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Conserved domains on  [gi|1269637131|gb|ATO58580|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Homotherium latidens]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-232 1.23e-56

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 189.33  E-value: 1.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00110  154 LVGSLPLLVALLYIQNNLGSLNFLLLQLWAQPLPNSWSNNLLWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00110  234 ILLKLGGYGMMRITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGAT 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMAS 232
Cdd:MTH00110  314 ALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSS 385
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-232 1.23e-56

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 189.33  E-value: 1.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00110  154 LVGSLPLLVALLYIQNNLGSLNFLLLQLWAQPLPNSWSNNLLWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00110  234 ILLKLGGYGMMRITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGAT 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMAS 232
Cdd:MTH00110  314 ALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSS 385
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 3-232 2.31e-12

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 66.18  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   3 G*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL**** 82
Cdd:pfam00361  45 GSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSGLLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAATL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  83 ********************************************************SHMALVIVAI********MGATAL 162
Cdd:pfam00361 125 VKAGGYGLIRRSLLYLPSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFH 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269637131 163 MIAHGLTS*MLFCLANS************A-RGLQTVL****************LPPSINLIGELFVVMAS 232
Cdd:pfam00361 205 LLTHGLFSAGLFLCAGSVIYRRVHTRNIRDyGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAA 275
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 1-78 2.41e-10

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 60.87  E-value: 2.41e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSnIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:COG1008   171 LAGSLLMLVAILALYFLAGALTFDIAELAAAPLPLTAQ-LLLFLAFFIAFAVKVPMFPFHTWLPDAHVEAPTAGSVLL 247
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-78 1.98e-07

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 51.86  E-value: 1.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269637131   1 LTG*LPLLVALTYIQNTTGtLNFLIIQYWALPISTTWsNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:TIGR01972 166 LAGSLLMLLAILGLYFLGG-GTFDLLELLNLPLPFGV-QTWLFLAFFIAFAVKVPLFPLHTWLPDAHVEAPTAGSVIL 241
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-232 1.23e-56

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 189.33  E-value: 1.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00110  154 LVGSLPLLVALLYIQNNLGSLNFLLLQLWAQPLPNSWSNNLLWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00110  234 ILLKLGGYGMMRITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGAT 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMAS 232
Cdd:MTH00110  314 ALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSS 385
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-231 1.79e-37

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 138.41  E-value: 1.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00124  154 LISSLPLLIAILYLHNQTGTLSLPMLQLTHPTLTNSWTNLLLWLACLMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00124  234 ILLKLGGYGIIRITLLLPPLSNTLHYPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAM 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMA 231
Cdd:MTH00124  314 ILMIAHGLTSSMLFCLANTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTS 384
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-231 2.84e-35

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 132.35  E-value: 2.84e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00068  154 LAGSLPLLIALLILQNSLGSLSLILLELMSPMQLMTYTNKIWWLACLLAFMVKMPLYGLHLWLPKAHVEAPIAGSMILAA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00068  234 VLLKLGGYGILRISILLTPLSKELSYPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQTPWSFSGAI 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMA 231
Cdd:MTH00068  314 ILMISHGLTSSALFCLANTNYERTHSRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVS 384
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-229 8.35e-34

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 128.53  E-value: 8.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00127  155 LAGSLPLLVALLLLQNSTGTLSMLTLQYSQPLQLSSWADKLWWAGCLLAFLVKMPLYGVHLWLPKAHVEAPIAGSMVLAA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00127  235 VLLKLGGYGMMRMMVMLDPLTKELSYPFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQTPWGFTGAL 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVV 229
Cdd:MTH00127  315 ILMIAHGLTSSALFCLANTNYERTHSRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMII 383
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-231 2.19e-27

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 110.41  E-value: 2.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALpisTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00206  153 LIGSLPLLIALLFLQNSLGSLSLYILYFSKL---TTWNNNLWWLACILAFLVKLPLYGVHLWLPKAHVEAPVAGSMVLAG 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00206  230 VLLKLGGYGMMRIILILGPSTKLSSYFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGSPWGFKGAL 309

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMA 231
Cdd:MTH00206  310 LLMIAHGLVSSALFCLANLLYERSHTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITS 380
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-229 2.93e-23

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 98.89  E-value: 2.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00044  155 LFGSLPLLISLIAIYSSSSSLSIPLSELNWLTSLSSNSSSIWWIFCILAFLVKMPIYGFHLWLPKAHVEAPVAGSMILAA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 ************************************************-**********SHMALVIVAI********MGA 159
Cdd:MTH00044  235 ILLKLGGYGLIRLINLFSLPSANNISFILIVFCCWGALITSIICLRQTdLKALIAYSSVGHMSLVAAGIFSGTNWGINGA 314

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131 160 TALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVV 229
Cdd:MTH00044  315 LILMIAHGLVSSALFCLANILYERSGTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLII 384
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 1-230 7.90e-18

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 83.11  E-value: 7.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIiqYWALPISTTWSNIFlWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00205  149 LCASLPLLIGLFFLNSLNFSLSMFF--NFPLNFSDFYLFLY-WIFLMLAFLVKLPMYFVHLWLPKAHVEAPVSGSMILAG 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00205  226 VLLKLGGYGLIRITSMLYKLNSNFSELFFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAI 305

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVM 230
Cdd:MTH00205  306 IMMVAHGLCSSGMFALANVNYERTNSRSMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIM 375
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-226 3.84e-17

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 81.33  E-value: 3.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWAlpiSTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00014  151 VTASLPLLMSILLIFYTNNSLSMLMSSMEP---PSIYLMNLWWLITILAFMVKMPLYTVHLWLPKAHVEAPVAGSMILAG 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00014  228 ILLKLGGYGLLRMSSLFMHINKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWGWQGAL 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGEL 226
Cdd:MTH00014  308 AMMIAHGLCSSALFALANMTYETTHTRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEI 373
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-178 3.29e-16

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 78.27  E-value: 3.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWAlpisttWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00163  148 LFASLPLLVGIFYLYNNSGSLSFFLLNFFG------SLNFLWYLSMILAFLVKMPMFFVHLWLPKAHVEAPVSGSMILAG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00163  222 VLLKLGGYGLLRVMSFFSKLGLKFNYIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSL 301

                         170
                  ....*....|....*...
gi 1269637131 161 ALMIAHGLTS*MLFCLAN 178
Cdd:MTH00163  302 LMMIGHGLCSSGLFCLAN 319
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 1-231 9.83e-16

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 76.80  E-value: 9.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWsniFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL** 80
Cdd:MTH00150  116 VGASLPLLLVILWMSSSYGSSFMLLISSLRKLLSSMG---LWGLLVFLAFLVKLPMYPFHLWLPKAHVEAPVAGSMILAG 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  81 **********************************************************SHMALVIVAI********MGAT 160
Cdd:MTH00150  193 ILLKLGGYGILRMMMVFSLSSSSFSIFLISLSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGAL 272

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269637131 161 ALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMA 231
Cdd:MTH00150  273 IMMVSHGFCSSGLFCLANYTYEKVHSRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPS 343
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 3-232 2.31e-12

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 66.18  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   3 G*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL**** 82
Cdd:pfam00361  45 GSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSGLLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAATL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  83 ********************************************************SHMALVIVAI********MGATAL 162
Cdd:pfam00361 125 VKAGGYGLIRRSLLYLPSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFH 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269637131 163 MIAHGLTS*MLFCLANS************A-RGLQTVL****************LPPSINLIGELFVVMAS 232
Cdd:pfam00361 205 LLTHGLFSAGLFLCAGSVIYRRVHTRNIRDyGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAA 275
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 1-78 2.41e-10

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 60.87  E-value: 2.41e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSnIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:COG1008   171 LAGSLLMLVAILALYFLAGALTFDIAELAAAPLPLTAQ-LLLFLAFFIAFAVKVPMFPFHTWLPDAHVEAPTAGSVLL 247
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 1-78 4.02e-09

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 57.13  E-value: 4.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYI----QNTTGTlnFLIIQYWALPISTTWSnIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSM 76
Cdd:PRK05846  171 LLGSLLMLVAIIYLvvvyYNATGT--FDIADLLNLPLPPGVQ-YWLFLAFFIAFAVKMPMFPLHTWLPDAHVQAPTAGSV 247


                  ..
gi 1269637131  77 VL 78
Cdd:PRK05846  248 LL 249
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 1-232 3.97e-08

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 54.16  E-value: 3.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFL-IIQYWALPISTTWSNIFLWL***MAfmVKMPLYGLHLWLPKAHVEAPIAGSMVL* 79
Cdd:MTH00226  192 LIGSVLMLLCLFSLYNIHGTTDYLtLASCSHVVSEQTQKWIFLGIFLAMA--VKIPIFPFHIWLPKAHVEAPVAGSVLLA 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269637131  80 *************************************************-**********SHMALVIVAI********MG 158
Cdd:MTH00226  270 GILLKLGGYGLVRLSWPILPLGAQNLAPAVIAMGIVGIVYGSFATCRQIdVKRLVAYSSVAHMGLVSITLVTHDIIGLTG 349

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1269637131 159 ATALMIAHGLTS*MLFCLANS************ARGLQTVL****************LPPSINLIGELFVVMAS 232
Cdd:MTH00226  350 SIFIMLAHGIVSSLLFILVTILYDRHHTRLIKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSS 423
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-78 1.98e-07

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 51.86  E-value: 1.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269637131   1 LTG*LPLLVALTYIQNTTGtLNFLIIQYWALPISTTWsNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:TIGR01972 166 LAGSLLMLLAILGLYFLGG-GTFDLLELLNLPLPFGV-QTWLFLAFFIAFAVKVPLFPLHTWLPDAHVEAPTAGSVIL 241
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 39-78 3.19e-07

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 51.06  E-value: 3.19e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1269637131  39 NIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:MTH00094  150 SWEMFFILSLSFMMKFPVYFLHLWLPKAHVEAPTTASMLL 189
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 1-78 1.19e-06

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 49.68  E-value: 1.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTtwsNIFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:MTH00204  173 FAGSVFMLLGIFQLYSITGTTDYQILLNIKLPLSI---QKWLLVGFFLSLAVKIPQIPFHIWLPQAHVEAPVAGSVIL 247
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 41-78 4.29e-05

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 44.66  E-value: 4.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1269637131  41 FLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:MTH00217  207 FIFLGFFLSLAIKIPKIPFHIWLPQAHVEAPVAGSVIL 244
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 40-78 9.12e-04

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 40.79  E-value: 9.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1269637131  40 IFLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:PRK12561  185 LLLYAGFLIAFGVKLPIFPLHTWLPDAHGEASAPVSMIL 223
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 1-78 1.68e-03

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 39.75  E-value: 1.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269637131   1 LTG*LPLLVALTYIQNTTGTLNFLIIQYWALPISTTWSNIfLWL***MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVL 78
Cdd:COG0651   167 LVGSALFLLGVGLLYGATGTLNMADLAARLAELDPGLLLA-AFALLLVGFGIKAALFPLHFWLPDAYPAAPSPVSALL 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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