGGkratGPMLQF 421
Cdd:TIGR04056  291 HNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTS----NIWGAL 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  422 TWFGRQVDVSQLKNYKDENGNDFNWNNSYYSNPYFIAYENTVGQKRDRIIGNAELNYKITSALSANFRTGNDYYTDRRKI 501
Cdd:TIGR04056  367 MLFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  502 KIAYGTNGTPFGSYEEDAYTVNENNT-----EGRLEFNKKLNsDFSIDILGGGNirtstFEQNDQKATKLAVNGLYTLSN 576
Cdd:TIGR04056  447 YYKNPYYYNATGGANNGYYSESNSRSrnyylEATLNYNRTFG-KHNVSALLGYS-----QQENKSSSYGGLLDDLPSLDA 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  577 SRDPLVSSNFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGSLILTEAFDIK--SDVLSFAK 654
Cdd:TIGR04056  521 GTSDASVSGSDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKklKKWLSFLK 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  655 IRGGWSKVG--KATDPYQLINTYSFTA---PFDGNPQQSANTIDL----NPNLLPEITKSAEAGAEIGLFDNRIKLDLSV 725
Cdd:TIGR04056  601 LRASYGIVGndNIGDRYPYLSLYNLGDggyNFGTNNGTSVTGITEsrygNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDY 680

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  726 YNTNSINQILKVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQKDFSWDINLNYSRNRSKVTELDKEGRISSYTigt 805
Cdd:TIGR04056  681 YYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPVKY--- 757

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  806 sgtlDVLAAVGQPYGTFFG----TAYQRDA-----AGQVIVG------ANGTPLIDPA-KQILGK-FTPNWIGGITNSFT 868
Cdd:TIGR04056  758 ----PYISKEGGPIGQIYGyiadGLFKDDDspkqtFGNVRPGdikykdVNGDGKIDDDdRVPIGYsNTPDLTYGFGNSFS 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  869 YRNFNLNFLVDARIGGKVFSGTNSTGTYTGVLASTMR-----------GRNAENGGLTYTTGGVTYNdgmifdgvladgt 937
Cdd:TIGR04056  834 YKGFDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLkivadnrwtpeNPNADYPRLSYGDSNNSNN------------- 900

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  938 kntkvisaeeyYKATTKsneeFVYSASYIKLREVRLSYNIPSQWVKKIGLQEANFSLVGRNLWIIHKdIPNIDPETafnt 1017
Cdd:TIGR04056  901 -----------YQASTR----WLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSK-YKGWDPEL---- 960

                         1050      1060
                   ....*....|....*....|....
gi 1272249726 1018 gnaQGLESLTLPTTRSFGFNLNFK 1041
Cdd:TIGR04056  961 ---QGNDGGAYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-1041 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 604.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   27 KITGTVTgNPDGETIPGASIIIKGKKSGTTTDGNGKFSLAADVNDVLSISYLGYATKEITITAATaTLNITLDVASNALS 106
Cdd:TIGR04056    2 TVTGVVV-DETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQK-NLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  107 EVVVTALGISKeKKSLGYAVQELKSKDIATAKETNLINSLAGKIAGVQTTNSQGDMG-SSRIIIRGETSISGNNQPLFVV 185
Cdd:TIGR04056   80 EVVVVGYGTQK-KKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGgDAEIWIRGISSFGGNNSPLYVI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  186 DGVPVDNsqnlgiagsrdfanTISDINSEDIESISVLKGPNAAALYGSRAAAGVILIKTKtgRGQKG-LGISVNSNTTFS 264
Cdd:TIGR04056  159 DGVPRDN--------------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTK--RGKEGkPKISYNAEFGFS 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  265 NLLTLPDYQNSFGQGTSGK-FSFVDGKGGGVNDGVDE--SWGPALDGRLIPQFNSKGvavpfiahpdnvKNFFETGYALN 341
Cdd:TIGR04056  223 TPTRLPEMLNAYEYAELYNeALLNRGSSPPDIYTDEEieAYRNGLDPDLYPNTDWQD------------EIFKRTAFNQR 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  342 NGIAIAGSGEKQDVRFSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNADNLPASGGkratGPMLQF 421
Cdd:TIGR04056  291 HNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTS----NIWGAL 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  422 TWFGRQVDVSQLKNYKDENGNDFNWNNSYYSNPYFIAYENTVGQKRDRIIGNAELNYKITSALSANFRTGNDYYTDRRKI 501
Cdd:TIGR04056  367 MLFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  502 KIAYGTNGTPFGSYEEDAYTVNENNT-----EGRLEFNKKLNsDFSIDILGGGNirtstFEQNDQKATKLAVNGLYTLSN 576
Cdd:TIGR04056  447 YYKNPYYYNATGGANNGYYSESNSRSrnyylEATLNYNRTFG-KHNVSALLGYS-----QQENKSSSYGGLLDDLPSLDA 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  577 SRDPLVSSNFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGSLILTEAFDIK--SDVLSFAK 654
Cdd:TIGR04056  521 GTSDASVSGSDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKklKKWLSFLK 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  655 IRGGWSKVG--KATDPYQLINTYSFTA---PFDGNPQQSANTIDL----NPNLLPEITKSAEAGAEIGLFDNRIKLDLSV 725
Cdd:TIGR04056  601 LRASYGIVGndNIGDRYPYLSLYNLGDggyNFGTNNGTSVTGITEsrygNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDY 680

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  726 YNTNSINQILKVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQKDFSWDINLNYSRNRSKVTELDKEGRISSYTigt 805
Cdd:TIGR04056  681 YYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPVKY--- 757

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  806 sgtlDVLAAVGQPYGTFFG----TAYQRDA-----AGQVIVG------ANGTPLIDPA-KQILGK-FTPNWIGGITNSFT 868
Cdd:TIGR04056  758 ----PYISKEGGPIGQIYGyiadGLFKDDDspkqtFGNVRPGdikykdVNGDGKIDDDdRVPIGYsNTPDLTYGFGNSFS 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  869 YRNFNLNFLVDARIGGKVFSGTNSTGTYTGVLASTMR-----------GRNAENGGLTYTTGGVTYNdgmifdgvladgt 937
Cdd:TIGR04056  834 YKGFDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLkivadnrwtpeNPNADYPRLSYGDSNNSNN------------- 900

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  938 kntkvisaeeyYKATTKsneeFVYSASYIKLREVRLSYNIPSQWVKKIGLQEANFSLVGRNLWIIHKdIPNIDPETafnt 1017
Cdd:TIGR04056  901 -----------YQASTR----WLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSK-YKGWDPEL---- 960

                         1050      1060
                   ....*....|....*....|....
gi 1272249726 1018 gnaQGLESLTLPTTRSFGFNLNFK 1041
Cdd:TIGR04056  961 ---QGNDGGAYPLQRTFSFGVNLT 981
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 85-800 1.09e-46

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 177.74  E-value: 1.09e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   85 ITITAATATLNITLDVASNALSEVVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLAgKIAGVQTTNSQGDMGS 164
Cdd:COG4771      7 LLLLALAAQAADALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGS 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  165 SRIIIRGetsiSGNNQPLFVVDGVPVDNSQNLGIAGsrdfantISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKT 244
Cdd:COG4771     86 SGISIRG----LGGDRVLVLIDGVPVNNPALGGGGD-------LSYIPPDDIERIEVIRGP-ASALYGSDAIGGVINIIT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  245 KTGRGQKGLGISVNSNTtfsnlltlpdyQNSFGQGTSGKFSFVDGKGggvndgvdeswgpaldgrlipqfnskgvavpfi 324
Cdd:COG4771    154 KKPTDELEGSVSLGYGS-----------NGNGTYSGSLSLGGPGDKL--------------------------------- 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  325 ahpdnvknffetgyalnnGIAIAGSGEKQDvrfSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNAD 404
Cdd:COG4771    190 ------------------SFLLSGSYRDRD---GYLDYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRD 248

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  405 NLPASGGkratgpmlqftwfgrqvdvsqlknykdengndfnwnnsyySNPYFIAYENTVGQKRDRIIGNAELNYKITSAL 484
Cdd:COG4771    249 GGPPTLG----------------------------------------DTEISSDNAGDRDTTTDRGNYSLRYNGDLGDNL 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  485 SANFrtgndyYTDRRKIKIAYGTNGTPFGSYEedayTVNENNTEGRLEFNKKLNSDFSIdILGGGnirtstfeqndqkat 564
Cdd:COG4771    289 DLSL------YYSRTDRDSTNGSLGGSTGSFS----DSDDTTYGLELDLTYPLGGNHTL-TLGAE--------------- 342

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  565 klavnglYTLSNSRDPLVSSNFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGSLILTEAFd 644
Cdd:COG4771    343 -------YRYDDLDSSSFLGGADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDNL- 414

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  645 iksdvlsfaKIRGGWSKVGKATDPYQLINTYSFTAPFDGNPqqsantidlNPNLLPEITKSAEAGAEIGLFDNRIKLDLS 724
Cdd:COG4771    415 ---------TLRASYGRGFRAPSLAELYGSGTGTPGRYVLG---------NPDLKPETSDNYELGLEYRLGNGGLSLSLT 476

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1272249726  725 VYNTNSINQILKVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQkdfsWDINLNYSRNRSKVTELDKEGRISS 800
Cdd:COG4771    477 GFYTDIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRLGKG----LTLTASYTYLDSKIDDGDTGEPLPN 548
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 126-802 8.92e-23

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 104.46  E-value: 8.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  126 VQELKSKDIAtAKETNLINSLAGKIAGVqTTNSQGDMGSSRIIIRGetsiSGNNQPLFVVDGVPVDNSqnlgiAGSRDFA 205
Cdd:cd01347      2 VSVITAEDIE-KQPATSLADLLRRIPGV-SVTRGGGGGGSTISIRG----FGPDRTLVLVDGLPLASS-----NYGRGVD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  206 NTIsdINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgRGQKGLGISVnsnttfsnlltlpdyqnSFGQGTSGKFS 285
Cdd:cd01347     71 LNT--IPPELIERVEVLKGP-SSALYGSGAIGGVVNIITK--RPTDEFGGSV-----------------TAGYGSDNSGS 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  286 FVDGKGGGVNDGVDESWGpalDGRLIPQFNSKGVAVPFIAHPDnvknffetgyalnngiaiagsgekqdvrfsynnltqg 365
Cdd:cd01347    129 SGGGGFDVSGALADDGAF---GARLYGAYRDGDGTIDGDGQAD------------------------------------- 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  366 gilpNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNADNlpasggkraTGPMLQFTWFGRQVDVSQLKNYkdeNGNDFN 445
Cdd:cd01347    169 ----DSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADG---------PGGTLPANGTGSSLGGGPSSNT---NGDRDW 232

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  446 WNNSYYSNPYFIAYENTVGQkrdriignaelnykitsaLSANFRTGNDYYTDRRKIKIAYGTNGTPFGSYEEDAYTVNEN 525
Cdd:cd01347    233 DYRDRYRKRASLGLEHDLND------------------TGWTLRANLSYSYTDNDGDPLILNGGNNAAGGDLGRSGYSSE 294

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  526 NTEGRLEFNKKLNSDFsidilgggnirtstfeQNDQKATKLAVNGLYtlsnsrdplvsSNFYSKLRTYSLFGSAQLGFRD 605
Cdd:cd01347    295 RDTTQLGFDAGLNAPF----------------GTGPVAHTLTLGVEY-----------RREELDEKQTALYAQDTIELTD 347

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  606 YAYLNLTARNDW------DSSLPEPNLSYFY----PSVNGSLILTEAFdiksdvlsfaKIRGGWSKVGKATDPYQLINTY 675
Cdd:cd01347    348 DLTLTLGLRYDHydqdskDTIAGGTTAKKSYshwsPSLGLVYKLTDGL----------SLYASYSQGFRAPSLGELYGGG 417

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  676 SFTAPFDGNpqqsantidlNPNLLPEITKSAEAGAEiGLFDNRIKLDLSVYNTNSINQILKVDVSSATGYTQKLINGGSI 755
Cdd:cd01347    418 SHGGTAAVG----------NPNLKPEKSKQYELGLK-YDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKA 486

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 1272249726  756 NNKGIEIQLGLTPIkqKDFSWDINLNYSRNRSKVTELDKEGRISSYT 802
Cdd:cd01347    487 RIRGVELEASYDLT--DGLGLTGSYTYTDTEVKRTDGATTGNRLPGI 531
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 118-239 5.13e-18

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 80.39  E-value: 5.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  118 EKKSLGYAVQELKSKDIATAKETNLINSLAGkIAGVQTTNSQGDmGSSRIIIRGetsiSGNNQPLFVVDGVPvdnsqnlg 197
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSVSSGGGG-GGSSISIRG----FGSNRVLVLVDGVP-------- 66

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1272249726  198 IAGSRDFANTISDINSEDIESISVLKGPnAAALYGSRAAAGV 239
Cdd:pfam07715   67 LNSGGGGSVDLNSIDPEDIERVEVLKGP-ASALYGSGAIGGV 107
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
89-245 9.18e-12

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 69.29  E-value: 9.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   89 AATATLNITLDVASNALSEVVVTALgiSKEKKSLGYAVqeLKSKDIATAKETNLINSLAGKIAGVQTT-NS-QGDMGSSR 166
Cdd:PRK13524    22 AAEAEDAKTDDTPASHEDTIVVTAA--EQNLQAPGVST--ITAEDIRKRPPANDVSEIIRTMPGVNLTgNStSGQRGNNR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  167 II-IRGetsiSGNNQPLFVVDGVPVD--NSQNLGIAGSRDfanTISDIN---SEDIESISVLKGPnAAALYGSRAAAGVI 240
Cdd:PRK13524    98 QIdIRG----MGPENTLILIDGKPVSsrNSVRYGWRGERD---TRGDTNwvpPEMIERIEVLRGP-AAARYGNGAAGGVV 169


                   ....*
gi 1272249726  241 LIKTK 245
Cdd:PRK13524   170 NIITK 174
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-1041 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 604.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   27 KITGTVTgNPDGETIPGASIIIKGKKSGTTTDGNGKFSLAADVNDVLSISYLGYATKEITITAATaTLNITLDVASNALS 106
Cdd:TIGR04056    2 TVTGVVV-DETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQK-NLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  107 EVVVTALGISKeKKSLGYAVQELKSKDIATAKETNLINSLAGKIAGVQTTNSQGDMG-SSRIIIRGETSISGNNQPLFVV 185
Cdd:TIGR04056   80 EVVVVGYGTQK-KKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGgDAEIWIRGISSFGGNNSPLYVI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  186 DGVPVDNsqnlgiagsrdfanTISDINSEDIESISVLKGPNAAALYGSRAAAGVILIKTKtgRGQKG-LGISVNSNTTFS 264
Cdd:TIGR04056  159 DGVPRDN--------------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTK--RGKEGkPKISYNAEFGFS 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  265 NLLTLPDYQNSFGQGTSGK-FSFVDGKGGGVNDGVDE--SWGPALDGRLIPQFNSKGvavpfiahpdnvKNFFETGYALN 341
Cdd:TIGR04056  223 TPTRLPEMLNAYEYAELYNeALLNRGSSPPDIYTDEEieAYRNGLDPDLYPNTDWQD------------EIFKRTAFNQR 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  342 NGIAIAGSGEKQDVRFSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNADNLPASGGkratGPMLQF 421
Cdd:TIGR04056  291 HNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTS----NIWGAL 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  422 TWFGRQVDVSQLKNYKDENGNDFNWNNSYYSNPYFIAYENTVGQKRDRIIGNAELNYKITSALSANFRTGNDYYTDRRKI 501
Cdd:TIGR04056  367 MLFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  502 KIAYGTNGTPFGSYEEDAYTVNENNT-----EGRLEFNKKLNsDFSIDILGGGNirtstFEQNDQKATKLAVNGLYTLSN 576
Cdd:TIGR04056  447 YYKNPYYYNATGGANNGYYSESNSRSrnyylEATLNYNRTFG-KHNVSALLGYS-----QQENKSSSYGGLLDDLPSLDA 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  577 SRDPLVSSNFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGSLILTEAFDIK--SDVLSFAK 654
Cdd:TIGR04056  521 GTSDASVSGSDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKklKKWLSFLK 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  655 IRGGWSKVG--KATDPYQLINTYSFTA---PFDGNPQQSANTIDL----NPNLLPEITKSAEAGAEIGLFDNRIKLDLSV 725
Cdd:TIGR04056  601 LRASYGIVGndNIGDRYPYLSLYNLGDggyNFGTNNGTSVTGITEsrygNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDY 680

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  726 YNTNSINQILKVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQKDFSWDINLNYSRNRSKVTELDKEGRISSYTigt 805
Cdd:TIGR04056  681 YYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPVKY--- 757

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  806 sgtlDVLAAVGQPYGTFFG----TAYQRDA-----AGQVIVG------ANGTPLIDPA-KQILGK-FTPNWIGGITNSFT 868
Cdd:TIGR04056  758 ----PYISKEGGPIGQIYGyiadGLFKDDDspkqtFGNVRPGdikykdVNGDGKIDDDdRVPIGYsNTPDLTYGFGNSFS 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  869 YRNFNLNFLVDARIGGKVFSGTNSTGTYTGVLASTMR-----------GRNAENGGLTYTTGGVTYNdgmifdgvladgt 937
Cdd:TIGR04056  834 YKGFDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLkivadnrwtpeNPNADYPRLSYGDSNNSNN------------- 900

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  938 kntkvisaeeyYKATTKsneeFVYSASYIKLREVRLSYNIPSQWVKKIGLQEANFSLVGRNLWIIHKdIPNIDPETafnt 1017
Cdd:TIGR04056  901 -----------YQASTR----WLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSK-YKGWDPEL---- 960

                         1050      1060
                   ....*....|....*....|....
gi 1272249726 1018 gnaQGLESLTLPTTRSFGFNLNFK 1041
Cdd:TIGR04056  961 ---QGNDGGAYPLQRTFSFGVNLT 981
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 85-800 1.09e-46

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 177.74  E-value: 1.09e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   85 ITITAATATLNITLDVASNALSEVVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLAgKIAGVQTTNSQGDMGS 164
Cdd:COG4771      7 LLLLALAAQAADALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGS 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  165 SRIIIRGetsiSGNNQPLFVVDGVPVDNSQNLGIAGsrdfantISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKT 244
Cdd:COG4771     86 SGISIRG----LGGDRVLVLIDGVPVNNPALGGGGD-------LSYIPPDDIERIEVIRGP-ASALYGSDAIGGVINIIT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  245 KTGRGQKGLGISVNSNTtfsnlltlpdyQNSFGQGTSGKFSFVDGKGggvndgvdeswgpaldgrlipqfnskgvavpfi 324
Cdd:COG4771    154 KKPTDELEGSVSLGYGS-----------NGNGTYSGSLSLGGPGDKL--------------------------------- 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  325 ahpdnvknffetgyalnnGIAIAGSGEKQDvrfSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNAD 404
Cdd:COG4771    190 ------------------SFLLSGSYRDRD---GYLDYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRD 248

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  405 NLPASGGkratgpmlqftwfgrqvdvsqlknykdengndfnwnnsyySNPYFIAYENTVGQKRDRIIGNAELNYKITSAL 484
Cdd:COG4771    249 GGPPTLG----------------------------------------DTEISSDNAGDRDTTTDRGNYSLRYNGDLGDNL 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  485 SANFrtgndyYTDRRKIKIAYGTNGTPFGSYEedayTVNENNTEGRLEFNKKLNSDFSIdILGGGnirtstfeqndqkat 564
Cdd:COG4771    289 DLSL------YYSRTDRDSTNGSLGGSTGSFS----DSDDTTYGLELDLTYPLGGNHTL-TLGAE--------------- 342

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  565 klavnglYTLSNSRDPLVSSNFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGSLILTEAFd 644
Cdd:COG4771    343 -------YRYDDLDSSSFLGGADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDNL- 414

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  645 iksdvlsfaKIRGGWSKVGKATDPYQLINTYSFTAPFDGNPqqsantidlNPNLLPEITKSAEAGAEIGLFDNRIKLDLS 724
Cdd:COG4771    415 ---------TLRASYGRGFRAPSLAELYGSGTGTPGRYVLG---------NPDLKPETSDNYELGLEYRLGNGGLSLSLT 476

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1272249726  725 VYNTNSINQILKVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQkdfsWDINLNYSRNRSKVTELDKEGRISS 800
Cdd:COG4771    477 GFYTDIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRLGKG----LTLTASYTYLDSKIDDGDTGEPLPN 548
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
105-793 3.21e-43

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 168.08  E-value: 3.21e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  105 LSEVVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLaGKIAGVQTTNSQGdmGSSRIIIRGetSISGNNQPLFV 184
Cdd:COG1629      1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLL-RRVPGVSVTSAGG--GAGQISIRG--FGGGGNRVLVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  185 VDGVPVDNSQNLGiagsrdfaNTISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgrgqkglgisvnsnttfs 264
Cdd:COG1629     76 VDGVPLNDPSGGD--------GGLSYIDPEDIERVEVLRGP-SSALYGSGALGGVINIVTK------------------- 127

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  265 nlltlpdyqnsfgQGTSGKFSFVDGKGGGVNDgvdeswgpaldgrlipqfnskgvavpfiahpdnvknffetgyaLNNGI 344
Cdd:COG1629    128 -------------KPKDGKGGEVSASYGSYGT-------------------------------------------YRASL 151

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  345 AIAGSGEKQDVRFSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNADNlpasggkratgpmlqftwf 424
Cdd:COG1629    152 SLSGGNGKLAYRLSASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQDS------------------- 212

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  425 grqvDVSQLKNYKDENGNDFNWNNSYYSNPyfiayentvgQKRDRIIGNAELNYKITSALSaNFRTGNDYYTDRRKIKIA 504
Cdd:COG1629    213 ----PGYLTLAALRPRGAMDDGTNPYSNDT----------DDNTRDRYSLSLEYEHLGDGL-KLSASAYYRYDDTDLDSD 277

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  505 YGTNGTPFGSYEEDAYTVNENNTEGRLEFNKKLNSDFSIdiLGGGNIRTSTFEQNDQkATKLAVNGLYTLSNSRDplvss 584
Cdd:COG1629    278 FTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTL--LVGLDYQRQDLDGSGY-PLDLGSGSLPTLTSGAD----- 349

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  585 nFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGslilteafdiKSDVLSFAKIRGGWskvgK 664
Cdd:COG1629    350 -DDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDSASGS----------RSYSAFSPSLGLTY----Q 414

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  665 ATDPYQLINTYS--FTAP--FDGNPQQSANTIDLNPNLLPEITKSAEAGAEIGLFDNRIKLDLSVYNTNSINQILKVDVS 740
Cdd:COG1629    415 LSPNLSLYASYSrgFRAPtfGELYANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEILSVPLP 494

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1272249726  741 SATGYTQKLINGGSINNKGIEIQLGLTPIKQkdfsWDINLNYSRNRSKVTELD 793
Cdd:COG1629    495 NDSGFSTYYTNAGKARSYGVELELSYQLTPG----LSLNASYSYTDAKFDDDT 543
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
108-302 3.20e-33

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 129.99  E-value: 3.20e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  108 VVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLAgKIAGVQTTNSQGDMGSSRIIIRGETSisgnNQPLFVVDG 187
Cdd:COG4206      1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSSGGPGSAASISIRGLGS----NQTLVLIDG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  188 VPVDNSQNlgiaGSRDFantiSDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKTGRGQKGLGISVN--SNTTFSN 265
Cdd:COG4206     76 VPLNDPSL----GGVDL----SLIPPDDIERIEVLKGA-ASALYGSDAIGGVINITTKKGKKGFKGSVSASygSFGTRRL 146

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1272249726  266 LLTLPDYQNSFGQGTSGKFSFVDGKGGGVNDGVDESW 302
Cdd:COG4206    147 SASLSGGAGKFSYSLSASYRRSDGYRYNDPDLRNNDG 183
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 126-802 8.92e-23

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 104.46  E-value: 8.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  126 VQELKSKDIAtAKETNLINSLAGKIAGVqTTNSQGDMGSSRIIIRGetsiSGNNQPLFVVDGVPVDNSqnlgiAGSRDFA 205
Cdd:cd01347      2 VSVITAEDIE-KQPATSLADLLRRIPGV-SVTRGGGGGGSTISIRG----FGPDRTLVLVDGLPLASS-----NYGRGVD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  206 NTIsdINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgRGQKGLGISVnsnttfsnlltlpdyqnSFGQGTSGKFS 285
Cdd:cd01347     71 LNT--IPPELIERVEVLKGP-SSALYGSGAIGGVVNIITK--RPTDEFGGSV-----------------TAGYGSDNSGS 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  286 FVDGKGGGVNDGVDESWGpalDGRLIPQFNSKGVAVPFIAHPDnvknffetgyalnngiaiagsgekqdvrfsynnltqg 365
Cdd:cd01347    129 SGGGGFDVSGALADDGAF---GARLYGAYRDGDGTIDGDGQAD------------------------------------- 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  366 gilpNSSQDKNSLLLNTSYRITPKLTLNASANYIKSNADNlpasggkraTGPMLQFTWFGRQVDVSQLKNYkdeNGNDFN 445
Cdd:cd01347    169 ----DSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADG---------PGGTLPANGTGSSLGGGPSSNT---NGDRDW 232

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  446 WNNSYYSNPYFIAYENTVGQkrdriignaelnykitsaLSANFRTGNDYYTDRRKIKIAYGTNGTPFGSYEEDAYTVNEN 525
Cdd:cd01347    233 DYRDRYRKRASLGLEHDLND------------------TGWTLRANLSYSYTDNDGDPLILNGGNNAAGGDLGRSGYSSE 294

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  526 NTEGRLEFNKKLNSDFsidilgggnirtstfeQNDQKATKLAVNGLYtlsnsrdplvsSNFYSKLRTYSLFGSAQLGFRD 605
Cdd:cd01347    295 RDTTQLGFDAGLNAPF----------------GTGPVAHTLTLGVEY-----------RREELDEKQTALYAQDTIELTD 347

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  606 YAYLNLTARNDW------DSSLPEPNLSYFY----PSVNGSLILTEAFdiksdvlsfaKIRGGWSKVGKATDPYQLINTY 675
Cdd:cd01347    348 DLTLTLGLRYDHydqdskDTIAGGTTAKKSYshwsPSLGLVYKLTDGL----------SLYASYSQGFRAPSLGELYGGG 417

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  676 SFTAPFDGNpqqsantidlNPNLLPEITKSAEAGAEiGLFDNRIKLDLSVYNTNSINQILKVDVSSATGYTQKLINGGSI 755
Cdd:cd01347    418 SHGGTAAVG----------NPNLKPEKSKQYELGLK-YDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKA 486

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 1272249726  756 NNKGIEIQLGLTPIkqKDFSWDINLNYSRNRSKVTELDKEGRISSYT 802
Cdd:cd01347    487 RIRGVELEASYDLT--DGLGLTGSYTYTDTEVKRTDGATTGNRLPGI 531
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
85-791 5.18e-21

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 98.85  E-value: 5.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   85 ITITAATATLNITLDVASNALSEVVVTALGISKEK-KSLGYAVQELKSKDIATAKETNLINSLAgKIAGVQTTNSQGDMG 163
Cdd:COG4772      3 RALAAALLLAAAAAAEAATTLETVVVTGSRAAEARlKDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDGFGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  164 SSRIIIRGeTSISGNNQPLFVVDGVPVdnSQNLGIAGSRDFANTIsdinsEDIESISVLKGPNAAaLYGSRAAAGVILIK 243
Cdd:COG4772     82 RPNIGIRG-LGPRRSRGITLLEDGIPI--APAPYGDPAAYYFPDL-----ERMERIEVLRGAAAL-RYGPQTVGGAINFV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  244 TKTGRGQKGLGISV--NSNTTFsnlltlpDYQNSFGqGTSGKFSFVdgkgggvndgvdeswgpaldgrlipqfnskgvav 321
Cdd:COG4772    153 TRTIPTAFGGELRVtgGSFGYR-------RTHASVG-GTVGNFGYL---------------------------------- 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  322 pfiahpdnvknffetgyalnngiaiagsgekqdvrFSYNNLTQGGILPNSSQDKNSLLLNTSYRITPKLTLNASANYIKS 401
Cdd:COG4772    191 -----------------------------------VEYSRKRGDGFRDNSGFDINDFNAKLGYRLSDRQELTLKFQYYDE 235

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  402 NAdNLPasGGkratgpmlqFTWFgrqvdvsqlknykdengnDFNwNNSYYSNPYFIAYENtvgqkrDRIIGNAELNYKIT 481
Cdd:COG4772    236 DA-NTP--GG---------LTDA------------------QFD-ADPRQSYRPADQFDT------RRTQLSLRYEHQLS 278

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  482 SALSANFRTgndYYTDRR---KIKIAYGTNGTPFGSYEEDAYTVNENNTEGRLEFNKKLNSDFSiDILGGGN-IRTSTFE 557
Cdd:COG4772    279 DNTTLTTTA---YYNDFSrnwYIRQNTADPNTPGLGLRGNPRGYRSYGIEPRLTHRFELGGVPH-TLEVGLRyHREEEDR 354

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  558 QNDQKATKLAVNGLYTLSNSRDPLVSSNFYSKLRtYSLFG--SAQLGFRdYAYLNLTaRNDWDSSLPEPNLSY------F 629
Cdd:COG4772    355 KQYVNTYGQGRSGAGLRRDRRFSADALAAYAQNR-FELTGrlTLTPGLR-YEHIRRD-RTDRYSTRTGGDDSGsnsyseF 431

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  630 YPSVNGSLILTEAFDIksdvlsFAkirgGWSKvgkatdpyqlintySFTAPfdgNPQQSANTIDLNPNLLPEITKSAEAG 709
Cdd:COG4772    432 LPGLGLLYQLTDNLQL------YA----NVSR--------------GFEPP---TFGDLAYGNGGNPDLKPEKSWNYELG 484

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  710 AEiGLFDNRIKLDLSVYNTNSINQIlkVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQKDFSWDINLNYSRNRSKV 789
Cdd:COG4772    485 TR-GRIGNGLSAEVALFYIDYDNEL--GSCSAAGGDRSTFTNAGETRHQGLELALDYDLLKGGGLGLPLFAAYTYTDAEF 561


                   ..
gi 1272249726  790 TE 791
Cdd:COG4772    562 TS 563
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 118-239 5.13e-18

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 80.39  E-value: 5.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  118 EKKSLGYAVQELKSKDIATAKETNLINSLAGkIAGVQTTNSQGDmGSSRIIIRGetsiSGNNQPLFVVDGVPvdnsqnlg 197
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSVSSGGGG-GGSSISIRG----FGSNRVLVLVDGVP-------- 66

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1272249726  198 IAGSRDFANTISDINSEDIESISVLKGPnAAALYGSRAAAGV 239
Cdd:pfam07715   67 LNSGGGGSVDLNSIDPEDIERVEVLKGP-ASALYGSGAIGGV 107
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-110 1.02e-17

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 78.79  E-value: 1.02e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   28 ITGTVTGNPDGETIPGASIIIKGKKSGTTTDGNGKFSLAA--DVNDVLSISYLGYATKEITITAA---TATLNITLDVAS 102
Cdd:pfam13715    1 ISGTVVDENTGEPLPGATVYVKGTTKGTVTDADGNFELKNlpAGTYTLVVSFVGYKTQEKKVTVSndnTLDVNFLLKEDA 80


                   ....*...
gi 1272249726  103 NALSEVVV 110
Cdd:pfam13715   81 LLLDEVVV 88
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 72-791 9.72e-17

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 85.33  E-value: 9.72e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   72 VLSISYLGYATKEITITAATATlnitlDVASNALSEVVVTAlgisKEKKSLGYAVqelksKDIATAKETNL--------- 142
Cdd:COG4773      4 LLAGSGLAAAAAGALAQAAAAA-----AAEATTLPEVTVTG----TAEGTGGYTA-----KSSSTATKLDTplretpqsv 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  143 ---------------INSLAGKIAGVQTTNSQGDmGSSRIIIRGetsISGNNqplFVVDGVPVDNSQNlgiagsrdfant 207
Cdd:COG4773     70 svvtrqliedqgattLDDALRNVPGVTVSSYDGG-GRDSFSIRG---FSIDN---YLRDGLPLGGFGG------------ 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  208 iSDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKTGRGQKGLGISVNSNttfsnlltlpdyqnSFGQGTSGkfsfV 287
Cdd:COG4773    131 -GQPDTANLERVEVLKGP-AGLLYGAGSPGGLVNLVTKRPTAEPQGEVSLSAG--------------SWDTYRAT----A 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  288 DGkGGGVNDgvDESWGpaldGRLIpqfnskgvavpfiahpdnvknffetgyalnngiaiaGSGEKQDvrfSYnnltqggi 367
Cdd:COG4773    191 DV-GGPLNE--DGTLR----YRLN------------------------------------AAYEDGD---SF-------- 216

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  368 LPNSSQDKNSLLLNTSYRITPKLTLNASANYIKSnadnlpasggkRATGPMLQFTWFGRQVDVSQLKNYkdenGNDFNWN 447
Cdd:COG4773    217 RDGVDNRRTLIAPSLDWDLTDDTTLTLGAEYQDD-----------DSTGDRGFLPLDGTLLDLPRSTNL----GEPWDYY 281

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  448 NsyysnpyfiayentvgqkRDRIIGNAELNYKITSALSANFRTGNDYYTDRRKIKIAYGTNGTPFGSYEEDAYTVNENNT 527
Cdd:COG4773    282 D------------------TETTTLFAELEHRFNDDWSLRANARYSDSDRDGRSAYAYGAPDAATGTLTRYASARDGDSR 343

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  528 EGRLEFNkkLNSDFSI-----DILGGGNIRTSTFEQNDQKATKLAVNGLYTLSNSRDPLVSSNFYSKLRTYSLFGSAQLG 602
Cdd:COG4773    344 SDSLDAN--LNGKFETgglehTLLVGADYSRYDSDSDSATAGTINIYNPVYGNLPEPDFDASDTDTTTRQTGLYAQDQIS 421

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  603 FRDYAYLNLTARNDWdsslpepnlsyfYPSVNGSLILTEAFDIKSDVLSFakiRGGWSkvgkatdpYQLINTY----SFT 678
Cdd:COG4773    422 LTDRLSLLLGGRYDW------------YETDSTNRLGGSTTSYDDSAFTP---RAGLV--------YDLTPGLslyaSYS 478

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  679 APFdgNPQqsaNTIDLNPNLL-PEITKSAEAGAEIGLFDNRIKLDLSVYNtnsINQ--ILKVDVSSATGYTQklinGGSI 755
Cdd:COG4773    479 ESF--EPQ---SGADNNGNPLdPETGKQYEAGVKGELFDGRLNATLAVFD---ITQknVATTDPDNPNFYVQ----VGEV 546

                          730       740       750
                   ....*....|....*....|....*....|....*.
gi 1272249726  756 NNKGIEIQLGLTPIKQkdfsWDINLNYSRNRSKVTE 791
Cdd:COG4773    547 RSRGVELELSGELTPG----LNLIAGYTYTDAKITK 578
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
151-791 9.33e-15

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 78.77  E-value: 9.33e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  151 AGVQTTNSQGDMGSsRIIIRGETSISGnnqplFVVDGVPVDNSQNlgiagsrdfantisdINSEDIESISVLKGPnAAAL 230
Cdd:COG4774     37 PGVTFGAGEGGNGD-SFSIRGFSASGD-----IYVDGLRDPGQYR---------------RDTFNLERVEVLKGP-ASVL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  231 YGSRAAAGVILIKTKTgrgqkglgisvnsnttfsnlltlPdyqnSFGQGTSGKFSFvdgkgggvndGVDESWGPALDgrl 310
Cdd:COG4774     95 YGRGSPGGVINLVTKR-----------------------P----TDEPFTEVTLTY----------GSDGQRRATLD--- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  311 ipqfnskgvavpfiahpdnvknffeTGYALNNGIA--IAGSGEKQDVRFSYNNLTQGGILPnssqdknSLllntSYRITP 388
Cdd:COG4774    135 -------------------------VNGPLGDDLAyrLNGMYRDSDSYRDGVDNDRWGIAP-------SL----TWRLGD 178

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  389 KLTLNASANYIKSnaDNLPASGgkratgpmLQFTWFGRQVDVSQLKNYkdengndfNWNNSYYsnpyfiayentvgqKRD 468
Cdd:COG4774    179 RTRLTLDYEYQDD--DRTPDYG--------VPAVANGRPVDVDRSTFY--------GQPDDYS--------------DSE 226

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  469 RIIGNAELNYKITSALSANFRTGndYYTDRRKIKIAYGTNGTPFGSYEEDAYTVNENNT--EGRLEFNKKLNS-DFSIDI 545
Cdd:COG4774    227 TDSATLRLEHDFNDNWTLRNALR--YSDYDRDYRNTYPTGGNATGTVTRSAYRRDQDNDtlSNQTDLTGKFDTgGVKHTL 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  546 LGGGNIRTSTFEQNDQKATKLAV-----NGLYTLSNSRDPLVSSNFYSKLRTYSLFGSAQLGFRDYAYLNLTARNDWdss 620
Cdd:COG4774    305 LAGVEYSREDSDNARYSGGGTAPtvnlyNPVYGAPVTGPTLGGADNDSRTDTTGLYLQDTISLTDRWSLLAGLRYDR--- 381

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  621 lpepnlsyfypsvngslILTEAFDIKSDVLSFAKIRGGWS-KVG---KATDPyqlINTY-----SFTaPFDGNPQQSANT 691
Cdd:COG4774    382 -----------------FDTDYTDRTTGATTSSYDDSAFSpRAGlvyKPTPN---LSLYasystSFN-PGGGAPSLSNAG 440

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  692 IDLNPnllpEITKSAEAGAEIGLFDNRIKLDLSVYNTNSINqILKVDVSSATGYTQklinGGSINNKGIEIQLGLTPIKQ 771
Cdd:COG4774    441 QALDP----EKSRQYEVGVKWDLLDGRLSLTAALFRIEKTN-VRTTDPANPGVYVQ----TGEQRSRGVELEATGELTPG 511

                          650       660
                   ....*....|....*....|
gi 1272249726  772 kdfsWDINLNYSRNRSKVTE 791
Cdd:COG4774    512 ----WSVLAGYTYLDAEITK 527
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 440-784 2.88e-14

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 76.73  E-value: 2.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  440 NGNDFNWNNSYYSNPYFIAYENTVGQKRDRIIGNAELNYKITSALSANFRTGNDYYTDRRKIKIAYGTNGTPFGSYEEDA 519
Cdd:pfam00593   33 TLDGYGNDGGYLGDRPLYYGRDYSDTDRKRLSLGYDYDLGDGLSWLSTLRLGLRYSSLDGDYTSNSSGLSGAGDYLSDDR 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  520 YTVNENNTegrleFNKKLNSDFSIDILGGGNIRTSTFEQNDQKATKlavnglYTLSNSRDPLVSSNFYSKLRTYSLFGSA 599
Cdd:pfam00593  113 LYGLYGLD-----GDLELSLDLSHDLLLGVELRTAGLDYRRLDDDA------YDPYDPANPSSSSYSDTTTDSYGLYLQD 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  600 QLGFRDYAYLNLTARNDWDSSLPEPNLSYFYPSVNGSLILTEAFDIKSDVLSFAKIRGGWSKVGKATDPYQLINTYSFTA 679
Cdd:pfam00593  182 NIKLTDRLTLTLGLRYDHYSTDGDDGNGGGDNFSRSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSGGG 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  680 PFDGNPQqsantidlNPNLLPEITKSAEAGAEigLFDNRIKLDLSVYNTNSINQILKV-DVSSATGYTQKLINGGSINNK 758
Cdd:pfam00593  262 GGAVAGG--------NPDLKPETSDNYELGLK--YDDGRLSLSLALFYIDIKNLITSDpDGPGLGGTVYTYTNVGKARIR 331

                          330       340
                   ....*....|....*....|....*.
gi 1272249726  759 GIEIQLGLTPikqkdfsWDINLNYSR 784
Cdd:pfam00593  332 GVELELSGRL-------WGLGLSGGG 350
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
89-245 9.18e-12

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 69.29  E-value: 9.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   89 AATATLNITLDVASNALSEVVVTALgiSKEKKSLGYAVqeLKSKDIATAKETNLINSLAGKIAGVQTT-NS-QGDMGSSR 166
Cdd:PRK13524    22 AAEAEDAKTDDTPASHEDTIVVTAA--EQNLQAPGVST--ITAEDIRKRPPANDVSEIIRTMPGVNLTgNStSGQRGNNR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  167 II-IRGetsiSGNNQPLFVVDGVPVD--NSQNLGIAGSRDfanTISDIN---SEDIESISVLKGPnAAALYGSRAAAGVI 240
Cdd:PRK13524    98 QIdIRG----MGPENTLILIDGKPVSsrNSVRYGWRGERD---TRGDTNwvpPEMIERIEVLRGP-AAARYGNGAAGGVV 169


                   ....*
gi 1272249726  241 LIKTK 245
Cdd:PRK13524   170 NIITK 174
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 87-245 2.02e-11

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 68.24  E-value: 2.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   87 ITAATATLNITLDVASNALSEVVVTALGISKEKKSLGYAVQELK---------SKDIATAKETNLINSLAGKIAGVQTT- 156
Cdd:PRK13528     5 VNKILWLLTVLLVGLNSPVSAAESSDDDNGETMVVEATAEQELKqqpgvsiitAEDIKKRPPVNDLSDIIRKMPGVNLTg 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  157 -NSQGDMGSSRII-IRGetsiSGNNQPLFVVDGVPVD--NSQNLGIAGSRDfanTISDIN---SEDIESISVLKGPnAAA 229
Cdd:PRK13528    85 nSASGTRGNNRQIdIRG----MGPENTLILIDGVPVTsrNSVRYSWRGERD---TRGDTNwvpPEMVERIEVIRGP-AAA 156

                          170
                   ....*....|....*.
gi 1272249726  230 LYGSRAAAGVILIKTK 245
Cdd:PRK13528   157 RYGSGAAGGVVNIITK 172
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 215-245 4.39e-10

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 55.28  E-value: 4.39e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1272249726  215 DIESISVLKGPNAAALYGSRAAAGVILIKTK 245
Cdd:TIGR04057    1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
28-98 8.28e-10

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 56.13  E-value: 8.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   28 ITGTVTgNPDGETIPGASIIIK----GKKSGTTTDGNGKFSLAADV--NDVLSISYLGYAT---KEITITA-ATATLNIT 97
Cdd:pfam13620    2 ISGTVT-DPSGAPVPGATVTVTntdtGTVRTTTTDADGRYRFPGLPpgTYTVTVSAPGFKTatrTGVTVTAgQTTTLDVT 80


                   .
gi 1272249726   98 L 98
Cdd:pfam13620   81 L 81
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 149-630 3.98e-07

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 53.96  E-value: 3.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  149 KIAGVQTTNSQGDMGSSRIIIRG---ETSISGnnqplFVVDGVPVDNSQNLGIagsrdfantisdINSEDIESISVLKGP 225
Cdd:TIGR01783   28 RVPGVVVGGSGGTTQFGNITIRGfglEVDIDN-----VYLDGVPLLSRGNLAI------------VDPAMVERVEVLRGP 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  226 NaAALYGSRAAAGVILIKTK------TGRGQKGLGISVNSNTTFSNLLTLPDyQNSF-----GQGTSGKfSFVDGKGGGV 294
Cdd:TIGR01783   91 A-SLLYGGSAPGGVINIVTKrpqdepKGSVTFGAGTRSGYRTAFDLGGPLGA-DGTFrgrlnGARQDGD-SFYDGAGEET 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  295 NDGvdeswGPALDgrlipqfnskgvavpfIAHPDNVKNFFETGY------ALNNGIAIAGSGEKQDVRFSYNNLTQGGIL 368
Cdd:TIGR01783  168 RLG-----ATATD----------------WQLDDRTLLRLGAYYqkerdrGGYGGLPASGGTSGRDLSSDRYLGTSSNRN 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  369 PNSSQDKNSLLLnTSYRITPKLTLNASANYIKSNADNLPASGGKratgpmlqFTWFGRQVDVSQLKNYKDENGNDFNWN- 447
Cdd:TIGR01783  227 YDDREYLSYGLS-LEYQFNDVWTGKQNLRYSYFDTDSNQVQASG--------YSSDGGLFGRSLTVVNVKQDRVQIDAGl 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  448 ----NSYYSNPYFIAYENTVGQKRDRIIGNAELNYKItsalsanfrtgnDYYTdrrkikiAYGTNGTPFGSYEEDAYTVN 523
Cdd:TIGR01783  298 dgefETGPIEHDLLLGVSYGQRTTNRFNNTGYPSDNI------------YSLT-------ATSSARTDIGDSPKDRALSS 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  524 ENNTEGR-LEFNKKLNSDFSIdILGGgnirtsTFEQNDQKATKlAVNGLYTLSNSRDPLVSSNF-YSKLRTYSLFGSAQL 601
Cdd:TIGR01783  359 TTKALNGvALQRILLADKWTL-TLGG------RYDSVDVKSNN-GVAGSTGKRDDSQFTPSLGVaYKPTDDWSLYASYAE 430

                          490       500
                   ....*....|....*....|....*....
gi 1272249726  602 GFRDYAYLNLTArnDWDSSLPEPNLSYFY 630
Cdd:TIGR01783  431 SFKPGGYYPKGA--GNSGDILEPEKGKNY 457
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 87-262 1.02e-06

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 52.96  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   87 ITAATATLNITLDVASNALSEVVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLaGKIAGVQTTNSqgdmGSSR 166
Cdd:PRK10064    12 LCASAISCAWPVLAVDDDGETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQLTNE----GDNR 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  167 --IIIRGETSisgnNQPLFVVDGVPVdNSQNLGIAGSrDFanTISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKT 244
Cdd:PRK10064    87 kgVSIRGLDS----SYTLILIDGKRV-NSRNAVFRHN-DF--DLNWIPVDAIERIEVVRGP-MSSLYGSDALGGVVNIIT 157

                          170
                   ....*....|....*...
gi 1272249726  245 KTgRGQKGLGiSVNSNTT 262
Cdd:PRK10064   158 KK-IGQKWHG-TVTVDTT 173
PRK13486 PRK13486
TonB-dependent receptor;
85-265 7.06e-06

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 50.02  E-value: 7.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   85 ITITAATATLNITLDVASNALSE--VVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLAGkIAGVQTTNSQGDM 162
Cdd:PRK13486     3 ITTLASVVIPCLGFSASSIAAAEdvMIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  163 GSSRIIIRGETSisgnNQPLFVVDGVpvdnSQNlgiaGSRDFA-NTISDINS------EDIESISVLKGPnAAALYGSRA 235
Cdd:PRK13486    82 GGLEISIRGMPA----SYTLILIDGV----RQG----GSSDVTpNGFSAMNTgfmpplAAIERIEVIRGP-MSTLYGSDA 148

                          170       180       190
                   ....*....|....*....|....*....|
gi 1272249726  236 AAGVILIKTKTGRGQKGLGISVNSNTTFSN 265
Cdd:PRK13486   149 MGGVVNIITRKNADKWLSSVNAGLNLQESN 178
PRK09840 PRK09840
catecholate siderophore receptor Fiu; Provisional
 676-791 2.18e-05

catecholate siderophore receptor Fiu; Provisional


Pssm-ID: 182105 [Multi-domain]  Cd Length: 761  Bit Score: 48.65  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  676 SFTAPFDGNPQqSANtidlNPNLLPEITKSAEAGAEIGLFDNRIKLDLSVYNTNSINQILKVDVSSATGYTQKLINGGSI 755
Cdd:PRK09840   545 NFALAQSGSGN-SAN----RTDFKPQKANTSEIGTKWQVLDKRLLLTAALFRTDIENEVEQNDDGTYSQYGKKRVEGYEL 619

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1272249726  756 NNKGieiqlGLTPikqkdfSWDINLNYSRNRSKVTE 791
Cdd:PRK09840   620 SVAG-----NITP------AWQVIAGYTQQKATVKN 644
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
108-268 1.40e-04

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 45.77  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  108 VVVTALGISKEKKSLGYAVQELKSKDIatakETNLINSLAGKIAGVQTTNSQGDMGSSRIIIRGetsISGNnQPLFVVDG 187
Cdd:PRK13484    33 LVVTASGFTQQLRNAPASVSVITSEQL----QKKPVSDLVDAVKDVEGISITGGNEKPDISIRG---LSGD-YTLILVDG 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  188 VPvDNSQNLGIAGSRDF-ANTISDInsEDIESISVLKGPnAAALYGSRAAAGVILIKTK-----TGRGQKGLGISVNSNT 261
Cdd:PRK13484   105 RR-QSGRESRPNGSGGFeAGFIPPV--EAIERIEVIRGP-MSSLYGSDAIGGVINIITKpvnnqTWDGVLGLGGIIQEHG 180


                   ....*..
gi 1272249726  262 TFSNLLT 268
Cdd:PRK13484   181 KFGNSTT 187
PRK13513 PRK13513
ligand-gated channel protein;
85-263 1.81e-04

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 45.53  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726   85 ITITAATATLNITLDVASNaLSEVVVTALGISKEKKSLGYAVQELKSKDIATAKETNLINSLAgKIAGVQTTnsqGDMGS 164
Cdd:PRK13513    16 AAAISSQAYAAEKTNTATP-TDTMVVTASGFQQRIQDAPASISVVTREQLENKAYRDVTDALK-DVPGVVVT---GGGST 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  165 SRIIIRGETSisgnNQPLFVVDGVPVD------NSQNLGIagSRDFANTIsdinsEDIESISVLKGPnAAALYGSRAAAG 238
Cdd:PRK13513    91 SDISIRGMAA----KYTLILVDGKRVDtrstrpNSDGSGI--EQGWLPPL-----AAIERIEVVRGP-MSSLYGSDAMGG 158

                          170       180
                   ....*....|....*....|....*
gi 1272249726  239 VILIKTKtgRGQKGLGISVNSNTTF 263
Cdd:PRK13513   159 VINIITR--KVQKEWHGSLRADATL 181
OMP_b-brl_3 pfam14905
Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB ...
 695-790 7.04e-04

Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.


Pssm-ID: 434300 [Multi-domain]  Cd Length: 407  Bit Score: 43.42  E-value: 7.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  695 NPNLLPEITKSAEAGAeigLFDNRIKLDLSVYNTNSINQILKVDVSSATGYTQKLINGGSINNKGIEIQLGLTPIKQKDF 774
Cdd:pfam14905  209 NPNLKPEYTNSFELGY---TYKWKLSLSLSYRYTNDVIQQTFITDDNDNVTYTTYENLGKSNSYGLELSASFNPTKWWSL 285

                           90
                   ....*....|....*.
gi 1272249726  775 SWDINLNYSRNRSKVT 790
Cdd:pfam14905  286 NGNLNGYYNKYKIDGS 301
btuB PRK10641
TonB-dependent vitamin B12 receptor BtuB;
160-257 1.62e-03

TonB-dependent vitamin B12 receptor BtuB;


Pssm-ID: 236730 [Multi-domain]  Cd Length: 614  Bit Score: 42.29  E-value: 1.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1272249726  160 GDMG-SSRIIIRGETSisgnNQPLFVVDGVPVDNSqnlGIAGSRDfantISDINSEDIESISVLKGPNAAaLYGSRAAAG 238
Cdd:PRK10641    78 GGLGqLSSLFIRGTNS----SHVLVLIDGVRLNQA---GISGSAD----LSQIPISLVQRIEYIRGPRSA-VYGSDAIGG 145

                           90
                   ....*....|....*....
gi 1272249726  239 VILIKTKtgRGQKGLGISV 257
Cdd:PRK10641   146 VVNIITT--RDKPGTTLSA 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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